Mussel-Inspired Hemostatic Hydrogel Adhesive Formulated from a Gelatin-Oxidized Dextrin Double Network.

Hydrogels are recognized for their excellent biocompatibility and biodegradability, making them promising candidates for hemostatic materials, especially in cases of intra-abdominal bleeding or injury to vital organs. In this study, a mussel-inspired adhesive hemostatic hydrogel, GMOD, is developed, which features injectability, outstanding biocompatibility, and biodegradability. The hydrogel is synthesized through Schiff base crosslinking of oxidized dextran and gelatin, enhanced with dopamine to form a robust double network structure.

A Biocompatible 4D Printing Shape Memory Polymer as Emerging Strategy for Fabrication of Deployable Medical Devices.

The rapid development of 4D printing provides a potential strategy for the fabrication of deployable medical devices (DMD). The minimally invasive surgery to implant the DMD into the body is critical, 4D printing DMD allows the well-defined device to be implanted with a high-compacted shape and transformed into their designed shape to meet the requirement. Herein, a 4D printing tissue engineering material is developed with excellent biocompatibility and shape memory effect based on the photocrosslinked polycaprolactone (PCL).

Comparison of the efficacy of rivaroxaban and dabigatran etexilate in preventing venous thrombosis after arthroplasty: A protocol of randomized controlled trial.

Background:: New oral anticoagulants (NOAC) are gradually accepted by clinical practice for its convenient route of administration and stable effect. Both rivaroxaban and dabigatran etexilate have been used in the prevention and treatment of venous embolism after arthroplasty, but there is a lack of direct comparison between the 2 effects. Therefore, the purpose of this randomized controlled trial was to evaluate the efficacy and safety of 2 new oral anticoagulants, rivaroxaban, and dabigatran etexilate, in the prevention of venous thromboembolism after joint replacement.