Analysis of clinical characteristics, diagnosis, treatment, and postoperative outcomes in deep infiltrating endometriosis: a retrospective study.

Objectives: To investigate the clinical characteristics of deep infiltrating endometriosis (DIE), summarize the experiences in its diagnosis and management, and identify potential peripheral blood indicators associated with the severity of pelvic adhesions.

Methods: Clinical data were collected from 185 patients with pathologically confirmed DIE admitted to Wuxi Maternal and Child Health Hospital between January 2015 and December 2024. A retrospective analysis was conducted on the general information, perioperative conditions, postoperative pregnancy outcomes, and recurrence status in patients with DIE.

Bladder Erosion and stone formation: a rare complication of laparoscopic cervical cerclage.

Background: Cervical cerclage represents a practical approach to addressing cervical insufficiency, but it also can bring serious complications. We present an extremely rare case of bladder erosion caused by the exposure of Mersilene tape after laparoscopic cervical cerclage for 3 years, which resulted in the formation of bladder calculi.

Case Presentation: The patient was a 35-year-old gravida 5 para 2 female with symptoms suggestive of urinary tract infections after 3 years of exposure to the Mersilene tape, including urinary frequency urinary urgency and painful micturition.

Elucidating the impact of intermolecular forces on the formation and internal structure of high-methoxyl pectin aggregates.

Achieving controllable aggregation of high-methoxyl pectin (HMP) and regulating the structure of resulting aggregates is crucial for tailored functional properties. We investigated the aggregation of HMP and the internal structure of HMP aggregates at varying conditions of SDS, urea, pH and NaCl, aiming to reveal the impact of different intermolecular forces. We discovered that HMP molecules self-assembled into aggregates comprising hydrophilic microdomains enclosing discrete hydrophobic microdomains.

Impact of Lactobacillus plantarum fermentation on the structural, physicochemical, emulsification, and digestibility properties of foxtail millet protein.

The digestibility of foxtail millet protein is greatly limited by its intrinsic structure. This study was aimed to assess the effect of fermentation on the structural, physicochemical, and digestibility properties of foxtail millet protein. Results showed that fermentation increased the porosity and roughness of protein particles, while producing small-molecule proteins and peptides.

The role of cholesterol/AlkB homolog 1/Integrin alpha 2b in thrombosis in the placental vessels of preeclampsia†.

The risk of multiple placental thrombosis is significantly elevated in preeclampsia, and the vascular endothelium plays a vital role in coagulation processes through the secretion of Integrin alpha 2b, von Willebrand factor, and tissue factor. However, the underlying pathological mechanisms remain unclear. In this study, placental blood vessels were collected from both preeclampsia and normal pregnancies.

Identification of exosome-related SERPINB1 as a novel predictor for tumor immune microenvironment and clinical outcomes in ovarian cancer.

Background: With a high global incidence of over three million new cases in 2020 and a high mortality of over two million fatalities, ovarian cancer is one of the most common malignant tumors in gynecology. Exosomes can control the immunological condition of the tumor microenvironment (TME) by participating in intercellular interactions. Therefore, we aimed to construct an exosome-related prognostic model to predict the clinical outcomes of ovarian cancer patients.

Foxtail millet prolamin-pectin nanoparticles enhanced the stability and bioavailability of β-sitosterol.

Herein, β-sitosterol-loaded foxtail millet prolamin (FMP)-pectin composite nanoparticles (FSNs) were successfully produced using an antisolvent precipitation method to encapsulate β-sitosterol and improve its bioaccessibility. Results indicated that the nanoparticles prepared at a FMP-to-pectin mass ratio of 10:2 not only showed lower particle size (401.7 ± 14.

Incomplete Nonpuerperal Uterine Inversion in an Adolescent Girl: A Case Report.

Background: Nonpuerperal uterine inversion (NPUI) is particularly rare and presents a significant diagnostic challenge. This case report describes the youngest case of incomplete NPUI, noteworthy due to the unidentified factor that triggered the uterine inversion.

Case: This case report presents a retrospective analysis of a 19-year-old female patient diagnosed with incomplete uterine inversion, the main symptoms of which were vaginal bleeding, abdominal pain.

CD47 is a tumor cell-derived exosomal signature and regulates tumor immune microenvironment and immunotherapy responses.

Background: The pathogenesis of ovarian cancer (OvCa) involves a complex interplay of genetic, environmental, and hormonal factors. With the in-depth exploration of tumor ecosystem, exosomes can mediate the immunological status of tumor microenvironment (TME). Therefore, we aimed to recognize the tumor-derived exosomes (TEXs) which can distinguish the immune-hot and cold tumors and reflect the immunotherapeutic responses.

FOXL2 Knockdown Inhibits the Progression of Endometriosis.

Problem: Endometriosis (EM) is known as a common estrogen-dependent chronic inflammatory disease. Elevated levels of Forkhead box L2 (FOXL2) have been observed in uterine diseases, including EM. However, the molecular mechanism of FOXL2 in EM needs to be further illustrated.

Emulsifying and ethanol-induced gelling properties of capsicum pectin: The impact of capsicum variety and deproteinization using the Sevag method.

This study investigated the emulsifying and ethanol-induced gelling properties of capsicum pectins from bell pepper and chili pepper, and also examined the effect of deproteinization (using the Sevag method). The research revealed that bell pepper pectin (BPP) formed smaller aggregates (337 nm at pH 2) with a higher hydrophobicity in solution due to its lower molecular weight (2.02 × 10 g/mol) and higher degree of esterification (82.

Pectin from steam explosion-treated citrus peel exhibits good emulsion properties and bioavailability-promoting effect in vitro of nobiletin.

Steam explosion (SE) is a potential method to modify pectin structure, which might be connected to its emulsifying characteristics and the bioavailability of encapsulated polymethoxyflavone like nobiletin. However, the relationship between SE-modified pectin and the bioavailability of encapsulated nobiletin is still unclear. In this study, nobiletin-loaded emulsion was fabricated using citrus pectin modified with SE (0.

The Interaction Effect of Obesity with Sleep Duration on Urinary Incontinence in Adult Females: A Cross-Sectional Study of the NHANES Database.

Introduction: This study aimed to explore the interaction between obesity and sleep duration on urinary incontinence (UI) in adult women.

Methods: Data of adult females were extracted from the National Health and Nutrition Examination Surveys (NHANES) database in 2005-2018 in this cross-sectional study. Weighted univariate and multivariate logistic regression analyses were utilized to screen covariates and investigate the associations of obesity and sleep duration with 3 types of UI, including stress urinary incontinence (SUI), urgency urinary incontinence (UUI), and mixed urinary incontinence (MUI).

Shikonin reduces M2 macrophage population in ovarian cancer by repressing exosome production and the exosomal galectin 3-mediated β-catenin activation.

Background: Shikonin (SK), a naphthoquinone with anti-tumor effects, has been found to decrease production of tumor-associated exosomes (exo). This study aims to verify the treatment effect of SK on ovarian cancer (OC) cells, especially on the production of exo and their subsequent effect on macrophage polarization.

Methods: OC cells SKOV3 and A2780 were treated with SK.

Constructing a Prognostic Model of Uterine Corpus Endometrial Carcinoma and Predicting Drug-Sensitivity Responses Using Programmed Cell Death-Related Pathways.

Uterine Corpus Endometrial Carcinoma (UCEC) is the most common type of cancer that develops in the uterus, specifically originating from the endometrium, the inner lining of the uterus. Programmed cell death (PCD) is a highly regulated process that eliminates damaged, aged, or unwanted cells in the body. Dysregulation of PCD pathways can contribute to the formation and progression of various cancers, including UCEC.

The role of inflammatory factors and T-cell subsets in the diagnosis of recurrence in epithelial ovarian cancer patients and the effect of olaparin treatment on them.

Background: The aim of the study is to investigate the role of serum inflammatory factors and T-cell subsets in the diagnosis of recurrence in epithelial ovarian cancer patients and the effect of olaparib on inflammatory factor and T-lymphocyte subsets in patients with recurrent epithelial ovarian cancer.

Methods: In this study, 100 patients diagnosed as recurrent epithelial ovarian cancer in our hospital and 100 patients without recurrent epithelial ovarian cancer in the same period were selected. According to the treatment plan, the recurrent patients were divided into conventional therapy group (Paclitaxel and Carboplatin) and combined therapy group (Paclitaxel, Carboplatin, and olaparib).

Clear cell carcinoma arising in an ovarian remnant 19 years after oophoerctomy: case report.

Background: Ovarian remnant syndrome (ORS) is a rare complication that occurs after oophorectomy, characterized by residual ovarian tissue causing pelvic pain, masses, and various symptoms. The clinical manifestations of ORS are nonspecific, and its diagnosis relies on histological examination. Since ORS typically represents a benign ovarian lesion, there have been few reported cases of malignant transformation.

CT radiomics prediction of CXCL9 expression and survival in ovarian cancer.

Background: C-X-C motif chemokine ligand 9 (CXCL9), which is involved in the pathological processes of various human cancers, has become a hot topic in recent years. We developed a radiomic model to identify CXCL9 status in ovarian cancer (OC) and evaluated its prognostic significance.

Methods: We analyzed enhanced CT scans, transcriptome sequencing data, and corresponding clinical characteristics of CXCL9 in OC using the TCIA and TCGA databases.

Gelling properties of lysine-amidated citrus pectins: The key role of pH in both amidation and gelation.

The amidation of pectin by amino acids has been widely applied due to its safety and excellent gelling properties. This study systematically examined the effects of pH on the gelling properties of lysine-amidated pectin during amidation and gelation. Pectin was amidated over the range of pH 4-10, and the amidated pectin obtained at pH 10 showed the highest degree of amidation (DA, 27.

Expression and significance of serum vitamin D and LL-37 levels in infants with bacterial pneumonia.

Objective: To investigate the significance of vitamin D and human antimicrobial peptide LL-37 in the occurrence and development of bacterial pneumonia in infants.

Methods: From January 2021 to January 2022, 80 infants with bacterial pneumonia were selected, including 33 cases of gram-positive bacterial infection (GP) and 47 cases of gram-negative bacterial infection (GN). During the same period, 40 infants who underwent health examination in The Affiliated Hospital of Hangzhou Normal University served as the healthy control group.

IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6.

Background: m6A-RNA modification mediated by the N6-methyladenosine RNA methylation-related molecule methyltransferase-like 3 has been implicated in the progression of endometriosis. However, the functions of other m6A regulators, especially in ovarian endometriosis, remain unknown.

Methods: Three datasets (GSE7305, GSE7307, and GSE37837) with diagnosed ovarian endometriosis were extracted from the Gene Expression Omnibus database.