Study on the mechanical properties and microscopic mechanism of xanthan gum improved red clay.

To mitigate the adverse ecological impacts of inorganic solidified materials on modified red clay and address the issues of low bearing capacity and extensive cracking under hydraulic erosion, this study investigates the use of low-environmental-impact materials to improve the mechanical fracturing of red clay. In this context, this study focuses on modifying red clay using an environmentally friendly biopolymer, xanthan gum (XG). Through a series of laboratory mechanical and microstructural tests, the effects of XG on the mechanical fracturing, California Bearing Ratio (CBR), and microstructural characteristics of red clay are examined.

(R)-STU104 and Brefeldin-A Synergistically Enhance the Therapeutic Effect On IBD By Inhibiting the TAK1-MKK3-P38 Signaling Pathway.

Introduction: Inflammatory Bowel Disease (IBD) imposes a huge burden on both patients and the society. Standard treatments are often ineffective and can lead to adverse effects. Biological Tumor Necrosis Factor (TNF-α) inhibitors, though effective, have issues with immunogenicity and high costs.

Diversity and antibiotic resistance of cultivable bacteria in bulk tank milk from dairy farms in Shandong Province, China.

Introduction: This study systematically analyzed bacterial diversity and antimicrobial resistance (AMR) profiles in bulk tank milk from five dairy farms ( = 30) in Shandong Province, China, to assess public health risks associated with microbial contamination and provide critical data for regional quality control and AMR risk assessment in dairy production systems.

Methods: Total bacterial counts were quantified, revealing significant inter-farm variation ( < 0.05) with a range of 3.

Mycobacterium marinum infection in an older woman with extensive verrucous skin lesions: a case report.

Mycobacterium marinum is a nontuberculous mycobacterium and an opportunistic pathogen which infects humans. Here, we report a case of an 87-year-old female who had extensive verrucous skin lesions on her upper limbs for 18 months. The patient was diagnosed with Mycobacterium marinum infection by pathology and quantitative polymerase chain reaction (qPCR) assay of skin tissue.

The diagnostic value of citrullinated antigens with multiple citrulline similar motif in patients with rheumatoid arthritis.

Background And Aims: Anti-cyclic citrulline peptide (anti-CCP) antibodies are among the most critical biomarkers for the diagnosis of rheumatoid arthritis (RA), with citrullinated antigens being pivotal in triggering their production. This study aimed to explore the potential diagnostic value of multiple citrulline similar-motif antigen (MCSM) in RA.

Material And Methods: A retrospective study was conducted on 135 patients with RA, 112 patients with other joint diseases (non-RA group), and 67 healthy controls from the Hangzhou Red Cross Hospital.

Comparison between tropical legumes and natural grasses in improving tropical rainforest soil health: a case study in guava (Psidium Guajava L.) orchards.

Tropical rainforest soils, or latosols, are distinguished by their low pH and low fertility. In orchards, co-cultivating grass has become popular as a way to improve soil quality and boost fruit production. Nevertheless, insufficient information is currently available about the response of soil microbial communities in tropical rainforest orchards to grass co-cultivation.

Clinical Outcomes and Prognostic Factors in Bullous Pemphigoid Patients: A 15-Year Review in China.

Background: There are limited data on clinical outcomes and prognosis factors for bullous pemphigoid (BP) at long-term follow-up.

Objective: We aimed to investigate the clinical outcomes and prognostic factors in BP patients.

Methods: This retrospective study was performed between January 1, 2009 and December 31, 2023 in Shandong Province, China.

Erythematous Plaques and Nodules in a Child.

A 10-year-old boy presented with plaques and nodules accompanied by itching on his trunk and extremities, persisting for 2 months. Initially, erythematous papules appeared, followed by vesicles that caused pain upon rupture. He was diagnosed with erythema elevatum diutinum (EED), a condition more commonly seen in adults and rarely in children, particularly boys.

Foxtail millet prolamin-pectin nanoparticles enhanced the stability and bioavailability of β-sitosterol.

Herein, β-sitosterol-loaded foxtail millet prolamin (FMP)-pectin composite nanoparticles (FSNs) were successfully produced using an antisolvent precipitation method to encapsulate β-sitosterol and improve its bioaccessibility. Results indicated that the nanoparticles prepared at a FMP-to-pectin mass ratio of 10:2 not only showed lower particle size (401.7 ± 14.

Development and evaluation of optimized PCR and indirect ELISA for the detection of in dairy cows.

Introduction: () is a Gram-negative opportunistic pathogen, whose increasing virulence and antibiotic resistance negatively impact dairy cow health and productivity, raising concerns in livestock health management. To mitigate this risk, rapid and reliable diagnostic methods for detection are essential. Currently, detection methods for are underdeveloped, prompting us to develop both pathogenic and serological detection methods, including an optimized PCR technique and an indirect enzyme-linked immunosorbent assay (I-ELISA).

Strategies for Survival of in Host Cells.

, a common pathogen, is capable of producing a significant array of toxins and can develop biofilms or small colony variants (SCVs) to evade detection by the immune system and resist the effects of antibiotics. Its ability to persist for extended periods within host cells has led to increased research interest. This review examines the process of internalization of , highlighting the impact of its toxins and adhesion factors on host cells.

Targeting CFTR restoring aggrephagy to suppress HSC activation and alleviate liver fibrosis.

Background And Aims: Multiple studies have shown that hepatic fibrosis, a progressive condition that represents the endpoint of various chronic liver diseases, is primarily marked by the extensive activation of hepatic stellate cells (HSCs). However, the exact impact of cystic fibrosis transmembrane conductance regulator (CFTR) on HSCs during the development of hepatic fibrosis remains unclear.

Methods: In our study, we measured CFTR levels in tissue samples and in HSCs activated by TGF-β stimulation.

SERS Analysis Platform Based on Aptamer Recognition-Release Strategy for Efficient and Sensitive Diagnosis of Colorectal Precancerous Lesions.

Background: Colorectal cancer (CRC) has become a significant global public health challenge, demanding immediate attention due to its high incidence and mortality rates. Regular CRC screening is essential for the early detection of precancerous lesions and CRC.

Methods: : We developed a novel surface-enhanced Raman scattering (SERS) analysis platform that employs high-throughput microarray chips as carriers and Au/SnO nanoring arrays (Au/SnO NRAs) as substrates.

Inactivation effects of combined thermosonication and potassium sorbate treatments on spores.

This study aimed to investigate the inactivation effect of combined TS (thermosonication) and PS (potassium sorbate) treatments on spores. The inactivation effect and potential mechanisms were examined using plate counts, OD values, nucleic acid leakage, DPA (dipicolinic acid) leakage, flow cytometry, and FTIR (Fourier transform infrared spectroscopy). The results showed that, after TS + PS treatments, the integrity of the inner membrane was lost, the permeability of the inner membrane to water molecules was increased, and the intraspore substances leaked.

Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells.

Most bacteria will use their toxins to interact with the host cell, causing damage to the cell and then escaping from it. When bacteria enter the cell, they will be transported via the endosomal pathway. Rab GTPases are involved in bacterial transport as major components of endosomes that bind to their downstream effector proteins.

Bacterial Diversity and Antimicrobial Resistance of Microorganisms Isolated from Teat Cup Liners in Dairy Farms in Shandong Province, China.

Global milk consumption exceeds 800 million tons a year and is still growing. Milk quality and its products are critical to human health. A teat cup makes direct contact with the cow's teats during milking and its cleanliness is very important for the quality of raw milk.