Degradation and ecological risk of a novel neonicotinoid insecticide imidaclothiz in aquatic environments: Kinetics, photodegradation and hydrolysis pathways, mechanism and metabolites toxicity evaluation.

Neonicotinoid insecticides residuals pose a threat to aquatic ecosystems and human health. Imidaclothiz, as a novel neonicotinoid pesticide, the metabolic mechanisms in aquatic environments was unclear. This study investigated the degradation characteristics of imidaclothiz in both pure and actual water, and analyzed the photodegradation and hydrolysis metabolites of imidaclothiz in aquatic environments and assessed their toxicity.

[Varicocele ligation with mobile phone microscope: Report of 5 cases and literature review].

Objective: To investigate the feasibility of varicocele ligation with mobile phone microscope.

Methods: The high-performance mobile phone and mobile phone stand were combined to act as a mobile phone microscope. And the varicocele ligation was performed under the mobile phone microscope.

Pulmonary Contusion Risk Assessment in Astronauts During Off-Nominal Earth-Return Capsule Landings.

Purpose: To investigate injury mechanisms and vulnerable regions for severe pulmonary contusion (PC) in astronauts during off-nominal capsule landings, establishing critical injury thresholds.

Methods: Six distinct high-intensity landing scenarios (≤52.1 g) were simulated using a drop-tower test stand and a Hybrid III anthropometric test device(ATD).

Melatonin regulates accumulation of lipids in the liver via the IP3R on the mitochondria-associated membranes (MAMs).

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic disease of the liver that can progress to hepatitis, cirrhosis, and even cancer in extreme cases. In this study, we investigated the effect of Melatonin (Mel) on lipid accumulation and explored the molecular mechanism behind it. Mel treatment reduced lipid accumulation and enhanced autophagy in oleic acid (OA) + palmitic acid (PA)-induced cells.

Bidirectional Mendelian randomization analysis of the causal relationship between inflammatory bowel disease and Hashimoto thyroiditis.

This study aimed to explore the bidirectional causal relationship between inflammatory bowel disease (IBD) and Hashimoto thyroiditis (HT) using Mendelian randomization (MR) analysis. While both conditions are characterized by persistent inflammation and immune dysregulation, the direction of causality remains unclear. We performed a 2-sample bidirectional MR analysis using summary statistics from genome-wide association studies for IBD and HT.

Robotic retrohepatic inferior vena cava thrombectomy using the caudate lobectomy technique: indications and initial outcomes.

Background: Liver mobilization is essential for exposing the retrohepatic inferior vena cava (IVC) during level II-III robot-assisted IVC thrombectomy (RA-IVCT), but complex cases present significant challenges with a high risk of severe complications. This study aimed to evaluate the safety and feasibility of caudate lobectomy in facilitating retrohepatic IVC exposure in these complex cases.

Methods: Sixteen patients with complex level II-III IVC tumor thrombus (IVC-TT) underwent RA-IVCT with caudate lobectomy in our institution from January 2021 to November 2023.

Multivariate distribution fitting for GANs via introducing variable correlations.

Mode collapse is a major unsolved problem in generative adversarial networks. In this study, we base our proposal on the distribution fitting method and explore methods to suppress mode collapse for multivariate data. We incorporate the covariance constraints that enforce similar linear correlations among the variables.

Multi-Label Conditioned Diffusion for Cardiac MR Image Augmentation and Segmentation.

Accurate segmentation of cardiac MR images using deep neural networks is crucial for cardiac disease diagnosis and treatment planning, as it provides quantitative insights into heart anatomy and function. However, achieving high segmentation accuracy relies heavily on extensive, precisely annotated datasets, which are costly and time-consuming to obtain. This study addresses this challenge by proposing a novel data augmentation framework based on a condition-guided diffusion generative model, controlled by multiple cardiac labels.

Effects of Amino-Substitution on the Gas-Phase Reactivity of Quinoline-Based Singlet Oxenium Cations.

The possibility of generating aryloxenium cations with triplet ground states was explored by comparing the gas-phase reactivities of amino-substituted quinolyloxenium cations to the corresponding unsubstituted cations studied previously. The amino-substituted cations were calculated to have a singlet electronic ground state by at least 3 kcal mol. None of them undergo radical reactions.

Preparation and performance evaluation of fluorescent nanofluid for oil displacement.

Oil displacement agent technology is an attractive technique for improving oil recovery efficiency, as it not only enhances oil recovery efficiency and extends oilfield lifespan, but also helps reduce environmental impact and improve the precision of oilfield management. However, the application of traditional oil displacement agents in oilfield development is limited by poor local fluidity and difficulty in monitoring their effectiveness. To improve oil displacement efficiency and achieve more accurate process monitoring, this paper designs an oil displacement agent that has both oil displacement and tracer functions.

LGI3 promotes the progression of TFE3-rearranged renal cell carcinoma through GEMIN6/AURKB axis.

Transcription factor binding to IGHM enhancer 3-rearranged renal cell carcinoma (TFE3-RCC) is characterized by its aggressive nature, limited treatment options, and poor prognosis. However, the downstream targets of TFE3 fusion protein responsible for its tumorigenesis and progression remain unclear. Here, we demonstrated that leucine-rich repeat LGI family member 3 (LGI3) is a direct target of TFE3 fusion protein.

Characteristics and associated cognitive indicators of decision-making decline over time in older people with mild cognitive impairment.

Background: Impaired decision-making (DM) under uncertainty in mild cognitive impairment (MCI) increases financial vulnerability and suboptimal medical decision-making OBJECTIVE: This two-year longitudinal study characterized DM changes in MCI and identified modifiable cognitive correlates for functional preservation.

Methods: Fifty-two MCI and 49 cognitively normal (CN) participants underwent annual Iowa Gambling Task (IGT), modeled via Outcome-Representation Learning (ORL) to quantify reward/punishment learning rates (A/A), memory decay (K), and win/deck perseverance (β/β). Concurrent neuropsychological assessments measured six domains.

The impact of eligibility criteria on KRASG12C inhibitor trials in patients with NSCLC.

Background: 20% of cancer patients are estimated to be ineligible for phase III trials due to restrictive eligibility criteria. In response, several groups, including the FDA, have advocated for more inclusive study designs. We examined KRAS G12C inhibitor trials to determine if inclusivity has shifted in the development of molecularly-targeted therapies.

Magnetic β-Cyclodextrin/UiO-66 Hybrid Composites as High-Performance Adsorbents for Organic Dye Removal.

Dye wastewater poses a significant environmental threat, making the development of efficient and reusable adsorbents essential. In this study, we prepared a magnetic UiO-66 composite modified by β-CD (UiO-66@β-CD@FeO) and evaluated the adsorption properties of this material on crystal violet and Congo red in aqueous solutions. β-CD was added to improve the host-guest interaction with dyes, and the FeO core made magnetic separation simple.

Analysis of the short-to-intermediate-term efficacy of autologous costochondral transplantation in treatment for Hepple V osteochondral lesion of talus.

Objectives: To analyze the feasibility, effectiveness and safety of autologous costochondral transplantation (ACT) in patients with Hepple V osteochondral lesion of talus (OLT), and to analyze the short-to-intermediate-term efficacy.

Methods: Clinical data of 27 patients (27 ankles) with Hepple V OLT admitted in Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital between February 2020 and February 2022 were retrospectively analyzed, of which were treated with ACT. The general information, operation time, and hospitalization days of the patients were recorded.

Dysregulated lipid metabolism mediates the association between brominated flame retardant exposure and hyperuricemia: Evidence from NHANES 2003-2004.

Brominated flame retardants (BFRs) represent a group of synthetic chemical compounds that have been ubiquitously incorporated into numerous consumer products. Human exposure to BFRs occurs through multiple routes, posing potential health risks. However, the association between BFR exposure and hyperuricemia and the role of lipid dysregulation remain unexplored.

Beyond Skin Clearance: Personalized Strategies for DLQI Improvement in Psoriasis -Insights From a Shanghai Prospective Cohort.

Introduction: Psoriasis is a chronic immune-mediated disease that significantly impacts patients clinically and psychologically. Physician-assessed severity measures, including Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), and Physician Global Assessment (PGA), often fail to capture patient-reported outcomes, particularly when clinical improvement and perceived quality-of-life gains are misaligned.

Purpose: To clarify the association between clinical improvements and Dermatology Life Quality Index (DLQI) outcomes, identify predictors of substantial DLQI improvement (≥90% reduction), and explore reasons for suboptimal DLQI responses in patients achieving skin clearance.

Effects of years of storage (1, 5, and 7 years) on bovine sperm ultrastructure, oxidative status, and fertilizing capacity.

The cryopreservation technique for sperm is a widely recognized approach utilized in artificial insemination. Previous studies have demonstrated that sperm quality is influenced by ice crystal formation and oxidative stress during the freezing process. Moreover, the time of cryostorage also has an impact on sperm quality.

promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis.

Background: Clear cell renal cell carcinoma (ccRCC) represents the predominant form of kidney cancer. The Ras homology (Rho) GTPases family plays essential roles in several tumors. However, few studies have reported the function and clinical value of the Rho GTPases family in ccRCC.

Roles of Pho regulon in bacterial pathogenicity.

Bacterial infections are a leading cause of global health loss. The prerequisites for bacteria to colonize and establish systemic infection in the host are environmental adaptability and the expression of virulence factors. Phosphorus constitutes the fifth most important element in terms of its cellular content, which is pivotal for DNA replication, metabolism, signal transmission, and microbial cell composition.

Detection of bone and soft tissue tumors using Mueller matrix polarimetry: a non-invasive approach for unfixed tumor identification.

Mueller matrix polarimetry (MMP) effectively captures the polarization characteristics of biological tissues. This study established a subcutaneous osteosarcoma model in mice, utilizing MMP to analyze fresh tumor samples. We selected multilayer perceptron (MLP) and Kolmogorov-Arnold networks (KAN) as our classifiers and compared them based on nearby pixel attributes and single-pixel attributes, using MMP parameters as inputs.

ZrS as a saturable absorber for the -cut Tm:YAP laser.

Zirconium disulfide () has gained significant interest as a two-dimensional semiconductor material due to its remarkable nonlinear optical performance. This study fabricated a saturable absorber (SA) via liquid-phase exfoliation, and its nonlinear optical properties were evaluated using the I-scan technique. For the first time, to our knowledge, was employed as an SA to realize a stable 1934 nm passively Q-switching Tm:YAP laser with modulation functionality.

Association of semaglutide use with outcomes in chronic plantar heel pain: a prospective observational cohort and a pilot interventional study.

Background: Whether patients with chronic plantar heel pain (PHP) can benefit from glucagon-like peptide-1 receptor agonists (GLP1-RAs) remained unclear.

Methods: This study included a prospective observational cohort and a pilot interventional component. In the observational arm, more than 3000 adults with chronic PHP (duration of symptoms >6 months) were recruited with at least two-year follow up from two medical centers.