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Mode collapse is a major unsolved problem in generative adversarial networks. In this study, we base our proposal on the distribution fitting method and explore methods to suppress mode collapse for multivariate data. We incorporate the covariance constraints that enforce similar linear correlations among the variables. This approach may mitigate the nonuniform sampling issue more effectively for multivariate data, thereby suppressing mode collapse. For images, we also offer a scheme for incorporating covariances by utilizing the difference matrices. The method could handle images better since it considers the distances between pixels and possesses a better tolerance for errors like offsets. The proposed methods inherit the benefits of the distribution fitting method, which circumvents reliance on regularization or network modules, enhancing compatibility and facilitating its practical application. Experiments demonstrate the effectiveness and competitive performance of the proposed method.
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http://dx.doi.org/10.1016/j.neunet.2025.108013 | DOI Listing |
Comput Struct Biotechnol J
August 2025
Institut de Recherche en Cancérologie de Montpellier (IRCM), Équipe Labellisée Ligue Contre le Cancer, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Digital twins (DTs) are emerging tools for simulating and optimizing therapeutic protocols in personalized nuclear medicine. In this paper, we present a modular pipeline for constructing patient-specific DTs aimed at assessing and improving dosimetry protocols in PRRT such as therapy. The pipeline integrates three components: (i) an anatomical DT, generated by registering patient CT scans with an anthropomorphic model; (ii) a functional DT, based on a physiologically-based pharmacokinetic (PBPK) model created in SimBiology; and (iii) a virtual clinical trial module using GATE to simulate particle transport, image simulation, and absorbed dose distribution.
View Article and Find Full Text PDFJ Biomed Opt
September 2025
Fraunhofer Institute for Microelectronic Circuits and Systems IMS, Duisburg, Germany.
Significance: The spatial and temporal distribution of fluorophore fractions in biological and environmental systems contains valuable information about the interactions and dynamics of these systems. To access this information, fluorophore fractions are commonly determined by means of their fluorescence emission spectrum (ES) or lifetime (LT). Combining both dimensions in temporal-spectral multiplexed data enables more accurate fraction determination while requiring advanced and fast analysis methods to handle the increased data complexity and size.
View Article and Find Full Text PDFIEEE Trans Med Imaging
September 2025
In ultrasound imaging, propagation of an acoustic wavefront through heterogeneous media causes phase aberrations that degrade the coherence of the reflected wavefront, leading to reduced image resolution and contrast. Adaptive imaging techniques attempt to correct this phase aberration and restore coherence, leading to improved focusing of the image. We propose an autofocusing paradigm for aberration correction in ultrasound imaging by fitting an acoustic velocity field to pressure measurements, via optimization of the common midpoint phase error (CMPE), using a straight-ray wave propagation model for beamforming in diffusely scattering media.
View Article and Find Full Text PDFLangmuir
September 2025
School of Resources and Safety Engineering, Chongqing University, Chongqing 400044, China.
Hydrogen energy is pivotal for driving sustainable development and achieving deep decarbonization; yet, its storage remains a significant challenge. Notably, depleted methane reservoirs can serve as a promising large-scale solution for underground hydrogen storage (UHS). Based on adsorption experiments, Monte Carlo and molecular dynamics methods, the adsorption behavior of H and CH in anthracite and the applicability of five models were discussed.
View Article and Find Full Text PDFInt J Epidemiol
August 2025
Department of Infectious Disease Epidemiology and Dynamics, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Background: The relationship between nutritional status and tuberculosis is critically important but poorly understood. We extended a 2009 review characterizing the relationship between body mass index (BMI) and tuberculosis risk.
Methods: We systematically searched for new studies published between 2009 and 2024 investigating BMI and tuberculosis risk in adults.