Robotic retrohepatic inferior vena cava thrombectomy using the caudate lobectomy technique: indications and initial outcomes.

Background: Liver mobilization is essential for exposing the retrohepatic inferior vena cava (IVC) during level II-III robot-assisted IVC thrombectomy (RA-IVCT), but complex cases present significant challenges with a high risk of severe complications. This study aimed to evaluate the safety and feasibility of caudate lobectomy in facilitating retrohepatic IVC exposure in these complex cases.

Methods: Sixteen patients with complex level II-III IVC tumor thrombus (IVC-TT) underwent RA-IVCT with caudate lobectomy in our institution from January 2021 to November 2023.

The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi.

Preoperative downstaging of renal cell carcinoma with a tumor thrombus (RCC-TT) makes thrombectomy feasible. However, treatment resistance is common and may partly be attributed to the tumor-promoting role of the tumor microenvironment (TME). Herein, we sequenced, integrated, and comprehensively analyzed multi-center, multi-omics data from 164 RCC-TT patients and identified two clinically relevant RCC-TT subtypes.

Risk Factors of Preoperative Renal Dysfunction and Its Impact on Survival in Patients with Renal Tumor and Inferior Vena Cava Tumor Thrombus.

Background: Renal tumor and inferior vena cava tumor thrombus (RT-IVCTT), as a unique model for investigating congestive renal injury, remains largely unexplored. Although chronic kidney disease significantly correlates with postoperative adverse events and long-term prognosis in both renal tumor and pan-cancer settings, there is no large-scale evidence specifically addressing RT-IVCTT. This study aimed to identify risk factors of preoperative renal dysfunction (pre-RD) and evaluate its contribution as a predictor for prognosis in patients with RT-IVCTT.

Single-Center Experience of Robot-Assisted Nephrectomy and Venous Tumor Thrombectomy: Indications, Surgical Strategies, and Long-Term Outcomes.

To introduce the indications and surgical strategies of robot-assisted nephrectomy and venous tumor thrombectomy (RA-N-VTT) and to assess the long-term outcomes in a high-volume, single-center setting. We retrospectively enrolled 309 patients with renal tumors and venous tumor thrombus who underwent a robotic procedure in our center between June 2013 and December 2023. To better define the indications and surgical strategies for RA-N-VTT, we proposed the Chinese People's Liberation Army General Hospital (PLAGH) classification system, incorporating three modifications to the Mayo Clinic classification system.

Impact of perirenal collateral on the surgical management and prognosis of nonmetastatic renal cell carcinoma and inferior vena cava tumor thrombus.

Purpose: To explore the influence of perirenal collateral (PRC) on the operation and prognosis of nonmetastatic renal cell carcinoma (RCC) and inferior vena cava (IVC) tumor thrombus.

Methods: A total of 10,260 patients with RCC who underwent surgical resection were retrospectively collected. Two hundred and forty-one patients (median age, 56.

Robotic versus open level III-IV inferior vena cava thrombectomy: A multicenter, retrospective, propensity-matched analysis.

Background: The safety and efficacy of robotic inferior vena cava thrombectomy (IVCTE) for level III-IV thrombus with a comparison to open IVCTE is still unclear. This study aimed to compare robotic vs open IVCTE for renal tumors with level III-IV tumor thrombus.

Materials And Methods: We performed a retrospective analysis of patients who underwent R-IVCTE or O-IVCTE in four academic tertiary centers between 2015 and 2023.

Safety and reliability of telesurgery in China: a multicenter, single arm, I phase clinical trial.

Background: The development and implementation of telesurgery are of significant strategic importance for the future expansion and evolution of the surgical robotics industry. Telesurgery has been demonstrated to improve access to advanced medical care but also enhances the overall healthcare delivery in these underserved regions. Here, we presented a telesurgery system that optimized surgical signals via a telesurgery host using real-time signal processing and multi-source signal interaction systems.

Prediction model for postoperative acute kidney injury and chronic kidney disease in patients with renal cell carcinoma and venous tumor thrombus.

Purpose: To develop nomograms to predict the risks for postoperative acute kidney injury (PO-AKI) and chronic kidney disease (CKD) in patients with renal cell carcinoma and venous tumor thrombus (RCC-VTT).

Methods: Consecutive postoperative patients with RCC-VTT (n = 353) were enrolled between January 2006 and June 2023. Clinicopathological, operative, and functional outcome data were analyzed.

Impact of Drying-Induced Structural Modifications on Flavor Release of Star Anise During Boiling.

Star anise, a traditional seasoning, plays a significant role in influencing consumer preferences through its flavor release during cooking. This study examines how drying techniques-hot air drying (HAD), heat pump drying (HPD), Far-infrared drying (FIRD), and microwave vacuum drying (MVD)-affect the visual appearance and flavor release of star anise. Among these techniques, HAD required the longest drying time (20.

Robotic surgical techniques and methods for treating renal cell carcinoma with inferior vena cava tumor thrombus.

Renal cell carcinoma with inferior vena cava (IVC) tumor thrombus (RCC-IVCTT) has a high mortality rate, and surgery is the only promising treatment. Open surgery has been the gold standard treatment for several decades. However, with the development of minimally invasive surgical technologies, the advantages of robotic surgery have gradually emerged.

T1-Hyperintense Cystic Renal Masses: MR Subtraction Imaging May Improve Interobserver Agreement and Diagnostic Performance in the Bosniak Classification.

Background: T1-hyperintensity in cystic renal masses (CRMs) complicates Bosniak classification assessment due to inherent signal interference from hemorrhage and proteinaceous content, potentially obscuring enhancement visibility.

Purpose: To investigate whether MR subtraction imaging improves interobserver agreement and diagnostic performance in the Bosniak classification of T1-hyperintense CRMs.

Study Type: Retrospective.

A urine DNA methylation assay for early detection of renal cancer.

Renal cancer (RC) is the most lethal urological malignancy with 30% late diagnosis. Over 50% RCs are asymptomatic and discovered incidentally. Current RC detection relies on imaging while it lacks satisfactory sensitivity for detecting small-size tumors.

Bench Surgery with Robot-assisted Kidney Autotransplantation for Complex Kidney Tumors: Technique and Outcomes from a Single Center.

Background And Objective: Bench surgery (BenS) with kidney autotransplantation serves as an alternative to nephron-sparing surgery (NSS) for patients harboring high-complexity renal tumors that are ineligible for in situ partial nephrectomy (PN). However, the experience of BenS with robot-assisted kidney autotransplantation (RAKAT) has been scarce in such cases. Here, we describe the operative techniques, and functional and oncological outcomes of BenS with RAKAT.

Novel Sb₂S₃-3,4,9,10-Perylene Tetracarboxylic Acid Composite for Enhanced Photocatalytic Reduction of Cr(VI) in Aqueous Media.

The construction of organic-inorganic semiconductor heterojunctions is an important way to improve the photocatalytic performance of semiconductors and inhibit the recombination of photogenerated charge carriers. In this paper, a novel Sb₂S₃-3,4,9,10-perylene tetracarboxylic acid (SbS-PTCA) heterojunction was prepared by hydrothermal method. Compared with SbS and PTCA, SbS-PTCA composite catalyst had better photocatalytic reduction ability for Cr(VI) in aqueous solution under visible light conditions.

New mouse models for exploring renal tumor extension into the inferior vena cava.

Renal tumors with inferior vena cava tumor thrombus (IVCTT) remain a challenge in urology. However, in vivo models remain unavailable, which hampers the elucidation of its pathogenesis, identification of therapeutic targets, and screening for effective drugs. In this study, we initially develop two IVCTT models in BALB/c and BALB/c-nu/nu mice using the mouse Renca cell line.

Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling.

Tumor cells often employ many ways to restrain type I IFN signaling to evade immune surveillance. However, whether cellular amino acid metabolism regulates this process remains unclear, and its effects on antitumor immunity are relatively unexplored. Here, we found that asparagine inhibited IFN-I signaling and promoted immune escape in bladder cancer.

Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC.

Primary cilia are present on renal tubules and are implicated to play a pivotal role in transducing signals during development; however, the oncogenic role of cilia in clear cell renal cell carcinoma (ccRCC) has not been examined. Here we show that VHL wild-type ccRCC cell lines have a high incidence of primary cilia, and a high frequency of primary cilia is positively correlated with VHL expression and poor prognosis. Besides, the depletion of KIF3A and IFT88, genes required for ciliogenesis, significantly inhibited tumor proliferation and metastasis in vitro and in vivo.

Development and Validation of a Nomogram for Predicting Postoperative Recurrence-Free Survival in Patients With Nonmetastatic Pathological T3a Stage Renal Cell Carcinoma.

Background: To establish a nomogram predicting postoperative recurrence-free survival (RFS) in patients with nonmetastatic renal cell carcinoma (RCC) of pathological T3a (pT3a) stage undergoing nephrectomy.

Materials And Methods: A retrospective review included 668 patients with pT3a RCC between 2008 and 2019, randomly divided into training and validation groups (7:3 ratio). Cox regression analysis established the RFS-predicting nomogram in the training group.

Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma.

While Stimulator-of-interferon genes (STING) is an innate immune adapter cruicial for sensing cytosolic DNA and modulating immune microenvironment, its tumor-promoting role in tumor survival and immune evasion remains largely unknown. Here we reported that renal cancer cells are exceptionally dependent on STING for survival and evading immunosurveillance via suppressing ER stress-mediated pyroptosis. We found that STING is significantly amplified and upregulated in clear cell renal cell carcinoma (ccRCC), and its elevated expression is associated with worse clinical outcomes.

Case report: Retroperitoneal solid pseudopapillary neoplasm associated with multiple hepatic metastases.

Solid pseudopapillary neoplasm (SPN) is a rare tumor mostly occurring in the pancreas. They are low-grade malignant tumors of the exocrine pancreas that occasionally metastasize, usually to the liver or peritoneum. Additionally, multiple metastases of extrapancreatic SPN to the liver are extremely rare and have been reported before.