Robotic retrohepatic inferior vena cava thrombectomy using the caudate lobectomy technique: indications and initial outcomes.

Background: Liver mobilization is essential for exposing the retrohepatic inferior vena cava (IVC) during level II-III robot-assisted IVC thrombectomy (RA-IVCT), but complex cases present significant challenges with a high risk of severe complications. This study aimed to evaluate the safety and feasibility of caudate lobectomy in facilitating retrohepatic IVC exposure in these complex cases.

Methods: Sixteen patients with complex level II-III IVC tumor thrombus (IVC-TT) underwent RA-IVCT with caudate lobectomy in our institution from January 2021 to November 2023.

Mechanisms of the effect of gut microbes on depression through the microbiota-gut-brain axis.

Depression is a significant public health issue which exerts profound psychological and social impacts on both individuals and society. However, existing therapeutic strategies often exhibit limited efficacy. Accumulating evidence underscores the vital role of gut microbiota in the pathophysiology of depression through the microbiota-gut-brain (MGB) axis.

The small-molecule pifithrin-α deactivates ETR1 to repress shade avoidance in .

Shade avoidance syndrome (SAS) commonly occurs in plants sensing shading and the proximity of neighbors, leading to morphological and physiological changes that are detrimental to plant health and consequently crop yield. Controlling SAS could be beneficial for sustainable agriculture. Here, we performed a phenotype-based chemical screening in and identified pifithrin-α (PFT-α) as a compound that suppresses shade-induced hypocotyl elongation and gene expression.

Adjunctive Human Urinary Kallidinogenase Enhances the Cognitive and Hemodynamic Outcomes of Anterior Circulation Stenting.

Chronic cerebral hypoperfusion due to anterior circulation stenosis contributes to cognitive decline. This study examined whether preoperative human urinary kallidinogenase (HUK) administration improves outcomes following percutaneous transluminal angioplasty with stenting (PTAS). In this prospective non-randomized controlled trial, 128 patients with severe anterior circulation stenosis were included in the HUK and control groups, respectively.

Single-Center Experience of Robot-Assisted Nephrectomy and Venous Tumor Thrombectomy: Indications, Surgical Strategies, and Long-Term Outcomes.

To introduce the indications and surgical strategies of robot-assisted nephrectomy and venous tumor thrombectomy (RA-N-VTT) and to assess the long-term outcomes in a high-volume, single-center setting. We retrospectively enrolled 309 patients with renal tumors and venous tumor thrombus who underwent a robotic procedure in our center between June 2013 and December 2023. To better define the indications and surgical strategies for RA-N-VTT, we proposed the Chinese People's Liberation Army General Hospital (PLAGH) classification system, incorporating three modifications to the Mayo Clinic classification system.

Topologically associating domains of chromatin on single-cell Hi-C data: a survey of bioinformatic tools and applications in the light of artificial intelligence.

Topologically associating domains (TADs) uncovered on bulk Hi-C data are regarded as fundamental building blocks of a three-dimensional genome, and they are believed to effectively participate in the regulatory programs of gene expression. The computational analysis of TADs on single-cell Hi-C (scHi-C) data in the era of single-cell transcriptomics has received continuous attention since it may provide information beyond that on bulk Hi-C data. Unfortunately, the contact matrix for a single cell is ultra-sparse due to the low sequencing depth.

Rapid 3D Saturation Transfer Imaging for Simultaneous Phosphocreatine and Glycogen Mapping in Human Muscle.

Objective: Phosphocreatine (PCr) and glycogen are key metabolites underpinning the skeletal muscle contractions. Simultaneous 3D imaging of these metabolites is valuable for understanding heterogeneous energetic events. While saturation transfer (ST) MRI can detect metabolites, 3D ST acquisition generally requires long scan times.

Association between red blood cell distribution width-to-albumin ratio and all-cause mortality in intracerebral hemorrhage.

Background: Intracerebral hemorrhage (ICH) remains a devastating cerebrovascular condition, marked by high fatality and limited availability of prognostic tools. The red blood cell distribution width-to-albumin ratio (RAR) has recently gained attention as a composite biomarker of systemic inflammation and nutritional condition, but its prognostic value in ICH remains unclear. We aim to examine how RAR relates to mortality risk among individuals with ICH.

Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit.

Background: Plasma concentration monitoring is crucial for optimizing vancomycin use, particularly in patients in the intensive care unit (ICU). However, the reference interval for vancomycin plasma concentration remains undetermined.

Aim: To evaluate the correlations of area under the curve (AUC) and trough concentration (C) with efficacy and nephrotoxicity in patients in the ICU.

A Cost-Effective Strategy for Mandibular Reconstruction: Fibula Flap With Existing Titanium Plates.

With the rapid advancement of digital and microsurgical techniques, immediate autologous bone grafting following resection of benign and malignant mandibular tumors has become a standard treatment. However, some patients are unable to undergo immediate autologous bone grafting due to various reasons. In such cases, titanium plate implantation (or combined with soft tissue free flap such as anterolateral thigh flap) serves as an alternative to prevent airway compression and maintain facial shape and function.

Microstructure-Dependent Ion Selectivity in Graphene Oxide-Based Membranes.

Graphene oxide (GO) membranes hold promise for precise separation due to their unique laminar structures and tunable separation properties. However, although water transport in GO membranes has been extensively investigated, the key mechanisms governing ion transport and selectivity remain poorly understood. In this work, we fabricated pristine and propylenediamine (PPD)/pentamethylenediamine (PTD)-cross-linked GO membranes via vacuum filtration and employed low-field nuclear magnetic resonance (LF-NMR) to elucidate their nanoscale pore architectures, including pinholes and structural defects.

Impaired glymphatic system is associated with secondary neuronal injury in the thalamus following cerebral cortical infarction.

Focal cerebral infarction leads to abnormal amyloid-β (Aβ) deposits, which relates to secondary neuronal injury in the ipsilateral thalamus and hinders post-stroke functional recovery. However, the mechanisms underlying Aβ-pathology in the thalamus remain unclear. This study was designed to investigate the potential associations of glymphatic system with Aβ deposits and delayed neuronal damage of the ipsilateral thalamus secondary to cerebral infarction.

GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common type of RCC. Even though the targeted drugs for the treatment of ccRCC have a certain therapeutic effect, due to the problem of drug resistance, the search for new targets for targeted therapy of ccRCC remains urgent. GAMT is an enzyme involved in creatine metabolism.

Managing Complications in Facial Cosmetic Treatment.

Objective: To investigate the clinical and pathologic characteristics of adverse reactions after minimally invasive facial cosmetic treatment and to summarize diagnostic and therapeutic experiences, providing reference for clinicians.

Methods: Forty-five patients who experienced complications from minimally invasive facial cosmetic procedures and were treated at School and Hospital of Stomatology, Wuhan University between June 2014 and June 2024 were selected. A retrospective analysis was conducted on the diagnosis, treatment methods, and prognostic outcomes of these adverse reactions.

Data-Driven Event-Triggered Sliding Mode Secure Control for Autonomous Vehicles Under Actuator Attacks.

This article investigates a comprehensive data-driven event-triggered secure lateral control of autonomous vehicles under actuator attacks. We consider stabilization issues of autonomous vehicles subject to modeling difficulties, limited communication resources, and actuator attacks. The dynamic model decomposition (DMD) from data is exploited to characterize the inherent lateral dynamics model of autonomous vehicles, the event-triggered transmission scheme is utilized to alleviate communication burden for limited bandwidth network, and the sliding mode control scheme is designed to ensure the security of autonomous vehicles under actuator attacks.

Three-Coordinate Iron(0) Complex-Catalyzed Regioselective C-H Alkylation of Indole Derivatives.

The synthesis of alkylated indoles, which are key intermediates for various drugs and bioactive molecules, is of great importance. However, most reports on the synthesis of functionalized indoles use toxic and expensive 4d or 5d metal catalysts, limiting the further application of these methods. Herein, we disclose a versatile regioselective C-H alkylation of indole derivatives using a well-defined three-coordinate iron(0) complex.

Association of elevated albumin-corrected anion gap with all-cause mortality risk in atrial fibrillation: a retrospective study.

Background: Compared to the conventional anion gap, the albumin-corrected anion gap (ACAG) offers a more precise measure of acid-base imbalance, providing superior prognostic insight. However, the prognostic relevance of ACAG in individuals of atrial fibrillation (AF) remains insufficiently explored. This research seeks to evaluate the correlation between ACAG levels and mortality risk in individuals with AF.

Deer antler reserve mesenchyme cells modified with miR-145 promote chondrogenesis in cartilage regeneration.

Deer antler-derived reserve mesenchyme cells (RMCs) are a promising source of cells for cartilage regeneration therapy due to their chondrogenic differentiation potential. However, the regulatory mechanism has not yet been elucidated. In this study, we analyzed the role of microRNAs (miRNAs) in regulating the differentiation of RMCs and in the post-transcriptional regulation of chondrogenesis and hypertrophic differentiation at the molecular and histological levels.

Unlocking Chiral Sulfinimidoyl Electrophiles: Asymmetric Synthesis of Sulfinamides Catalyzed by Anionic Stereogenic-at-Cobalt(III) Complexes.

Asymmetric catalysis involving a sulfoxide electrophile intermediate presents an efficient methodology for accessing stereogenic-at-sulfur compounds, such as sulfinate esters, sulfinamides, , which have garnered increasing attention in modern pharmaceutical sciences. However, as the aza-analog of sulfoxide electrophiles, the asymmetric issues about electrophilic sulfinimidoyl species remain largely unexplored and represent a significant challenge in sulfur stereochemistry. Herein, we exhibit an anionic stereogenic-at-cobalt(III) complex-catalyzed asymmetric synthesis of chiral sulfinamides via chiral sulfinimidoyl iodide intermediates.

Pharmacokinetic Interaction between Imatinib and Tacrolimus in Rats.

Objective: Tacrolimus, a calcineurin inhibitor (CNI), is the first-line treatment for chronic myeloid leukemia (CML) and advanced gastrointestinal stromal tumors (GIST). Imatinib and tacrolimus are both substrates of the hepatic enzymes CYP3A4/5 and efflux transporter P-gp, so drug-drug interactions may occur during their co-administration treatment. Therefore, this study aimed to evaluate the pharmacokinetic interaction between imatinib and tacrolimus in rats.

Inhibition of CCR2 attenuates NLRP3-dependent pyroptosis after myocardial ischaemia-reperfusion in rats via the NF-kB pathway.

Myocardial infarction (MI) is a leading cause of mortality worldwide, contributing significantly to long-term cardiac dysfunction and heart failure. Effective therapeutic strategies are urgently needed to mitigate the extensive damage caused by MI and subsequent ischemia-reperfusion (I/R) injury. This study investigates the role of the Chemokine receptor 2 (CCR2) in regulating NLRP3-dependent cardiomyocyte pyroptosis following myocardial ischemia-reperfusion (MIR), elucidating its molecular mechanisms.

Quasi-Solid-State Conversion with Fast Redox Kinetics Enabled by a Sulfonamide-Based Electrolyte in Li-Organic Batteries.

The serious dissolution of organic electrode materials (e.g., perylene-3,4,9,10-tetracarboxylic dianhydride, PTCDA) in electrolytes is a major challenge, deteriorating their electrochemical performances and hindering the interpretation of the fundamental redox reaction mechanisms including the intrinsic kinetics and the solvent cointercalation.