Mechanisms of the effect of gut microbes on depression through the microbiota-gut-brain axis.

Depression is a significant public health issue which exerts profound psychological and social impacts on both individuals and society. However, existing therapeutic strategies often exhibit limited efficacy. Accumulating evidence underscores the vital role of gut microbiota in the pathophysiology of depression through the microbiota-gut-brain (MGB) axis.

Preliminary study of apatinib combined with fluzoparib in the treatment of HRP ovarian cancer via the HR pathway.

Background: Ovarian cancer is the gynecological malignancy with the highest mortality rate. Due to late detection and easy recurrence, the 5-year survival rate of advanced ovarian cancer patients is less than 30%. The current standard treatment for ovarian cancer includes platinum-based combination therapy.

Maternal Immune Activation: Implications for Congenital Heart Defects.

Congenital heart defects (CHD) are the most common major birth defects and one of the leading causes of death from congenital defects after birth. CHD can arise in pregnancy from the combination of genetic and non-genetic factors. The maternal immune activation (MIA) hypothesis is widely implicated in embryonic neurodevelopmental abnormalities.