Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit.

Background: Plasma concentration monitoring is crucial for optimizing vancomycin use, particularly in patients in the intensive care unit (ICU). However, the reference interval for vancomycin plasma concentration remains undetermined.

Aim: To evaluate the correlations of area under the curve (AUC) and trough concentration (C) with efficacy and nephrotoxicity in patients in the ICU.