Effect of digital virtual reality simulator on pre-clinical dental surgical skill training: a retrospective study.

Aim: Dental surgical skills training assumes critical importance for aspiring dentists. Our present study aimed to investigate the effectiveness of innovative DVRS approach in assessing competency and improving skill in preclinical dental surgical skill training.

Methods: A total of 142 students participated in this study.

Repairing composite mandibular defects with the chimeric deep circumflex iliac artery perforator flap.

Mandibular defects caused by congenital anomalies, oncologic resections, trauma, or infections impair essential functions such as mastication, speech, and facial aesthetics, necessitating reconstruction to restore both biomechanical integrity and quality of life. While fibula osteocutaneous flaps remain the gold standard for complex defects due to their versatility, the deep circumflex iliac artery (DCIA) bone flap-historically limited by inconsistent vascular anatomy and technical harvesting challenges-provides anatomical advantages but lacks reliable soft tissue utility. The chimeric DCIA perforator flap (DCIAPF) addresses these limitations by utilizing terminal DCIA skin perforators to create thin, well-vascularized skin paddles independent of muscular branches, thereby reducing bulk and donor-site morbidity.

Extracellular vesicle manufacture via FACTORY: fully automated collection technology and optimum machinery for clinical translational applications.

Extracellular vesicles (EVs) hold significant potential as therapeutic agents and drug carriers. However, current isolation techniques severely limit their clinical application, due to heavy reliance on manual operation, making large-scale isolation of EVs impractical and failing to meet the requirements for clinical translation. Here, we set up the fully automated collection technology and optimum machinery (FACTORY) platform, allowing the efficient collection of high-quality EVs.

The dual effects of macrophage-derived extracellular vesicles on tumor cell behavior: mechanisms and clinical potential.

Macrophages, key players in the immune system, exhibit diverse roles in tumor progression and regulation. Macrophages release extracellular vesicles (EVs), membrane-bound particles that facilitate intercellular communication and cargo transfer. Macrophage-derived EVs (M-EVs) demonstrate a complex dual function in tumor development, with their effects dependent on their origin and the tumor microenvironment.

A Cost-Effective Strategy for Mandibular Reconstruction: Fibula Flap With Existing Titanium Plates.

With the rapid advancement of digital and microsurgical techniques, immediate autologous bone grafting following resection of benign and malignant mandibular tumors has become a standard treatment. However, some patients are unable to undergo immediate autologous bone grafting due to various reasons. In such cases, titanium plate implantation (or combined with soft tissue free flap such as anterolateral thigh flap) serves as an alternative to prevent airway compression and maintain facial shape and function.

Distinctive lymph node metastasis characteristics and predictive model for young oral squamous cell carcinoma patients under 30.

Occult cervical lymph node metastasis (OCLNM) significantly influences clinical management and prognosis in young oral squamous cell carcinoma (OSCC) patients under 30 years old, who demonstrate distinct disease features compared to older cohorts. This retrospective study analyzed 66 OSCC patients under 30 treated between 2012 and 2024 to identify risk factors for cervical lymph node metastasis (CLNM) and develop a predictive model. Among the cohort, 36.

A novel approach for reconstruction of anterior cheek defects: Series connection of cheek mucosal flap and buccal fat pad.

Background: The buccal mucosa is a frequent site of precancerous lesions, and surgical excision often leaves a mucosal defect. owing to the inherent limited length of the buccal fat pad, its efficacy in covering mucosal defects is confined. In cases where the defect is anterior in the cheek, reliance solely on buccal fat pad is insufficient for complete coverage of the affected area.

New Perspectives on Maxillofacial Reconstruction in Patients With Skeletal Malocclusion: Deep Integration of Maxillofacial Reconstruction and Orthognathic Surgery Concepts.

The application of computer-assisted design and manufacturing (CAD/CAM) technology and digital guides has made maxillofacial defect reconstruction surgery faster, more convenient, precise, and highly accurate in restoration. However, in addressing maxillofacial reconstruction for patients with skeletal malocclusion, the restoration of facial contours has received less attention, and surgical planning for such cases remains challenging. In this study, we report a case where the deep integration of maxillofacial reconstruction and orthognathic surgery concepts was applied.

Periapical Cysts Exhibit Multilocular Characteristics Similar to Odontogenic Keratocysts and Ameloblastomas.

The clinical imaging typically presents as a multicystic lesion in the jawbone, which is mostly diagnosed as ameloblastoma, myxoma, or odontogenic keratocyst. Preoperative biopsy is often challenging due to the intraosseous location of these lesions. Consequently, clinicians frequently rely on these characteristic multicystic imaging features to diagnose either ameloblastoma or odontogenic keratocyst, subsequently planning treatments ranging from marginal resection to mandibular segmental osteotomies with concurrent autogenous bone grafting.

Urease-powered micro/nanomotors: Current progress and challenges.

Enzyme-powered micro/nanomotors (MNMs) (EMNMs) use natural enzymes to facilitate the decomposition of fuels, including hydrogen peroxide (HO), glucose, triglycerides, and urea to provide power. EMNMs can achieve self-propulsion through the utilization of biofuels without additional fuels, exhibiting excellent biocompatibility and significant potential for application in the biomedical field. Compared with HO, which may cause oxidative damage to the body, urea exhibits superior biosafety characteristics.

Immune-featured stromal niches associate with response to neoadjuvant immunotherapy in oral squamous cell carcinoma.

Tumor stromal cells (TSCs) play a crucial yet underexplored role in the tumor microenvironment (TME). This study uses single-cell sequencing and spatial transcriptomics on paired tumor specimens from 22 patients with oral squamous cell carcinoma (OSCC) enrolled in a randomized two-arm phase 2 trial, receiving neoadjuvant anti-PD-1 mono-immunotherapy or anti-PD-1 plus docetaxel-cisplatin-5-fluorouracil (TPF) immunochemotherapy. Single-cell analysis reveals increased TSCs within the TME of responders in immunochemotherapy.

Micro/nanomotors in targeted drug delivery: Advances, challenges, and future directions.

The therapeutic efficacy of drugs is highly dependent on their successful delivery to the target site. However, achieving targeted drug delivery to diseased areas remains a significant challenge. Current drug delivery systems based on nanocarriers often suffer from inefficiencies due to their lack of intrinsic propulsion and active targeting capabilities.

Managing Complications in Facial Cosmetic Treatment.

Objective: To investigate the clinical and pathologic characteristics of adverse reactions after minimally invasive facial cosmetic treatment and to summarize diagnostic and therapeutic experiences, providing reference for clinicians.

Methods: Forty-five patients who experienced complications from minimally invasive facial cosmetic procedures and were treated at School and Hospital of Stomatology, Wuhan University between June 2014 and June 2024 were selected. A retrospective analysis was conducted on the diagnosis, treatment methods, and prognostic outcomes of these adverse reactions.

PERK+ Macrophages Drive Immunotherapy Resistance in Lymph Node Metastases of Oral Squamous Cell Carcinoma.

Purpose: Neoadjuvant anti-PD-1 immunotherapy combined with chemotherapy has shown promising pathologic responses in various cancers, including oral squamous cell carcinoma (OSCC). However, the pathologic response of lymph node (LN) metastases remains poorly understood. This study aims to systematically evaluate the pathologic response rates (pRR) of LN metastases in patients with OSCC and identify potential targets to improve therapeutic outcomes.

[Practice and thoughts of standardized training of oral and maxillofacial surgery specialists].

The standardized training of oral and maxillofacial surgery specialists is an important part of post-graduation education in oral and maxillofacial surgery, and has been transferred from the initial local pilot to the full implementation stage. Hospital of Stomatology, Wuhan University is the first batch of national oral and maxillofacial surgery training bases in China, with a total of 25 students enrolled since 2018. The author is one of the first batch of oral and maxillofacial surgery trainees and instructors in China.

"Hammock" Mucosal advancement flaps:a new reconstruction method for lip defects.

Lips play a crucial role in facial aesthetics, and lip defects not only impact appearance but also function. Repairing lip defects has long been a big challenge for surgeons. Currently, "V" shaped excisions are commonly employed in lip tumor surgeries, encompassing both the lesion and surrounding normal tissue, which facilitates wound closure.

Unique clinical features and prognostic risk factors of oral squamous cell carcinoma in patients under 30 years old.

Background: Individuals under 30 years old with oral squamous cell carcinoma (OSCC) are a relatively rare subgroup but require attention. However, literature on the clinicopathological characteristics of OSCC patients under 30 is currently lacking.

Methods: A total of 66 OSCC patients under 30 were included in this study.

Application of Anterolateral Thigh Chimeric Flap in Reconstruction of Orbitomaxillary Defects.

Objective: This study aimed to investigate the feasibility and applicability of anterolateral thigh chimeric flap in the reconstruction of orbitomaxillary defects.

Methods: This retrospective study involved 3 patients with orbitomaxillary defects due to maxillary or maxillary sinus tumors invading the orbit, who underwent anterolateral thigh chimeric flap reconstruction from November 2013 to February 2023.

Results: All 3 patients were males, with maxillary sinus or maxillary tumors invading the orbit, and all underwent extended maxillectomy and orbital exenteration.

Identification and management of recurrent oral squamous cell carcinoma in the clinical presentation of osteoradionecrosis: a single-center case series for treatment experience sharing.

Introduction: Radiotherapy is an integral component of the comprehensive and sequential treatment approach for advanced oral squamous cell carcinoma (OSCC). One of the significant complications associated with radiotherapy is osteoradionecrosis (ORN), which most frequently affects the mandible. Differentiating between osteoradionecrosis (ORN) and recurrent oral squamous cell carcinoma (ORSCC) can be challenging when relying solely on clinical and radiologic characteristics.

Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial.

Patients with locally advanced oral squamous cell carcinoma (OSCC) have poor outcomes with standard care. Neoadjuvant therapy is shown to be effective for these patients. In the randomized, two-arm, phase 2, non-comparative trial, we investigate the efficacy and safety of the neoadjuvant programmed cell death 1 (PD-1) inhibitor camrelizumab with or without docetaxel-cisplatin-5-fluorouracil (TPF) chemotherapy in patients with resectable locally advanced OSCC.

Enhancing immunotherapy efficacy in oral cancer through AKB-9778-mediated vascular normalization.

Tumor vasculature exhibit numerous abnormal features distinct from those of healthy vessels, potentially advancing tumor development by establishing an aberrant microenvironment. Therefore, vascular normalization has proven to be an effective tactic for substantially enhancing treatment efficacy across multiple tumors. However, the methods to attain vascular normalization may vary among tumor types.

Preparation of anterolateral thigh flap from polio-affected lower limb: A safe surgical option that preserves patient's motor function.

The anterolateral thigh (ALT) flap is a commonly used donor site for reconstructive surger, especially in head and neck reconstructions. The flap's success is primarily determined by the quality and quantity of its perforating vessels, which is why clinicians typically prefer harvesting from a healthy leg with intact vascular anatomy. Poliomyelitis typically causes unilateral lower limb paralysis, resulting in muscle atrophy and deformities.

Diagnostic and Therapeutic Approach to Rare Tongue Lipoma.

Lipomas are benign soft tissue tumors composed of mature adipocytes, commonly found in subcutaneous tissues. Despite their prevalence in various body regions, they are relatively rare in the oral and maxillofacial regions. This study retrospectively analyzed the clinical and imaging characteristics, as well as the treatment outcomes of 57 patients diagnosed with lipoma.

Advances in subpopulation separation and detection of extracellular vesicles: for liquid biopsy and downstream research.

Extracellular vesicles (EVs) are carriers of a diverse array of bioactive molecules, making them valuable clinical tools for liquid biopsy in disease diagnosis and prognosis evaluation. These molecules play critical roles in various physiological and pathological conditions, and effective separation of EVs is essential to achieve these objectives. Due to the high heterogeneity of EVs, particularly with regard to their cargo molecules, merely isolating the general EV population is inadequate for liquid biopsy and biological function studies.

Rare Delayed Immune Thrombocytopenic Purpura Associated With Neoadjuvant Immunotherapy.

Background: Immunotherapy targeting the PD-L1/PD-1 checkpoint pathway with monoclonal antibodies has demonstrated significant and durable efficacy across various malignancies. However, these immunotherapies can induce adverse reactions, collectively referred to as immune-related adverse events (irAEs). Most irAEs occur during immunotherapy.