New Perspectives on Maxillofacial Reconstruction in Patients With Skeletal Malocclusion: Deep Integration of Maxillofacial Reconstruction and Orthognathic Surgery Concepts.

The application of computer-assisted design and manufacturing (CAD/CAM) technology and digital guides has made maxillofacial defect reconstruction surgery faster, more convenient, precise, and highly accurate in restoration. However, in addressing maxillofacial reconstruction for patients with skeletal malocclusion, the restoration of facial contours has received less attention, and surgical planning for such cases remains challenging. In this study, we report a case where the deep integration of maxillofacial reconstruction and orthognathic surgery concepts was applied.

MiR-590-5p regulates cell proliferation, apoptosis, migration and invasion in oral squamous cell carcinoma by targeting RECK.

Objective: To discover the role of miR-590-5p in oral squamous cell carcinoma (OSCC) progression and the corresponding mechanism via the targeting RECK.

Methods: OSCC (n=85) and normal oral tissues (n=60) were collected to quantify the miR-590-5p expression by using qRT-PCR. Then SCC-15 and OEC-M1 cells were selected and divided into Mock, inhibitor NC, miR-590-5p inhibitor, si-RECK and miR-590-5p inhibitor + si-RECK groups.

LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression.

The study aims to investigate how DANCR can alter the growth and metastasis of oral squamous cell carcinoma (OSCC) cells by regulating miR-216a-5p. The expression of DANCR and miR-216a-5p in OSCC patients and cells were measured. SCC15 and CAL-27 cells were selected to divide into Control, sh-NC, DANCR shRNA, DANCR, miR-216a-5p mimic, and DANCR + miR-216a-5p mimic groups.