Pharmacological Targeting of DHHC9-Mediated STRN4 Palmitoylation to Suppress YAP-Driven Cancer Metastasis.

Protein S-palmitoylation, a dynamic and reversible post-translational modification involving the attachment of palmitate to cysteine residues, is a key regulator of protein functionality and cellular signalling. Dysregulation of this modification has emerged as a critical driver of cancer progression. Among the 23 DHHC palmitoyl transferases responsible for catalysing S-palmitoylation, aberrant expression of specific members is linked to tumorigenesis and development, underscoring their potential as promising therapeutic targets.

Association between neutrophil-to-HDL cholesterol ratio and the risk of gout or hyperuricemia: evidence from NHANES 2007-2018.

Background: Neutrophil-to-HDL-C ratio (NHR) has recently emerged as a composite biomarker integrating lipid metabolism and inflammatory status. Nevertheless, its potential association with the risk of gout or hyperuricemia remains inadequately explored. The present study aimed to examine the possible link between NHR and both conditions.

Quantitative proteomics reveals the mechanism of L-glu-induced phenolics enrichment in wheat (Triticum aestivum L.) sprouts under NaCl stress.

The purpose of this study was to reveal the effect and mechanism of L-Glu treatment on the enrichment of phenolic compounds in wheat sprouts under NaCl stress. Results of data independent acquisition (DIA) proteomics analysis showed that there were 978 DAPs in NaCl compared to CK, and 3813, 202, and 3413 DAPs in L-Glu, glutamate receptor antagonist 6,7-dinitriquinoxaline-2,3-dinoe (DNQX), and L-Glu plus DNQX compared to NaCl, respectively. These DAPs were mainly related to cellular metabolism, organic matter metabolism, and polyphenol compound metabolism.

Dual . isolated anti-Ro antibody positivity in rheumatoid arthritis.

Objective: This study aimed to evaluate the clinical and immunological significance of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies in rheumatoid arthritis (RA), particularly the association of dual antibody positivity with disease severity, systemic manifestations, and therapeutic resistance.

Methods: We conducted a cohort study involving 670 RA patients, stratified into four groups according to anti-Ro52 and anti-Ro60 antibody status: Ro52+/Ro60+, Ro52+/Ro60-, Ro52-/Ro60+, and Ro52-/Ro60-. Clinical characteristics, disease activity scores (DAS28-ESR, DAS28-CRP), systemic complications, and treatment responses were compared among groups.

Research and advances in mouse models of diabetic nephropathy: a narrative review.

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD), and thus, appropriate animal models are critically needed to investigate its pathogenesis and identify new therapeutic targets. DN mouse models are important tools for studying the mechanisms of DN and exploring therapeutic strategies. Common features of the renal pathology in diabetic patients include thickening of the glomerular basement membrane, mesangial expansion, glomerulosclerosis, tubular injury, and interstitial fibrosis.

Dual-ferroptosis induction-based microneedle patches for enhanced chemodynamic/photothermal combination therapy against triple-negative breast cancer.

Triple-negative breast cancer (TNBC) remains a refractory subtype of breast cancer due to its resistance to various therapeutic strategies. In this study, we introduce a "brake-release and accelerator-pressing" approach to engineer a microneedle patch embedded with copper-doped Prussian blue nanoparticles (Cu-PB) and the ferroptosis inducer sorafenib (SRF) for raised chemodynamic (CDT)/photothermal (PTT) combination therapy against TNBC. Upon transdermal insertion, the dissolving microneedles swiftly disintegrate and facilitate the release of SRF.

Exploring the influencing factors of teacher beliefs and their impact on teacher behaviors.

Background: With the continuous advancement of educational technology and the growing variety of educational models, teachers' roles and duties have experienced significant transformations. To adapt to these rapidly evolving educational demands, teachers must adjust their teacher strategies. teacher beliefs are central to their instructional decisions and significantly impact educational quality and student learning outcomes.

Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy.

Word count of the full article: 4834Diabetic cardiomyopathy (DCM) is defined as myocardial dysfunction in diabetes mellitus (DM) patients independent of coronary artery disease (CAD) or hypertension (HTN). With high morbidity and mortality, DCM poses a significant threat to patient health. Its underlying pathogenesis remains incompletely elucidated, and the prolonged subclinical phase renders early diagnosis and precise treatment clinically challenging.

Tracking Engagement with Remote Patient Monitoring in Prenatal Care and Detection of Preeclampsia: A Retrospective Review.

Mobile technology may enhance traditional prenatal care by supporting screening and patient compliance. Although prior studies report high satisfaction with mobile prenatal technologies, the impact of integrating remote patient monitoring (RPM) into routine workflows on clinical outcomes remains uncertain. This retrospective study assessed whether higher engagement with RPM via the Babyscripts™ digital health platform was associated with increased detection of preeclampsia (PEC).

The mitigative effects of 1009924 on DSS-induced intestinal inflammation.

Introduction: The gut microbiota plays a crucial role in the treatment of inflammatory bowel disease (IBD). Recent studies have shown that the abundance of is associated with host inflammatory bowel disease (IBD), yet its specific mechanism of action remains to be further investigated.

Methods: The strain 1009924 ( 1009924) was isolated from fresh fecal samples, and its biological characteristics and genomic features were analyzed.

A percolating path to green iron.

About 1.9 gigatons of steel is produced every year, emitting 8% (3.6 gigatons) of global CO in the process.

Effects of dietary supplementation with periplaneta americana-derived antimicrobial peptides on (PA-AMPs) growth performance, immune function, and gut health in yellow-feathered broilers.

This study aimed to comprehensively investigate the effects of American cockroach antimicrobial peptide (PA-AMPs) on yellow-feathered broilers. Three hundred one-day-old yellow-feathered broilers were randomly divided into five groups: the control group (CON) fed a basal diet, three PA-AMPs treatment groups with 100 mg/kg, 200 mg/kg, and 300 mg/kg PA-AMPs added to the basal diet respectively, and the ARY group with 20 mg/kg chlortetracycline in the basal diet. Each group had six replicates of 10 chickens each, and the experiment lasted for 70 days.

Spatial proximity effects on cognitive processing of multimedia learning among college students: evidence from functional near-infrared spectroscopy.

Aim: From a cognitive perspective, the spatial proximity effect suggests that during the process of the brain processing information, the degree of information processing and construction varies with spatial distance. However, most previous studies mainly relied on behavioral experiments.

Methods: To investigate the neural mechanisms underlying the spatial proximity effect, this study employed functional near-infrared spectroscopic imaging (fNIRS) to monitor and analyze the neural activity in the prefrontal cortex of 36 college students while they engaged in learning tasks with different graphic formats (proximity vs.

Hourly Relative Humidity and Fall Injuries in China: A Nationwide Case-Crossover Study Based on 4.19 Million Cases.

Falls represent a significant public health issue worldwide. Previous studies have demonstrated associations of temperature with fall risk, but the effect and burden of hourly relative humidity and fall morbidity have been rarely investigated. Fall data and meteorological data were collected from the National Injury Surveillance System during 2006-2021 in China.

Formulation Optimization and Quality Evaluation of Walnut Protein Sausage Based on Fuzzy Mathematics Sensory Evaluation Combined With Random Centroid Optimization.

To explore new plant protein resources and develop novel walnut-based protein products, sensory scores were adopted as an evaluation index, and seven optimization factors, which included salt, sugar, modified starch, egg white powder, walnut oil, lab-prepared spices, and walnut tissue protein, were selected. A fuzzy mathematics sensory evaluation model integrated with random centroid optimization was developed to optimize the processing parameters of walnut protein sausage. A comparative analysis was conducted, with soy protein sausages, wheat protein sausages, and commercially available vegetarian sausages, based on the basic physicochemical properties, texture characteristics, nutritional functions, and biomimetic sensory qualities of walnut protein sausages.

Epidemiology of tuberculosis and HIV coinfection among inpatients in chengdu, china, 2018-2022.

Background: Tuberculosis (TB) and human immunodeficiency virus (HIV) infection are infectious diseases that pose serious threats to human health. TB and HIV can interact to promote the progression of diseases. This study aims to provide basic evidence for the formulation of disease prevention and control strategies.

Dual positivity for Anti-Ro52 and Anti-Ro60 antibodies is linked to greater organ involvement and disease progression in systemic sclerosis.

Objectives: To investigate the distinct and combined effects of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies on the clinical features and prognosis of patients with systemic sclerosis (SSc).

Methods: A single-center observational study was conducted using data from the Renji Scleroderma Longitudinal Cohort (Renji-SLOC), including 379 SSc patients with at least 1 year of follow-up. The patients were categorized into four groups based on serological status: double-negative (Ro52/Ro60), isolated anti-Ro52/TRIM21 positive (Ro52), isolated anti-Ro60/SSA positive (Ro60), double-positive (Ro52/Ro60).

Effects of dietary (black goji berry) branches supplementation on growth performance, meat quality, and muscle amino acid and fatty acid composition in sheep.

Introduction: The aim of this study was to investigate the effect of a preparation of black goji berry branches () on growth performance, meat quality, amino acid and fatty acid content of sheep.

Methods: The experiment was a one-way completely randomized trial, in which 40 male sheep of the F1 generation of Dupo × Lake sheep crosses at four months of age were randomly divided into four groups of ten lambs each. Each group was fed an isoenergetic and isonitrogenous total mixed pellet ration containing 0% (CON), 10% (H1), 20% (H2) and 30% (H3) of branches.

Lipid Droplet-Mediated Extraction of Perilla Seed Oil: Stability, Absorbability and Carrier Potential.

Perilla seed oil (PSO), rich in unsaturated α-linolenic acid, faces challenges such as oxidation susceptibility, low solubility, and poor bioaccessibility, limiting its applications. In this study, PSO was extracted from Perilla seeds as lipid droplets (LDs) using sucrose density gradient centrifugation. The resulting PSLDs exhibited a spherical morphology with a diameter of 1.

Bioactive Polysaccharides Prevent Lipopolysaccharide-Induced Intestinal Inflammation via Immunomodulation, Antioxidant Activity, and Microbiota Regulation.

Intestinal inflammation involves barrier impairment, immune hyperactivation, and oxidative stress imbalance. Bioactive polysaccharides universally alleviate inflammation via anti-inflammatory, antioxidant, and microbiota-modulating effects, yet exhibit distinct core mechanisms. Elucidating these differences is vital for targeted polysaccharide applications.

Fracture Behavior of Steel-Fiber-Reinforced High-Strength Self-Compacting Concrete: A Digital Image Correlation Analysis.

In this study, steel fibers were used to improve the mechanical properties of high-strength self-compacting concrete (HSSCC), and its effect on the fracture mechanical properties was investigated by a three-point bending test with notched beams. Coupled with the digital image correlation (DIC) technique, the fracture process of steel-fiber-reinforced HSSCC was analyzed to elucidate the reinforcing and fracture-resisting mechanisms of steel fibers. The results indicate that the compressive strength and flexural strength of HSSCC cured for 28 days exhibited an initial decrease and then an enhancement as the volume fraction () of steel fibers increased, whereas the flexural-to-compressive ratio linearly increased.

Integrative multi-omics analysis N4-acetylcytidine modification landscape and the role of TMEM65 in breast cancer.

N4-acetylcytidine (ac4C), an evolutionarily conserved RNA modification regulated by NAT10, is increasingly recognized for its role in post-transcriptional gene regulation. However, the modification patterns and clinical significance of ac4C remain largely unclear in breast cancer (BC). In this study, we performed single-cell transcriptomic analysis to investigate the heterogeneity of ac4C-related gene (acRG) activity within the BC microenvironment for the first time.

AISI and MASLD: a nonlinear association in U.S. adults (NHANES 2017-2020).

Background: Systemic inflammation is recognized as a key driver in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). While emerging evidence suggests that the Aggregate Index of Systemic Inflammation (AISI) may reflect overall inflammatory burden, its association with MASLD prevalence remains poorly understood, especially in large population-based studies.

Methods: This is a population-based, cross-sectional study analyzed NHANES data (2017-2020) from 5,948 U.