Study of independent diagnostic efficacy and co-diagnostic strategies of molecular markers for diabetic cardiomyopathy.

Word count of the full article: 4834Diabetic cardiomyopathy (DCM) is defined as myocardial dysfunction in diabetes mellitus (DM) patients independent of coronary artery disease (CAD) or hypertension (HTN). With high morbidity and mortality, DCM poses a significant threat to patient health. Its underlying pathogenesis remains incompletely elucidated, and the prolonged subclinical phase renders early diagnosis and precise treatment clinically challenging.

Tuning Magnetism of Metal-Organic Framework by Different Types of Pressure.

The properties of metal-organic frameworks (MOFs) are expected to be sensitive to external pressures because of their inherently flexible structures. Although pressure-driven structural transitions have been intensively studied, the influence of pressure on magnetism has been less exploited for MOFs. Especially, the efficiency of applied pressure may strongly depend on the pressure-transmitting medium (PTM), which may have a complex interaction with MOFs.

An efficient approach for the extraction of glycoproteins from American ginseng by natural deep eutectic solvent.

Glycoproteins have not been reported in the previous studies of American ginseng. This study focuses on developing an efficient method for the extraction of glycoproteins from American ginseng (GAG). Three choline chloride (ChCl)-based natural deep eutectic solvents (NADES) and three extraction techniques including microwave-, ultrasound-, and heating and stirring-assisted extraction were evaluated in the study.

O-RADS US versus IOTA simple rules in the diagnosis of benign and malignant adnexal masses: a prospective study.

Background: Although many studies have validated the diagnostic performance of Ovarian-Adnexal Reporting and Data Systems ultrasound (O-‎RADS US), most have been observed by experienced sonologists, and relatively few by junior sonologists. The purpose of this study was to compare the diagnostic performance of the O-RADS US and the International Ovarian Tumor Analysis (IOTA) Simple Rules (SRs) in senior and junior sonologists to determine a more suitable assessment model for general clinical use.

Methods: We prospectively recruited 228 patients diagnosed with adnexal masses (AMs).

Unraveling evolutionary pathways: allopolyploidization and introgression in polyploid Prunus (Rosaceae).

Allopolyploidization, resulting from hybridization and subsequent whole-genome duplication (WGD), is a fundamental mechanism driving evolutionary diversification across various lineages within the Tree of Life. The polyploid Prunus (Rosaceae), significant for its economic and agricultural value, provides an ideal model for investigating the evolutionary dynamics associated with allopolyploidy. In this study, we utilized deep genome skimming (DGS) data to demonstrate a comprehensive analytical framework for elucidating the underlying allopolyploidy that includes a newly adapted tool (DGS-Tree2GD) tailored explicitly for accurately detecting WGD events.

Serum uric acid reduction through SGLT2 inhibitors: evidence from a systematic review and meta-analysis.

Background: Elevated serum uric acid (SUA) is strongly associated with adverse clinical outcomes. Sodium-glucose-cotransporter-2 (SGLT2) inhibitors not only lower blood glucose levels but also reduce UA. However, comparative data on the SUA-lowering effects among different SGLT2 inhibitors remain sparse, hindering evidence-based drug selection.

Effects of sodium-glucose cotransporter-2 inhibitors on serum urate levels and gout in patients with and without type 2 diabetes: a systematic review and network meta-analysis.

Background: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors can decrease serum uric acid (sUA) levels and have potential in the management of glucose levels and cardiorenal protection in patients.

Aim: This systematic review and network meta-analysis aimed to investigate the effects of SGLT-2 inhibitors on sUA levels and incidence of gout in patients with or without type 2 diabetes.

Method: A systematic search of PubMed, Embase, Cochrane Central Register of Controlled Trials, and Clinical Trials databases was performed to retrieve relevant articles published from inception to April 27, 2025, focusing on the impact of SGLT-2 inhibitors on sUA levels or the incidence of gout in the study participants.

Retinal vessel metric analysis of type 1 diabetes mellitus in OCT angiography.

Purpose: To investigate retinal vascular characteristics in type 1 diabetes mellitus (T1DM) patients at different stages via optical coherence tomography angiography (OCTA).

Design: A retrospective observational study.

Method: 63 T1DM patients (110 eyes) who underwent OCTA (3*3 mm) examination and 40 age-matched healthy individuals (79 eyes) were included.

L-Phenylalanine preharvest spraying effectively enhances the reactive oxygen metabolism and antioxidant capacity in postharvest broccoli.

Broccoli exhibits a high susceptibility to quality deterioration during postharvest storage. Previous studies have shown that preharvest spraying of 2 mmol/L L-phenylalanine (L-Phe) can effectively inhibit the chlorophyll degradation of broccoli during storage, thereby delaying yellowing. However, its effect on reactive oxygen species (ROS) homeostasis and corresponding antioxidant defense mechanisms and antioxidant capacity has not been elucidated.

A study on the effectiveness and safety of interventional embolization using drug-loaded microspheres in combination with sorafenib and envafolimab for intermediate and advanced renal cell carcinoma.

Objective: To investigate the effectiveness and safety of drug-loaded microsphere interventional embolization (D-TAE) in conjunction with sorafenib and envafolimab in the management of intermediate and advanced renal carcinoma.

Methods: 120 cases of intermediate and advanced renal cell carcinoma cured in the Oncology Department of our hospital from January 2022 to December 2023 were selected. Individuals in the combination group received D-TAE paired with sorafenib and envafolimab.

CAVIN3 deficiency promotes vascular normalization in ocular neovascular disease via ERK/JAG1 signaling pathway.

Multiple members of the caveolae-associated protein (Cavin) family are implicated in angiogenesis. However, the specific role of CAVIN3 in pathological angiogenesis within the eye remains unclear. The present study demonstrated that CAVIN3 knockdown in endothelial cells (ECs) promoted vascular normalization in ocular pathological neovascularization.

Beautiful and regular vascularization in a borderline ovarian seromucinous tumor detected by microvascular imaging.

Background: In clinical practice, borderline seromucinous ovarian tumor (SMBT) is hard to differentiate preoperatively on ultrasound.

Case: We presented a case of SMBT. In this case, microvascular imaging, particularly three-dimensional (3D) microvascular imaging of ultrasound showed the regular distribution of vascularity along the axis of the papillary trunk and branches.

Bilateral deformable attention transformer for screening of high myopia using optical coherence tomography.

Myopia is a visual impairment caused by excessive refractive power of the cornea or lens or elongation of the eyeball. Due to the various classification criteria associated with high myopia, such as spherical equivalent (SE) and axial length (AL), existing methods primarily rely on individual classification criteria for model design. In this paper, to comprehensively utilize multiple indicators, we design a multi-label classification model for high myopia.

Global research trends of home pharmaceutical care: a bibliometric analysis via CiteSpace.

Background: This study aimed to systematically review the research on home pharmaceutical care and to identify emerging trends and research hotspots using bibliometric methods.

Methods: Publications related to home pharmaceutical care, published from inception to 6 February 2025, were extracted from the Web of Science Core Collection (WoSCC). The bibliometric tool CiteSpace was employed to analyze various metrics, including the number of publications, contributing countries, institutions, authors, keywords, cited references, and research trends in the field of home pharmaceutical care.

Cesarean Scar Pregnancy Prognostic Classification System Based on Machine-Learning and Traditional Linear Scoring Models.

Objectives: Cesarean scar pregnancy (CSP) refers to a special type of pregnancy with a variable prognosis. We aimed to establish a prognostic classification system using ultrasound and clinical features to provide a reference for management strategies.

Methods: Exactly 230 patients with CSP were included and categorized into three groups based on treatment and prognosis: Group A (favorable prognosis), Group B (moderate prognosis), and Group C (poor prognosis).

Risk of intraocular pressure elevation associated with triamcinolone acetonide administration via different routes in macular edema: a systematic review and network meta-analysis of randomized controlled trials.

Purpose: The local application of triamcinolone acetonide (TA) in patients with macular edema (ME) is off-label and the data are limited. We designed a systematic review and network meta-analysis to compare risk of intraocular pressure (IOP) elevation among TA for different routes of administration used by patients diagnosed with macular edema.

Methods: We obtained data from the PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials for randomized controlled trials (RCTs).

investigation of PEDV transmission via nasal infection: mechanisms of CD4 T-cell-mediated intestinal infection.

The porcine epidemic diarrhea virus (PEDV), a highly pathogenic coronavirus, poses significant challenges to global swine agriculture with severe economic consequences. Our research reveals that in addition to known transmission routes, PEDV can be airborne, initially invading the nasal mucosa and subsequently being transported by dendritic cells and peripheral blood T cells, ultimately leading to intestinal disease in piglets. This study elucidates the cellular mechanisms behind the process, demonstrating how PEDV is internalized by CD4 T cells after being transferred by dendritic cells, where it establishes a latent infection.

Mussel-inspired modification of bamboo fibers via co-deposition of polydopamine cross-linked polyethyleneimine for advanced interfacial compatibility improvement in PLA composites.

Interfacial modification has been extensively studied in the realm of plant fiber-reinforced bio-composites, with biomimetic polydopamine (PDA) modification garnering significant attention in recent years. This paper presents a novel strategy involving the one-pot co-deposition of PDA cross-linked with polyethyleneimine (PEI) to modify bamboo fibers (BF) for reinforcing polylactic acid (PLA). This approach enhances the interfacial compatibility between BF and PLA through robust linkages in a convenient, green, and non-destructive way.

Anomalous Magnetodielectric Effect in the Metal-Organic Framework [CHNH][Co(HCOO)].

We have investigated the anisotropic magnetodielectric effect in the perovskite metal-organic framework [CHNH][Co(HCOO)] single crystals. At 2 K, the spin reorientation along the [101] direction induces a notable dielectric peak, while the ferromagnetic ground state along the [010] direction gives rise to a pronounced positive magnetodielectric effect, which is attributed to the strong magnetic anisotropy of the [CHNH][Co(HCOO)] compounds. At the critical temperature of magnetic ordering, the maximum magnetodielectric effect is observed when both magnetic and electric fields are applied along the [010] or [101] directions, with Δε/ε values of -0.

Risk of diabetic ketoacidosis caused by sodium glucose cotransporter-2 inhibitors in patients with type 1 diabetes: a systematic review and network meta-analysis of randomized controlled trials.

Background: The benefits of sodium-glucose-cotransporter-2 (SGLT2) inhibitors in the treatment of type 1 diabetes mellitus (T1DM) have been demonstrated, but the occurrence of diabetic ketoacidosis (DKA) limits their use. The risk of DKA associated with different doses of SGLT2 inhibitous in the treatment of T1DM is unknown. We conducted a network meta-analysis to evaluate the incidence of DKA at different doses in the treatment of T1DM.

Novel 2D/3D vascular biomarkers reveal association between fundus changes and coronary heart disease.

Purpose: To compare structural and vascular differences in the macular region of the retina using optical coherence tomography (OCT)/OCT angiography (OCTA) between coronary angiography (CAG)-confirmed coronary heart disease (CHD) patients and non-CHD individuals.

Methods: The study included 340 eyes from 180 CHD patients and 136 eyes from 68 controls. Imaging was conducted using the AngioVue OCT device with a macula-centered 6 mm ∗ 6 mm field of view.

BCT-Net: semantic-guided breast cancer segmentation on BUS.

Accurately and swiftly segmenting breast tumors is significant for cancer diagnosis and treatment. Ultrasound imaging stands as one of the widely employed methods in clinical practice. However, due to challenges such as low contrast, blurred boundaries, and prevalent shadows in ultrasound images, tumor segmentation remains a daunting task.

Efficacy of different routes of triamcinolone acetonide administration on macular edema: A systematic review and network meta-analysis.

There is different administration routes of triamcinolone acetonide (TA) administration for macular edema, but the efficacy ranking remains unclear. The purpose of this study is to assess the efficacy of different administration routes of TA employed in macular edema. PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials were systematically searched for published articles comparing macular edema in patients with triamcinolone acetonide in different administration.

Axial length to corneal curvature radius ratio is negatively correlated with choroidal blood flow in myopic children.

Background: The pathophysiologic mechanisms underlying early-onset myopia remain unclear; in this study, we investigate the pathogenesis by examining the interrelationships between axial length to corneal curvature radius ratio ( ) and choroidal blood flow.

Methods: This cross-sectional study included 202 eyes from myopic children, categorized into 141 eyes with mild myopia, 47 eyes with moderate myopia, and 14 eyes with high myopia. Optical coherence tomography angiography (OCTA) was used to measure choroidal blood flow perfusion within a 6 mm × 6 mm area of the macular region, divided into nine subareas based on ETDRS partitioning: macular fovea, nasal side 1, superior 1, temporal side 1, inferior 1, nasal side 2, superior 2, temporal side 2, and inferior 2.