Comments on Two Controversial Oriental Assassin Bug Species of the Genus (Heteroptera: Reduviidae: Harpactorinae), with the Description of sp. nov. from China.

The two closely related Oriental species of the genus , (Stål, 1867) and (Fabricius, 1787), exhibit remarkable morphological similarity, particularly in their overall red and black body coloration, including the head, thorax, and abdomen. Based on the examination of type specimens and non-type material collected from various localities of southern China, we found these two congeners were misidentified in many previous publications. Due to the restricted distribution and limited population size of in China, most taxonomic, biological, and biocontrol studies conducted under the name or should be instead attributed to To address this confusion regarding these two species, the present study clarifies the taxonomic status of the two controversial species- and .

Synthesis of Cyclopropyl Carbocyclic Nucleosides via P(NMe)-Mediated Reductive Cyclopropanation.

We have successfully developed P(NMe)-mediated reductive cyclopropanation, which provides a new, facile, and efficient protocol for the synthesis of cyclopropyl carbocyclic nucleosides, wherein the cyclopropyl group is linked to the nucleobase via a methylene group. This method utilizes safe, commercially available α-keto esters for metal-free cyclopropanation under mild conditions with high yield and diastereoselectivity, demonstrating broad applicability and practical utility in carbocyclic nucleoside synthesis.

Clinical risk assessment of serum creatinine abnormalities during vancomycin therapy: a retrospective study using machine learning models.

Introduction: Vancomycin is a widely used antibiotic for the treatment of serious Gram-positive bacterial infections. However, its clinical utility is often limited by the risk of nephrotoxicity, typically reflected by abnormalities in serum creatinine levels, which may indicate the occurrence of acute kidney injury (AKI). Timely identification of patients at increased risk is essential for early intervention and improved clinical outcomes.

SIRT6 Lysine-Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE-Cadherin Pathway Regulating Vascular Endothelial Barrier.

Cardiovascular diseases (CVDs) progression is significantly modulated by epigenetic mechanisms, particularly through Sirtuin 6 (SIRT6), a key NAD⁺-dependent deacetylase in the sirtuin family. Though essential for cardiovascular homeostasis, the effects of SIRT6-mediated lysine myristoylation on CVDs progression remain largely unexplored due to detection limitations. This study developes an innovative lysine-myristoylated peptide enrichment technique, identifying mutant SIRT6 (H133Y) with high myristoyl affinity but deficient demyristoylase activity.

Design and performance evaluation of flexible terahertz ultra-wideband stop-band filters.

This paper, to the best of our knowledge, introduces a novel ultra-wideband stop-band filter based on the metal-dielectric-metal structure. The filter makes use of flexible polydimethylsiloxane as the dielectric material, leveraging its high refractive index to achieve the desired filter benefits with minimal loss. For the metal layers, we combine copper with gold, thereby saving costs and reducing the oxidation of the copper.

Emerging biomedical applications of herbal extracts-based biomaterials.

Bioactive herbal extracts have garnered significant attention due to their multitarget regulation and low toxicity, yet their clinical applications are limited by poor solubility, low bioavailability, and insufficient targeting. This review systematically summarizes the pharmacological properties of terpenoids, alkaloids, flavonoids, polysaccharides, and other components, and explores their synergistic integration with biomaterials such as nanoparticle delivery systems, microneedles, and hydrogels. Functionalized nanocarriers enhance the stability and targeting efficiency of paclitaxel, berberine, and other bioactive herbal extracts.

Controllable Assembly of Planar Defect-Rich Bimetallic Oxide Interfaces for Efficient Ammonia Production.

The electrocatalytic nitrate reduction reaction (NitRR) is a promising dual-functional strategy for carbon-free ammonia synthesis and sustainable wastewater treatment. The complexity of the eight-electron/nine-proton transfer process in the NitRR highlights the need for improved catalysts to optimize reaction pathways and suppress competitive side reactions. Herein, the successful growth of CuCoO nanowires with tailored defect structures is reported with the assistance of graphdiyne (GDY) through an atomic-level heterointerface engineering strategy.

Glycyrrhizic Acid From Glycyrrhiza uralensis Fish: A Novel Therapeutic Candidate for Alzheimer's Disease Targeting the JNK Signaling Pathway.

Alzheimer's disease (AD) has emerged as a prevalent public health concern. This study aims to investigate the mechanism of Glycyrrhiza uralensis Fish. in AD through the utilization of network pharmacology, molecular docking, and in vitro validation techniques.

Pre-treatment peripheral blood TCR repertoire as a predictor of response in patients with NSCLC treated with immunochemotherapy.

Background: Although there has been progress in developing T-cell receptor (TCR)-based biomarkers to predict clinical benefit (CB) in patients treated with immune checkpoint blockade (ICB) therapy, studies on the circulating TCR repertoire in non-small cell lung cancer (NSCLC) remain limited. Therefore, further investigation and validation of the TCR repertoire as a potential biomarker for predicting the benefit of immune checkpoint inhibitor therapy are needed.

Methods: Blood samples were collected from patients with advanced NSCLC before initiating anti-programmed cell death 1 (anti-PD-1) antibody treatment in combination with chemotherapy.

An antibacterial hydrogel coating with pH-regulated rifampicin loading for prevention of catheter-associated infections.

Medical catheters often fail due to bacterial infections during clinical use. An antibacterial coating offers an effective material solution to this issue. Herein, we prepared a polyelectrolyte hydrogel coating with tunable antibiotic loading.

Primary closure and prophylactic antibiotics for treatment of traumatic wounds caused by mammals, a systematic review and meta-analysis.

Purpose: To compare primary closure (PC) with delayed/no closure (DC/NC), and compare prophylactic use of antibiotics (PUA) with no use of antibiotics (NUA) in the treatment of traumatic wounds caused by mammals by a systematic review and meta-analysis.

Methods: PubMed and Embase databases were searched for eligible randomized clinical trials (RCTs) and observational studies. Qualities of RCTs were assessed according to Cochrane risk of bias tool, qualities of observational studies were assessed according to Newcastle-Ottawa Scale.

Surface Amorphization of Bismuth for Efficient Acidic CO Electrolysis.

The electrochemical conversion of CO into valuable chemicals under acidic conditions provides a promising solution to challenges, such as carbon loss and catalyst instability caused by carbonate precipitation. However, acidic CO electroreduction remains severely constrained by intense competition from the hydrogen evolution reaction (HER) and sluggish CO activation kinetics. Here, we report a bismuth (Bi) nanoparticle catalyst with an amorphous surface layer (-Bi), which demonstrates high catalytic activity and selectivity toward formic acid (HCOOH) formation in acidic electrolytes.

Gestational Diabetes Mellitus Rats Induce Anxiety-Depression-Like Behavior in Offspring: Association with Neuroinflammation and NF-κB Pathway.

The gestational diabetes mellitus (GDM) rat model was established through a combination of high-fat diet and streptozotocin. GDM is a common disease during pregnancy with high morbidity, which is associated with a high risk of neurological changes in the offspring. Neuroinflammation plays an important role in the development of anxiety-depression-like behavior.

Tool use aids prey-fishing in a specialist predator of stingless bees.

Tool use is widely reported across a broad range of the animal kingdom, yet comprehensive empirical tests of its function and evolutionary drivers remain scarce, predominantly focused on a few relatively intelligent vertebrate lineages. In this study, we provide a comprehensive examination of tool use behavior in the assassin bug , a specialist predator of stingless bees that exploits resin droplet from bee nest entrance to facilitate hunting. Field behavioral experiments demonstrated that resin use is critical for hunting success, as the predator uses resin to stimulate the colonial defense of stingless bees, luring attacking bees toward its optimal hunting position.

Imaging the evolution of lithium-solid electrolyte interface using operando scanning electron microscopy.

The quality of Li-solid electrolyte interface is crucial for the performance of solid-state lithium metal batteries, particularly at low stack pressure, but its dynamics during cell operation remain poorly understood due to a lack of reliable operando characterization techniques. Here, we report the evolution of Li-electrolyte interface with high spatial resolution using operando scanning electron microscopy under realistic operating conditions. By tracking the stripping process of both Li and Li-rich Li-Mg alloy anodes, we show that multiple voids coalesce into a single gap and eventually delaminate the interface in Li, whereas the voids split and collapse to partially recover interfacial contact in Li-Mg.

Sustainable and cost-efficient hydrogen production using platinum clusters at minimal loading.

Proton exchange membrane water electrolysis stands as a promising technology for sustainable hydrogen production, although its viability hinges on minimizing platinum (Pt) usage without sacrificing catalytic efficiency. Central to this challenge is enhancing the intrinsic activity of Pt while ensuring the stability of the catalyst. We herein present a MoTiC MXene-supported Pt nanocluster catalyst (MoTiC-Pt) that requires a minimal Pt content (36 μg cm) to function, yet remains highly active and stable.

Cardiosplenic axis-targeted immunomodulatory liposome for myocardial ischemia-reperfusion injury treatment.

Monocyte/macrophage (Mo/Mϕ) infiltration is critical in myocardial ischemia-reperfusion injury (MIRI). However, the complex composition of the myocardium severely hinders drug accumulation and makes it challenging to modulate the Mo/Mϕ immune response at the MIRI site. The spleen, acting as a Mo/Mϕ reservoir, plays a crucial role in the development of MIRI along the cardiosplenic axis.

In situ protein corona-camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis.

Arterial thrombosis is commonly accompanied by poor recanalization and high recurrence, typically caused by a fibrinolysis-resistant microenvironment. We identify elevated levels of plasminogen activator inhibitor-1 (PAI-1) and, notably, its strong correlation with inflammation in arterial thrombosis. To address this, small molecular inhibitors of PAI-1 and inflammation are used as bioregulators to restore vascular homeostasis.

Single-atom Fe anchored graphdiyne for high-efficiency nitrate-to-ammonia conversion under ambient conditions.

The electrocatalytic conversion of wastewater nitrate (NO) to ammonia (NH) under industrial-grade current densities at ambient conditions presents a sustainable alternative to the energy-intensive Haber-Bosch process, yet remains fundamentally challenging. Here, a highly efficient NO to NH electrocatalyst with single Fe atoms dispersed on graphdiyne (GDY) is constructed through an growth method. Experimental analysis demonstrates the formation of high-density atomic active sites on GDY, ensuring the high intrinsic activity of the electrocatalyst.

Cascade Nanozyme Delivering miRNA to Ischemic Heart to Alleviate Myocardial Ischemia-Reperfusion Injury.

Myocardial infarction (MI) causes cardiac dysfunction and threatens global health. Timely reperfusion following MI unavoidably contributes to additional cardiomyocyte death, a phenomenon known as myocardial ischemia/reperfusion injury (I/RI). The surge in free radicals and extensive cardiomyocyte loss significantly promote the progression toward heart failure, a condition that remains a major therapeutic challenge.

27-hydroxycholesterol impairs placental development via p53/p21/Cdk6 pathway: Implications for nutrient transport and cellular senescence.

Aberrant placental development and function contribute to various pregnancy complications. 27-hydroxycholesterol (27-OHC), a recognized mediator linking hypercholesterolemia and metabolic diseases, has an undefined role in placental development. This study investigates the impact of 27-OHC on placental development and its underlying mechanisms, particularly in relation to cellular senescence.

Turning lances into shields: flower mantids stretch their raptorial forelegs to avert and deflect predator attack.

Evolutionary co-option, in which existing traits acquire novel adaptive functions, is a key strategy by which organisms adapt to new environmental challenges. Although such co-option has been widely documented at the genetic and morphological levels, its incidence at the behavioural level remains largely unknown. Mantids stretch their forelegs to capture prey; however, some flower mantids also perform foreleg stretches in the absence of prey.

Complete heart block after occlusion and repair for perimembranous ventricular septal defect.

Background: Complete atrioventricular conduction block (CAVB) is a major complication of the repair and occlusion of perimembranous ventricular septal defects (pmVSDs).

Objective: This study aimed to analyse the incidence and risk factors of CAVB after occlusion and repair of pmVSD.

Methods: We reviewed patients with pmVSDs who underwent occlusion and repair between January 2010 and January 2022.

An Air-Operated, High-Performance Fe-Ion Secondary Battery Using Acidic Electrolyte.

Fe have emerged as the ideal charge carriers to construct aqueous batteries as one of the most competitive candidates for next-generation low-cost and safe energy storage. Unfortunately, the fast oxidation of Fe into Fe at ambient conditions inevitably requires the assembly process of the cells in an oxygen-free glovebox. Up to date, direct air assembly of aqueous Fe-ion battery remains very desirable yet highly challenge.