Validation of the GERAADA Score for Predicting 30-Day Mortality Rate in Acute Type A Aortic Dissection: A Single-Center Study in China.

Background: This study aimed to validate the predictive performance of the GERAADA (German Registry for Acute Type A Aortic Dissection) score in predicting 30-day mortality rate in patients with acute type A aortic dissection in China.

Methods: We retrospectively analyzed 526 patients who underwent surgical treatment for acute type A aortic dissection at our institution between 2018 and 2021. The predictive performance of the GERAADA score was evaluated using calibration (observed-to-expected ratio and Hosmer-Lemeshow test) and discrimination (area under the receiver operating characteristic curve).

Relationship between glycolipid metabolism and aortic dissection in a hypertensive population: a early diagnostic model with internal training and external validation.

Background: The relationship between glycolipid metabolism and acute type A aortic dissection in patients with hypertension remains unknown.

Materials And Methods: All patients with hypertension from six centers over the past five years were enrolled in this retrospective multi-center study. Participants from the leading institution were classified into the training set and those from the participating institutions were classified into the validation set.

Prevalence and factors associated with thirst in children after congenital heart disease surgery: a cross-sectional study.

Background: Thirst is a prevalent and intense symptom experienced in children after congenital heart disease (CHD) surgery. Identifying independent risk factors for thirst is crucial for early prevention and management. This study aimed to investigate the incidence, severity, and influencing factors of thirst in children after CHD surgery.

Transcriptome profiling and weighted gene co-expression network analysis reveal changes of hub genes and molecular pathways in rat lungs following deep hypothermic circulatory arrest.

Background: The incidence of acute lung injury (ALI) following aortic dissection repair surgery that involves deep hypothermic circulatory arrest (DHCA) is notably high. We analyzed hub genes and signaling pathways in rat lung tissues post-DHCA using transcriptome sequencing and weighted gene co-expression network analysis (WGCNA).

Methods: A rat model of DHCA was established, and lung tissues were collected after the procedure.

Triple-Branched Stent Graft for Acute Type A Aortic Dissection Complicated by Imaging Cerebral Malperfusion: A Multicentre Retrospective Study.

Background: Patients with acute type A aortic dissection (ATAAD) complicated by imaging cerebral malperfusion (ICM) have poor prognoses. In this study we aimed to evaluate the clinical efficacy of the modified triple-branched stent graft (MTBSG) in these patients.

Methods: In this retrospective comparative study we analyzed consecutive patients with ATAAD complicated by ICM between 2010 and 2019 who underwent either MTBSG implantation or conventional total arch replacement with frozen elephant trunk.

Association between geriatric nutritional risk index and In-Hospital mortality in acute aortic dissection patients: a retrospective cohort study.

Background: The impact of the geriatric nutritional risk index (GNRI) on the prognosis of patients with acute Stanford type A aortic dissection (AAAD) remains unclear. This study sought to explore the predictive value of GNRI for in-hospital mortality in patients with AAAD.

Methods: We conducted a retrospective analysis of patients who underwent surgery for AAAD from January 2014 to December 2022.

Predictive Significance of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio in Post-Percutaneous Coronary Intervention Contrast-Induced Nephropathy Among Patients with Coronary Artery Disease.

Purpose: This study aimed to examine the connection between monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and contrast-induced nephropathy (CIN) and to introduce a novel perspective to early clinical diagnosis of CIN.

Patients And Methods: This single-center bidirectional cohort study included 1771 patients with coronary artery disease (CAD) who underwent elective percutaneous coronary intervention (PCI) from January 2017 to July 2022 at the Fujian Medical University Union Hospital. The study collected data retrospectively through an electronic medical record system with postoperative follow-up.

C-reactive protein-triglyceride glucose index and heart failure in US adults from NHANES 2001-2010.

The C-reactive protein(CRP)-triglyceride glucose index (CTI) is a new composite biomarker used to assess inflammation and insulin resistance(IR) severity. Heart failure (HF) poses a substantial epidemiological threat with increasing incidence and mortality worldwide. However, the relationship between CTI and HF has not been extensively investigated.

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2 Smooth Muscle Cells.

Obesity is a significant risk factor for thoracic aortic dissection (TAD), as supported by UK Biobank data showing obese individuals have a higher risk of TAD. The study investigates leptin, a hormone elevated in obesity, and finds that hyperleptinemia is common in TAD patients, suggesting its role in disease pathogenesis. Using leptin-knockout mice, it is demonstrated that exogenous leptin exacerbates TAD by promoting phenotypic transitions in vascular smooth muscle cells (VSMCs).

HMGB2 regulates pyroptosis of smooth muscle cells in aortic dissection by modulating ROS-TLR4-NF-κB pathway.

Background And Aims: Inflammatory processes are closely associated with the pathogenesis of aortic dissection (AD). Pyroptosis, a caspase-dependent programmed cell death mechanism, plays a pivotal role in amplifying inflammatory cascades. High-mobility group box 2 (HMGB2), a pro-inflammatory mediator released by immune cells, has emerged as a critical regulator in cardiovascular pathologies.

The latent class and influencing factors of kinesiophobia in patients after cardiac surgery with cardiopulmonary bypass: A prospective longitudinal study.

Background: Kinesiophobia is common in patients after cardiac surgery with cardiopulmonary bypass (CPB), affecting their recovery and well-being. This study aimed to explore kinesiophobia trajectories and their influencing factors to inform personalized interventions.

Methods: A prospective longitudinal study was conducted in a tertiary hospital in southern China, enrolling 301 patients who underwent cardiac surgery with CPB between January and July 2023 via continuous sampling method.

Expert Consensus on Clinical Application of Implantable Biventricular Assist Devices.

While biventricular assist devices (BiVADs) remain underutilized in Western countries for biventricular heart failure (BHF), their application is expanding in China. This consensus synthesizes international guidelines, medical evidence, and Chinese clinical expertise to establish standardized protocols for BiVAD management. Key recommendations include: (1) Preoperative right heart catheterization and echocardiography for central venous pressure (CVP): pulmonary capillary wedge pressure (PCWP) ratio and pulmonary artery pulsatility index (PAPi) assessment (Class I); (2) BiVAD indication in refractory BHF or high-risk right heart failure post-left ventricular assist device (LVAD) implantation (Class IIa); (3) Right atrial implantation as the preferred surgical approach (Class IIa); (4) Warfarin-based anticoagulation (INR 2.

Predictive role of serum sST2 for heart failure in children with severe pneumonia.

Objective: To evaluate the predictive value of soluble suppression of tumorigenesis-2 (sST2) for heart failure (HF) in children hospitalized with severe pneumonia.

Methods: A total of 109 children with severe pneumonia who were admitted to our hospital between January 2022 and December 2023 were selected. They were divided into HF and non-HF groups based on whether they developed HF.

Association between inflammatory burden index and prognosis in patients with coronary heart disease: A retrospective study.

Background: Increasing evidences indicate that systemic inflammation plays a significant role of adverse prognosis in patients with coronary heart disease (CHD). The inflammatory burden index (IBI) is a novel biomarker that reflects systemic inflammation. The aim of this study was to investigate the association between IBI and prognosis of CHD patients.

Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis.

Aortic aneurysm and dissection (AAD) are severe cardiovascular conditions that carry significant risks and currently lack an effective treatment. Ursodeoxycholic acid (UDCA) can delay the onset of various metabolic diseases such as type 2 diabetes and obesity. However, it remains unclear whether UDCA can delay the onset of AAD.

Design and performance verification of a novel vascular anastomosis connector.

Rapid and safe vascular anastomosis can improve the success rate of surgical procedures and further promote wound healing in patients. Vascular anastomosis connectors (VACs) hold significant potential for facilitating rapid and safe anastomosis. In this study, polylactic acid (PLA) and polycarbonate (PC-ISO) are selected as the materials to prepare VACs.

Nonlinear association between visceral fat metabolism score and heart failure: insights from LightGBM modeling and SHAP-Driven feature interpretation in NHANES.

Objective: Using 2005-2018 NHANES data, this study examined the association between the visceral fat metabolism score (METS-VF) and heart failure (HF) prevalence in U.S. adults, leveraging machine learning (LightGBM/XGBoost) and SHAP for classfication performance evaluation and feature interpretation.

Development and validation of a novel prognostic score to improve prognostic prediction in patients with type B aortic dissection.

Objective: Type B aortic dissection (TBAD) is a life-threatening aortic disease with an increasing incidence, which requires accurate risk stratification tools for thoracic endovascular aortic repair (TEVAR). This multicenter retrospective study aimed to enhance the risk prediction of severe adverse events post TEVAR in patients with TBAD by improving the Age, Creatinine, and Ejection Fraction (ACEF) score.

Methods: This multicenter retrospective study enrolled 547 patients with TBAD who underwent TEVAR between 2015 and 2020.

The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease.

Background And Objective: The Naples Prognostic Score (NPS) is a tool for assessing inflammation and nutrition, widely used in outcome evaluation. However, its association with adverse outcomes in patients with coronary artery disease (CAD) has not been explored. This study aims to investigate the prognostic value of NPS in CAD patients.

Neutrophil Percentage to Albumin Ratio Is Associated With In-Hospital Mortality in Patients With Acute Type A Aortic Dissection.

The neutrophil percentage to albumin ratio (NPAR) has been associated with prognosis of various cardiovascular diseases, but its role in acute type A aortic dissection (AAAD) mortality remains unclear. The aim of this study was to investigate the relationship between preoperative NPAR and in-hospital mortality in AAAD patients. Clinical data from patients who underwent AAAD surgery at the Cardiac Medical Center of Fujian Province between January 2020 and April 2024 were retrospectively analyzed.

Symptom characteristics in patients undergoing acute type A aortic dissection surgery post-discharge phase: a prospective observational study.

Objectives: In recent years, most studies on symptom characteristics in patients undergoing cardiac surgery have focused on the preoperative and postoperative phases. Relatively little knowledge is available related to the post-discharge phase. In this context, this paper aimed to analyze the symptoms and needs of patients with acute type A aortic dissection (AAAD) during the post-discharge phase.

CXCL2 Mediates Lactate Secretion and Promotes Aortic Dissection Formation through the p38/JNK/C-myc Pathways.

Aortic dissection (AD) is a critical cardiovascular condition with high mortality risk, and elevated lactate levels are linked to increased postoperative mortality in AD patients. CXCL2 is recognized for its significant involvement in cardiovascular pathologies. Nevertheless, the mechanisms by which CXCL2 regulates lactate levels in AD remain to be fully elucidated.

A Cross-Sectional Study on Emotional Eating and Its Influencing Factors Among Clinical Nurses.

Aims: The aim of this study is to investigate the prevalence of emotional eating and the influencing factors among clinical nurses in China.

Background: Emotions are closely associated with eating behaviours, and individuals' coping mechanisms for various emotions may manifest in their eating habits. Emotional eating may harm nurses' physical and mental health, ultimately affecting the quality of care.

Metformin and Risks of Aortic Aneurysm and Aortic Dissection: A Mendelian Randomization Study.

Background: Previous research has suggested that metformin may inhibit the dilation of an abdominal aortic aneurysm (AAA); however, these findings are controversial. Additionally, limited reporting exists on the relationships between metformin and thoracic aortic aneurysm (TAA) and aortic dissection (AD). Therefore, this study aimed to assess the potential relationship between metformin and the risk of aortic aneurysm (AA)/AD using the Mendelian randomization (MR) analysis.