C-reactive protein-triglyceride glucose index and heart failure in US adults from NHANES 2001-2010.

The C-reactive protein(CRP)-triglyceride glucose index (CTI) is a new composite biomarker used to assess inflammation and insulin resistance(IR) severity. Heart failure (HF) poses a substantial epidemiological threat with increasing incidence and mortality worldwide. However, the relationship between CTI and HF has not been extensively investigated.

Nonlinear association between visceral fat metabolism score and heart failure: insights from LightGBM modeling and SHAP-Driven feature interpretation in NHANES.

Objective: Using 2005-2018 NHANES data, this study examined the association between the visceral fat metabolism score (METS-VF) and heart failure (HF) prevalence in U.S. adults, leveraging machine learning (LightGBM/XGBoost) and SHAP for classfication performance evaluation and feature interpretation.

Para-aortic lymph node dissection in left-sided colorectal cancer: Risk factors, prognostic impact, and therapeutic value.

Aim: This study aimed to clarify risk factors, prognostic impact, and the therapeutic value of para-aortic lymph node (PALN) dissection in left-sided colorectal cancer.

Method: One hundred and fifty-four patients who underwent primary tumor resection and PALN dissection for left-sided colorectal cancer were included. Logistic regression analysis was used to identify risk factors for PALN metastasis.

c.835-5T>G Variant in SMN1 Gene Causes Transcript Exclusion of Exon 7 and Spinal Muscular Atrophy.

Spinal muscular atrophy (SMA) is an autosomal recessive genetic disorder caused by survival motor neuron (SMN) protein deficiency leading the loss of motor neurons in the anterior horns of the spinal cord and brainstem. More than 95% of SMA patients are attributed to the homozygous deletion of survival motor neuron 1 (SMN1) gene, and approximately 5% are caused by compound heterozygous with a SMN1 deletion and a subtle mutation. Here, we identified a rare variant c.