AI-driven and Traditional Radiomic Model for Predicting Muscle Invasion in Bladder Cancer via Multi-parametric Imaging: A Systematic Review and Meta-analysis.

Rationale And Objectives: This study systematically evaluates the diagnostic performance of artificial intelligence (AI)-driven and conventional radiomics models in detecting muscle-invasive bladder cancer (MIBC) through meta-analytical approaches. Furthermore, it investigates their potential synergistic value with the Vesical Imaging-Reporting and Data System (VI-RADS) and assesses clinical translation prospects.

Methods: This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Tumor-targeting and redox dual-responsive hyaluronic acid-based polymeric micelles loaded with celastrol for breast cancer treatment.

Hyaluronic acid derivatives have broad prospects in the in vivo targeted delivery of insoluble antitumor drugs. In this study, rhein-selenocystamine-hyaluronic acid (RSeHA) polymeric micelles (PMs) were designed and developed to load celastrol (Cela) to solve its poor water solubility, low bioavailability, and severe toxicity for breast cancer treatment. Cela-loaded RSeHA PMs (Cela/RSeHA PMs) with a particle size of 159.

The gut-liver axis in progressive steatotic liver disease: A focus on bile acid dysregulation.

Introduction: The gut-liver axis regulates metabolic homeostasis, with bile acids (BAs) serving as key signalling molecules. BA dysregulation is implicated in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction- and alcohol-associated liver disease (MetALD), yet consistent identification of BA markers and their mechanistic roles across different stages of these diseases remain elusive.

Methods: We integrated three complementary studies to examine BA dysregulation: a population-based cohort (1522 females from TwinsUK with serum BA and liver biomarker data), a clinical cohort (30 patients with steatotic liver disease, fibrosis stages F0-F4, and 4 controls), and rodent models (20 rats with MASLD/MetALD vs.

Adverse events of pexidartinib for the treatment of TGCT: a real-world disproportionality analysis using FDA Adverse Event Reporting System database.

Introduction: Pexidartinib, an oral selective colony-stimulating factor 1 receptor (CSF1R) inhibitor, is the only systemic therapy approved by the U.S. Food and Drug Administration (FDA) for tenosynovial giant cell tumor (TGCT).

Identification of a dominant stripe rust resistance gene YrXY on chromosome 6R in hexaploid triticale.

Breeding resistant cultivars is the most effective strategy to control stripe rust in cereal crops. The hexaploid triticale line Xinyi is highly resistant to stripe rust at the seedling and adult plant stages. A segregating F population derived from a cross between Xinyi and the susceptible hexaploid triticale cultivar Zhongsi1048 was assessed to understand the genetic architecture of stripe rust resistance.

Toward preclinical evaluation of a thermosensitive PEG-poly(-alanine) hydrogel: A study on sterilization, storage stability, and in vivo performance.

Poly(amino acid)-based thermosensitive hydrogels hold great potential for clinical translation. Herein, we employ a thermosensitive methoxy poly(ethylene glycol)-block-poly(-alanine) (mPEG-PAla) hydrogel that undergoes a sol-to-gel transition upon heating as the model system to systematically evaluates its sterilizability, storage stability, in vivo degradation and in vivo drug release profiles-critical factors for clinical translation. mPEG-PAla copolymers are synthesized via ring-opening polymerization using the optimized amount of crown ether as the catalyst, ensuring controlled polymerization while minimizing catalyst usage.

Os-Ru nanozyme with peroxidase-mimicking activity for rapid dual-readout colorimetric analysis of catechins in green tea beverages.

Catechin, a phenolic-active substance extracted from natural plants, exhibits a wide range of biological activities. However, exceeding safe levels can harm human health, making accurate quantification essential. Current assay methods, however, do not provide efficient or precise catechin measurements.

[Study on effectiveness and changes in immunoglobulin levels of transverse tibial transport in treatment of Wagner grade 3-4 type 2 diabetic foot ulcer].

Objective: To investigate the effectiveness of tibial transverse transport (TTT) in treating Wagner grade 3-4 type 2 diabetic foot ulcers and analyze dynamic changes in immunoglobulin levels.

Methods: The clinical data of 68 patients with Wagner grade 3-4 type 2 diabetic foot ulcers treated with TTT between May 2022 and September 2023 was retrospectively analyzed. The cohort included 49 males and 19 females, aged 44-91 years (mean, 67.

Nonvolatile Homogeneous InSe Transistors Regulated by Substrate Engineering.

This study proposes a polarity regulation in two-dimensional InSe via substrate engineering. By selecting different substrates (h-BN and multilayer graphene (MLG)/SiO), controllable doping of p-type and n-type regions on the same piece of two-dimensional InSe material is achieved. Utilizing this characteristic, a high-performance homogeneous PN junction is constructed.

Total X-ray scattering and big-box modeling of pressure-induced local disorder and partial amorphization in CsPbBr.

The mechanisms governing pressure-induced amorphization and its reversibility in halide perovskites are not yet fully understood, particularly the contribution of local disorder. We performed high-pressure synchrotron total X-ray scattering and reverse Monte Carlo (RMC) big-box modeling using CsPbBr as a model system to investigate short-range structural evolution in both the ordered and partially amorphous phases. While diffraction data indicate that long-range order persists up to 2 GPa, pair distribution function (PDF) analysis reveals significant local distortions, including PbBr octahedral tilting and Cs displacement, which influence the bandgap through a complex interplay between bond compression and angular tilting.

Early Supportive and Nutritional Care For Adults With Pancreatic Cancer: A Pilot Study.

Context: Individuals diagnosed with advanced pancreatic cancer face a poor prognosis, heightening the importance of interventions aimed at improving quality of life. Quality of life for individuals with pancreatic cancer is highly influenced by symptom burden and nutritional status. Programs are needed that coordinate palliative and nutrition care for this population.

Measurements of source emittance and beam coherence properties of the upgraded Advanced Photon Source.

The Advanced Photon Source (APS) has been upgraded with a multi-bend achromat lattice, achieving significantly reduced electron beam emittance and enhanced X-ray coherence. Precise characterization of these properties is essential for optimizing beamline performance and enabling new experiments that take full advantage of the upgraded source. We report on measurements of source size and transverse coherence properties using grating interferometry at two beamlines: the APS 3-ID-B undulator beamline and the 1-BM-B bending magnet beamline.

DESERT DUST, SANDSTORMS, AND INFECTIOUS DISEASES: A SCOPING REVIEW.

Desert dust and sandstorms influence air quality by elevating particulate matter concentrations and transporting anthropogenic pollutants, microorganisms, and toxic biogenic allergens. Although there is increasing concern about their role in spreading infectious diseases, the evidence remains limited. This scoping review synthesizes epidemiological literature on the association between desert dust exposure and infectious disease and identifies critical research gaps.

Reduced complex I activity in the retinal pigment epithelium, but not in rod photoreceptors, affects light signaling without impacting cell survival.

Mutations in the mitochondrial respiratory complex I accessory subunit NADH:ubiquinone oxidoreductase subunit S4 (ndufs4) can cause the mitochondrial disease Leigh syndrome, which may be associated with vision loss. We previously demonstrated that mice with global deletion of ndufs4 exhibited impaired in vivo photoreceptor light responses prior to the early death of the mice around postnatal day 50. However, ex vivo electrophysiology recordings performed on retinas from ndufs4 mice were normal, suggesting that the in vivo phenotype may reflect altered homeostasis of the extracellular environment of photoreceptors rather than their intrinsic metabolic dysfunction.

Axial Compression Behavior of Bamboo Scrimber-Filled Steel Tubular (BSFST) Column Under Different Loading Modes.

Bamboo scrimber is an environmentally friendly biomass building material with excellent mechanical properties. However, it is susceptible to delamination failure of the transverse fibers under compression, which limits its structural performance. To address this problem, this study utilizes steel tubes to encase bamboo scrimber, forming a novel bamboo scrimber-filled steel tubular column.

Cyanuric acid in Paramecium secretions is an efficient quorum sensing inducer.

Quorum sensing is a process of bacterial chemical communication via extracellular signal molecules known as autoinducers, allowing synchronized collective behavior changes related to population density. However, the ecological significance of quorum sensing in multi-species communities, particularly coexisting with predators, remains unaddressed. In this study, we discovered that cyanuric acid (CA), a compound secreted by the widespread protozoan Paramecium, significantly influences the LuxR-type quorum sensing in Pseudomonas aeruginosa PAO1.

Prognosis of radical prostatectomy combined with pelvic lymph node dissection in patients with intermediate- and high-risk prostate cancer: a systematic review and single-arm meta-analysis.

Background: The efficacy of pelvic lymph node dissection (PLND) in enhancing the prognosis of patients with intermediate- and high-risk prostate cancer (PCa) has been a subject of ongoing debate. It is noteworthy that a majority of existing studies on this topic are retrospective and have shorter follow-up durations. This meta-analysis is therefore purposed to assess the prognosis of intermediate to high-risk PCa patients who have undergone a combination of radical prostatectomy (RP) and PLND.

Stretchable, Adhesive, Anti-Freezing Hydrogel Electrolytes with Dual-Functional Water Regulation Enabled by Amide Group-Salt-Water Interactions for All-Climate Zinc-Ion Batteries.

Aqueous zinc-ion batteries (AZIBs) are promising candidates for next-generation energy storage due to their intrinsic safety and environmental compatibility. However, parasitic reactions induced by active water molecules in conventional aqueous electrolytes severely degrade electrochemical performance and cycling stability. Herein, a stretchable, adhesive, anti-freezing hydrogel electrolyte with dual-functional water regulation is synthesized via a one-pot radical polymerization strategy, where acetate (Ac) anions and hydrophilic amide (─CONH) groups on polyacrylamide (PAM) chains synergistically regulate water activity.

Elevated EGR1 binding at enhancers in excitatory neurons correlates with neuronal subtype-specific epigenetic regulation.

Background: Brain development and neuronal cell specification are accompanied by epigenetic changes that enable the regulation of diverse gene expression patterns. During these processes, transcription factors interact with cell-type-specific epigenetic marks, binding to unique sets of cis-regulatory elements in different cell types. However, the detailed mechanisms through which cell-type-specific gene regulation is established in neurons remain to be explored.

Dual-layer spectral detector CT-based scoring system for noninvasive TP53 expression assessment and adjuvant chemotherapy response prediction in gastric cancer a multicenter cross-sectional study.

Background: No-invasive early prediction of TP53 is a key strategy for improving the prognosis of gastric cancer (GC) patients. To establish a novel, noninvasive and simple scoring system using dual-layer spectral detector computed tomography (DLCT) for preoperative prediction of TP53 expression, prognosis and response to adjuvant chemotherapy (ACT) with retrospective and prospective validation.

Methods: Between April 2021 and March 2025, 568 GC patients were retrospectively and prospectively recruited from two hospitals into a training cohort (TC), a validation cohort (VC), an internal test cohort (ITC), and an external test cohort (ETC).

Long-term trends in the burden of fracture of vertebral column in China: a comprehensive analysis from 1990 to 2021 based on the global burden of disease study 2021.

Background: Fracture of vertebral column (FVC) is a major public health problem, but the epidemiological investigation of FVC based on large population in China is still limited. This study aims to comprehensively analyze the disease burden of FVC in China from 1990 to 2021, so as to provide insights for public health policies and intervention measures.

Methods: Based on the Global Burden of Disease (GBD) database (1990-2021), the incidence, prevalence, and years lived with disability (YLDs) of FVC were evaluated.

Synthesis of Gold Hydride at High Pressure and High Temperature.

Gold is an unreactive metal and its chemical interactions with hydrogen have only recently been explored. Here, we report the formation of gold hydride above 40 GPa and 2200 K in X-ray free electron laser heated diamond anvil cells using various hydrocarbons as hydrogen sources. Above 40 GPa, a hexagonal phase emerges close to the gold melting point, corresponding to a hydride with stoichiometry , with increasing from 0 to near 1 with pressure from 40 to 80 GPa.

Unraveling the link: exploring what risk factor for sleep disorders among paediatric migraine.

Background: Migraine is closely related to sleep disorders. Vitamin D is known to regulate sleep, cell proliferation and differentiation. The aim of our study was to measure the predictive value of vitamin D for sleep disorders in paediatric migraine.