Tumor-targeting and redox dual-responsive hyaluronic acid-based polymeric micelles loaded with celastrol for breast cancer treatment.

Hyaluronic acid derivatives have broad prospects in the in vivo targeted delivery of insoluble antitumor drugs. In this study, rhein-selenocystamine-hyaluronic acid (RSeHA) polymeric micelles (PMs) were designed and developed to load celastrol (Cela) to solve its poor water solubility, low bioavailability, and severe toxicity for breast cancer treatment. Cela-loaded RSeHA PMs (Cela/RSeHA PMs) with a particle size of 159.

Synthesis and preclinical evaluation of a Ga-labeled peptide for PET imaging of transferrin receptor 1 in tumor.

Purpose: Transferrin receptor 1 (TfR1) is a transmembrane glycoprotein that mediates cellular iron uptake. Despite its potential as a target for tumor diagnosis, the lack of suitable TfR1 ligands has hindered the development of effective TfR1 imaging agents. We labeled a recently discovered TfR1 ligand, TfRB1G3, with Ga-68 and evaluated its potential for TfR1 imaging through preclinical experiments.

Medium-assisted scalable printing of LIPSS via femtosecond laser projection manufacturing.

Femtosecond laser has been widely applied for manufacturing micro-/nanostructures in micro-optics, microelectronics, and biomedical engineering. However, tight focusing remains restricted by efficiency, and large-field scanning with a scanning mirror sacrifices precision. In this paper, we proposed a medium-assisted femtosecond laser projection manufacturing (MA-FPM) approach, which enables the fabrication of controllable patterns that incorporate 115 nm periodic laser-induced periodic surface structures (LIPSS).

Whole-genome sequencing of Fusarium spp. causing sugarcane root rot on both chewing cane and sugar-making cane.

Previously we isolated three Fusarium strains (a F. sacchari strain namely GXUF-1, and another two F. commune strains namely GXUF-2 and GXUF-3), and we verified that GXUF-3 was able to cause sugarcane root rot to the chewing cane cultivar Badila.

Soil pH restricts the ability of biochar to passivate cadmium: A meta-analysis.

Soil acidification is the main cause for aggravation of soil cadmium (Cd) pollution. Biochar treatment can increase the soil pH and decrease the Cd availability in soils. However, there is limited information in literature on the comprehensive assessment of the response of Cd fractions to biochar.

TIGAR/AP-1 axis accelerates the division of Lgr5 reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation.

During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve intestinal stem cells (ISCs) and secretory progenitor cells are both reported to replenish damaged cells and contribute to crypt regeneration.

New molecular insights into the tyrosyl-tRNA synthase inhibitors: CoMFA, CoMSIA analyses and molecular docking studies.

Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be a potent target in combating drug-resistant bacteria.