Promotion of Biomimetic Mineralization Preinfiltration of Mineral Precursors.

Intrafibrillar mineralization plays an important role in dentin repair. Current research on intrafibrillar mineralization primarily focuses on the precise positioning of mineral precursors within collagen and the reduction of mineralization time. Inspired by the multifunctionality of noncollagenous proteins (NCPs), we developed a dual-analogue system, 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) followed by 3-(3,4-dihydroxyphenyl)-l-alanine (l-DOPA)-stabilized amorphous calcium phosphate (M + LA), which integrated a nucleation inhibitor l-DOPA and inducer 10-MDP.

Metal(loid) Source Apportionment and Spatial Drivers in Irrigated Terrace Soils in a Typical Pb-Zn Mining Area.

Metal(loid) contamination levels and the factors governing metal(loid) accumulation patterns in terraced agricultural systems were studied using 1250 surface (0-20 cm depth) soil samples. The average concentrations of Cr, Ni, Cu, As, Cd, Pb, and Zn were 132, 62.3, 140, 42.

PNI as a predictive biomarker: a novel nomogram of immunotherapy efficacy in advanced breast cancer.

Purpose: There has been a persistent upward trend in breast cancer (BC) incidence in recent years. The advancement of immunotherapy has introduced promising therapeutic options. This study focuses on identify potential biomarkers to predict clinical outcomes in advanced BC patients receiving immunotherapy.

High-efficiency decontamination of pharmaceutical wastewater from γ-InSe/MoS/graphene composite driven by broad-spectrum absorption spanning ultraviolet to near-infrared irradiation.

Antibiotic contamination in water bodies poses a grave challenge to both environmental sustainability and human health. Among the emerging technologies for pharmaceutical pollutant decontamination, photocatalysis has garnered significant attention due to its superior efficiency. This study introduces a groundbreaking wide-spectral responsive γ-InSe/MoS/graphene composite system, fabricated through van der Waals interactions.

Allostatic Load and Physical Frailty Increase the Risk of Depression Recurrence in Middle-Aged and Older Adults: A Prospective Cohort Study.

Aims: Individuals with prior depressive episodes have a more fragile homeostasis, but the exploration of depression recurrence remains limited. Our study aimed to explore the associations of allostatic load (AL) and frailty with the risk of depression recurrence.

Methods: This study included 9,936 individuals from the UK Biobank who reported depression prior to recruitment.

In silico design, synthesis and biological evaluation of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment.

Melanoma, a highly aggressive skin cancer, presents significant therapeutic challenges owing to its metastatic potential. Targeting deoxyhypusine synthase (DHPS), a pivotal enzyme in the activation of eukaryotic translation initiation factor 5A (eIF5A), emerges as a promising therapeutic strategy for melanoma. In this study, we designed and synthesized a series of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivatives as novel allosteric DHPS inhibitors.

Prevalence of Isolated Iliac Aneurysm in Patients with Acute Aortic Dissection.

Background: The relationship between isolated iliac aneurysms (IIAs) and acute aortic dissection (AAD) is uncertain. We aimed to determine the prevalence of IIAs in patients with AAD and evaluate the independent risk factors for the presence of IIAs in them.

Methods: Seven patients were confirmed to have AAD with IIAs (AAD + IIA group) who had undergone computed tomography angiography (CTA).

Harringtonine (HT) targets PARP-1 to inhibit TS mRNA m6A modification, blocks STAT3-induced miR-4521/TS axis and attenuates 5-fluorouracil (5-FU) resistance in NSCLC.

Background: Harringtonine (HT), derived from the genus Cephalotaxus, has demonstrated anti-proliferative effects against non-small cell lung cancer (NSCLC). 5-Fluorouracil (5-FU), a cost-effective chemotherapy, faces resistance issues in NSCLC. Thus, exploring HT's mechanisms in inhibiting NSCLC proliferation and overcoming 5-FU resistance is clinically important.

Boosting thermoelectric performance of ferroelectric monolayer α-InSe strongly enhanced phonon scattering induced by site-specific Te doping.

The thermoelectric properties of ferroelectric monolayer α-InSe with site-specific Te doping are systematically investigated using first-principles calculations and on-the-fly machine-learning-assisted phonon transport simulations. Te substitution at different atomic layers leads to a substantial reduction in lattice thermal conductivity, primarily due to enhanced phonon scattering induced by mass contrast and local structural asymmetry. The electronic transport characteristics, including band dispersion, carrier effective mass, and Seebeck coefficient, remain largely unaffected, ensuring preserved power factor.

Design of Realistic and Artistically Expressive 3D Facial Models for Film AIGC: A Cross-Modal Framework Integrating Audience Perception Evaluation.

The rise of virtual production has created an urgent need for both efficient and high-fidelity 3D face generation schemes for cinema and immersive media, but existing methods are often limited by lighting-geometry coupling, multi-view dependency, and insufficient artistic quality. To address this, this study proposes a cross-modal 3D face generation framework based on single-view semantic masks. It utilizes Swin Transformer for multi-level feature extraction and combines with NeRF for illumination decoupled rendering.

Incoherent beam combining of laser array on extended areas based on a gradient light intensity trap and optimization algorithm.

This paper proposes a method for incoherent beam combining on extended areas (or extended targets) based on a gradient light intensity trap, which is effectively created through intensity weighted modulation, and with the help of a proper optimization algorithm, light spots will be guided into this trap to achieve beam combination. A physical model of this method is established, which determines the optimal surface profile of the gradient light intensity trap, thereby aiding in achieving ideal results for multi-channel beams in both modulation and non-modulation. Subsequently, the feasibility of the method is verified in the laboratory, where tip/tilt aberrations are corrected by adaptive fiber-optics collimators during the beam-combining process.

Phase control method for generating orbital angular momentum beams using coherent beam combining based on deep learning.

In recent years, orbital angular momentum (OAM) beams have shown great potential for applications in laser communication, laser processing, optical imaging, and detection. For free-space optical communication, high-power, high-quality vortex beams with a high signal-to-noise ratio are critical for long-distance communication. Coherent beam combining (CBC) of vortex beams enables the enhancement of power while maintaining high beam quality.

Bergamotane-family sesquiterpenes from histone deacetylase inhibitor modified cultures of the fungicolous fungus Montagnula donacina (Niessl) Wanas., E.B.G. Jones & K.D. Hyde.

Epigenetic modification is an effective strategy for uncovering novel metabolites in fungi. In this study, chemical epigenetic manipulation was applied to culture of the fungicolous fungus Montagnula donacina, resulting in significant changes of its specialised metabolite profile. Seventeen undescribed (nor)-bergamotane-type sesquiterpenoids (1-17) were isolated from the culture broth of M.

Impact of Covid-19 Pandemic on Knowledge and Attitude of Nursing Students Regarding Vaccination and Vaccine Hesitancy in China: A Cross-Sectional Study.

Background And Aims: To analyze the impact of the COVID-19 pandemic on vaccine acceptance among nursing students by assessing their knowledge, attitudes towards vaccination, and levels of vaccine hesitancy, thereby addressing the research gap in this area to inform public health strategies.

Methods: A total of 1013 nursing students (544 freshmen and 469 seniors) from Binzhou Medical University, Shandong Second Medical University, and Shandong First Medical University were enrolled during the 2024 academic year. This cross-sectional study used a self-reported questionnaire, and descriptive statistics were applied to illustrate trends in the data.

MKRN1 degrades AGC1 to trigger chemotherapy resistance of colorectal Cancer.

Unlabelled: Oxaliplatin (Oxa) has been extensively employed in treatment of colorectal cancer (CRC), yet frequent occurrence of chemoresistance poses a significant obstacle to achieving long-term disease-free survival for CRC patients. In this study, we employed a CRISPR/Cas9 sgRNA library targeting 1,117 human ubiquitination-related genes to screen key regulators of sensitivity to Oxa and identified the Makorin Ring Finger Protein 1 (MKRN1), an E3 ligase, as an Oxa-resistant gene of CRC cells. Clinically, MKRN1 is highly expressed in CRC tissues compared with the adjacent normal tissue, and its upregulation is correlated with poor therapeutic response, disease progression, and worse overall survival of CRC patients treated with Oxa-based regimens.

Synergically enhanced anti-tumor immunity of in vivo panCAR by circRNA vaccine boosting.

Chimeric antigen receptor (CAR) T cell therapy has shown promise in treating hematologic malignancies, but it still faces challenges, including high costs, a time-consuming manufacturing process, and the necessity of lymphodepletion. Here, we generate circular RNAs (circRNAs) encoding CAR proteins, referred to as circRNA, which mediates remarkable tumor killing in human primary T cells. We demonstrate that circRNA, delivered with immunocyte-tropic lipid nanoparticles (LNPs), can form in vivo panCAR cells (CAR-T, CAR-natural killer [NK], and CAR-macrophage), significantly inhibit tumor growth, and reshape the tumor microenvironment in mice.

Synergistic regulation of fluorescence thermometer sensitivity based on LSPR effect and energy transfer.

Fluorescence intensity ratio (FIR) thermometry is an ideal non-contact temperature measurement method with rapid response and high sensitivity. Improving sensitivity and stability is always the research hotspot in this field. Energy transfer between the emission centers plays a key role to improve temperature sensitivity.

On-Demand Fabrication of Transferable and Repairable Nanoneedle Arrays for Multisurface Applications via the Breath-Figure Method.

This study proposes a novel strategy for fabricating transferable and repairable nanoneedle arrays (NNAs) using the breath-figure (BF) method, which enables the reproducible construction of high-aspect-ratio nanostructures on various substrates, including rigid, flexible, and curved surfaces. The fabricated nanoneedles exhibit excellent mechanical stability and can be selectively repaired by retransferring the BF membrane to the damaged areas. Hydrophilic modification imparts excellent underwater antibubble and superoleophobic properties to the NNAs, with oil droplet contact angles of >170° and 96.

The association between cerebral small vessel disease and unfavorable hematoma morphology in primary intracerebral hemorrhage.

Objective: To study the association between cerebral small vessel diseases (CSVD) and unfavorable hematoma morphology in primary intracerebral hemorrhage (ICH).

Methods: Patients with primary ICH who were admitted to West China Hospital of Sichuan University from March 2012 to January 2021 were consecutively included. The unfavorable hematoma morphology included any hypodensity, any irregularity, black hole, blend sign, Barras shape score ≥3, Barras density score ≥3, immature hematoma and combined Barras total score (CBTS) ≥4.

Multiparametric ultrasound techniques are superior to AI-assisted ultrasound for assessment of solid thyroid nodules: a prospective study.

Objectives: To evaluate the diagnostic performance of multiparametric ultrasound (mpUS) and AI-assisted B-mode ultrasound (AI-US), and their potential to reduce unnecessary biopsies to B-mode for solid thyroid nodules.

Methods: This prospective study enrolled 226 solid thyroid nodules with 145 malignant and 81 benign pathological results from 189 patients (35 men and 154 women; age range, 19-73 years; mean age, 45 years). Each nodule was examined using B-mode, microvascular flow imaging (MVFI), elastography with elasticity contrast index (ECI), and an AI system.

Synthesis of NH·BH and Its -Alkyl Analogues: Toward the Polyhedral Azaboranes, M[NHBH] (M = Na, K).

Improved and effective methods for the synthesis of NH·BH and its -alkyl analogues have been developed with synthetically satisfying yield under mild conditions. The single-crystal structure of NH·BH was determined for the first time, although it was found decades ago. These complexes possess high stability, suggesting promising potential applications in various reactions.

Evolutionary trajectory and functional diversity of SWEET sugar transporters in plants.

SWEET (sugars will eventually be exported transporter) proteins are vital for sugar transport in plants, mediating the movement of glucose, fructose, and sucrose, and playing key roles in growth, development, and stress responses. This study identified 1246 SWEET proteins across 59 plant species, spanning from chlorophytes to eudicots. Phylogenetic analysis revealed that SWEET proteins originated in chlorophytes and diverged into four clades (I-IV).