The Effects of Pseudostellaria heterophylla Polysaccharide on Humoral Immunity and Gene Expression of Splenic Lymphocytes in Chicks.

This study aimed to evaluate the effects of dietary Pseudostellaria heterophylla Polysaccharide (PHP) on humoral immunity and spleen lymphocyte gene expression in chicks. A total of 270 one-day-old healthy Gushi chicks were randomly allocated into three groups: Group A was fed the basic diet without vaccination; Group B received the basic diet and underwent immunization; Group C was provided with the basic diet supplemented with 200 mg/kg PHP, coupled with immunization. Samples were collected at 7, 14, 21, 28, 35, 42, and 49 days.

In silico design, synthesis and biological evaluation of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment.

Melanoma, a highly aggressive skin cancer, presents significant therapeutic challenges owing to its metastatic potential. Targeting deoxyhypusine synthase (DHPS), a pivotal enzyme in the activation of eukaryotic translation initiation factor 5A (eIF5A), emerges as a promising therapeutic strategy for melanoma. In this study, we designed and synthesized a series of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivatives as novel allosteric DHPS inhibitors.