Risk prediction and driver tracking based on watershed resilience dynamics: A case study in Dahei River Basin, China.

The watersheds face increasing pressure from both human activities and natural factors, which exacerbate potential risks and pose significant challenges to integrated watershed management. This study developed an effective methodology to evaluate watershed sustainability and predict potential risks based on watershed resilience dynamics by combining catastrophe theory, adaptive cycle theory, and the Copula-Bayesian Network. Taking the Dahei River Basin (DRB) in China as a case study, we systematically evaluated the resilience dynamics, diagnosed risks, and tracked key driving factors to propose management strategies.

PNI as a predictive biomarker: a novel nomogram of immunotherapy efficacy in advanced breast cancer.

Purpose: There has been a persistent upward trend in breast cancer (BC) incidence in recent years. The advancement of immunotherapy has introduced promising therapeutic options. This study focuses on identify potential biomarkers to predict clinical outcomes in advanced BC patients receiving immunotherapy.

Pharmacological properties and therapeutic potential of berberine: a comprehensive review.

In recent decades, the pharmacological properties of botanical drugs have been investigated with increasing depth, offering novel insights into their potential for enhancing healthcare. Berberine (BBR) is an alkaloid extracted from the roots, rhizomes and stem tubers of plants such as s, , , and several other plants, which is used not only as an anti-inflammatory and antibacterial agent, but also for the treatment of cancer and chronic diseases. BBR has demonstrated remarkable therapeutic efficacy in the management of disorders affecting the nervous, cardiovascular, and endocrine systems, characterized by its high safety profile and minimal adverse effects.

Harnessing Membrane-Targeting Photosensitizers to Evoke Ferroptosis and Pyroptosis Dual-Modal Cell Death for Antitumor Therapy.

Photodynamic therapy (PDT), a noninvasive and spatiotemporally controlled cancer treatment, often suffers from the mitochondrial or lysosomal accumulation of conventional photosensitizers (PSs), primarily triggering apoptosis and limiting efficacy against apoptosis-resistant tumors. Targeting the plasma membrane offers a promising, yet less explored, strategy to induce immunogenic cell death pathways like ferroptosis and pyroptosis, which can overcome therapeutic resistance. However, PSs capable of simultaneously targeting the plasma membrane and activating both ferroptosis and pyroptosis are scarce.

Associations of accelerometer-measured weekend sleep catch-up and loss with risk of type 2 diabetes: a prospective cohort study.

Aims: To investigate the relationship between weekend sleep catch-up and loss and risk of type 2 diabetes (T2D).

Methods: This study included 80,414 adults aged 43-79 years from the UK Biobank. Weekend sleep catch-up and loss were derived from wrist-worn accelerometer data.

Heterogeneous network drug-target interaction prediction model based on graph wavelet transform and multi-level contrastive learning.

Reliable prediction of drug-target interaction (DTI) is essential for accelerating drug discovery, yet remains hindered by data imbalance, limited interpretability, and neglect of protein dynamics. Here, we present GHCDTI, a heterogeneous graph neural framework designed to overcome these challenges through three synergistic innovations. First, cross-view contrastive learning with adaptive positive sampling improves generalization under extreme class imbalance (positive/negative ratio<1:100).

Augmented recruitment of host Grb2 by Helicobacter pylori tyrosine phosphorylated CagA EPIYA-D motif promotes cellular oncogenic transformation.

CagA, one of the key virulence factors of Helicobacter pylori, plays a significant role in H. pylori-associated gastric cancer by actively participating in neoplastic transformation. Among CagA variants, East Asian type CagA (CagA) bearing the EPIYA-D motif exhibits a higher risk than the Western-type (CagA) with EPIYA-C motifs.

Ultrahigh-Performance Photovoltaic GaO Solar-Blind Ultraviolet Detectors via Two-Dimensional Step-Flow Growth and Drift Region Optimization.

Photovoltaic solar-blind ultraviolet photodetectors (SBPDs) operate independently of an external power source, addressing critical demands in extreme environments, such as forest fire detection and atmospheric ozone layer monitoring. Gallium oxide (GaO) offers significant potential for extreme applications due to its radiation resistance and high-temperature stability. Here, we present a novel homoepitaxy strategy to produce an "atomic smooth" step-flow GaO photosensitive layer, successfully fabricating device-grade GaO/n-GaO homojunctions for photovoltaic SBPDs.

ECHS1: pathogenic mechanisms, experimental models, and emerging therapeutic strategies.

The ECHS1 (short-chain enoyl-CoA hydratase 1) gene is critical for mitochondrial fatty acid β-oxidation and branched-chain amino acid metabolism. Mutations in ECHS1 lead to severe mitochondrial dysfunction and are implicated in rare metabolic and neurodegenerative disorders. This review summarizes current understanding of how ECHS1 participates in key molecular processes, including energy metabolism, oxidative stress regulation, and apoptosis, and discusses its influence on mitochondrial function.

Mining and quantitative evaluation of the laboratory biosafety policy in China.

Policies play a pivotal role in guiding and overseeing laboratory biosafety management. To ensure that laboratory biosafety management is underpinned by scientifically robust and well-founded policies, an analysis and evaluation of existing policies were conducted. The object was to identify their merits and limitations, thereby offering references for future policy development.

SPAT inhibits LUAD metastasis by targeting SF1-mediated splicing.

Lung adenocarcinoma (LUAD) progression involves alterations in oncogenes and tumor suppressor genes, collectively shaping tumorigenic landscape. However, the precise interactions within this landscape remain inadequately understood. Here, we present a functional characterization of a novel long non-coding RNA (lncRNA), SPAT (splice associated transcript).

Molecular docking and SARs guiding the gradual development of thiazole-2-yl amide derivatives containing biphenyl groups as promising antifungal scaffolds.

Background: The antifungal activities ofthe initially synthesized thiazol-2-ylbenzamide derivatives were relatively limited, suggesting potential for structural optimization. Inspired by the promising bioactivities of biphenyl scaffolds, and guided by molecular docking and structure-activity relationships (SARs), 42 thiazol-2-ylamide derivatives containing a biphenyl scaffold were synthesized through gradual structural modification, and their antifungal and anti-oomycete activities were assessed. Furthermore, the most potent compound G41 was selected for preliminary mechanistic studies.

Tannic acid-iron nanomaterial enhances rice growth and antioxidant defense under salt stress.

Salinity stress severely impacts plant growth by reducing water uptake and biomass accumulation, while nanomaterial applications have emerged as effective solutions. This study introduces tannic acid-iron nanomaterial (TA-Fe Nanomaterial), a biocompatible nanomaterial synthesized via self-assembly, as a novel solution to mitigate salt stress. Characterized by lamellar morphology (200 nm average size) and robust thermal stability, TA-Fe Nanomaterial demonstrated potent reactive oxygen species (ROS) scavenging capabilities.

High-stability electrohydrodynamic inkjet printing based on double closed-loop fuzzy control.

Electrohydrodynamic (EHD) printing is a promising micro-nano manufacturing technology. However, the EHD printing process is susceptible to interferences like charge repulsion, electric field, airflow, and platform motion, leading to unstable jetting and nonuniform deposition morphology. In this paper, a double close-loop fuzzy control method based on jet image recognition and micro-current measurement was designed to monitor and control the EHD printing process.

ATRA upregulates OTUD6B to recruit CD8 T cells to suppress colorectal liver metastasis by stabilizing DDX5/STAT3/CXCL11 axis.

OTU deubiquitinase 6B (OTUD6B) study in tumors is gradually increasing; however, studies on the role of OTUD6B in colorectal cancer (CRC) are rare. OTUD6B was overexpressed in some human CRC and liver metastasis samples. Although OTUD6B facilitated migration and invasion in CRC cells, it exhibited opposite effects on liver metastasis in immunodeficient and immunocompetent mice.

IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma.

Tyrosine kinase inhibitors (TKIs) are the standard treatment for advanced hepatocellular carcinoma (HCC). However, their therapeutic efficacy is often limited by drug resistance, primarily driven by tumoral intrinsic mechanisms. In this study, we demonstrate that IFNγ in the tumor microenvironment can potentiate TKI response, and that ablation of IFNγ receptor on HCC cells leads to TKI resistance in vivo.

Effects of Mavacamten on Cardiac Magnetic Resonance Features in Chinese Patients With Obstructive Hypertrophic Cardiomyopathy.

Background: Mavacamten, a first-in-class cardiac myosin inhibitor and the only approved cardiac myosin inhibitor worldwide, improved clinical symptoms and health status in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in phase 3 EXPLORER-HCM (Clinical Study to Evaluate Mavacamten [MYK-461] in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy; NCT03470545) and EXPLORER-CN (A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCM; NCT05174416).

Objectives: The purpose of this work was to study the effect of mavacamten on cardiac structure and function by cardiac magnetic resonance (CMR) imaging in Chinese participants in EXPLORER-CN.

Methods: Eligible patients with obstructive HCM underwent CMR imaging at screening and week 30.

Recent Advances in the Therapeutic Effects and Molecular Mechanisms of Baicalin.

Baicalin, a kind of polyphenolic flavonoid, is a major bioactive flavone derived from the root of , which has been widely utilized in clinical practice in China for thousands of years. In recent years, it has attracted increasing attention due to its potential therapeutic properties observed in preclinical studies involving various disease models. However, the precise mechanisms underlying its biological activities have not been fully elucidated.

Enhanced Trained Immunity in Peripheral Monocytes in Unstable Angina With Elevated High-Sensitivity C-Reactive Protein.

Despite effective secondary prevention for coronary heart diseases, recurrent events remain high. Elevated high-sensitivity C-reactive protein (hsCRP) indicates increased inflammation risk. This study aimed to investigate the trained immunity of circulating monocytes in unstable angina (UA) patients with elevated hsCRP.

Endothelial soluble epoxide hydrolase links polyunsaturated fatty acid metabolism to oxidative stress and atherosclerosis progression.

Atheroslcerosis manifests as localized lesions within the vascular tree, preferentially affecting arteries at branch points, the outer wall of bifurcations and the inner walls of curvatures. Such spatial localized sensitivity to atherosclerosis, can be partially attributed to endothelial cell heterogeneity which compromises vascular fitness and contributes to the pathogenesis of the diseases. Here we identified that in a subcluster of aortic endothelial cells characterized with atheroprone gene signatures, the polyunsaturated fatty acids (PUFAs) metabolic enzyme soluble epoxide hydrolase (sEH) is selectively upregulated.

Alpha-Linolenic Acid and Mortality Among Adults With Type 2 Diabetes: Findings From Two National Cohorts.

Background: Dietary alpha-linolenic acid (ALA) regulates lipid metabolism and insulin sensitivity, but few studies have investigated the association between ALA and the risk of mortality among adults with type 2 diabetes (T2D). This study examines whether increasing dietary ALA intake contributes to the long-term survival of adults with T2D.

Methods: This cohort study included 9603 participants with T2D, including 7953 adults from the National Health and Nutrition Examination Survey (NHANES; 1999-2018) and 1650 adults from the China Health and Nutrition Survey (CHNS; 1997-2011).

Transcriptomic analysis of theca cells in a PCOS rat model: insights into follicular development.

Background: This study aimed to analyze differentially expressed genes in theca cells of polycystic ovary syndrome (PCOS) rats using transcriptomic sequencing. Bioinformatics analysis and PCR validation were performed to identify genes involved in follicular development regulation in PCOS.

Methods: Twenty 6-week-old female SD rats with regular estrous cycles were divided into two groups (PCOS and control, n = 10 each).

Identification of risk factors for high-risk dedifferentiation in papillary thyroid carcinoma and construction of discriminative model.

Objective: We initially found that the thyroid differentiation score (TDS) was associated with the prognosis of papillary thyroid carcinoma (PTC) patients. Therefore, this study aimed to investigate the influencing factors and construct a discriminative model of high-risk dedifferentiation, and to explore the possible mechanisms.

Methods: Data were sourced from the TCGA database.