Augmented recruitment of host Grb2 by Helicobacter pylori tyrosine phosphorylated CagA EPIYA-D motif promotes cellular oncogenic transformation.

CagA, one of the key virulence factors of Helicobacter pylori, plays a significant role in H. pylori-associated gastric cancer by actively participating in neoplastic transformation. Among CagA variants, East Asian type CagA (CagA) bearing the EPIYA-D motif exhibits a higher risk than the Western-type (CagA) with EPIYA-C motifs.

East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity.

CagA is a significant oncogenic factor injected into host cells by , which is divided into two subtypes: East Asian type (CagA), characterized by the EPIYA-D motif, and western type (CagA), harboring the EPIYA-C motif. CagA has been reported to have higher carcinogenicity than CagA, although the underlying reason is not fully understood. SHIP2 is an intracellular phosphatase that can be recruited by CagA to perturb the homeostasis of intracellular signaling pathways.

The phosphotransferase system gene ptsH affects persister formation in Klebsiella pneumoniae by regulating cyclic adenosine monophosphate levels.

Klebsiella pneumoniae is one of the most common opportunistic pathogens causing hospital- and community-acquired infections. Antibiotic resistance in K. pneumoniae has emerged as a major clinical and public health threat.

Oceanospirillum sediminis sp. nov., Isolated From Coastal Sediment in the Yellow Sea.

A novel Gram-negative, motile, aerobic, spiral-shaped bacterium designated D5, was isolated from a coastal sediment collected in the Yellow Sea. Optimal growth occurred at 30 °C, pH 7.0-8.

Vibrio marinisediminis sp. nov., Isolated from Marine Sediment.

A novel Gram-stain-negative, facultative anaerobic, motile bacterium, designated as 404, was isolated from a marine sediment sample in the Bohai Gulf, China. Growth was observed at 10-35 °C (optimum, 20-25 °C) and in the presence of 1.0-6.