Genetic burden and multidimensional predictors in prenatal diagnosis of fetal congenital diaphragmatic hernia.

This study aims to assess the genetic burden of fetal congenital diaphragmatic hernia (CDH) and identify prenatal, perinatal, and postnatal predictors to improve early diagnosis, monitoring, and intervention. This study included 130 CDH fetuses who underwent invasive prenatal diagnosis, with fetal prognosis evaluated using imaging parameters such as observed-to-expected lung-to-head ratio (o/e LHR), observed-to-expected total lung volume (o/e TLV), and percent predicted lung volume (PPLV). Clinical outcomes included neonatal outcomes, extracorporeal membrane oxygenation (ECMO) requirement, and post-neonatal prognosis.

PEDUNCLE LENGTH 1 regulates wheat peduncle elongation through brassinosteroid signaling pathway.

This study identifies TaPL1, a MADS-box transcription factor underlying the QFiriti-6B QTL, as a key regulator of peduncle elongation in wheat. TaPL1 enhances brassinosteroid signaling through direct suppression of TaBKI1, and its loss-of-function alleles exhibit reduced plant height and peduncle length, but increased grain weight, offering valuable targets for yield improvement in wheat breeding.

Noninvasive assessment of glymphatic system alterations as potential biomarkers for predicting overall survival in glioma.

Objective: In this retrospective study, authors aimed to evaluate the glymphatic function alterations associated with glioma and explore the prognostic value of these alterations by calculating the index for diffusivity along the perivascular space (ALPS index).

Methods: The authors utilized data from the publicly available University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) dataset, which includes 501 adult patients with histopathologically confirmed diffuse glioma, per the 2021 WHO classification, who underwent preoperative MRI, initial tumor resection, and tumor genetic testing at a single medical center from 2015 to 2021.The ALPS index was calculated from diffusivity maps for noninvasive glymphatic system (GS) analysis.

Discovery of Cytotoxic Barbiturate-Bridged Dimeric Chrolactomycins from TX15.

Six new spirotetronate polyketides, chrolactomycins A-F (-), and the known chrolactomycin () were isolated and identified from TX15. Chrolactomycins D-F (-) feature an unprecedented dimeric skeleton bridged by a rare barbiturate unit. Sequencing and characterization of a type I polyketide synthase biosynthetic gene cluster led to the proposal of a biosynthetic pathway for -.

Experiences and Needs in the Dietary Management of Chronic Kidney Disease: A Qualitative Study of Patient, Caregiver and Healthcare Professionals' Perspectives.

Dietary management is crucial in the disease management of patients with chronic kidney disease (CKD). However, there is still a lack of research on the genuine experiences and needs of patients, caregivers, and healthcare professionals involved in CKD dietary management, especially in the Chinese context. To explore the experiences and needs of Chinese patients with CKD, caregivers, and healthcare professionals regarding dietary management.

Multi-omics analysis of immunologically relevant genes in multiple sclerosis to identify potential drug target.

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and immune dysregulation. Despite the established link with immune function, the genetic and pathological mechanisms connecting immune-related genes to MS remain incompletely understood.

Methods: We systematically integrated genome-wide association study (GWAS) data for various quantitative trait loci (QTLs) from public databases and literature, along with GWAS summary statistics for MS from IMSGC and FinnGen.

Pixel-level transformer GAN for enhanced parametric mapping of DCE MRI analysis.

Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays a crucial role in the diagnosis and monitoring of cancers, as it reveals physiological and vascular characteristics of tumors. Traditional pharmacokinetic modeling necessitates high temporal resolution, resulting in relatively low signal-to-noise ratio (SNR) and spatial resolution with limited allocated time for each phase.

Purpose: To explore the feasibility of using deep learning with sparse DCE MRI phases to generate dense temporal resolution DCE-MRI-derived parametric map.

Uncovering novel functions of NUF2 in glioblastoma and MRI-based expression prediction.

Glioblastoma multiforme (GBM) is a lethal brain tumor with limited therapies. NUF2, a kinetochore protein involved in cell cycle regulation, shows oncogenic potential in various cancers; however, its role in GBM pathogenesis remains unclear. In this study, we investigated NUF2's function and mechanisms in GBM and developed an MRI-based machine learning model to predict its expression non-invasively, and evaluated its potential as a therapeutic target and prognostic biomarker.

Reducing priority polycyclic aromatic hydrocarbons in coal tar pitch through alkylation: Mechanism and potential toxicity evaluation.

Coal tar pitch (CTP) is a carbon material with abundant yield in China, but the toxic polycyclic aromatic hydrocarbons (PAHs) contained in it have restricted its broader applications. In order to reduce the PAHs content, an alkylation method was developed in this study to modify CTP (MCTP) by using 1-dodecene as the alkylating reagent, and the optimal reaction conditions (temperature 170 °C, time 4 h, solvent dosage 60 times that of CTP, and alkylating reagent dosage 4 times that of CTP) for synthesizing the MCTP were determined by alkylation modification with model compounds. Compared with CTP, the content of PAHs in MCTP was reduced by 97.

Cultivation Method-Driven Aroma Diversification in : GC-IMS and Bioelectronic Sensors Reveal Distinctive Volatile Fingerprints.

, a renowned rare medicinal fungus in China, is rich in active components, exhibiting pharmacological effects, such as liver protection, hypoglycemic activity, and anti-tumor properties. Aiming to address the lack of horizontal comparative studies on volatile components of under different culture methods and the limitations of traditional detection methods, this study investigated the mycelia of cultured by solid-state culture (SAC), liquid culture (LAC), and dish culture (DAC). The flavor profiles were comprehensively evaluated using a combination of electronic tongue (E-tongue), electronic nose (E-nose), gas chromatography-ion mobility spectrometry (GC-IMS), and multivariate statistical methods.

Effect of Two-Stage Goal-Directed Crystalloid versus Colloid Fluid Therapy on Postoperative Quality of Recovery in Patients Undergoing Laparoscopic Hepatectomy: A Randomized Controlled Trial.

Objective: This study aimed to investigate the impact of two-stage goal-directed crystalloid versus colloid fluid therapy on postoperative quality of recovery in patients undergoing laparoscopic hepatectomy.

Patients And Methods: A total of 116 patients scheduled for elective laparoscopic hepatectomy were randomly assigned to two groups: the goal-directed fluid therapy (GDFT) crystalloid group and the GDFT colloid group. Both groups were monitored for stroke volume variation (SVV) using the FloTrac/Vigileo system, and GDFT was guided based on SVV values.

A Systematic Survey of the Optimal Strategy for Dealing With Missing Binary Outcomes in Simulation Studies of Randomized Controlled Trials.

Aim: To summarize the optimal strategies for dealing with missing binary outcome data (MBOD) in randomized controlled trials (RCTs) as informed by simulation studies, and to summarize the quality of reporting in these studies.

Methods: To identify simulation studies comparing at least two strategies to deal with MBOD and evaluating their performance (bias, coverage and power), we searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials via Ovid, Web of Science, and JSTOR from their inception up to December 20, 2023. We evaluated reporting quality using established criteria for simulation studies in medical statistics.

Probiotic paradox: bacillibactin from drives pathogenic proliferation through siderophore piracy.

The opportunistic pathogen dominates iron-depleted marine ecosystems, likely driven by its diverse repertoire of siderophore receptors that enable iron piracy from exogenous sources. While the ability to utilize xenosiderophores via piracy can be advantageous under iron limitation, the identities of exogenous siderophore producers interacting with remain poorly characterized. Here, we show that 17.

Exploring the effects of maternal anemia on neonatal neurodevelopment: a systematic review and meta-analysis.

Background: Maternal anemia, particularly iron deficiency anemia (IDA), affects about 30% of women globally. Iron is vital for fetal brain development, influencing myelination and oxygen transport. The extent of maternal anemia's effect on neonatal neurodevelopment remains unclear.

A Comprehensive Analysis and Forecast of Rabies Epidemic and Elimination Challenges - China, 2005-2023.

Introduction: The 2030 global target for eliminating dog-mediated human rabies, jointly proposed by the World Health Organization (WHO) and other international organizations, presents significant challenges for China. This study analyzes epidemiological trends (2005-2023), forecasts future case numbers, and compares China's progress with elimination strategies from the United States, Japan, and Brazil to optimize national rabies prevention and control approaches.

Methods: Descriptive statistics were used to analyze the spatiotemporal distribution of human rabies cases across China.

Solar Membrane Crystallizer with Ultralow Salt Adhesion for Zero Liquid Discharge of Hypersaline Wastewater.

Solar-driven zero-liquid discharge (ZLD) is a promising wastewater management strategy for freshwater recovery and salt resource harvesting. However, currently developed interfacial solar crystallizers fail to maintain high evaporation capability when treating hypersaline wastewater due to the salt scaling problem. The accumulated salt on the solar crystallizers hinders the efficiency of solar-driven ZLD.

Nanozymes in marine antifouling applications: a focus on haloperoxidase activity.

Marine biofouling is the buildup of microorganisms, plants, and animals on underwater surfaces. It causes major economic and environmental problems. Traditional antifouling methods often use toxic chemicals.

Empagliflozin combined with bortezomib in the treatment of heavy and light chain amyloidosis with secondary diabetes: A case report.

Rationale: Primary heavy and light chain amyloidosis (AHL) is extremely rare globally. This study aimed to report the first clinical treatment of AHL secondary diabetes. We also analyzed fasting blood glucose levels across various treatments.

Antigen-presenting cells orchestrate mixed inflammatory endotypes in atopic dermatitis.

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis involving aberrant activation of multiple immune responses. In recent years, targeted biologics have demonstrated significant efficacy in treating moderate to severe AD due to their precise mechanisms. However, the complex inflammatory profile of AD poses challenges for single-target biologics, leading to suboptimal therapeutic responses.

Synergistic volatiles removal via diffusion inhibition and catalysis degradation by photothermal-photocatalytic hydrogel distillation membranes for sustainable water purification.

Photothermal membrane distillation (PMD) faces critical challenges in volatile organic compounds (VOCs) penetration due to their inherent volatility. Herein, we propose a hierarchically engineered photothermal-photocatalytic hydrogel (PPH) membrane with dual defense barriers, integrating an alginate (Alg) hydrogel layer as a kinetic diffusion suppressor and a BiOBr/carbon nanotube layer as a photocatalytic promoter on a hydrophobic substrate. This design enables simultaneous stable water production (2.

Characterization of the structure and properties of carboxymethyl sesbania gum and its antioxidant activity evaluation.

Carboxymethylation is a widely recognized method for modifying galactomannans, often employed to enhance their solubility, stability, and biological activities. In this study, carboxymethyl sesbania gum (CMSG) was synthesized under different reaction conditions, and the influence of these conditions on the degree of substitution was systematically assessed. Alkaline conditions were crucial for carboxymethylation, with reaction temperature, time, and etherifying agent concentration significantly affecting the degree of substitution.

Bioelectrochemistry increases the risk of resistance genes proliferation and transfer with sulfamethoxazole pressure decreasing in constructed wetlands: An overlooked double-edged effect.

Microbial electrochemical system-enhanced constructed wetland (MES-CW) attracts more attention for antibiotic-contaminated wastewater treatment, but the effect of bioelectrochemistry on resistance genes is still unclear with the removal of antibiotic. In this study, the antibiotic resistance genes (ARGs) dynamics, driving factors and transmission mechanism in effluent and substrate samples were investigated under decreasing sulfamethoxazole (SMX) pressure. Bioelectrochemistry was suitable for reducing the risk of ARGs proliferation and transmission at concentration of 0.

Multiscale structure, physicochemical properties, and in vitro digestibility on complex of static magnetic field modified rice starch with quercetin.

This study investigated the effects of static magnetic field-quercetin synergistic modification on the multiscale structure (morphological, crystalline, short-range, and long-range ordered structure), physicochemical properties, and in vitro digestibility of rice starch. The results demonstrated that the synergistic treatment significantly improved starch solubility while reducing swelling power and viscosity. SEM revealed enhanced surface porosity, fissures, and decreased particle size.

[Progress on the Migration Mechanism and Toxic Effects of Nanoplastics in Terrestrial Plants].

Nanoplastics are widely distributed in soil as an emerging environmental contaminant. Recently, the effects of nanoplastics on terrestrial plants have gained significant attention. The mechanisms through which terrestrial plants absorb and transport nanoplastics include surface adsorption, intercellular transport, cleavage uptake, and stomatal uptake.

The association between genetic risk and traditional Chinese medicine syndromes in T2DM patients: A latent class analysis.

Traditional Chinese medicine (TCM) syndromes play a vital role in treating diabetes, and genetics have long been recognized as influcing factor of diabetes. This study aimed to confirm the latent classes of TCM syndromes in type 2 diabetes mellitus (T2DM) patients and to explore the association between genetic risk and those TCM syndromes classes. A total of 1045 T2DM patients from the Ningxia province of China were included in this study.