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Article Abstract
Six new spirotetronate polyketides, chrolactomycins A-F (-), and the known chrolactomycin () were isolated and identified from TX15. Chrolactomycins D-F (-) feature an unprecedented dimeric skeleton bridged by a rare barbiturate unit. Sequencing and characterization of a type I polyketide synthase biosynthetic gene cluster led to the proposal of a biosynthetic pathway for -. Compounds - exhibited antibacterial activities, while - displayed cytotoxicity to multiple cancer cell lines, with dimer demonstrating the most potent effects (IC = 2.2-7.7 μM).
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