A covalent organic polymer fluorescent probe for highly selective and sensitive UO detection in water and food samples.

A highly sensitive, selective, and simple method for detecting uranyl ions (UO) is crucial for human health and environmental safety. Amidoxime-based nanomaterials have been widely employed for UO detection, but their higher affinity for vanadium than UO limits their practical applications. Herein, a novel covalent organic polymer fluorescent probe (TT-COP) for UO detection was innovatively developed by a one-step Schiff-base condensation reaction between 3,3',5,5'-tetramethylbenzidine (TMB) and 2,4,6-triformylphloroglucinol (Tp).

Discovery of novel xanthotoxin-pyridine quaternary ammonium derivatives with membrane-targeting mode of action as potential antimicrobials against methicillin-resistant Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus (MRSA) is a major global health threat owing to its multi-drug resistance, creating an urgent need for novel antibiotics. This study focused on developing anti-MRSA agents by designing and synthesizing 30 xanthotoxin-pyridine quaternary ammonium derivatives, followed by evaluating their antibacterial activity and dissecting their mechanism of action against MRSA. Among all derivatives, III13 demonstrated as the most promising candidate: it exhibited potent anti-MRSA activity (MIC = 1 μg/mL), low cytotoxicity, minimal hemolysis, rapid bactericidal effects, and the ability to disrupt biofilms.

T-2 Toxin Exploits Gut-Derived Staphylococcus Saprophyticus to Disrupt Hepatic Macrophage Homeostasis.

T-2 toxin, a mycotoxin that frequently causes hidden contamination in food and animal feed, poses a substantial threat to both human and animal health. Staphylococcus saprophyticus (S. saprophyticus) is an opportunistic pathogen that widely infects humans and various animals.

STAT1-VAMP8 axis drives nasopharyngeal carcinoma progression via autophagy enhancement.

Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high risk of invasion and metastasis. Elucidating the molecular underpinnings of NPC may uncover new diagnostic and therapeutic targets. Vesicle associated membrane protein 8 (VAMP8) is overexpressed and plays an oncogenic role in various tumors.

Synergistic effect of oxalic acid and siderophore on uranium fractions and microbial community traits in rhizosphere soil enhances uranium accumulation in plant roots.

Chelating agent contributes to the remediation of heavy metal contaminations, but it remains unclear how they affect the transformation of radioactive pollutants and microbial traits in phytoremediation. We comprehensively investigated on the uranium (U) speciation and microbial communities in the rhizosphere of Macleaya cordata, Paspalum scrobiculatum and Bamboo willow, and analyzed the accumulation of U in the three plants after the addition of chelating agents including 0.1 mmol kg siderophore (DFO) and 2.

Theoretical model for estimation and control of radon exposure dose considering ventilation pressure drop in ventilation networks.

To minimize the occupational radiation hazards for workers in uranium or associated radioactive underground mines, it is necessary to control the radon exposure dose in each branch of the mine ventilation network. Firstly, a mathematical model of determining potential alpha energy concentration (PAEC) of radon daughters in a single branch was proposed on the basis of the previous radon concentration calculation model in the ventilation network considering ventilation pressure drop. Then, two estimation models of radon exposure dose based on the equilibrium radon concentration and PAEC of radon daughters are introduced.

Visible-Light-Induced Organic-Dye-Catalyzed Bromination of Activated Alkenes with Sodium Bromide.

The direct introduction of a bromine atom into organic molecules is valuable because of its versatility in synthetic intermediates and modular building blocks but traditionally suffers from poor selectivity and relatively complicated and/or harsh reaction conditions. We herein present the first visible-light-driven organic-dye-catalyzed bromination protocol under mild conditions with high regioselectivity. This methodology leverages rapid intramolecular radical trapping to achieve regioselective monobromination of alkenes, thus effectively suppressing competing dibromination and electrophilic bromination pathways.

Differential Expression of ATP6V1D and Its Diagnostic Potential in IgA Nephropathy.

Objective: IgA nephropathy (IgAN) is the most prevalent form of primary glomerular disease. However, its diagnosis is contingent on kidney biopsy. Therefore, noninvasive biomarkers are urgently needed for diagnosis.

[Determination of 79 pesticide residues in fruits and vegetables by QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry].

Pesticide residues in fruits and vegetables are becoming a serious issue. These residues can affect the quality of agricultural products and people's health. Therefore， it has become crucial to effectively monitor and control pesticide residues in the food safety field.

Clinical gene therapy restores hearing: a paradigm shift.

Recent breakthroughs in gene therapy for autosomal recessive deafness 9 (DFNB9) caused by OTOF mutations have transformed treatment paradigms for hereditary hearing loss (HHL). To date, eight clinical trials targeting DFNB9 have been registered in 51 centers across eight countries, demonstrating the rapid progress of gene therapy in auditory medicine. These pioneering studies establish the framework for the clinical translation of gene therapy targeting HHL.

Association between Systemic Immune-Inflammation Index and female breast cancer based on NHANES data (2001-2018): A cross-sectional study.

Worldwide cancer statistics have shown that breast cancer dominates female cancer incidence and remains a leading cause of death. The Systemic Immune-Inflammation Index (SII) is a new prognostic indicator of systemic inflammation used to assess systemic immune-inflammatory response levels in the human body. It is associated with the prognosis of various diseases, such as malignant tumors, cardiovascular diseases, and autoimmune diseases.

PARP (Poly ADP-ribose Polymerase) Family in Health and Disease.

The poly(ADP-ribose) polymerase (PARP) family consists of 17 members of nicotinamide adenine dinucleotide (NAD⁺)-dependent enzymes that regulate key biological processes by catalyzing adenosine diphosphate (ADP)-ribosylation, either poly(ADP-ribosyl)ation (PARylation) or mono(ADP-ribosyl)ation (MARylation). These biological processes encompass DNA repair, metabolism, telomere maintenance, and immune responses. Based on structural and functional features, the PARP family is classified into subcategories, such as DNA-dependent PARPs, Tankyrase, CCCH-type PARPs, MacroPARPs, and atypical PARPs.

A new deep learning model for predicting IMRT dose distributions for lung cancer with dose masks.

Purpose: 3D U-Net deep neural networks are widely used for predicting radiotherapy dose distributions. However, dose prediction for lung cancer IMRT is limited to conventional radiotherapy, with significant errors in predicting the intermediate and low-dose regions.

Methods: We included a mixed dataset of conventional radiotherapy and simultaneous integrated boost (SIB) radiotherapy with various prescription schemes.

An in-depth analysis of research on posthepatectomy liver failure (2006-2024): exploring trends and future directions through a bibliometric approach.

Objective: This study aims to identify global hotspots and future trends within the research on posthepatectomy liver failure (PHLF).

Design: Bibliometric analysis through science mapping and performance analysis.

Data Sources: The Web of Science Core Collection.

Development and validation of a machine learning-based prediction model for frailty in older adults with diabetes: a study protocol for a retrospective cohort study.

Introduction: Frailty is a common condition in older adults with diabetes, which significantly increases the risk of adverse health outcomes. Early identification of frailty in this population is crucial for implementing timely interventions. However, there is a lack of specific prediction models for frailty in older adults with diabetes.

Improvement of Spermogenesis Impairment Induced by High-Fat Diet in Obese Mice through Pyrroloquinoline Quinone Regulation of Glycolysis Pathway.

This research utilized obese mouse models to investigate the impact of PQQ intervention on both reproductive system function and the glycolytic pathway in mice. The findings demonstrated that PQQ notably boosted glycolytic pathway activity in obese mice, enhancing glucose breakdown and metabolism, which in turn improved energy supply efficiency. These changes not only enhanced the overall metabolic status of the mice but also significantly supported the function of their reproductive system.

Hydrogen sulfide (HS) Alleviates Diabetic Myocardial Fibrosis by Suppressing Pyroptosis via Inhibiting DNMT3a-mediated Sestrin2 CpG Promoter Hypermethylation.

Background: Diabetic cardiomyopathy (DCM) represents an important concern associated with diabetes, inhibiting pyroptosis has shown promising results in alleviating DCM symptoms. The objective of this work is to investigate the role and underlying mechanism of hydrogen sulfide (HS) in the suppression of pyroptosis in the context of diabetic myocardial fibrosis (MF).

Methods: The effect of HS on pyroptosis was detected using CCK-8, ELISA, and flow cytometry.

Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.

Objective: This study aimed to integrate network pharmacology, bioinformatics analysis, molecular docking, and experimental validation to construct a "component-target-pathway" multidimensional network model, systematically elucidate the potential mechanisms underlying the therapeutic effects of the extract of Potentilla freyniana Bornm. (PFB) on hepatocellular carcinoma (HCC), and thereby clarify its pharmacological basis.

Methods: HCC datasets were retrieved from GEO and TCGA databases, and the DEGs were screened.

Comparative evaluation of transmediastinal and minimally invasive McKeown esophagectomy for esophageal cancer: perioperative and oncologic outcomes.

Background: Esophageal squamous cell carcinoma remains a major health burden in China, where surgical resection is the mainstay of curative therapy. The conventional minimally invasive McKeown esophagectomy (MIE-McKeown), although oncologically effective, entails transthoracic access and single-lung ventilation, often resulting in higher postoperative morbidity. Thoraco-laparoscopic transmediastinal esophagectomy has emerged as a novel alternative that may mitigate these risks while preserving oncologic integrity.

Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis.

De novo DNA synthesis plays crucial roles in life science. Enzymatic oligonucleotide synthesis (EOS) has attracted interest due to longer synthesized chains, simple procedure, cost-effectiveness, and environmental friendliness. However, unlike chemical synthesis dominated by small molecule, the EOS relies on enzyme reacting with primers.

A copper complex with a thiazole-modified tridentate ligand: synthesis, structural characterization, and anticancer activity in B16-F10 melanoma cells.

Copper serves as a crucial trace element in various biological systems. Copper ions form complexes with different ligands, amplifying reactive oxygen species (ROS) levels and promoting intracellular ROS accumulation in multiple cancer cell types. In this study, a copper(II) complex, dichlorido[4-(5-bromothiazol-2-yl)-2,2'-bipyridine] copper(II) (Cu1), was synthesized using a terpyridine derivative as the ligand.

Mini-review: Serum immunoglobulins and MASLD.

With the development of society and the economy, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major chronic disease in contemporary society. Finding a safe, effective, and economical diagnostic method is essential for the prevention of MASLD. Serum immunoglobulin is a protein produced by the B cells after the body is stimulated by an external antigen or pathogen.

SFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin.

Introduction: Mitochondria, situated at the center of intricate signaling networks, play crucial roles in maintaining health and driving disease progression. SFXN2, a recently identified member of the mitochondrial transporter family, is localized to the outer mitochondrial membrane and regulates several critical mitochondrial functions, including iron metabolism, heme biosynthesis, bioenergetics, and redox homeostasis. New evidence also suggests a connection between SFXN2 and mitochondrial dysfunction related human diseases such as Parkinson's disease (PD).

Altered voxel-wise degree centrality of brain networks in patients with chronic rhinosinusitis: a resting-state functional magnetic resonance imaging study.

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of the paranasal sinus and nasal cavity. Previous studies have demonstrated that patients with CRS have an increased risk of emotional and cognitive disorders. Although neuroimaging studies have identified brain alterations in CRS, the specific etiology of these neurological changes remains unclear.

Deinagkistrodon acutus Venom Promotes Apoptosis of Vascular Tissue Cells Through PAR1, Leading To Mesenteric Vascular Damage.

The Deinagkistrodon acutus is the most widely distributed venomous snake in China, and its clinical manifestations are primarily characterized by hemorrhage and coagulation disorders. Previous studies have suggested that mesenteric vascular injury induced by Deinagkistrodon acutus venom may be the primary cause of hemorrhage in envenomation. Protease-activated receptor 1 (PAR1) is highly expressed in vascular tissues and plays an important role in regulating the structure and function of blood vessels.