PreRBP: Interpretable Deep Learning for RNA-Protein Binding Site Prediction with Attention Mechanism.

In the complex process of gene expression and regulation, RNA-binding proteins occupy a pivotal position for RNA. Accurate prediction of RNA-protein binding sites can help researchers better understand RNA-binding proteins and their related mechanisms. And prediction techniques based on machine learning algorithms are both cost-effective and efficient in identifying these binding sites.

A covalent organic polymer fluorescent probe for highly selective and sensitive UO detection in water and food samples.

A highly sensitive, selective, and simple method for detecting uranyl ions (UO) is crucial for human health and environmental safety. Amidoxime-based nanomaterials have been widely employed for UO detection, but their higher affinity for vanadium than UO limits their practical applications. Herein, a novel covalent organic polymer fluorescent probe (TT-COP) for UO detection was innovatively developed by a one-step Schiff-base condensation reaction between 3,3',5,5'-tetramethylbenzidine (TMB) and 2,4,6-triformylphloroglucinol (Tp).

The effect of automatic brake system on the response of the lower limbs based on active muscle force.

This article employs a finite element model integrated with the Hybrid III dummy to investigate how automatic braking and active muscle forces influence lower-limb injuries in frontal collisions. Prolonged braking can increase the tibial index, indicating more severe injury to the lower leg. Braking mitigated thigh injury at 50 km/h but exacerbated it at 40 km/h.

Connexin43 and Its Regulation of Astrocyte Gap Junction Function: Influencing Depression Progression by Mediating Electrical and Chemical Signals.

Background: Depression is a common mental illness with a high relapse rate, which has a serious negative impact on national economic development and happiness. At present, the pathogenesis of depression is still unclear, and there are inevitable limitations in first-line clinical treatment. Therefore, it is very important to clarify the pathological mechanism of depression for the development of safe and effective antidepressants.

Sweroside Inhibits Inflammation and Alleviates Endothelial Injury and Atherosclerosis in Mice.

The underlying mechanisms in atherosclerotic vascular diseases are not entirely clear, posing a challenging hurdle to treatment. Inflammation is a root cause of atherosclerosis (AS); therefore, anti-inflammatory agents have potential for its management. Sweroside, possessing anti-inflammatory properties, emerges as a potential agent to impede AS progression.

Synergistic effect of oxalic acid and siderophore on uranium fractions and microbial community traits in rhizosphere soil enhances uranium accumulation in plant roots.

Chelating agent contributes to the remediation of heavy metal contaminations, but it remains unclear how they affect the transformation of radioactive pollutants and microbial traits in phytoremediation. We comprehensively investigated on the uranium (U) speciation and microbial communities in the rhizosphere of Macleaya cordata, Paspalum scrobiculatum and Bamboo willow, and analyzed the accumulation of U in the three plants after the addition of chelating agents including 0.1 mmol kg siderophore (DFO) and 2.

Visible-Light-Induced Organic-Dye-Catalyzed Bromination of Activated Alkenes with Sodium Bromide.

The direct introduction of a bromine atom into organic molecules is valuable because of its versatility in synthetic intermediates and modular building blocks but traditionally suffers from poor selectivity and relatively complicated and/or harsh reaction conditions. We herein present the first visible-light-driven organic-dye-catalyzed bromination protocol under mild conditions with high regioselectivity. This methodology leverages rapid intramolecular radical trapping to achieve regioselective monobromination of alkenes, thus effectively suppressing competing dibromination and electrophilic bromination pathways.

Enzyme-Responsive Metallopeptide Hydrogel Enables Cancer Cell-Selective Prodrug Activation via Bioorthogonal Catalysis.

Chemotherapy is often hindered by systemic toxicity and poor selectivity. To address these issues, we develop an enzyme-responsive metallopeptide hydrogel (HY-Pd) that integrates enzyme-instructed self-assembly (EISA) and bioorthogonal catalysis for selective tumor-targeted prodrug activation. Upon exposure to alkaline phosphatase (ALP), which is overexpressed in osteosarcoma cells (Saos-2), HY-Pd selectively accumulates and self-assembles into catalytic nanofibers.

The rice cation/calcium exchanger OsCCX2 is involved in calcium signal clearance and osmotic tolerance.

Hyperosmolality-triggered physiological drought hinders plant growth and development, leading to a drop in crop yields. Hyperosmolality triggers calcium signaling, and yet how osmotic-induced calcium signaling participates in cellular osmotic response remains enigmatic. To date, several Ca channels and transporters have been identified to regulate osmotic-induced calcium signal generation (CaSG) or Ca homeostasis.

Differential Expression of ATP6V1D and Its Diagnostic Potential in IgA Nephropathy.

Objective: IgA nephropathy (IgAN) is the most prevalent form of primary glomerular disease. However, its diagnosis is contingent on kidney biopsy. Therefore, noninvasive biomarkers are urgently needed for diagnosis.

[Causal relationship between insomnia and erectile dysfunction based on heart-kidney intersection theory: A two-sample Mendelian randomization study].

Objective: Previous studies have shown that insomnia is closely related to erectile dysfunction（ED）. However, the causal relationship between them is still unclear. Mendelian randomization (MR) provides a new method for studying the relationship between the two, and the theory of heart-kidney interaction in TCM provides a new idea for exploring the causal relationship between them.

Enhanced *COOH Adsorption over Edge-Rich Ni-N Sites for Efficient Acidic CO Electroreduction.

Single-atom Ni catalysts hold great promise for the acidic CO reduction reaction (CORR), owing to their high CO selectivity. However, their performance under industrially relevant high current conditions is limited by the weak interaction between isolated Ni-N sites and *COOH intermediates, restricting efficient CO conversion. Here, we introduced edge-rich Ni-N sites via support vacancy engineering to enhance *COOH adsorption, thereby boosting the CORR activity and selectivity in acidic media.

A dual-site doping strategy to enhance the sodium storage performance of an O3-type layered sodium oxide cathode.

The O3-type NaNiFeMnO material is modified by introducing Sr into the Na sites and Al into the transition metal (TM) sites. The inactive Sr and Al serve as structural pillars within the NaO and TMO slabs, respectively, expanding the interlayer spacing and boosting the stability of the structure. The optimized cathode demonstrates a good rate performance of 117.

Iminoboronate chemistry enables multifunctional and reprocessable polyphenol-derived vitrimers.

Polyphenol-derived vitrimers offer compelling prospects for sustainable materials owing to their intrinsic recyclability, reprocessability and biodegradability. However, practical development remains constrained by structure degradation under harsh reprocessing conditions and the need for sophisticated modifications of the bio-sourced precursors. Herein, we reported a strategy that integrates commercially available polyphenols and low-molecular-weight PDMS through adaptable iminoboronate chemistry, obviating the need for structural modifications.

The emergence of amorphous materials approaching the single-layer limit.

Amorphous materials with thickness thinned down to the single-layer limit have attracted increasing interest due to their well-defined disorder and emerging unique properties, such as disorder-dominated electronic states, high-density unsaturated coordination, enhanced quantum confinement, These features could enable innovative applications in electronics, photoelectronics, catalysis, and beyond. In this perspective, we provide an overview of recent advances in two-dimensional (2D) amorphous materials approaching the single-layer limit. We first introduce newly-developed key structural descriptors for these systems, including local bonding, topological disorder, and chemical composition.

SFB flagellin mediates cell adhesion, endocytosis and immune regulation in germ-free mice.

Introduction: Segmented filamentous bacteria (SFB) colonization dynamics are crucial for host immune regulation. Given this, the present study specifically examined the functions of SFB flagellin in bacterial adhesion, cellular internalization, and immune modulation.

Methods: and were engineered to express murine and rat SFB flagellin genes.

Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression.

Background: Isowighteone, an isoflavonoid compound derived from L.f. (, Moraceae), has demonstrated significant anti-inflammatory properties in prior studies.

Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.

Purpose: This study aims to investigate the efficacy of electroacupuncture in treating inflammatory bowel disease (IBD) accompanied by depressive symptoms. The potential mechanisms of electroacupuncture are also investigated, particularly in terms of its modulation of oxidative stress and NLRP3 inflammasomes to influence microglial activation and neuroinflammation, thereby alleviating depressive symptoms.

Material And Methods: The inflammatory bowel disease model in mice was induced by dextran sulfate sodium (DSS), and the mice were randomly assigned to the CON group, DSS group, DSS+EA group, and DSS+ MCC950 group.

The protective role of TIGIT+ B cells in attenuating type 1 diabetes progression.

Aims: Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing pancreatic β-cells. While T cells are well-known critical, growing evidence shows that B cells also play a key role in T1D development. T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), as an inhibitory immune checkpoint, is important in maintaining immune homeostasis and has become a therapeutic target for several autoimmune diseases.

Selective Catalysis-Mediated Interface to Stabilize Antimony Atom-Cluster Anode for Robust Potassium-Ion Batteries.

Controlling the electrode-electrolyte interfacial behavior is crucial for achieving a high-quality solid electrolyte interphase (SEI) and ensuring sustainable battery performance. Here, we propose a selective catalysis strategy to stabilize antimony atom-cluster (Sb) anode/electrolyte interface for robust potassium-ion batteries (PIBs). Specifically, the electrode featuring Sb in porous carbon (Sb/PC) as "electrocatalyst" unduly catalyzes the reduction of the dimethyl ether-based electrolyte, resulting in loose SEI layer and rapid capacity decay.

Electrochemistry-Accelerated Water-Gas Shift Reaction on IrN-RhN Dual Sites Catalysts for Efficient Hydrogen Production.

The water-gas shift reaction (WGSR) is crucial to the hydrogen economy, which is hampered by the harsh conditions and complicated purification process. In this work, the spatially separated efficient CO conversion and high-purity H production are realized by electrochemistry-accelerated water-gas shift reaction (WGSR) with IrN-RhN dual sites single atom catalysts (IrRh-NC) in high-temperature polymer-electrolyte-membrane electrolyzer. In this reaction, the Ir single atoms in the catalysts can rapidly dissociate HO at an extremely low potential to supply abundant *OH, which ensures the *OH groups bind to the spontaneously adsorbed *CO on neighboring Rh sites to further accelerate CO conversion.

Double Nanofoaming Enhanced Interfacial Polymerization toward Ultra-High-Performance Nanofiltration Membranes.

Polyamide (PA) nanofiltration (NF) membranes represent a promising approach to safe drinking water production. Yet, selective removal of contaminants while retaining essential minerals remains a critical challenge for cost-effective water treatment processes. Here, we employed ammonia bicarbonate (AB) as an economical additive to modify interfacial polymerization (IP) for developing high-performance NF membranes suitable for drinking water applications.

Autophagy in colorectal cancer: Current understanding of mechanisms and future therapeutic directions.

Colorectal cancer (CRC) ranks among the most prevalent malignancies globally, distinguished by its high incidence, significant mortality, and poor prognosis. Despite advancements in early screening and therapeutic strategies, clinical outcomes remain suboptimal. In recent years, autophagy has emerged as a pivotal focus in CRC research.

Impact of telomere length on autoimmune thyroid disease in Europeans: insights from Mendelian randomization.

Objective: This study aimed to investigate the causal relationship between Telomere Length (TL) and Autoimmune Thyroid Disease (AITD) in Europeans using Mendelian Randomization (MR).

Methods: Single nucleotide polymorphisms associated with TL and AITD were obtained from genome-wide association studies. MR analysis was conducted using inverse variance weighted as the primary method.