Impact of telomere length on autoimmune thyroid disease in Europeans: insights from Mendelian randomization.

Objective: This study aimed to investigate the causal relationship between Telomere Length (TL) and Autoimmune Thyroid Disease (AITD) in Europeans using Mendelian Randomization (MR).

Methods: Single nucleotide polymorphisms associated with TL and AITD were obtained from genome-wide association studies. MR analysis was conducted using inverse variance weighted as the primary method.

Comparison of ciprofol and propofol for endoscopic retrograde cholangio-pancreatography anesthesia: a systematic review and meta-analysis.

Objective: The potential of ciprofol in endoscopic anesthesia is receiving increasing attention. Compared to propofol, ciprofol exhibits stronger sedative effects and requires a lower dosage. This study aimed to compare the safety of ciprofol and propofol in Chinese patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) anesthesia.

Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions.

Heart failure (HF) is an end-stage cardiovascular syndrome caused by structural or functional cardiac abnormalities. Its high morbidity and mortality underscore the urgent need for novel therapeutic strategies. In recent years, the dynamic regulatory mechanisms underlying macrophage polarization in the onset and progression of HF have attracted widespread attention.

Deciphering diabetic neuropathy: immune cell causality revealed.

Objective: This study assessed the causal effects of immune cell phenotypes on diabetic neuropathy (DN) using Mendelian randomization (MR) analysis.

Methods: Datasets of immune cell phenotypes and DN were collected from the European Bioinformatics Institute and FinnGen. Single nucleotide polymorphisms that met the specified criteria were subjected to a stepwise selection based on the hypotheses of association, independence, and exclusivity.

Microbiota and enteric nervous system crosstalk in diabetic gastroenteropathy: bridging mechanistic insights to microbiome-based therapies.

Diabetes mellitus has emerged as a global public health crisis, with over half of patients experiencing gastrointestinal (GI) symptoms that exacerbate glucose fluctuations and impair quality of life. While prior research on the pathophysiology of diabetic gastroenteropathy (DGE) focused primarily on autonomic neuropathy, particularly involving the vagus nerve, recent studies have shifted toward the impairment of the enteric nervous system (ENS). As the largest autonomous neural network governing GI motility independent of central control, structural and functional abnormalities of the ENS constitute the fundamental pathological basis for DGE.

Potential of ciprofol as an alternative to propofol in elderly patients undergoing gastrointestinal endoscopy: a meta-analysis and trial sequential analysis.

Objective: Ciprofol is increasingly being used for sedation and induction of anesthesia in China. However, it remains unclear whether ciprofol is a more appropriate sedative than propofol in gastrointestinal endoscopy, especially in the elderly population. This study aimed to compare the safety of ciprofol with propofol in elderly patients undergoing gastrointestinal endoscopy.

Deciphering the Pharmacological Mechanism of Huayu Jiedu Formula in Acute Cerebral Infarction by Ultra-High-Performance Liquid Chromatography-Quadrupole-Exactive-Mass Spectrometry, Network Pharmacology, and Experimental Validation.

Huayu Jiedu formula (HYJDF), a traditional Chinese herbal compound effective against acute cerebral infarction (ACI), lacks a defined mechanism of action. HYJDF's bioactive components were identified via ultra-high-performance liquid chromatography-Quadrupole-Exactive-mass spectrometry (UHPLC-QE-MS). Network pharmacology integrated the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database-predicted ACI targets and multiple databases to construct herb-component-target networks (Cytoscape).

Identification of characteristic genes ofanddeficiency constitutions: an integrated analysis based on bioinformatics and machine learning.

Objective: To utilize the Traditional Chinese Medicine constitution (TCMC) as a complementary and alternative approach for early disease detection and treatment, with a focus on and deficiency constitutions, which serve as key references for disease prevention and management.

Methods: The dataset containing the data of and deficiency constitution was identified through the Gene Expression Omnibus database. This database was used for differential expression genes (DEGs) analysis and weighted gene co-expression network analysis (WGCNA), and the characteristic genes were then obtained in the dataset using a machine learning method.

Impact of probiotics on sleep quality and mood states in patients with insomnia: a systematic review and meta-analysis.

Background: Probiotics have garnered increasing attention for their potential role in managing insomnia. This meta-analysis evaluated the effects of probiotics on sleep quality and mood in patients with insomnia.

Methods: Eight public databases were searched to identify relevant randomized controlled trials (RCTs) published before December 2024.

Unveiling the causal effects of phosphatidylethanolamine (18:1_0:0) via glutamine conjugate of CHO (2) and X-23648 in Parkinson's disease: insights from mediation Mendelian randomization.

Objective: The effects of lipidome and its metabolites on Parkinson's disease (PD) have not been fully elucidated. This study aimed to assess the causal effects of lipidome on PD and the mediated effects of metabolites using Mendelian randomization (MR).

Methods: Datasets of the lipidome, metabolites, and PD were acquired from genome-wide association studies, and single nucleotide polymorphisms were screened according to the basic assumptions of MR.

Chinese herbal foot baths as a new strategy for diabetic foot with Wagner grade of 0 or 1: a meta-analysis and data mining.

Objective: The benefit of Chinese herbal foot-baths in treating diabetic foot remains unclear. This study aims to assess the efficacy of Chinese herbal foot-baths for diabetic foot with Wagner grade of 0 or 1 and identify key candidate herbs.

Methods: A comprehensive search of eight databases was conducted for studies published up to 24 May 2025.

Ciprofol vs Propofol for Gastrointestinal Endoscopy Sedation: a Systematic Review and Meta-analysis.

Background: Ciprofol, a propofol derivative, is increasingly used for sedation in China. However, the specific benefits of ciprofol in gastrointestinal endoscopic sedation have not been fully evaluated. This meta-analysis aimed to compare the efficacy and safety of ciprofol with propofol in gastrointestinal endoscopy.

Manual acupuncture for the treatment of chronic spontaneous urticaria: a systematic review and meta-analysis.

Background: The benefits and risks of manual acupuncture for treating chronic spontaneous urticaria (CSU) remain unclear. To address this gap, this systematic review and meta-analysis aimed to evaluate the efficacy and safety of manual acupuncture for treating CSU.

Methods: Seven major databases were searched for relevant literature published up to 1 January 2025.

Acupuncture for retinitis pigmentosa: a comprehensive review.

No notable developments in the existing therapeutic approaches for retinitis pigmentosa (RP) exist to date, leaving many patients seeking alternative treatments. Among these alternatives, acupuncture has gained increasing popularity among physicians due to its perceived effectiveness. Acupuncture has been applied in the treatment of RP and has achieved good therapeutic effects, as reflected in the improvement of vision.

Compound Xuanju capsules combined with phosphodiesterase-5 inhibitors as a new strategy for erectile dysfunction: a meta-analysis and trial sequential analysis.

Objective: The efficacy of compound Xuanju capsule (CXC) in the treatment of erectile dysfunction (ED) remains unclear. This study aimed to quantitatively assess the benefits and risks of CXC in the treatment of ED.

Methods: Eight major databases were systematically searched for relevant literature published till 10 May 2025.

Association of lipidome with senility and the mediated effect of metabolites: A Mendelian randomization study.

The aim of this study was to assess the causal effects of lipidome on senility and the mediated effects of metabolites by Mendelian randomization (MR). Lipidome, metabolites, and senility datasets were acquired in genome-wide association study, and single nucleotide polymorphisms were screened according to the underlying assumptions of MR. Subsequently, inverse variance-weighted was used as the primary method to analyze the causal effect of lipidome on senility and the mediated effect of metabolites.

Meta-analysis of acupuncture combined therapies for amblyopia: efficacy and safety insights.

Background: Acupuncture, a traditional Chinese medicine therapy, is widely used for the management of amblyopia. This study aimed to perform a meta-analysis of the efficacy and safety of acupuncture combined with conventional treatments for amblyopia.

Methods: We searched eight databases for relevant studies published before December 31, 2024.

Association of the lipidome with type 1 diabetes and the mediated effect of metabolites: A Mendelian randomization study.

The effects of lipidome and their metabolites on type 1 diabetes (T1D) have not been entirely elucidated, and this study aimed to explore the causal effects of lipidome on T1D and the mediated effects of metabolites by Mendelian randomization (MR). Data on lipidome, metabolites, and T1D were obtained from the genome-wide association study, and single nucleotide polymorphisms were screened according to the basic assumptions of MR. Subsequently, inverse variance weighted was used to analyze the causal relationship between lipidome and T1D, as well as the mediated effect of metabolites.

Prostate and urinary microbiomes in prostate cancer development: focus on .

Prostate cancer (PCa) is one of the most prevalent malignancies among men, with its incidence steadily increasing worldwide. Recent advances in microbiome research have opened new avenues for understanding and treating PCa; however, studies focusing specifically on the prostate tissue microbiome remain limited. Evidence suggests that the microbial communities within PCa tissues exhibit significant diversity and regional variability, with certain bacteria potentially contributing to PCa initiation and progression through chronic inflammation.

Artificially sweetened beverages do not influence metabolic risk factors: a systematic review and meta-analysis.

Introduction: The influence of artificially sweetened beverages (ASBs) on metabolic risk factors for non-communicable diseases (NCDs) remains unclear. This study aimed to systematically review the literature concerning whether the effects of ASBs on body weight and metabolic risk factors are equivalent to those of unsweetened beverages (USBs).

Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library databases from their establishment until March 3, 2025.

Acupoint injection increases the efficacy of vitamin B12 for diabetic neuropathy: a meta-analysis and trial sequential analysis.

This study aims to systematically evaluate the efficacy and safety of vitamin B12 acupoint injections compared to other administration routes in treating diabetic neuropathy (DN). We included 20 randomized controlled trials published before March 1, 2024, sourced from eight public databases, involving 1688 participants. Subsequently, we recorded their basic data, investigated their risk of bias, and then carried out a meta-analysis and trial sequential analysis (TSA).

Efficacy and optimal acupoints of auricular acupressure for treating prediabetes: a meta-analysis and data mining.

Background And Purpose: Auricular acupressure has potential in treating prediabetes; however, its effectiveness remains unclear. We aimed to evaluate the effect of auricular acupressure on blood glucose levels in patients with prediabetes and to identify optimal acupoints.

Methods: We searched nine public databases for randomized controlled trials published before March 1, 2025, according to pre-established inclusion and exclusion criteria.

Natural small molecules regulating the mitophagy pathway counteract the pathogenesis of diabetes and chronic complications.

Diabetes mellitus (DM) is a chronic metabolic disorder marked by sustained hyperglycemia. These disturbances contribute to extensive damage across various tissues and organs, giving rise to severe complications such as vision loss, kidney failure, amputations, and higher morbidity and mortality rates. Furthermore, DM imposes a substantial economic and emotional burden on patients, families, and healthcare systems.

Interference between rheumatoid arthritis and autoimmune thyroid diseases: A bidirectional Mendelian randomization.

The relationship between rheumatoid arthritis (RA) and autoimmune thyroid disease (AITD) remains controversial. This study aimed to analyze the causal relationship between RA and AITD by bidirectional Mendelian randomization (MR). Single nucleotide polymorphisms for RA, autoimmune thyroiditis (AIT), and Graves' disease (GD) were obtained from the FinnGen database.