Parents' understanding and attitudes toward the application of AI in pediatric healthcare: a cross-sectional survey study.

Objective: To investigate parents' understanding and attitudes toward the application of Artificial Intelligence (AI) in pediatric healthcare.

Methods: An observational, cross-sectional study was conducted using an questionnaire. Between February and April 2025, 200 family members of children receiving care at our hospital voluntarily participated in the study.

Type B3 Thymoma With a Novel KMT2A::MAML3 Fusion: Expanding the Spectrum of Gene Fusions Beyond the MAML2 Gene.

Mastermind-like transcriptional coactivator (MAML) gene fusions have been documented in Thymic Epithelial Tumors (TETs). Specifically, lysine methyltransferase 2A (KMT2A)::MAML2 gene fusions are associated with type B2 and B3 thymomas. Here, we report for the first time a young patient with invasive type B3 thymoma harboring a novel KMT2A::MAML3 gene fusion.

A pilot study investigating the efficiency of an Internet of things (IOT)-aided warehouse management system in the management of consumables for the operating room in a Chinese setting.

The aim of this study was to investigate the value of an Internet of things (IOT)-aided warehouse management system (IAWMS) to improve the efficiency of consumables management for the operating room (OR). Indices in three domains (error alerts, time taken for work, and level of satisfaction) were selected. Records were compared for two groups, namely the IAWMS group (records after implementation of IAWMS from March 2024 to September 2024) and the control group (manual work before implementation of IAWMS from July 2023 to December 2023).

Single-Atom Cu Anchored on a UiO-66 Surface-Enhanced Raman Scattering Sensor for Trace and Rapid Detection of Volatile Organic Compounds.

Volatile organic compounds (VOCs) serve as critical biomarkers in exhaled breath for early-stage cancer patients, and their rapid, trace-level detection holds marked implications for cancer screening. Surface-enhanced Raman scattering (SERS) technology demonstrates strong potential for trace VOC gas detection due to its ultra-high sensitivity and immunity to water interference. However, while surface plasmon resonance (SPR)-free semiconductor substrates offer superior spectral stability and selectivity, their sensitivity toward VOC detection remains suboptimal.

Experiences of complete decongestive therapy for patients with lower limb lymphedema: A descriptive phenomenological study.

Background: Lower limb lymphedema can cause significant physical and psychological distress. Complete decongestive therapy is recognized as the gold standard for non-surgical management of this condition. However, the lived experiences of patients undergoing complete decongestive therapy have been largely overlooked in existing research.

Pharmacokinetic study of isavuconazonium in human plasma measured by HPLC-MS/MS and its use in healthy Chinese subjects.

Aims: To establish a rapid, sensitive HPLC-MS/MS method for quantifying isavuconazonium in human plasma and characterize its pharmacokinetics in healthy Chinese subjects under fasting and postprandial conditions.

Materials & Methods: Plasma samples were processed via acetonitrile protein precipitation. Separation was performed on an LC-20ADXR Plus C18 column with gradient elution (0.

Increased diversity by cushion plants enhances alpine community productivity and stability.

The relationship between biodiversity and ecosystem functioning is well documented in multiple ecosystems such as grasslands and forests, yet in harsh alpine environments where the formation and maintenance of diversity face significant challenges, it remains largely underexplored. This study examines the role of multiple alpine cushion plant species in promoting plant diversity and enhancing ecosystem functioning through assessments of community biomass production and spatial stability. Cushion-constructed microcommunities (CCMC) exhibit a substantial increase in plant species richness, ranging from 83% to 150%, compared to bare ground areas.

Association between uric acid to high-density lipoprotein cholesterol ratio and moderate-to-severe perivascular spaces burden: a retrospective cross-sectional study.

Background: Perivascular spaces (PVS) are critical for waste clearance in the central nervous system and are implicated in various neurological disorders. The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel inflammatory-metabolic marker, but its association with PVS burden remains unexplored. This study investigated the association between UHR and moderate-to-severe PVS burden.

Biomarker profile of a Chinese ALS cohort: A comprehensive clinical-biomarkers-imaging analysis.

Background: Amyotrophic lateral sclerosis (ALS) is a fatal central nervous system neurodegenerative disease, but the relationships among genetic mutations, plasma biomarkers, glymphatic system and clinical variables remain unclear.

Methods: This study retrospectively collected data from April 2015 to November 2024 from the Department of Neurology of First Affiliated Hospital, Fujian Medical University, China. ALS patients (including genetic ALS (gALS) and sporadic ALS (sALS)), Alzheimer's disease (AD) patients, and healthy controls (HC) were included.

Identification of characteristic genes ofanddeficiency constitutions: an integrated analysis based on bioinformatics and machine learning.

Objective: To utilize the Traditional Chinese Medicine constitution (TCMC) as a complementary and alternative approach for early disease detection and treatment, with a focus on and deficiency constitutions, which serve as key references for disease prevention and management.

Methods: The dataset containing the data of and deficiency constitution was identified through the Gene Expression Omnibus database. This database was used for differential expression genes (DEGs) analysis and weighted gene co-expression network analysis (WGCNA), and the characteristic genes were then obtained in the dataset using a machine learning method.

Permethrin Stimulates Fat Accumulation via Regulating Gut Microbiota and Its Metabolites in Mice.

Permethrin, a commonly used type I pyrethroid insecticide, has been shown to induce insulin resistance and adipogenesis, however the molecular mechanisms driving these effects remain unclear. This research demonstrated that permethrin disrupts the balance of gut microbiota, particularly altering and ratios, leading to increased adipogenesis and metabolic disorders. Antibiotic treatment significantly alleviated the effects of permethrin, highlighting the potential role of gut microbiota in obesity and insulin resistance.

Voltage-controlled terahertz metasurface modulator for gallium nitride films.

The dynamic control of terahertz (THz) metasurfaces is one of the key research directions in the development of THz devices. By integrating semiconductor materials with metasurfaces and applying external excitation, it is possible to dynamically modulate THz metasurfaces, thereby enabling advanced tunable functionalities. Gallium nitride (GaN) possesses excellent optoelectronic properties, including a long diffusion length, a tunable bandgap, and outstanding carrier mobility.

Amorphous-Crystalline Synergy in CoSe/CoS Heterostructures: High-Performance SERS Substrates for Esophageal Tumor Cell Discrimination.

Although surface-enhanced Raman scattering (SERS) spectroscopy is applied in biomedicine deeply, the design of new substrates for wider detection is still in demand. Crystalline-amorphous CoSe/CoS heterojunction is synthesized, with high SERS performance and stability, composed of orthorhombic (o-CoSe) and amorphous CoS (a-CoS). By adjusting feed ratio, the proportion of a-CoS to o-CoSe is regulated, where CoSe/CoS-S50 with a 1:1 ratio demonstrates the best SERS performance due to the balance of two components.

hsa_circ_0099682 exacerbates the development of diabetic retinopathy by promoting pathological neoangiogenesis via the miR-125b-5p/HNRNPU axis.

Objective: Diabetic retinopathy (DR) is a leading cause of vision loss, driven by hyperglycemia-induced human retinal microvascular endothelial cell (HRMEC) dysfunction, mitochondrial impairment, oxidative stress, inflammation, and aberrant angiogenesis. Circular RNAs (circRNAs) have emerged as critical regulators in various ocular pathologies, yet their contributions to DR remain unclear. This study identified and characterized hsa_circ_0099682, derived from the alpha motif domain-containing protein 1B (ANKS1B) gene, and investigated its role and molecular mechanism in high glucose (HG)-induced HRMEC injury.

Characteristics of four natural poliovirus type 1 variants with six-nucleotide deletion (2,783-2,788 nt) in the VP1 region.

Since the establishment of the Chinese acute flaccid paralysis (AFP) case surveillance system in 1999, around 7,200 strains of poliovirus (PV) type 1 have been identified and isolated. Among these, the VP1 region of 5,649 strains has been sequenced. Based on the existing VP1 region sequence library, four strains of type 1 PV with six-nucleotide deletion in the VP1 region, identified from AFP cases, healthy children, and environmental sewage samples, were identified, and their biological characteristics were investigated.

Applications of magnetic nanoparticles for boundarics in biomedicine.

Accurate mapping of boundarics in biomedicine is crucial for improving early diagnosis, crafting individualized medical regimens, and evaluating therapeutic efficacy. Magnetic nanomaterials have attracted considerable attention in the diagnosis and treatment of disease lesions, due to their unique physicochemical properties (e.g.

Constructing a Type-II CuO@amorphous FeO Core-Shell p-n Heterostructure for Highly Efficient Surface-Enhanced Raman Scattering.

Amorphous semiconductors have been proposed as ideal platforms for chemical mechanism (CM) based surface-enhanced Raman spectroscopy (SERS). Nevertheless, the high recombination rates of photo-generated excitons hinder further enhancement of their SERS performance. Here, a type-II CuO@amorphous FeO (a-FeO) core-shell p-n heterostructure is demonstrated as a novel platform for highly sensitive SERS detection.

Potential Role of PARVB in Macrophage-Mediated Immunosuppression and Cervical Cancer Progression.

This study aimed to identify and characterize novel macrophage-related molecular mechanisms underlying immunosuppression and tumor progression in cervical cancer. Through a systematic integrative analysis guided by immune-related gene signatures and robust regression modeling, we identified PARVB as a novel macrophage-associated prognostic gene with strong predictive value across multiple data sets. Further validation using large-scale transcriptomic data and single-cell RNA-sequencing profiles revealed that PARVB likely activates the SMAD signaling axis, leading to the upregulation of TNFSF13, a key driver of M2 macrophage polarization.

Post-diagnosis statin use and survival among lung cancer patients in the Military Health System.

Background: There have been no studies examining the relationship between statin use and lung cancer survival in the U.S. Military Health System (MHS), a universal healthcare system.

Enhancing adversarial transferability via transformation inference.

The transferability of adversarial examples has become a crucial issue in black-box attacks. Input transformation techniques have shown considerable promise in enhancing transferability, but existing methods are often limited by their empirical nature, neglecting the wide spectrum of potential transformations. This may limit the transferability of adversarial examples.

Lineage trajectories and fate determinants of postnatal neural stem cells and ependymal cells in the developing ventricular zone.

The ventricular zone (VZ) harbors the largest neurogenic niche in the adult mammalian brain and is consisted of neural stem cells (NSCs) and multiciliated ependymal cells (EPCs). Previous lineage tracing studies showed that both NSCs and EPCs were derived from radial glial cells (RGCs). However, the transcriptomic dynamics and the molecular mechanisms guiding the cell fate commitment during the differentiation remain poorly understood.

Harnessing Pyridinic N Vacancy Defect in Microporous Structures to Induce the Pre-Adsorption of Oxygen and Boost Oxygen Reduction Reaction Kinetics.

Defect structures within the carbon matrix play a crucial role in enhancing the oxygen reduction reaction (ORR) activity of Fe single atom and nitrogen-doped catalysts (Fe-N-C SACs). However, overlooking the O pre-adsorption process induced by defective structures hampers the precise identification of active sites and the investigation of the reaction mechanism in Fe-N-C SACs. Hence, we report a Fe SAC with abundant pyridinic N vacancy defects in microporous structures (Fe-N-C SAC) and propose a synergistic effect between pyridinic N vacancy defects and O molecules that promotes the kinetics of ORR.

Efficacy and safety of Kunxinning granules in patients with menopausal syndrome: a multicenter, randomized, double-blinded, and placebo-controlled trial.

Background: Menopausal syndrome is a general term for a series of physical and psychological symptoms that women experience during menopause and perimenopause, which can lead to the occurrence of a variety of diseases. Many ingredients in Kunxinning granules have been used clinically to treat menopausal syndrome. However, evidence for its effectiveness is lacking.