Applications of magnetic nanoparticles for boundarics in biomedicine.

Accurate mapping of boundarics in biomedicine is crucial for improving early diagnosis, crafting individualized medical regimens, and evaluating therapeutic efficacy. Magnetic nanomaterials have attracted considerable attention in the diagnosis and treatment of disease lesions, due to their unique physicochemical properties (e.g.

Nanomaterial-assisted pancreatic cancer theranostics.

Pancreatic cancer is one of the most lethal malignancies, largely due to the limitations of current imaging technologies and treatment strategies, which hinder early diagnosis and effective disease management. Achieving precise theranostics for pancreatic cancer has become a priority, and recent advances have focused on the development of novel nanomaterials with enhanced imaging capabilities and therapeutic functionalities. These nanomaterials, through surface modifications, can significantly improve the targeting and precision of both diagnostic and therapeutic applications.

New insights of transition metal sulfide nanoparticles for tumor precision diagnosis and treatment.

Transition metal sulfide nanoparticles (TMSs), with their unique photothermal conversion effects, Fenton-like catalytic activity, engineerable structure, and good biocompatibility, are becoming a cutting-edge research focus in the field of tumor precision diagnosis and therapy. This review systematically explores the groundbreaking potential of TMSs (MS, M = Fe, Mn, Cu, Mo, Co, Ni, W, etc.) in tumor precision diagnosis, specific non-invasive treatment, and multimodal synergistic therapy from the perspective of "structural design-function regulation-integrated diagnosis and therapy.

Photoswitchable Gold Nanoparticles for Super-Resolution Radial Fluctuation Imaging in Nanostructured Materials.

Camera-based super-resolution approaches surpass the diffraction limit of conventional optical microscopy by relying on the stochastic activation and precise localization of fluorescent molecules. However, traditional probes such as organic dyes and quantum dots present challenges such as photobleaching and blinking variability, which limit their application in super-resolution imaging, particularly in non-liquid environments. Herein, the study demonstrates the potential of gold nanoparticles as a promising alternative for localization-based super-resolution imaging.

Carbon dots with wide-spectrum absorption for enhanced anti-aging of poly(vinyl chloride) films.

The aging of poly(vinyl chloride) (PVC) films, driven predominantly by ultraviolet (UV) radiation and environmental factors, restricts their long-term utility. This study explores the incorporation of wide-spectrum-absorbing carbon dots (CDs) as an innovative additive to enhance the anti-aging properties of PVC films. The CDs were synthesized from rind through an environmentally friendly solvothermal method.

Advances in the treatment of atherosclerotic plaque based on nanomaterials.

Atherosclerosis is the leading cause of cardiovascular disease worldwide, posing not only a significant threat to cardiovascular health but also impairing the function of multiple organs, with severe cases potentially being life-threatening. Consequently, the effective treatment of atherosclerosis is of paramount importance in reducing the mortality associated with cardiovascular diseases. With the advancement of nanomedicine and a deeper understanding of the pathological mechanisms underlying atherosclerosis, nanomaterials have emerged as promising platforms for precise diagnosis and targeted therapeutic strategies.

Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy.

Cuproptosis, a newly identified programmed cell death form, is characterized by excessive copper accumulation in cells, resulting in mitochondria damage and toxic protein stress, ultimately causing cell death. Given the considerable therapeutic promise of copper toxicity in cancer treatment, copper-based nanomaterials that induce copper death have attracted interest as a promising approach for tumor therapy. This review comprehensively introduces the mechanisms of cuproptosis and the associated regulatory genes, including both positive and negative regulatory regulators, and systematically summarizes the application of various nanoparticles in inducing cuproptosis, ranging from inorganic copper compounds to delivery systems.

Insights into Non-Metallic Magnetic Resonance Imaging Contrast Agents: Advances and Perspectives.

Traditional metal-based magnetic resonance imaging contrast agents (MRI CAs), such as gadolinium, iron, and manganese, have made significant advancements in diagnosing major diseases. However, their potential toxicity due to long-term accumulation in the brain and bones raises safety concerns. In contrast, non-metallic MRI CAs, which can produce a nuclear magnetic resonance effect, show great promise in MRI applications due to their adaptable structure and function, good biocompatibility, and excellent biodegradability.

The association between dietary consumption habits and psoriasis: a two-sample Mendelian randomization study.

Background: Psoriasis is a chronic inflammatory skin disease characterized primarily by erythema and scales, having a wide-ranging impact globally. Previous studies have suggested that dietary consumption habits may influence psoriasis. The objective of this study was to determine the causal relationship between dietary consumption habits and psoriasis using the Mendelian Randomization (MR) approach.

Identification and expression analysis of bZIP transcription factors in in response to dehydration stress.

Among the largest transcription factor families in plants, bZIPs are crucial for various developmental and physiological processes, particularly abiotic stress resistance. has become a model for understanding stress resistance mechanisms. In this study, we identified 90 bZIP transcription factors in the genome.

Association of partial infections with the risk of psoriasis: A two-sample Mendelian randomization study.

Background: As a common chronic recurrent inflammatory skin disease, psoriasis is characterized by erythema and scaly skin lesions, with infection as an integral part of the pathogenesis of many diseases. Many previous cases reported the impact of psoriasis on infection. However, the existing research fails to completely clarify the infection factors associated with the potential of these diseases and causality.

Oxygen-defect bismuth oxychloride nanosheets for ultrasonic cavitation effect enhanced sonodynamic and second near-infrared photo-induced therapy of breast cancer.

Sonodynamic therapy (SDT) relies heavily on the presence of oxygen to induce cell death. Its effectiveness is thus diminished in the hypoxic regions of tumor tissue. To address this issue, the exploration of ultrasound-based synergistic treatment modalities has become a significant research focus.

Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving the ROS-induced toxicity therapy mediated by ROS producers and antioxidant therapy by ROS scavengers. Nanotechnology advancements have led to the development of numerous nanomaterials with ROS-modulating capabilities, among which carbon dots (CDs) standing out as noteworthy ROS-modulating nanomedicines own their distinctive physicochemical properties, high stability, and excellent biocompatibility.

Peptide-Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy.

The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity and integration of imaging and therapeutic functions. The multifaceted nature of inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, and biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class of materials that have emerged in this context are peptide-functionalized inorganic oxide nanomaterials (PFIONs), which have demonstrated excellent performance in multifunctional imaging and therapy, making them potential candidates for advancing solid tumor diagnosis and treatment.

Exploring the comorbidity mechanisms between psoriasis and obesity based on bioinformatics.

Background: Psoriasis is a chronic, recurrent, immune-mediated inflammatory skin disease characterized by erythematous scaly lesions. Obesity is currently a major global health concern, increasing the risk of diseases such as cardiovascular diseases and diabetes. Since the correlation between psoriasis and obesity, as well as hypertension, diabetes, and cardiovascular diseases, has been clinically evidenced, it is of certain clinical significance to explore the mechanisms underlying the comorbidity of psoriasis with these conditions.

Prevalence of depression in melasma: a systematic review and meta-analysis.

Background: Due to cosmetic disfigurement, melasma can negatively affect the quality of life and emotional and mental health, further leading to depression.

Objective: Prevalence rates of depression in patients with melasma vary widely across studies. The aim of this systematic review and meta-analysis was to estimate the prevalence of depression among melasma patients.

Janus mesoporous organosilica/platinum nanomotors for active treatment of suppurative otitis media.

We report a Janus mesoporous organosilica/platinum (MOS/Pt) nanomotor for active targeted treatment of suppurative otitis media, as a new type of multi-functional ear drop. The efficient propulsion of MOS/Pt nanomotors in hydrogen peroxide ear-cleaning drops significantly improves their binding efficiency with and enhances their antibacterial efficacy.

A highly sensitive method for the detection of p-Aminophenol based on Cu-Au nanoparticles and KIO.

Background: As a common industrial raw material and chemical intermediate, p-Aminophenol (pAP) is recognized as a serious pollutant that poses harm to both the environment and human health. The traditional detection methods for pAP have the advantages of good selectivity and high sensitivity, but their complex operation and time-consuming defects limit their application in on-site detection. Therefore, it is necessary to develop a simple, low-cost, rapid and high-sensitivity method for the detection of pAP.

Bismuth-based two-dimensional nanomaterials for cancer diagnosis and treatment.

The intrinsic high X-ray attenuation and insignificant biological toxicity of Bi-based nanomaterials make them a category of advanced materials in oncology. Bi-based two-dimensional nanomaterials have gained rapid development in cancer diagnosis and treatment owing to their adjustable bandgap structure, high specific surface area and strong NIR absorption. In addition to the single functional cancer diagnosis and treatment modalities, Bi-based two-dimensional nanomaterials have been certified for accomplishing multi-imaging guided multifunctional synergistic cancer therapies.

Amorphous Nitrogen-Doped Carbon Nanocages with Excellent SERS Sensitivity and Stability for Accurate Identification of Tumor Cells.

The surface-enhanced Raman scattering (SERS) bioprobe's strategy for identifying tumor cells always depended on the intensity difference of the Raman signal compared with that of normal cells. Hence, exploring novel SERS nanostructure with excellent spectra stability, a high enhancement factor (EF), and good biocompatibility is a primary premise for boosting SERS signal reliability and accuracy of tumor cells. Here, high SERS EF (5.

Upconversion-nanoparticle-functionalized Janus micromotors for efficient detection of uric acid.

We report enzyme-powered upconversion-nanoparticle-functionalized Janus micromotors, which are prepared by immobilizing uricase asymmetrically onto the surface of silicon particles, to actively and rapidly detect uric acid. The asymmetric distribution of uricase on silicon particles allows the Janus micromotors to display efficient motion in urine under the propulsion of biocatalytic decomposition of uric acid and simultaneously detect uric acid based on the luminescence quenching effect of the UCNPs modified on the other side of SiO. The efficient motion of the motors greatly enhances the interaction between UCNPs and the quenching substrate and improves the uric acid detection efficiency.

Dual-responsive biohybrid neutrobots for active target delivery.

Swimming biohybrid microsized robots (e.g., bacteria- or sperm-driven microrobots) with self-propelling and navigating capabilities have become an exciting field of research, thanks to their controllable locomotion in hard-to-reach areas of the body for noninvasive drug delivery and treatment.

Bubble-Propelled Janus Gallium/Zinc Micromotors for the Active Treatment of Bacterial Infections.

We report a bubble-propelled Janus gallium/zinc (Ga/Zn) micromotor with good biocompatibility and biodegradability for active target treatment of bacteria. The Janus Ga/Zn micromotors are fabricated by asymmetrically coating liquid metal Ga on Zn microparticles and display self-propulsion in simulated gastroenteric acid (pH 0.5) at a speed of up to 383 μm s , propelled by hydrogen bubbles generated by the zinc-acid reaction.