Genome-wide characterization and expression analysis of the growth-regulating factor family in Mikania micrantha.

Background: Growth-regulating factors (GRFs) are plant-specific transcription factors involved in growth, development, and stress responses. Mikania micrantha, a highly invasive weed, displays rapid growth and adaptability, yet the GRF gene family in this species remains largely unexplored.

Results: We identified and characterized 16 GRF genes in M.

Engineered S-Scheme Heterojunction for Efficient CO Photoreduction on Bismuth Oxybromide.

Artificial photosynthesis presents a highly promising approach for addressing global energy and environmental challenges. However, its efficiency remains constrained by rapid charge recombination and inefficient CO activation. To overcome these limitations, cobalt-nickel layered double hydroxide (CN-LDH) is decorated onto BiOBr nanosheets to enhance Lewis alkaline sites and facilitate charge separation.

Defect-phase engineered NiTi-TiO enabling near-unity selective photocatalytic CO-to-methanol conversion.

Scaling up methanol yields by artificial photosynthesis at a modest cost remains thermodynamically challenge. Designing concerted reaction sites to control intermediate evolution and stimulate proton-coupled electron transfer (PCET) is necessary. Here we show a nickel-titanium-based catalyst that achieves near-millimolar hourly methanol yields with 99.

CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis.

A key factor that limits the therapeutic benefits for non-small cell lung cancer (NSCLC) patients is chemoresistance. Even so, a detailed understanding of the process involved in chemoresistance acquisition and development at molecular level in NSCLC is still lacking. Here, we established chemo-resistant NSCLC cells with obvious resistance to vincristine and paclitaxel and found the abnormal up-regulation of Carnitine O-Octanoyltransferase (CROT) in these cells by means of transcriptomics.

Genomic insights on Mikania micrantha invasiveness: gene family expansion, transposable elements, gene expression, and population structure.

Mikania micrantha is an aggressive climbing vine that poses significant threats to ecosystems and causes severe agricultural and economic losses. However, the molecular mechanisms underlying its adaptive evolution and invasion dynamics remain unclear. Comprehensive genomics and resequencing analyses were conducted to unravel the factors driving the adaptive evolution and invasion dynamics of M.

Noise and artifact suppression in SQUID and wearable OPM-MEG: A systematic review of background, physiological, and Technical interference.

Magnetoencephalography (MEG) is a non-invasive imaging technique that captures neural activity with high spatio-temporal resolution. In recent years, novel wearable devices based on Optically Pumped Magnetometer (OPM) have emerged as a new driving force for advancing MEG due to their cost-effectiveness, portability, and mobility. In practical applications, MEG signals are frequently influenced by various interference sources, resulting in degradation of signal quality.

Tangerine Peel Exosome-like Nanoparticles (TPELNs) Mitigate Intestinal Inflammation via Gut Microbiome Remodeling and Immune Modulation.

Plant exosome-like nanoparticles (PELNs) have the potential to modulate inflammatory responses. In this study, tangerine peel exosome-like nanoparticles (TPELNs) were isolated from Yongquan honey tangerine peel by differential centrifugation and PEG precipitation for characterization . In the present study, we used a mouse dextran sodium sulfate (DSS) model of severe intestinal inflammation to investigate its mitigating effect on intestinal inflammation and its modulating effect on intestinal flora and metabolites.

Genetic diversity and relationships of broomcorn millet based on trnT-trnL and GBSSI sequences.

Broomcorn millet (Panicum miliaceum L.) is the oldest crop originating in China. The routes of transmission have been the focus of broomcorn millet research.

Endoscopic versus percutaneous drainage placement after left-sided pancreatectomy: multi-state model for defining objectifiable variables on interventional treatment for pancreatic fistula.

Background: Postoperative pancreatic fistula (POPF) remains a prevalent complication after left-sided pancreatectomy. Interventional treatment is regularly required and relies on interdisciplinary concepts, including interventional radiology and endoscopy. Evidence on the correct indication and clinical algorithms for available treatment modalities are needed.

Antibiotic use for common illnesses in children living with disability: a multi-country study across 42 low- and middle-income countries.

Background: Approximately 240 million children worldwide are living with disabilities. Understanding the association between disability status and reported antibiotic use for common illnesses can help develop strategies to address the critical intersection of antimicrobial resistance (AMR) and disability.

Methods: Data were collected from 42 low- and middle-income countries through the UNICEF-supported Multiple Indicator Cluster Survey (2017-2023).

Polymer-linked growth wafer-sized Ruddlesden-Popper perovskite single-crystal films.

Wafer-sized two-dimensional Ruddlesden-Popper perovskite single-crystal thin films (SCTFs) hold immense potential as alternatives for fabricating large-scale optoelectronic devices and are anticipated to achieve commercial application in technologies such as high-performance micro-PeLEDs and integrated panels for advanced displays of the future. However, wafer-sized growth of perovskite single-crystal films remains challenging, primarily attributed to the inherent difficulties in controlling the nucleation process and managing the anisotropic growth behavior. These factors lead to rapid nucleation rate and high nucleation density, which impede crystal wafer-sized growth.

Submolecular Resolution of β‑Sheet Plasticity: Decoding Mutations and PTMs in Protein Aggregation Disorders.

The functional diversity of proteins often arises from the remodeling of conformational ensembles, particularly through mutations and post-translational modifications (PTMs). However, experimentally characterizing such ensembles remains challenging due to their heterogeneous and transient nature. Here, we report the determination of the conformational substates of β-sheets and the effect associated with mutations and PTMs in human islet amyloid polypeptide (hIAPP) via scanning tunneling microscopy (STM).

Effect of exercise training on cardiac function and glucose metabolism in the ischemic border zone: insights from multi-modal imaging techniques.

Aims: This study aimed to evaluate the impact of early exercise following acute myocardial infarction (AMI) on cardiac function, myocardial remodeling, glucose metabolism, and its molecular changes using cardiac magnetic resonance (CMR) imaging and positron emission tomography (PET).

Methods And Results: Thirteen rats (MI-exercise, MIE) underwent an 8-week treadmill exercise training initiated 1 week after AMI. Longitudinal assessments were conducted using 7T CMR and F-FDG PET/CT imaging at baseline, 4 weeks and 8 weeks following the commencement of exercise.

The role of gut microbiota in Tirzepatide-mediated alleviation of high-fat diet-induced obesity.

Purpose: In this study, we aim to explore the effects of tirzepatide on the gut microbiota in mice with obesity induced by a high-fat diet.

Methods: Forty male C57BL/6J mice, aged six weeks, were randomly assigned to one of four experimental groups: normal control diet, normal control diet with tirzepatide treatment (NCD + TZP), high-fat diet and high-fat diet with tirzepatide treatment (HFD + TZP). Mice in the HFD group were fed a high-fat diet for ten weeks to establish an obesity model.

Submolecular Resolution Imaging of Amyloid Aggregation: An STM Approach to Decipher Missense Mutation Effects in α-Synuclein.

Intrinsically disordered regions (IDRs) are critical regulators of cellular function, and their aberrant phase transitions into amyloid fibrils underlie the pathogenesis of amyloidosis. Missense mutations modulate IDR aggregation, but mechanisms remain unclear. Here, we investigate the impact of Parkinson's disease-associated mutations (A53V and T72M) on the aggregation dynamics of α-synuclein (α-Syn), a prototype protein containing IDRs, using scanning tunneling microscopy (STM).

Effects of dietary nitrate supplementation on isometric performance and physiological responses in college bodybuilders: a randomized, double-blind, crossover study.

Introduction: In bodybuilding competitions, athletes are required to hold static poses for extended periods. This study aimed to evaluate the effects of acute beetroot juice (BJ) supplementation on isometric muscle endurance in college bodybuilding athletes.

Methods: Sixteen male college bodybuilding athletes participated in a randomized, double-blind, crossover study conducted over three weeks with four laboratory visits.

Occurrence, ecology and health risk assessment of organophosphate triesters and diesters in surface and ground water from southwest of China.

The occurrence of organophosphate triesters (OPEs) and organophosphate diesters (m-OPEs) in ground water is still unclear. To fill the blank, ground water samples in dry and wet seasons, surface river water and paired sediment samples were collected in Sichuan province and analyzed for 14 kinds of OPEs and 7 m-OPEs. Except Trimethyl phosphate was scarcely detected, the other OPEs were extensively found in aquatic environment.

A multimodal nomogram for predicting disease progression in diabetic patients with coronary artery disease: integrating clinical, ultrasound, and angiographic data.

Objective: The long-term prognosis of diabetic patients with coronary artery disease (CAD) is influenced by various clinical variables and biomarkers. This study aimed to develop and validate a prognostic model that integrates clinical, echocardiographic, and angiographic data to predict disease progression.

Methods: We retrospectively analyzed 396 diabetic CAD patients with a 3-year follow-up starting from their first coronary angiography.

A dual-mode sensor for rapid detection of procymidone: "Dark box" qualitative analysis and electrochemical quantification mediated by PdHPCN-222/PEI-rGO and CRISPR/Cas12a.

This study presents an integrated dual-mode sensing strategy, in which qualitative fluorescence screening is followed by quantitative electrochemical detection, improving detection efficiency and enabling rapid PCM analysis. It develops a novel fluorescence electrochemical aptasensor that combines in vitro "Dark-box" applications with CRISPR/Cas12a system electrode surface sensing technology. PCM activates the DNA walker, and the DNAzyme induces cyclic cleavage of DNA strands bearing the Carboxyfluorescein (FMA) group.

Redox Additive Electrolytes for Supercapacitors: A Mini-Review on Recent Developments and Future Directions.

Supercapacitors are promising energy storage devices that combine high power density, fast charge/discharge rates, and excellent cycling stability. However, their relatively low energy density compared to batteries remains a major challenge. To address this limitation, redox additive electrolytes have emerged as a key strategy to introduce reversible Faradaic reactions, significantly enhancing the energy storage capacity of supercapacitors.

SIRT5 Alleviates Apoptosis of Vascular Endothelial Cells Under Simulated Microgravity via Desuccinylation of ERO1A.

The adverse effects of weightlessness on the human cardiovascular system greatly hinder the process of long-term and long-distance space exploration. Succinylation is an important type of protein post-translational modification. However, whether succinylation modification is able to play a role in altered vascular endothelial cell function under microgravity or simulated microgravity has not been reported.

An Exploration on Aperiodic Activities and Transient Oscillations During Semantic Processing: A Study With Wearable MEG.

The processing of semantic information is pivotal in language cognition. However, there is a scarcity of research exploring the semantic-related patterns associated with aperiodic and transient periodic brain activities. In this study, recently developed algorithms were employed to parameterize the time-frequency characteristics of neural activities captured with optically pumped magnetometers-based wearable Magnetoencephalography from participants engaged in a Chinese semantic-based task.

Targeting Poly (ADP-ribose) polymerase-1 (PARP-1) for DNA repair mechanism through QSAR-based virtual screening and MD simulation.

Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme in the base excision repair pathway, crucial for maintaining genomic stability by repairing DNA breaks. In cancers with mutations in DNA repair genes, such as BRCA1 and BRCA2, PARP-1 activity becomes essential for tumor cell survival, making it a promising target for therapeutic intervention. This study employs QSAR modeling, virtual screening, and molecular dynamics (MD) simulations to identify potential PARP-1 inhibitors.

Recyclable Molecular Ferroelectrics to Harvest Mechanical Energy for Sustained Hydrogen Generation.

Production of hydrogen fuel from water and renewable energy offers one of the most promising pathways for carbon neutrality and sustainable development. However, existing hydrogen generation technologies struggle with durability issues, such as poisoning, coking, and fouling, so it is a crucial economic concern to find a long-term hydrogen generation catalyst or approach. Herein, we report a recyclable cyclic supersaturation strategy harnessing molecular ferroelectric (TMFM)(TMCM)CdCl (MF-1) for hydrogen generation, which enables cycles of recrystallization and dissolution of molecular ferroelectric nanocrystals in supersaturated aqueous solution systems.