Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.

Purpose: This study aims to investigate the efficacy of electroacupuncture in treating inflammatory bowel disease (IBD) accompanied by depressive symptoms. The potential mechanisms of electroacupuncture are also investigated, particularly in terms of its modulation of oxidative stress and NLRP3 inflammasomes to influence microglial activation and neuroinflammation, thereby alleviating depressive symptoms.

Material And Methods: The inflammatory bowel disease model in mice was induced by dextran sulfate sodium (DSS), and the mice were randomly assigned to the CON group, DSS group, DSS+EA group, and DSS+ MCC950 group.

Species diversity and systematic taxonomy of Sarcosomataceae (Ascomycota, Pezizales), with an emphasis on subtropical regions of China.

The aim of this study is to update the species diversity of Sarcosomataceae in subtropical China. Taxonomic and phylogenetic studies were carried out through ecological observation, morphological examination, and molecular phylogenetic analyses inferred from five molecular loci (ITS + nrLSU + + + ). By using Bayesian inference (BI) and maximum likelihood (ML) methods, six lignicolous species were identified, including four novel taxa: , , , and ; and two new distribution records: and .

Platycodin D attenuates diabetic renal ischemia/reperfusion injury by enhancing mitophagy and suppressing MAPK/NF-κB signaling activation.

The global incidence of diabetes mellitus (DM) is rapidly rising, and DM worsens renal ischemia/reperfusion (I/R) injury, a major cause of high-mortality acute kidney injury (AKI). Therefore, preventing renal I/R injury in DM is crucial. Platycodin D (PD), a compound from Platycodon grandiflorum roots, is known to activate AMP-activated protein kinase (AMPK).

Design, Synthesis and Herbicidal Activity of 5-(1-Amino-4-phenoxybutylidene)barbituric Acid Derivatives Containing an Enamino Diketone Motif.

In continuation of our efforts to identify novel herbicide lead compounds, twenty new 5-(1-amino-4-phenoxybutylidene)barbituric acid derivatives containing an enamino diketone motif were synthesized and evaluated for their herbicidal activities. The greenhouse bioassay results indicated that several of the target compounds, including , , , , and , exhibited notable post-emergence herbicidal activity, with sum inhibition rates exceeding 70% at a dosage of 150 g ha, which was superior to that of the commercial herbicide flumiclorac-pentyl (FP). The structure-activity relationship analysis demonstrated that the steric and electronic effects of the R group, as well as the lipophilicity of the target compounds, significantly influenced herbicidal activity.

A Sandwich-Type Impedimetric Immunosensor for the Detection of Tau-441 Biomarker.

The human Tau protein stands for one of the most conspicuous and crucial hallmarks of Alzheimer's disease (AD) diagnosis, along with other tauopathies. However, the assay for direct detection of tiny Tau protein concentrations in human samples continues to pose a significant challenge for the early diagnosis of AD. Thus, an amplification-based strategy is required.

Machine learning driven semi-automated framework for yeast sporulation efficiency quantification using ilastik segmentation and Fiji nuclear enumeration.

Accurate quantification of yeast sporulation efficiency is essential for genetic studies, but manual counting remains time-consuming and susceptible to subjective bias. Although deep learning tools like cellpose provide automated solutions, there exists a compelling need for alternative approaches that enable the quantification of spores. Our methodology employs ilastik's texture-feature optimization to reliably segment sporulating mother cells, intentionally avoiding explicit tetrad discrimination to ensure robustness across diverse spore morphologies.

Efficacy of digital-based exercise intervention in adults with metabolic associated fatty liver disease: study protocol for a randomised controlled trial in Nanjing, China.

Introduction: Metabolic associated fatty liver disease (MAFLD) is internationally prevalent, resulting in considerable health and economic costs. Lifestyle adjustments, especially exercise, constitute fundamental treatments; nonetheless, sustained adherence poses significant challenges. This study is to assess the effectiveness of a 12-week digital exercise intervention in decreasing liver fat and enhancing metabolic outcomes in individuals with MAFLD.

Shaping Long-term Care Insurance Intentions Among Chinese Adults Aged 50-70: Role of Information Interventions in Health Risks.

Background And Objectives: China's population aging, especially increasing numbers of older people with disability and dementia, challenges the public health care system. Long-term care insurance (LTCI) is essential to provide care for China's fast-growing aging population, yet there is a lack of evidence on how the health risks of disability and dementia influence the acceptance of LTCI in China. This study explores the effects of health risk information about disability or dementia on the LTCI intentions of the Chinese aged 50-70.

Multi-omics combining bioinformatic network with kidney-entry constituents revealed the bioactive components and potential mechanisms of Zhijun Tangshen decoction against diabetic nephropathy.

Ethnopharmacological Relevance: Diabetic nephropathy (DN) is a common and severe complication of diabetes which could ultimately progress to end-stage renal disease. Zhijun Tangshen Decoction (ZJTSD), a traditional Chinese herbal formula, has shown clinically beneficial effects in the treatment of DN. However, the mechanisms of ZJTSD against DN remain unclear.

Research progress of circular RNA and N6-methyladenosine modification in colorectal cancer.

Circular RNA (circRNA) and N6-methyladenosine (m6A) methylation modification have attracted much attention in the field of cancer research. CircRNAs represent a class of covalently closed-loop non-coding RNA (ncRNA) that are abundantly expressed in the cytoplasm. These molecules exhibit remarkable evolutionary conservation and exceptional stability, making them ideal candidates for regulatory functions.

Prevalence and risk factors for antenatal anxiety in the first trimester among Chinese pregnant women.

Background: Antenatal anxiety (AA) is a common mental disorder during pregnancy and adversely affects the well-being of both pregnant women and their offspring. The prevalence of AA is exceptionally high in the first trimester, yet there is a lack of studies focusing exclusively on AA in the first trimester.

Aims: This study aimed to investigate the prevalence and risk factors of AA among Chinese pregnant women during the first trimester.

The Efficacy of Sub-Anesthesia S-Ketamine on Postoperative Depressive Symptoms in Patients Undergoing Abdominal Tumor Resection: A Randomized Controlled Trial.

Background: Cancer patients undergoing major surgery often have perioperative depression symptoms, and are associated with worsened outcomes.

Aims: We aimed to evaluate the efficacy of S-ketamine in alleviating depressive symptoms after abdominal Tumor surgery.

Methods: A prospective, double-blind, placebo-controlled randomized trial was conducted, enrolling 230 patients with newly screened mild-to-severe depressive symptoms scheduled for abdominal tumor resection.

Perfectionism, obsessive-compulsory behaviour, and anxiety in young adults: a moderated mediation model of mobile phone addiction.

Background: Mobile phone addiction is becoming a topical concern among young adults. Recent research argues that mobile phone addiction is related to perfectionism, anxiety, and obsessive-compulsory behaviour. Yet, there is a lack of an integrated model encompassing these factors to explain mobile phone addiction.

Coated nanoparticles enhance immune efficacy of Helicobacter pylori outer membrane vesicles by activating Th1/Th2/Th17 responses.

Antibiotic resistance has emerged as a pressing global public health crisis. The development of a safe and efficient Helicobacter pylori vaccine has become an important measure to eradicate Hpylori infection. Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria are immunogenic and have received increasing attention in the development of vaccines against bacterial infections.

IL-4-JAK1-STAT6 Pathway Mediates Electroacupuncture's Effect on Microglial M2 Polarization to Treat Inflammatory Bowel Disease With Comorbid Depression.

Aims: Depression is prevalent in inflammatory bowel disease (IBD) and linked to neuroinflammation. However, the underlying mechanisms remain unclear. Therefore, we investigated the efficacy of electroacupuncture in mice with IBD and depression.

Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases.

Interleukin-1 receptor-associated kinase 4 (IRAK4) is a promising therapeutic target for inflammatory diseases. However, solely inhibiting IRAK4 kinase activity fails to fully block inflammatory signaling, resulting in limited efficacy. Herein, we describe the design and synthesis of novel IRAK4 degraders based on a proteolysis-targeting chimera (PROTAC) strategy.

Multi-Modal Multi-Kernel Graph Learning for Autism Prediction and Biomarker Discovery.

Graph learning-based multi-modal integration and classification is one of the most challenging tasks for disease prediction. To effectively offset the negative impact among modalities in the process of multi-modal integration and heterogeneous information extractions from graphs, we propose a novel method called Multi-modal Multi-Kernel Graph Learning (MMKGL). To solve the problem of negative impact among modalities, we propose a multi-modal graph embedding module to construct a multi-modal graph.

A novel image segmentation network with multi-scale and flow-guided attention for early screening of vaginal intraepithelial neoplasia (VAIN).

Background: Vaginal intraepithelial neoplasia (VAIN) is a rare precancerous lesion, and early diagnosis is crucial for preventing its progression to invasive vaginal cancer. However, the subtle differences in morphology and color between VAIN lesions and normal vaginal tissue make the automatic segmentation of VAIN highly challenging. Existing methods struggle to achieve precise segmentation, impacting the efficiency of early screening.

TRPM6 and TRPM7 genetic polymorphisms, dietary magnesium, plasma magnesium, and gestational diabetes mellitus.

Genetic variation in TRPM6 and TRPM7 contributes to magnesium (Mg) absorption defects. We aimed to verify the combined influence of Mg intake and these genetic polymorphisms on plasma Mg concentrations and the risk of gestational diabetes mellitus (GDM). We involved 1323 pregnant women from Tongji Maternal and Child Health Cohort.

Nomogram models for predicting lymph node metastasis and prognosis in early gastric cancer 60 or older: a population-based cohort study.

Background: Lymph node metastasis (LNM) is a critical determinant significantly impacting the prognosis of early gastric cancer (EGC).

Methods: In this study, we included 1516 elderly EGC from the Surveillance, Epidemiology, and End Results (SEER) database and 130 patients from China to identify the independent risk factors influencing LNM, overall survival (OS) and cancer-specific survival (CSS) among elderly EGC (60 or older), respectively.

Results: Within the SEER database, the training cohort revealed that four variables (tumor size, grade, T stage, and examined lymph node count (ELNC)), six variables (age, sex, tumor size, T stage, N stage, and ELNC), and six variables (age, sex, tumor size, tumor location, T stage, and N stage) were identified as essential components in the development of nomograms for LNM, OS, and CSS prediction, respectively.

Parallel multi-frame blind deconvolution with the macopt minimizer based on NUMA nodes.

Multi-frame blind deconvolution (MFBD) can obtain high-resolution images degraded by the atmospheric turbulence with limited prior information, but it is time-consuming. To improve the efficiency of MFBD, we integrate the macopt minimizer into the alternate minimization framework and investigate the detailed parallelization methods using a message passing interface (MPI) and open multiprocessing (OpenMP) based on a multicore architecture. Three sets of simulated seasat images with sizes of 128 ∗ 128, 256 ∗ 256, 512 ∗ 512, and one set of real solar observations with size of 1600 ∗ 1600 are used for restoration experiments.

Integrated experiments and molecular dynamics simulation to decipher the interaction of marine phospholipids with myosin: Focus on binding mechanisms, conformation, and functional properties.

Marine phospholipids enhance the quality of meat products, but the fundamental mechanism remains unclear. This study aimed to decipher the binding and interaction mechanisms of the main component of marine phospholipids, docosahexaenoic acid-containing phosphatidylcholine (PC-DHA), with functional protein (myosin) of meat products by multi-spectroscopy and molecular dynamics simulations (MDS). Furthermore, this study experimentally analyzed the functional properties of myosin-PC-DHA complex.

I‑GAT: Interpretable Graph Attention Networks for Ligand Optimization.

Designing selective and potent ligands for target receptors remains a significant challenge in drug discovery. Computational approaches, particularly advancements in machine learning (ML), offer transformative potential in addressing this challenge. In this study, our goal was to develop a composite ML model capable of predicting ligand selectivity and potency with high accuracy while also providing interpretable insights to guide ligand optimization.