An In Vitro Tribological Astringency Assessment Method Based on Astringency Perception Mechanism.

Astringency is a complex oral sensation characterized by dryness and constriction in the mouth. It is typically induced by polyphenol-rich foods and beverages such as wine and tea. The quantitative assessment of astringency intensity has become a prominent research focus in the food science field.

Case Report: Hepatocellular adenoma due to long-term oral stanozolol administration.

This article presents a case of a 15-year-old male with a 6-year history of aplastic anemia treated with long-term oral stanozolol to promote hematopoiesis. Throughout this period, he underwent regular outpatient follow-up assessments of blood and liver function parameters. While abnormal liver function was recorded on several occasions and treated with oral hepatoprotective drugs, no abdominal imaging test was conducted.

A monolithically integrated near-infrared imager with crystallization- and oxidation-modulated tin-lead perovskites.

The fast crystallization and facile oxidation of Sn of tin-lead (Sn-Pb) perovskites are the biggest challenges for their applications in high-performance near-infrared (NIR) photodetectors and imagers. Here, we introduce a multifunctional diphenyl sulfoxide (DPSO) molecule into perovskite precursor ink to response these issues by revealing its strong binding interactions with the precursor species. The regulated perovskite film exhibits a dense morphology, reduced defect density and prolonged carrier diffusion length.

UBA1-depleted neutrophils disrupt immune homeostasis and induce VEXAS-like autoinflammatory disease in mice.

VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a haemato-rheumatoid disease caused by somatic UBA1 mutations in hematopoietic stem cells (HSCs). The pathogenic cell type(s) responsible for the syndrome are unknown and murine models recapitulating the disease are lacking. We report that loss of Uba1 in various mouse hematopoietic cell types resulted in pleiotropic consequences and demonstrate that murine mutants with about 70% loss of Uba1 in neutrophils induced non-lethal VEXAS-like symptoms.

[Research progress in key technologies for the development of Dendrobium officinale: from a rare and endangered species to a 10-billion-RMB-level industry].

Dendrobium officinale(DO) is a traditional Chinese medicinal and edible plant, while it is critically endangered worldwide. This article, primarily based on the original research findings of the author's team and available articles, provides a comprehensive overview of the factors contributing to the endangerment of DO and the key technologies for the conservation, efficient cultivation, and value-added utilization of this plant. The scarcity of wild populations, low seed-setting rates, lack of endosperm in seeds, and the need for symbiosis with endophytic fungi for seed germination under natural conditions are identified as the primary causes for the rarity and endangerment of DO.

Genetic variants of LncRNA associated with splicing regulation and their impact on ovarian cancer development.

Ovarian cancer (OC) is a highly lethal gynecologic malignancy that lacks reliable early biomarkers. Numerous long non-coding RNAs (lncRNAs) have been found to play critical regulatory roles in OC, yet the mechanisms underlying most of them remain unclear. Recently, lncRNAs have emerged as key regulators of RNA splicing, while splicing dysregulation is widespread and plays critical roles in cancer.

Burden of dementia following stroke subtypes: a study integrating the GBD database and Mendelian randomization.

Background: A large number of studies have previously established a causal association between stroke and dementia, and have demonstrated a strong correlation between ischemic or hemorrhagic stroke and all-cause dementia, respectively. Given the overall increasing prevalence of all-cause dementia worldwide and the absence of data from randomized clinical trials confirming the existence of effective dementia interventions.The aim of this paper is to apply the GBD database to estimate the proportion and trends of dementia following ischemic and hemorrhagic strokes globally and within regions, and to discuss potential risk factors for vascular dementia using Mendelian randomization (MR).

Coronary Flow Reserve Measured by Myocardial Perfusion Imaging in Patients Following Percutaneous Coronary Intervention.

Background: Despite achieving complete revascularization, patients with coronary artery disease (CAD) may experience adverse outcomes, potentially attributable to coronary microvascular dysfunction (CMD). Coronary flow reserve (CFR), which integrates both epicardial and microvascular coronary function, and a reduced CFR following complete revascularization indicates the presence of CMD.

Aims: This study aimed to measure CFR in patients who underwent percutaneous coronary intervention (PCI) for complete revascularization using myocardial perfusion imaging (MPI) and analyzed the prevalence of CMD and its correlation factors.

Engineered S-Scheme Heterojunction for Efficient CO Photoreduction on Bismuth Oxybromide.

Artificial photosynthesis presents a highly promising approach for addressing global energy and environmental challenges. However, its efficiency remains constrained by rapid charge recombination and inefficient CO activation. To overcome these limitations, cobalt-nickel layered double hydroxide (CN-LDH) is decorated onto BiOBr nanosheets to enhance Lewis alkaline sites and facilitate charge separation.

Non-structural carbohydrates constrain xylem formation of Picea crassifolia under drought year in the Qilian Mountains of Northwest China.

Tree xylem formation is highly dependent on non-structural carbohydrates content and microenvironments. However, it is still less understood that the key variables regulating cambial activity and xylem formation under different environmental conditions, nor the specific contribution of each variable to the number of cells in different stages of xylogenesis. Here, we monitored the xylogenesis and xylem non-structural carbohydrates dynamics of Picea crassifolia during the growing seasons of 2021 and 2022 along an altitude gradient in the Qilian Mountains.

Gut Microbiota-Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-Altitude: Gut Microbiota and Associated Metabolites Impart Heart Health in Plateau.

Young migrants, particularly those at high altitudes, are predisposed to heart health abnormalities, including high-altitude heart disease. Despite the profound impact of hypobaric hypoxia on the gut microbial community, the understanding of the roles played by gut microbiota and gut microbiota-associated serum metabolites in high-altitude heart diseases remains limited. Therefore, we conducted a comprehensive multi-omics analysis involving 230 graduates from the same university, with 163 Tibetan Plateau migrants and 67 Chengdu Plain residents, and identified 206 differential metabolites (82 in serum and 124 in feces) and 369 species that differed between migrants and residents.

Advances in bone organoids research and future perspectives.

Skeletal diseases pose a significant threat to both physical and mental health, emerging as a critical global issue. A thorough understanding of bone physiology and the development of effective clinical interventions necessitate robust research methodologies. Recently, organoids have gained widespread attention as three-dimensionalmodels capable of recapitulating complexenvironments, addressing key limitations of traditional two-dimensional cell cultures and animal models.

Association between the dietary index for gut microbiota and Alzheimer's disease: A cross-sectional study from the National Health and Nutrition Examination Survey (2004 to 2018).

Introduction: Emerging evidence implicates gut microbiota (GM), shaped by diet, in Alzheimer's disease (AD) pathogenesis. However, the association between the dietary index for GM (DI-GM) and AD remains unclear.

Methods: This cross-sectional study analyzed data from 28,830 adults aged ≥20 years in the 2004-2018 National Health and Nutrition Examination Survey (NHANES).

How lead entrepreneurs resilience influence entrepreneurial performance in crisis time: A team-level perspective.

Recently, the topic of entrepreneur resilience has attracted great attention. However, existing research has largely overlooked the interpersonal effect of entrepreneur resilience and the underlying team-level mechanisms through which it influences entrepreneurial performance. Drawing on social information processing theory and Marks et al.

Defect-phase engineered NiTi-TiO enabling near-unity selective photocatalytic CO-to-methanol conversion.

Scaling up methanol yields by artificial photosynthesis at a modest cost remains thermodynamically challenge. Designing concerted reaction sites to control intermediate evolution and stimulate proton-coupled electron transfer (PCET) is necessary. Here we show a nickel-titanium-based catalyst that achieves near-millimolar hourly methanol yields with 99.

Rhodiola crenulata extract inhibits cell pyroptosis to ameliorate pulmonary vascular remodeling in rats through the regulation of decadienylcarnitine/NLRP3/GSDMD axis.

Ethnopharmacological Relevance: Our previous work verified that decadienyl-L-carnitine (C10:2) biosynthesis has therapeutic-target capacity for RCE inhibiting pulmonary vascular remodeling to modulate experimental pulmonary hypertension(PH). However, the profound molecular mechanism remains incompletely elucidated.

Aim Of Study: This study aims to investigate whether C10:2 biosynthesis regulates pulmonary vascular remodeling by activating cell pyroptosis.

Enhanced sensitive detection of bisphenol F via an electrode with dual-layered modification of carbon nanocages and Prussian blue nanocubes.

An electrochemical sensor demonstrating exceptional sensitivity was constructed for bisphenol F analysis. Carbon nanocages and Prussian blue nanocubes were synthesized and then applied to modify a glassy carbon electrode layer by layer, creating the unique sensing platform. The combination of carbon nanocages and Prussian blue nanocubes greatly improved the charge transfer rate and offered a substantial surface area for bisphenol F adsorption.

Magnetic Morphogenesis of Programmable Photonic Architectures through Field-Directed Droplet Engineering.

The creation of dynamically tunable hierarchical architectures in photonic materials represents a crucial frontier in nanoscale science, yet deterministic multi-scale structural control under non-equilibrium conditions persists as an unresolved core limitation despite advances in field-guided assembly technologies. This study demonstrates a magnetic morphogenesis platform combining field-driven droplet deformation and non-equilibrium colloidal assembly to resolve multi-scale structural control. Systematic phase mapping (100-1500 G, 0.

Molecular subtypes, prognostic factors, and treatment optimization in pediatric medulloblastoma: a real-world study from China.

Background: Medulloblastoma (MB) is the most common malignant pediatric brain tumor, yet systematic studies on molecular characteristics and treatment efficacy in Chinese pediatric MB remain scarce. This study evaluates recurrence and mortality risk factors and the feasibility of intensified chemotherapy.

Methods: A retrospective analysis of 381 MB patients (WNT: 63, SHH: 106, Group 3: 27, Group 4: 185) was conducted.

Effects of S-ketamine on emergence agitation after sevoflurane anesthesia for children: A randomized clinical trial.

BackgroundWith the use of sevoflurane, the incidence of emergence agitation (EA) has also increased.ObjectiveWe aimed to investigate whether S-ketamine can prevent EA after sevoflurane anesthesia in children.MethodsChildren undergoing otolaryngology surgery were assigned to one of four groups randomly.

The synergistic pro-inflammatory effect of butyric and propionic acid on human periodontal ligament cells via activation of G-protein-coupled receptor 41.

Purpose: Periodontitis is a chronic disease that ultimately leads to tooth loss. This study aimed to investigate the inflammatory effects of short-chain fatty acids (SCFAs) on human periodontal ligament cells (hPDLCs).

Methods: Immunofluorescence was employed to assess the expression of G protein-coupled receptors (GPRs) in hPDLCs.

Model-informed individualized administration of ceftazidime-avibactam in critically ill patients: population pharmacokinetics studies and a parametric time-to-event analysis.

Objectives: Ceftazidime-avibactam is effective against resistant Gram-negative bacteria but associated with a risk of acute kidney injury (AKI), with incidence rates ranging from 13.3% to 33.0%.

Clinical applications and mechanisms of vagus nerve stimulation in the treatment of immune diseases: a review.

Vagus nerve stimulation (VNS) is a widely used neurostimulation technique for managing neurological diseases such as drug-resistant epilepsy and depression. Moreover, VNS has shown considerable potential for application in immune diseases. Herein, clinical studies on VNS application in immune disease treatments, such as for rheumatoid arthritis and Crohn's disease, have been systematically reviewed, with a focus on stimulation methods, clinical efficacy, mechanisms of action, and safety.

The phytochemistry, pharmacology and modern applications of Cotinus coggygria Scop.-A comprehensive review with future perspectives.

Ethnopharmacological Relevance: Cotinus coggygria Scop. (syn Rhus cotinus L.), a plant with a longstanding medicinal history, has been traditionally employed in Asian ethnomedicine for the management of hepatic disorders and gastrointestinal ailments.

Single-cell atlas reveals heterogeneous response to FcRn blockade in anti-AChR antibody-positive generalised myasthenia gravis.

Background: Myasthenia gravis (MG) is an autoimmune disease predominantly driven by autoantibodies targeting acetylcholine receptor (AChR), resulting in muscle weakness. Efgartigimod, a neonatal Fc receptor (FcRn) blocker, reduces pathogenic immunoglobulin G in anti-AChR antibody-positive generalised MG (gMG). This study aimed to identify immune mechanisms underlying MG pathology and response to efgartigimod.