Model-informed individualized administration of ceftazidime-avibactam in critically ill patients: population pharmacokinetics studies and a parametric time-to-event analysis.

Objectives: Ceftazidime-avibactam is effective against resistant Gram-negative bacteria but associated with a risk of acute kidney injury (AKI), with incidence rates ranging from 13.3% to 33.0%.

Pseudogene pair-based prognostic model reveals LAT as a biomarker of immune response in head and neck squamous cell carcinoma.

Background: Patients with head and neck squamous cell carcinoma (HNSCC) often exhibit only partial responses to immunotherapy, resulting in poor prognosis and potential overtreatment. While pseudogenes are known to significantly impact the tumor microenvironment (TME) and tumor prognosis, their specific role in HNSCC remains unclear.

Methods: A prognostic risk profile for HNSCC patients was developed and validated using pseudogene pairs.

Breath and Bottle: Evaluating Pharmacotherapy for Alcohol Use Disorder on COPD Exacerbation Outcomes.

Background: The role of pharmacotherapy for alcohol use disorder (AUD) in mitigating COPD exacerbations remains underexplored. This study aims to evaluate the impact of AUD pharmacotherapy on COPD-related clinical outcomes.

Methods: A retrospective cohort study was conducted on 635 COPD patients with comorbid AUD.

Nutritional status of patients with driver gene mutation-negative non-small cell lung cancer after postoperative adjuvant chemotherapy.

Background: Non-small cell lung cancer (NSCLC) remains a significant challenge for public health and is closely associated with malnutrition; however, few studies have attempted to examine the malnutrition experienced by patients with driver gene-negative NSCLC who have undergone combined chemotherapy after surgery. This study aimed to evaluate the nutritional status of patients with driver gene-negative NSCLC who received adjuvant chemotherapy after surgery and examined the application value of three nutritional screening tools: Nutritional Risk Screening Scale 2022 (NRS-2002), the Prognostic Nutritional Index (PNI), and the Patient-Generated Subjective Global Assessment Scale (PG-SGA).

Methods: Data from patients with driver gene-negative NSCLC who underwent sleeve surgery and adjuvant chemotherapy at Shanghai Pulmonary Hospital from January 2021 to December 2021 were prospectively collected.

Per- and polyfluoroalkyl substances (PFAS) in drinking water systems in the lower Yangtze River: source, fate, and health risk assessment.

The Yangtze River is significantly impacted by industrial activities related to per- and polyfluoroalkyl substances (PFAS) in China, posing potential threats to drinking water safety. So far, our knowledge of PFAS occurrence in the river and their fate in the whole drinking water supply systems remains limited. We conducted a comprehensive investigation of PFAS in Jiangsu's drinking water systems, using the target screening method.

Metal effect boosts the photoelectric properties of two-dimentional Dion-Jacobson (3AMPY)(MA)MI perovskites.

Two-Dimentional (2D) Dion-Jacobson (DJ) perovskites are emerging photovoltaic materials due to their excellent rigid structures and improved environmental stability compared to 2D Ruddlesden-Popper (RP) perovskites. Herein, we adopt 3-(aminomethyl)pyridine (3AMPY) as the divalent interlayer spacer to alleviate the toxicity of lead and explore more highly potential DJ alternatives, the optoelectronic and photovoltaic performance of lead-free DJ (3AMPY)(MA)MI perovskites are investigated by first-principles calculations, where the central metals are considered as Ba, Cd, Cu, Ge, Mg, Mn, Ni, Sn and Zn to replace Pb. Our findings reveal that introducing Mn, Cd, Ni, and Ge can effectively tune the bandgap within the optimal range of 0.

Fecal microbiota transplantation alleviates radiation enteritis by modulating gut microbiota and metabolite profiles.

This study investigates the safety and underlying mechanisms of fecal microbiota transplantation (FMT) in treating radiation enteritis (RE). A rat model of RE was established with six groups: NC, RT, H-FMT, modified FMT (M-FMT), L-FMT, and BTAC. The therapeutic effects of FMT were assessed using the Disease Activity Index (DAI), histological analysis, and biochemical tests, including ink-propelling, xylitol exclusion, and enzyme-linked immunosorbent assay (ELISA).

Anxiety disorders and the gut microbiota: a bibliometric and visual analysis.

Introduction: Anxiety disorder is a common mental illness, yet its specific mechanisms remain unclear. Recent research has revealed a connection between gut microbiota and anxiety disorders. This study aims to assess the current global research landscape, highlight current topics of interest, and explore future research directions in the field of anxiety disorders and gut microbiota.

Drainage from intentional extramacular holes after internal limiting membrane insertion to treat macular hole retinal detachment in highly myopic eyes.

Purpose: The purpose is to evaluate the effect of drainage from intentional extramacular holes after internal limiting membrane insertion to treat macular hole retinal detachment (MHRD) in highly myopic eyes.

Methods: This study is a retrospective, observational, and comparative case series that included 25 consecutive highly myopic eyes with MHRD. All eyes underwent standard 23-gauge vitrectomy, inverted internal limiting membrane insertion into the macular hole, subretinal fluid drainage from an intentionally created extramacular retinal hole, and tamponade with either silicone oil (SO group, n = 13) or perfluoropropane (CF group, n = 12).

Comparative Analysis of CXCR5 Circulating DNA Methylation Levels in Autoimmune Rheumatic Diseases.

Objective: To assess CXC chemokine receptor 5 (CXCR5) circulating DNA methylation differences in autoimmune rheumatic diseases and their relation with clinical features.

Methods: Targeted methylation sequencing was performed using peripheral blood from 164 rheumatoid arthritis (RA), 30 systemic lupus erythematosus (SLE), 30 ankylosing spondylitis (AS), 30 psoriatic arthritis (PsA), 24 Sjögren's syndrome (SS) patients, and 30 healthy controls (HC).

Results: Significant differences in CXCR5 cg19599951 methylation were found between RA and HC, as well as AS and SLE.

Modulation of β secretase and neuroinflammation by biomimetic nanodelivery system for Alzheimer's disease therapy.

Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder. The vicious circle between amyloid-β peptide (Aβ) overgeneration and microglial dysfunction is an important pathological event that promotes AD progression. However, therapeutic strategies toward only Aβ or microglial modulation still have many problems.

Magnesium-related gene ITGAL: a key immunotherapy predictor and prognostic biomarker in pan-cancer.

Background: Integrin subunit alpha L (ITGAL) is crucial for activating CD8 T cells through magnesium-mediated immune synapse formation and specific cytotoxicity. ITGAL might exert an important function in the growth and transformation of cancer.

Methods: Our study comprehensively analyzed ITGAL expression across various cancers, validated by Immunochemistry (IHC) in the laboratory.

Clinical characteristics and prognosis analysis of pseudomonas aeruginosa bloodstream infection in adults: a retrospective study.

Pseudomonas aeruginosa bloodstream infections (PA BSIs) in adults, especially those complicated by sepsis, are associated with high rates of morbidity and mortality. Early identification of risk factors for both mortality and sepsis-induced coagulopathy (SIC) is critical to optimizing patient management and improving outcomes. We conducted a retrospective analysis of 118 adult patients diagnosed with PA BSIs at the Affiliated Hospital of Xuzhou Medical University from January 2022 to February 2024.

A W/Al Co-doped NaMnO Cathode Material for Enhanced Sodium-Ion Storage.

The NaMnO cathode has attracted enormous interest owing to its low cost, low toxicity, and stable structure, but its practical application is still hindered by the limited sodium storage sites. Element doping is widely used to improve its capacity. However, cation and anion substitution could barely reach a satisfactory compromise between the structural stability and reversible capacity.

Tumor-related IGF2BP1-derived molecular subtypes to predict prognosis and immune microenvironment in head and neck squamous cell carcinoma.

Background: Recent studies have underscored the biological significance of RNA modifications in tumorigenicity and progression. However, the potential roles of RNA modifications in immune regulation and the formation of the tumor microenvironment (TME) in head and neck squamous carcinoma (HNSC) remain unclear.

Methods: We collected 199 untreated HNSC samples and clinicopathological data from Fujian Provincial Cancer Hospital.

Correlation of dietary flavonoid intake with chronic bronchitis, emphysema, and asthma in U.S. adults: A large, national, cross-sectional study.

Objective: To explore the relationship between dietary flavonoids and bronchitis, emphysema and asthma.

Method: A total of 11743 United States adults were extracted from the National Health and Nutrition Examination Survey (NHANES) in 2007-2008, 2009-2010 and 2017-2018. Of these, 47.

Establishment and validation of circulating cell-free DNA signatures for nasopharyngeal carcinoma detection.

Background: Early detection of nasopharyngeal carcinoma (NPC) poses a significant challenge. The absence of highly sensitive and specific diagnostic biomarkers for nasopharyngeal carcinoma contributes to the unfavourable prognosis of NPC patients. Here, we aimed to establish a non-invasive approach for detecting NPC using circulating cell-free DNA (cfDNA).

Sarcopenia Is Associated with Neoplasm of Bone and Articular Cartilage: Findings from Mendelian Randomized Study.

Exploring the causal relationship between sarcopenia and neoplasm of bone and articular cartilage (NBAC) by bidirectional Mendelian randomization (MR). Genome-wide association study (GWAS) data on sarcopenia-associated traits including appendicular lean mass, low handgrip strength (including criteria from the European Working Group on Sarcopenia in Older People and the Foundation for the National Institutes of Health), and usual walking speeds were obtained from the UK Biobank. GWAS data for NBAC (benign and malignant) were provided by the Finnish Genetic Database.

Extracellular vesicles-derived ferritin from lipid-induced hepatocytes regulates activation of hepatic stellate cells.

Introduction: : Extracellular vesicles (EVs) have emerged as key players in intercellular communication within the context of non-alcoholic fatty liver disease (NAFLD). This study aims to explore the intricate crosstalk between hepatocytes and hepatic stellate cells (HSCs) mediated by EVs in NAFLD.

Materials And Methods: EVs ferritin was detected in hepatocytes stimulated with free fatty acids (FFA) as well as in NAFLD mice.

Methyl jasmonate enhances the safe production ability of Cd-stressed wheat by regulating the antioxidant capacity, Cd absorption, and distribution in wheat.

Identifying green and effective measures for reducing wheat Cd toxicity and grain Cd accumulation is crucial. This study used seedling sand culture and full-grown pot experiments of wheat cultivars 'Luomai23' (LM) and 'Zhongyu10' (ZY). The purpose was to determine the effects of exogenous MeJA on the phenotype, photosynthesis, antioxidant system, Cd accumulation and distribution, transporter gene expression, and cell wall properties of Cd-stressed wheat.

A progress update on the biological effects of biodegradable microplastics on soil and ocean environment: A perfect substitute or new threat?

Conventional plastics are inherently difficult to degrade, causing serious plastic pollution. With the development of society, biodegradable plastics (BPs) are considered as an alternative to traditional plastics. However, current research indicated that BPs do not undergo complete degradation in natural environments.