Association of antidepressant use during pregnancy and pregnancy-induced hypertension: a systematic review and meta-analysis.

Background: The association between antenatal antidepressant use and pregnancy-induced hypertension (GH/PE) remains controversial, with conflicting evidence on whether depression itself confounds this risk.

Methods: We searched PubMed, Web of Science, Medline, Embase, Cochrane Library, and the China National Knowledge Infrastructure electronic databases from inception to Dec. 31, 2024.

Treponema pallidum inhibits CD4+ T-cell proliferation through METAP2: insights from Mendelian randomization analysis.

Neurosyphilis (NS) is a chronic central nervous system infection caused by Treponema pallidum. Owing to its diverse clinical manifestations and the limited sensitivity of current diagnostic methods, NS is difficult to diagnose. Understanding the molecular mechanisms of NS and identifying reliable biomarkers are essential for improving diagnostic and therapeutic strategies.

The Outer Membrane Protein Tp92 of Induces BeWo Cells Apoptosis and Oxidative Stress via the Nrf2/keap1 Pathway.

can be transmitted from the mother to the newborn via the placenta. Pregnancy complications that can arise from this include congenital syphilis, stillbirth, miscarriage, preterm birth, and fetal growth limitation. Tp92 is a protein located in the outer membrane of and has a β-barrel structure.

Erratum: SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

[This corrects the article on p. 2797 in vol. 9, PMID: 31911863.

Pseudogene pair-based prognostic model reveals LAT as a biomarker of immune response in head and neck squamous cell carcinoma.

Background: Patients with head and neck squamous cell carcinoma (HNSCC) often exhibit only partial responses to immunotherapy, resulting in poor prognosis and potential overtreatment. While pseudogenes are known to significantly impact the tumor microenvironment (TME) and tumor prognosis, their specific role in HNSCC remains unclear.

Methods: A prognostic risk profile for HNSCC patients was developed and validated using pseudogene pairs.

Clinical study on modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in the treatment of severe pneumonia.

Objective: This study aimed to evaluate the clinical efficacy of modified Shenzhe Zhenqi Decoction combined with ambroxol hydrochloride in treating severe pneumonia.

Methods: This was a single-center, prospective, double-blind, randomized controlled trial. A total of 138 patients with severe pneumonia were randomly divided into two groups.

Ascertaining the association between smoking behaviors and viral hepatitis risk: A Mendelian randomization approach.

Introduction: Viral hepatitis, caused by various hepatitis viruses, is a global health threat leading to chronic liver disease, hepatic cirrhosis, hepatic failure, and hepatocellular carcinoma. Smoking, a known risk factor for numerous chronic diseases, has been implicated in the pathogenesis of viral hepatitis. However, understanding the relationship between smoking and viral hepatitis is complex due to the presence of confounding factors and the potential for reverse associations.

Home-based medication safety: constructing health education for community-dwelling older adults with chronic diseases in China.

Background: Chinese older adults with chronic diseases often require long-term medication use. While medication safety education can improve health outcomes and mitigate risks, existing programs lack systematic and comprehensive frameworks. This study aimed to develop Delphi-based consensus content to enhance home-based medication safety education for this population.

Predictors of early complete nodule shrinkage in symptomatic benign thyroid nodules treated with radiofrequency ablation with or without sclerotherapy: a retrospective study.

Objectives: To identify factors influencing the early complete shrinkage of symptomatic benign thyroid nodules following radiofrequency ablation (RFA) with or without sclerotherapy and to predict complete nodule resolution within 2 years, thereby alleviating concerns regarding long-term follow-up outcomes.

Materials And Methods: Patients with symptomatic benign thyroid nodules who underwent RFA were retrospectively enrolled. The patients were grouped according to whether their nodules had completely shrunk within 2 years.

Achieving High-Performance Defect-Free LiCoO Cathode via a Dopant-Free Approach.

Elevating the charging voltage of layered oxide cathodes to achieve higher capacity induces phase transitions associated with transition metal slab gliding, which significantly impacts the material's structural stability. Doping with inert elements is commonly employed to delay such phase transitions to higher voltages. However, these electrochemically inactive elements do not participate in redox reactions, thereby compromising lithium storage capacity.

Dynamic covalent bonding based polysaccharide hydrogels and their applications in wound dressings: A review.

Polysaccharide hydrogels have emerged as pivotal wound dressings due to their inherent biocompatibility and extracellular matrix-mimicking properties. However, conventional systems employing permanent covalent or physical crosslinks suffer from irreversibility, poor self-repair capacity, and limited responsiveness that compromise clinical efficacy. To address these challenges, dynamic covalent bonding strategies have been innovatively integrated into polysaccharide networks, enabling unprecedented functionalities through reversible bond reconfiguration.

Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors.

Background: Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients, the majority do not benefit from ICIs, indicating a need for predictive biomarkers to better inform treatment decisions.

Methods: A de-identified pan-cancer cohort from the Tempus multimodal real-world database was used for the development and validation of the Immune Profile Score (IPS) algorithm leveraging Tempus xT (648 gene DNA panel) and xR (RNA sequencing) (N=1,707 development cohort; N=1,600 validation cohort).

To predict cervical lymph node tuberculosis based on clinical-multimodal ultrasound radiomics model.

Objectives: In practical clinical work, when sonographers extract image features, there may be large intra-observer and inter-observer variability in subjective description and visual evaluation. Lymph node tuberculosis is often confused with other diseases of lymphadenopathy. To avoid the shortcomings of ultrasound such as strong subjectivity and low repeatability, we discussed the clinical value of imaging models based on B-mode ultrasound (B-US), elastic ultrasound (EUS) and contrast-enhanced ultrasound (CEUS) images in predicting cervical lymph node tuberculosis (CLNT).

Association of metformin with risk of digestive tract cancers from a drug target mendelian randomization and cell experiments.

Background: Digestive tract cancers account for a significant proportion of the global cancer burden, and their prevention and treatment pose a worldwide challenge. Metformin, as a first-line treatment for diabetes, offers advantages such as high safety and affordability. Previous research has suggested that the use of metformin may reduce the risk of cancers, but there is still a lack of strong evidence regarding its causal relationship with digestive tract cancers.

2-Methoxyestradiol attenuates lung injury induced by chronic intermittent hypoxia via inhibiting the HIF1-α/SLC7A11 pathway.

Ferroptosis is a novel type of programmed cell death associated with lung injury induced by chronic intermittent hypoxia (CIH). 2-Methoxyestradiol (2-ME2), as an inhibitor of Hypoxia-inducible factor 1 alpha (HIF-1α), affects HIF-1α-related biological processes. This study aimed to explore the role and mechanism of 2-ME2 on CIH-induced lung injury.

Porous platinum nanozyme-amplified capacitance immunoassay for alpha-fetoprotein with hepatocellular carcinoma on an interdigitated gold micro-comb array.

Background: Hepatocellular carcinoma, one of the most common malignancies, is the worldwide three cause leading the mortality of cancers. Alpha-fetoprotein (AFP) is a typical tumor marker for the recurrences of HCC, and can be utilized potentially during routine follow-up after HCC resection. Therefore, sensitive and accuracy detection of AFP is very critical at the early stage of hepatocellular carcinoma.

[Effect of Biyan Jiedu Capsules on proliferation and apoptosis of nasopharyngeal carcinoma cells based on PI3K/Akt pathway].

To investigate the effects of Biyan Jiedu Capsules on the proliferation and apoptosis of nasopharyngeal carcinoma cells and their molecular mechanism, nasopharyngeal carcinoma cells CNE1 and CNE2 were used. They were divided into control group(30% blank serum medium), low-(10% drug-containing serum + 20% blank serum medium), medium-(20% drug-containing serum + 10% blank serum medium), and high-(30% drug-containing serum medium) concentration group of Biyan Jiedu Capsules according to in vitro experiment. After 24 h of intervention, the effects of Biyan Jiedu Capsules on the proliferation of CNE1 and CNE2 were detected by CCK-8 assay, clonal formation experiment, and EdU staining.

Exploring the influencing factors of abdominal aortic calcification events in chronic kidney disease (CKD) and non-CKD patients based on interpretable machine learning methods.

Background: Calcification is prevalent in CKD patients, with abdominal aortic calcification (AAC) being a strong predictor of coronary calcification. We aimed to identify key calcification factors in CKD and non-CKD populations using machine learning models.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES), including demographics, blood and urine tests, and AAC scores, were analyzed using machine learning models.

HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses.

Syphilis, caused by Treponema pallidum (Tp), represents a significant public health challenge. The clinical manifestations of syphilis are attributed to local inflammatory responses induced by Tp, notably monocyte infiltration into local lesions and the secretion of inflammatory cytokines. However, the mechanisms driving cytokine production in response to Tp infection remain largely unknown.

Contezolid, a novel oxazolidinone antibiotic, acts as a potential anti-inflammatory agent.

Contezolid, a novel oxazolidinone antibiotic, has comparable or superior antibacterial efficacy and safety to linezolid, now widely used for treating multidrug-resistant Gram-positive bacterial infections. Although numerous studies have investigated the immunomodulatory effects of oxazolidinone antibiotics, the immunomodulatory properties of contezolid remain poorly understood. This study aimed to investigate the anti‑inflammatory effects of contezolid using LPS-stimulated RAW264.

Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from -Hydroxy Ketones and Cyano Compounds.

A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction of -hydroxy ketones and cyano compounds. The reaction proceeds under relatively mild conditions, utilizes readily available starting materials, and exhibits good functional group tolerance and high yields. Notably, this reaction obviates the need for expensive metal catalysts and introduces crucial functional groups such as amino and cyano moieties.

Identification of molecular subtypes and a prognostic risk model based on mitochondrial dynamic related genes in clear cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) represents the most prevalent histological subtype and primary contributor to unfavorable prognosis in renal cancer. While mitochondrial dynamics serve as a critical quality control mechanism linked to tumor malignancy, their clinical significance and specific mechanisms in ccRCC remain poorly understood.

Methods: Consnsuclusterplus was used to consensus clustering and molecular subtype screening, Kaplan-Meier analysis was used to analyze survival in different subtypes.

A Mendelian randomization study investigating the causal associations of 35 blood and urinary metabolite biomarkers with breast cancer development.

Breast cancer is the most common cancer among women worldwide. The present study utilized a bidirectional Mendelian randomization methodology to explore the causal associations between 35 blood and urinary metabolic markers and distinct subtypes of breast cancer. The MR-PRESSO method was employed to detect and correct for pleiotropic effects, with statistical significance adjusted using the false discovery rate (FDR).

Unraveling Atomic-Level Mechanisms of Structural Transitions in Lithium Cobalt Oxide under High-Voltage Conditions.

High-voltage cycling of layered cathode materials in lithium-ion batteries presents challenges related to structural instability. Deciphering atomic-scale structural degradation mechanisms is essential for improving their electrochemical performance at high voltages. This study utilized advanced electron microscopy and principal component analysis to detect subtle spinel-like structure induced by the migration of cobalt atoms within LiCoO subjected to high-voltage cycling at charge voltages of 4.

USP24 promotes hepatocellular carcinoma progression by deubiquitinating and stabilizing YAP1.

Yes-associated protein 1 (YAP1) plays a pivotal role in promoting the progression of hepatocellular carcinoma (HCC). Emerging evidence shows that inducing YAP1 degradation represents a promising strategy. Here, we identified USP24 as a bona fide deubiquitinating enzyme for YAP1.