Dialysis dependence is associated with poor prognosis in multiple myeloma: a multicenter retrospective cohort study.

Background: Patients with multiple myeloma (MM) and renal impairment (RI), particularly those requiring dialysis, have historically experienced poor outcomes. Despite advancements in targeted therapies, the prognosis of dialysis-dependent MM and factors influencing dialysis independence remain unclear.

Objectives: This study aimed to provide a comprehensive analysis of the clinical manifestations and treatment outcomes of dialysis-dependent MM patients in China, and to explore the factors associated with dialysis independence and long-term survival.

Comparison of pregnancy outcomes after history-indicated and ultrasound-indicated cervical cerclage: A systematic review and meta-analysis.

Objective: To compare maternal and neonatal outcomes in women with a previous history of pregnancy loss and/or preterm delivery who underwent ultrasound-indicated cerclage (UIC) or history-indicated cerclage (HIC).

Methods: PubMed, Web of Science, Scopus, and Embase databases were searched for observational studies and randomized controlled trials (RCT) from inception to 30 April 2024. Eligible studies should have compared the outcomes of women with singleton pregnancies who underwent UIC or HIC.

Heparin administration at first medical contact vs immediately before primary percutaneous coronary intervention: the HELP-PCI trial.

Background And Aims: The beneficial effect of pre-treatment with unfractionated heparin (UFH) at first medical contact (FMC) before primary percutaneous coronary intervention (PPCI) in all-comers with ST-elevation myocardial infarction (STEMI) remains uncertain.

Methods: HELP-PCI was an investigator-initiated, randomized controlled trial conducted at 36 clinical centres in China. Patients with STEMI presenting ≤12 h after symptom onset undergoing PPCI were randomly assigned (1:1) to intravenous administration with UFH (100 U/kg) at FMC or in the Cath Lab through a catheter sheath.

Enzymological and transcriptomic analyses reveal the insecticidal mechanism of 4-propargyloxybenzenesulfonamide as a V-ATPase inhibitor.

The vacuolar-type H-ATPase (V-ATPase) has emerged as a promising molecular target for the development of new pesticides. In our previous work, we employed computer-aided drug design (CADD) strategies targeting the V-ATPase H subunit of the Mythimna separata. Through homology modeling, virtual screening, and lead compound synthesis, we successfully identified 4-propargyloxybenzenesulfonamide as a potent insecticidal compound.

Overlooked synergisms of flotation organic reagents and toxic metals in water: Formation of tridentate cadmium-xanthate complexes.

Mining activities release a substantial quantity of toxic metals and organic flotation reagents into the aquatic environment, causing severe pollution and potential health risks. However, the synergisms and mechanisms associated with these mixed pollutants are largely overlooked. The combined application of atomic force microscopy, high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy, isothermal titration calorimetry, and quantum chemical calculations revealed that cadmium (Cd) was capable of forming tridentate coordination complexes with typical organic beneficiation reagents, namely xanthates (ethyl, isopropyl, and butyl xanthates).

Integrating multi-omics and machine learning strategies to explore the "gene-protein-metabolite" network in ischemic heart failure with Qi deficiency and blood stasis syndrome.

Background: Ischemic heart failure (IHF) is a multifaceted syndrome associated with significant mortality and high hospitalization rates globally. According to traditional Chinese medicine (TCM) theory, Qi Deficiency and Blood Stasis (QXXY) Syndrome serves as the pathological basis of IHF. This study aims to investigate the biological basis of QXXY syndrome in IHF patients through an integrated multi-omics approach.

Cellular hierarchy for understanding heterogeneity of acute myeloid leukaemia with t(8;21)/RUNX1-RUNX1T1.

Objectives: Differentiation hierarchies in myeloid malignancies influence therapeutic response and prognosis. Acute myeloid leukaemia (AML) with t(8;21) is one of the most recurrent genetic subtypes of AML and is considered a distinct entity with shared characteristics. However, clinical outcomes remain markedly heterogeneous.

Attacking cooperative multi-agent reinforcement learning by adversarial minority influence.

This study probes the vulnerabilities of cooperative multi-agent reinforcement learning (c-MARL) under adversarial attacks, a critical determinant of c-MARL's worst-case performance prior to real-world implementation. Current observation-based attacks, constrained by white-box assumptions, overlook c-MARL's complex multi-agent interactions and cooperative objectives, resulting in impractical and limited attack capabilities. To address these shortcomes, we propose Adversarial Minority Influence (AMI), a practical and strong for c-MARL.

Association between deep gray matter iron deposition, white matter hyperintensity, and hypertensive cognitive impairment.

Background: Deep gray matter (DGM) iron deposition and white matter hyperintensity (WMH) often occur simultaneously in hypertensive patients. However, their relationship and effect on cognition in hypertension remain unclear. We aimed to investigate the correlation between DGM iron deposition, WMH, and cognitive impairment.

Interfacial Polarons Driven by Charge Transfer in WSe/Cuprate Superconductor Systems.

Understanding the electronic properties of doped copper-oxygen planes remains a significant challenge in condensed matter physics and is crucial to unraveling the mechanisms behind high-temperature superconductivity in cuprates. Recently, the observation of charge transfer and interfacial polarons in a superconducting interface has aroused extensive research interest. However, experimental data to investigate charge transfer on the CuO plane and the presence of polarons are still missing.

KRAS mutation status critically determines the clinical outcome of patients with KMT2A-rearranged acute myeloid leukemia.

Background: KMT2A(11q23)-rearranged acute myeloid leukemia (KMT2A-r AML) represents a clinically aggressive subtype with heterogeneous outcomes. Current evidence remains inconclusive regarding the prognostic relevance of fusion partners in 11q23/KMT2A-rearranged AML. The comprehensive mutational landscape and prognostic implications of co-occurring driver mutations remain poorly characterized.

Design, Synthesis, and Insecticidal Activity of Sulfonamide Structures Containing Methoxyamine as Potential Inhibitors of V-ATPase.

Pesticides that act on unique targets are favored in pesticide research because of their unique mechanism of action and lower proneness to developing cross-resistance. In the previous work, the natural product cingulin V, which was isolated from Celastrus angulatus Maxim in our laboratory, was determined to act on the subunit H on V-ATPase. After homology modeling and virtual docking of the subunit H on V-ATPase, the highest scoring compound was selected for structural modification; two critical functional groups-the sulfonamide and propargyloxy moieties-were ultimately identified as being essential for the significant enhancement of insecticidal activity.

Accuracy and cost comparison of 3D-printed guides in complex spinal deformity correction: direct vs indirect design.

Background: The treatment of complex spinal deformities poses significant challenges, as the placement of pedicle screws and the execution of osteotomies within deformed vertebral structures carry an elevated risk of neurological complications. Numerous techniques have been developed to enhance the safety and accuracy of pedicle screw placement and osteotomies. Among these techniques, patient-specific guides, which feature pre-defined and pre-validated trajectories, present an attractive solution for achieving precision in screw placement and osteotomies.

Improving metabolic engineering design with enzyme-thermo optimization.

Metabolic target and strategy design play a critical role in enhancing the DBTL (Design-Build-Test-Learn) cycle in metabolic engineering. Classical stoichiometric algorithms such as OptForce and FSEOF narrow the experimental search space but fail to account for thermodynamic feasibility and enzyme-usage costs, leaving a space for their predictive performance. In this study, we introduce ET-OptME, a framework integrating two algorithms that systematically incorporate enzyme efficiency and thermodynamic feasibility constraints into genome-scale metabolic models.

Interpretable Machine Learning Models for Differentiating Glioblastoma From Solitary Brain Metastasis Using Radiomics.

Purpose: To develop and validate interpretable machine learning models for differentiating glioblastoma (GB) from solitary brain metastasis (SBM) using radiomics features from contrast-enhanced T1-weighted MRI (CE-T1WI), and to compare the impact of low-order and high-order features on model performance.

Methods: A cohort of 434 patients with histopathologically confirmed GB (226 patients) and SBM (208 patients) was retrospectively analyzed. Radiomic features were derived from CE-T1WI, with feature selection conducted through minimum redundancy maximum relevance and least absolute shrinkage and selection operator regression.

Selective efficacy of venetoclax in unfit patients with acute myeloid leukemia with myelodysplasia-related gene mutations under low-intensity therapy.

According to the 2022 International Consensus Classification (ICC) guidelines, nine myelodysplasia-related (MDS-related) gene mutations are classified as adverse-risk markers in acute myeloid leukemia (AML) under intensive therapy (INT). Although venetoclax (VEN) has demonstrated clinical benefit in subsets of AML with MDS-related gene mutations (AML-MR), its efficacy across all nine mutations remains unclear. In this retrospective study involving 453 AML-MR patients, the overall composite complete remission (CRc) rate was 62.

Porous platinum nanozyme-amplified capacitance immunoassay for alpha-fetoprotein with hepatocellular carcinoma on an interdigitated gold micro-comb array.

Background: Hepatocellular carcinoma, one of the most common malignancies, is the worldwide three cause leading the mortality of cancers. Alpha-fetoprotein (AFP) is a typical tumor marker for the recurrences of HCC, and can be utilized potentially during routine follow-up after HCC resection. Therefore, sensitive and accuracy detection of AFP is very critical at the early stage of hepatocellular carcinoma.

Genome-Wide Identification and Expression Pattern Analysis of SBP Gene Family in .

: SQUAMOSA promoter-binding protein (SBP) genes encode a group of plant-specific transcription factors that play crucial roles in plant growth, development, and stress responses. To date, genes have been reported in a number of plant species, but the SBP gene family has not been identified in , an important fast-growing species referred to as a 'miracle tree' and recognized for its potential medicinal value in Southeast Asia. : Bioinformatics approaches were employed to conduct a comprehensive analysis of the NcSBP gene family, including investigations into physicochemical characteristics, phylogenetic relationships, gene structure, chromosomal localization, conserved motifs, -acting elements, and expression patterns.

Epitaxial Growth of 1D Phosphorus Nanoribbons on Ag(110) Substrate: the Essential Role of Pentagonal Nature and Interfacial Adatoms in Realizing 1D Phosphorus Systems.

Controlling the dimensionality plays a critical role in manipulating the electronic structures and the emergent novel quantum properties. Despite intensive reports on controlling and fabricating 2D materials, the investigation of fabricating well-controlled 1D materials system remains insufficient. Here, through a comprehensive investigation with the combination of scanning tunneling microscopy and first-principles calculations, it reveals that the magic pentagonal nature plays a vital role in stabilizing the 1D phosphorus nanoribbons (PNRs), as revealed by the binding energies and bonding characteristics of 0D and 1D models with exceptional stability in pentagonal and hexagonal configurations.

Metabolic products comparison in autotrophic and heterotrophic nitrogen removal: Insights into membrane fouling.

Metabolic products play a significant role in membrane fouling during biological wastewater treatment. However, the differences in metabolic product composition and membrane fouling potentials between autotrophic (anammox, AN) and heterotrophic (denitrification, DN) nitrogen removal systems are not well understood. This study cultivated autotrophic and heterotrophic nitrogen removal systems and analyzed the compositions of their metabolic products.

Dasatinib and CAR T-Cell Therapy in Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Nonrandomized Clinical Trial.

Importance: A combination of tyrosine kinase inhibitors and chimeric antigen receptor (CAR) T cells has made a breakthrough in refractory or relapsed Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). However, it remains unclear if this treatment in newly diagnosed Ph-positive ALL is associated with high rates of complete molecular remission (CMR) and leukemia-free survival.

Objective: To evaluate the efficacy and safety of dasatinib in combination with CAR T cells as frontline therapy in adults with newly diagnosed Ph-positive ALL.

Surgical strategies for mitral valve diseases associated with pectus excavatum: a narrative review of approaches and outcomes.

Objectives: To develop a decision-making framework for the surgical management of coexisting mitral valve (MV) prolapse and pectus excavatum, addressing the challenges posed by anatomical complexity and functional compromise.

Methods: A narrative review of reported cases involving coexisting MV prolapse and pectus excavatum was conducted. Each case was analysed to evaluate the characteristics, personalized surgical strategies and operational details, with a focus on the associated benefits and risks.

Roles of sea ice and seasonal heat storage in determining the seasonal Arctic surface warming are studied with CMIP6 simulations.

In recent decades, Arctic surface warming has reached its maximum (minimum) during the cold season (summer) because of increased seasonal ocean heat storage (SHS) release (formation). Reanalysis data suggest that increased land ice melt dominates summer Arctic surface warming. The absence of land ice melt decreases Arctic surface warming in Phase 6 Coupled Model Intercomparison Project (CMIP6) simulations.

Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study.

Background: Seronegative Hashimoto's thyroiditis is often underdiagnosed due to the lack of antibody markers. Combining ultrasound radiomics with machine learning offers potential for early detection in patients with normal thyroid function.

Methods: Data from 164 patients with single thyroid lesions and normal thyroid function, treated surgically between 2016 and 2024, were retrospectively collected from four hospitals.

Highly-sensitive and logic platform based on spatially-constrained T7 transcription enhanced Cas13a for DNA repair enzyme detection and intracellular imaging.

The activity of DNA repair enzymes, particularly Flap endonuclease 1 (FEN1) and apurinic/apyrimidinic endonuclease 1 (APE1), plays a critical role in disease prevention, diagnosis, and prognosis. Accurate detection of these enzymes is therefore essential. Recent advancements in CRISPR-Cas technology, particularly its programmable and trans-cleavage activity, have paved the way for the development of innovative detection methods.