Efficacy and safety of cold snare polypectomy for outpatient treatment of sessile polyps smaller than 10mm.

Background: Screening colonoscopy plays a critical role in reducing colorectal cancer incidence by identifying and removing polyps. Simple and safe treatment is the most common request of both doctors and patients. Cold snare polypectomy (CSP) is increasingly favored for polyps < 10 mm, yet concerns remain regarding residual tissue.

A Study on the Negative Friction Mechanisms in Piles Within Recycled Dredged Waste Fills.

Green and low-carbon filling materials, primarily composed of dredged waste fills, are commonly used in the foundation of coastal highways. These materials possess high water content and under-consolidation characteristics, which can lead to differential settlement between piles and the surrounding environment. However, mechanical models of negative friction in piles within recycled dredged waste fills are insufficiently developed and presented.

Study on Compression Properties and Construction Applications of Loess Filling Materials for High Embankments Along G85 Expressway in Eastern Gansu Province.

Based on the G85 high-fill subgrade project in east Gansu Province, this study conducts one-dimensional compression tests in the laboratory on both disturbed and in situ-compacted loess. Through the combination of the test results of remolded soil, compaction standards for each layer of the subgrade fill are established, and quality inspections of the compacted subgrade are performed. The experimental results demonstrate that the compression deformation of remolded loess exhibits a positive correlation with compaction degree and a negative correlation with moisture content.

Transcatheter valve-in-valve mitral valve replacement with SAPIEN 3 valve for bioprosthetic mitral valve failure: one-year outcomes in 26 patients.

Objectives: To evaluate the one-year outcomes of valve-in-valve transcatheter mitral valve replacement (ViV-TMVR) using the SAPIEN 3 valve for treating mitral bioprosthetic valve failure.

Methods: A retrospective analysis was conducted on 26 patients with mitral bioprosthetic valve failure who underwent ViV-TMVR at West China Hospital, Sichuan University, between November 2022 and July 2024. The age of patients was 71.

Hydrogen sulfide ameliorates peritoneal fibrosis: inhibition of high mobility group box-1 expression to block the activation of the transforming growth factor-beta/Smad3 pathway.

JOURNAL/mgres/04.03/01612956-202606000-00004/figure1/v/2025-08-18T154854Z/r/image-tiff Hydrogen sulfide (H2S) holds significant potential for clinical applications in the alleviation of fibrosis. This study aimed to verify the role of H2S in combating peritoneal fibrosis and elucidate its molecular mechanisms.

High-precision transdermal drug delivery enabled by a dual-pump parallel valveless piezoelectric micropump integrated with hollow microneedles.

Transdermal drug delivery (TDD) system based on piezoelectric micropumps is a novel route of drug delivery that is wearable and highly patient-compliant. The advantage of valveless micropumps, such as their simple structure, high reliability and low cost, have been investigated in comparison to valve-based micropumps. However, the flow pulsation and backflow effect of valveless pump can reduce the controllability and precision of the system.

Polysaccharide-based nanosystems as vaccine adjuvants: A review.

Vaccines serve as effective tools for preventing infectious diseases, with adjuvants playing a pivotal role in enhancing immunogenicity, reducing antigen dosage, and minimizing adverse reactions. To mitigate the suboptimal efficacy and safety concerns that constrain current adjuvants, novel formulations exhibiting enhanced safety and potency are required for development. Natural polysaccharides have been employed as vaccine adjuvants.

The association between the lactate to albumin ratio and all-cause mortality in cardiac arrest patients: an analysis of the MIMIC-IV database.

Introduction: Cardiac arrest (CA) is a critical condition with high mortality, despite advances in post-resuscitation care. Severe ischemia-reperfusion injury, systemic inflammation, nutritional status, and organ dysfunction contribute to poor prognosis, highlighting the need for reliable prognostic markers for early risk stratification. Lactate and albumin are well known to be involved in these pathological processes, making them potential biomarkers for prognostic assessment.

Enzymological and transcriptomic analyses reveal the insecticidal mechanism of 4-propargyloxybenzenesulfonamide as a V-ATPase inhibitor.

The vacuolar-type H-ATPase (V-ATPase) has emerged as a promising molecular target for the development of new pesticides. In our previous work, we employed computer-aided drug design (CADD) strategies targeting the V-ATPase H subunit of the Mythimna separata. Through homology modeling, virtual screening, and lead compound synthesis, we successfully identified 4-propargyloxybenzenesulfonamide as a potent insecticidal compound.

Chemical reprogramming of human blood cells to pluripotent stem cells.

Chemical reprogramming offers a fundamentally innovative approach for generating human chemically induced pluripotent stem (hCiPS) cells using small molecules. Our recent studies showed that this approach was highly efficient in reprogramming human fibroblasts to hCiPS cells. However, generating hCiPS cells from human blood cells, which are the most accessible and convenient source for reprogramming, remains a challenge.

Enhancing nonlinear compensation efficiency with multi-task neural networks for coherent optical systems.

Traditional nonlinear compensation techniques often involve complex models that introduce significant computational overhead, particularly in high-speed, high-capacity optical communication systems. To address this challenge, we propose a low-complexity nonlinear compensation method based on a multi-task neural network (MT-NN), combined with a complexity-aware mean square error (MSE) and partial grid search optimization for coherent optical communication systems. The proposed framework exploits shared network weights to simultaneously process multiple symbols, thereby reducing redundant computations while maintaining compensation accuracy.

Decoupled digital filtering-enabled simplification and fast convergence of IM/DD system linearization algorithms for strong band-limited power fading channels.

Chromatic dispersion limits practically achievable transmission distances of high data-rate intensity modulation and direct detection (IM/DD) optical transmission systems at C-band. Previously reported IM/DD system linearization algorithms can improve their transmission performances, which are, however, sensitive to the band limitation effect. In this paper, for linearizing IM/DD fiber channels with severe power fading and band-limitation, we propose and evaluate numerically and experimentally a decoupled system linearization scheme called equalization-cascaded multi-constraint iterative algorithm (EC-MCIA) using decoupled, channel partial-aware adaptive digital filters and a multiple constraint iteration algorithm.

Improved DC and RF Characteristics of GaN HEMT Using a Back-Barrier and Locally Doped Barrier Layer.

To enhance the DC and RF performance of AlGaN/GaN HEMTs, a novel device structure was proposed and investigated through simulation. The key innovation of this new structure lies in the incorporation of an AlInGaN back-barrier layer and an N-type locally doped AlGaN barrier layer (BD-HEMT), based on conventional device architecture. The AlInGaN back-barrier layer effectively confines electrons within the channel, thereby increasing the electron concentration.

The effect of time on delay discounting in younger and older adults.

Objective: Delay discounting refers to the devaluation of future rewards as a function of time. Previous studies proposed the relationship between time perception and delay discounting in ageing, while there is a lack of evidence about the effect of different dimensions of time.

Method: This study explored the effect of delay length (1-day, 1-month, 6-month, 1-year, 5-year), time framing (delay, date) and time estimation (internal clock) on delay discounting in younger and older adults.

Biweekly CAPOX versus triweekly CAPOX in the adjuvant therapy of post-surgery CRC: A randomized controlled trial.

Purpose: This study aims to compare the safety and efficiency of modified biweekly CAPOX and conventional triweekly CAPOX in high-risk stage II and stage III post-surgery colorectal (CRC) patients.

Methods: From July 25, 2018, to May 14, 2021, high-risk stage II and stage III post-surgery CRC patients were randomized in the control triweekly group (intravenous infusion of oxaliplatin 130 mg/m2 on day 1 and oral capecitabine 1000 mg/m2, twice daily from day 1 to day 14) and the experimental biweekly group (intravenous infusion of oxaliplatin 85 mg/m2 on day 1 and oral capecitabine 1000 mg/m2, twice daily from day 1 to day 10). The primary endpoint was the incidence rate of thrombocytopenia.

Histone lactylation-driven YTHDF2 promotes non-small cell lung cancer cell glycolysis and stemness by recognizing m6A modification of SFRP2.

Histone lactylation is involved in non-small cell lung cancer (NSCLC) by transcriptional regulation of gene expression. YTH N6-methyladenosine RNA binding protein F2 (YTHDF2) is a N6-methyladenosine (m6A) "reader" that recognizes m6A methylation of mRNA and can be regulated by histone lactylation. This study aimed to investigate the role of histone lactylation in NSCLC and the underlying mechanism using in vitro experiments.

Consolidation analysis of soft ground with air-boosted vacuum preloading considering attenuation of vacuum and boost pressure.

Air-boosted vacuum preloading (AVP), an innovative soil improvement methodology extensively employed in subgrade enhancement projects, demonstrates exceptional efficacy in accelerating soil consolidation processes and improving load-bearing characteristics of soft foundation. Current understanding remains constrained by insufficient theoretical exploration of AVP consolidation mechanisms, particularly regarding underdeveloped analytical frameworks. Therefore, this investigation establishes an analytical model for AVP-assisted consolidation incorporating attenuation of vacuum and boost pressure.

Preference of negatively charged membranes in magnesium and lithium separation by nanofiltration.

Despite the traditional co-ion competition theory suggesting that positively charged nanofiltration (NF) membranes are best for Li⁺/Mg²⁺ separation, practical applications predominantly utilize negatively charged membranes. Furthermore, most biological ion channels in nature are characterized by negatively charged functional groups. To address this theoretical discrepancy, we conducted a comprehensive study that integrates experimental data with molecular dynamics simulations to explore the transport behavior of Mg²⁺ and Li⁺ through negatively charged NF membranes.

Preparation of an exogenous additive from Psoralea corylifolia fruit and its flavor-modifying effects on cigar tobacco leaves.

Psoralea corylifolia fruit (PCF) is a well-known traditional Chinese medicine and food, but its potential applications as a flavor-modifying exogenous additive (EA) for cigar fermentation has rarely been reported. In this study, a new type of PCF-derived EA was developed by enzymatic hydrolysis using a combination of single-factor and response surface experiments. The flavor compounds were analyzed by gas chromatography‒mass spectrometry (GC‒MS), and the flavor-modifying effects on cigar tobacco leaves were validated.

Spatially resolved C1QC macrophage-CD4 T cell niche in colorectal cancer microenvironment: implications for immunotherapy response.

Colorectal cancer (CRC), including both microsatellite instability (MSI) and microsatellite stability (MSS) subtypes, frequently exhibits intrinsic resistance to immunotherapy. However, the spatial tumor microenvironment (TME) and its role in distinguishing immunotherapy responders from non-responders remain poorly understood. In this study, spatial multiomics, including imaging mass cytometry (n = 50 in-house), spatial proteomics (n = 50 in-house), and spatial transcriptomics (n = 9 in-house), were employed to elucidate the spatial TME of metastatic CRC (mCRC) patients receiving immunotherapy.

From Brain to Shopping Cart: Neural Signals of Willingness to Buy Innovative Products.

Exploring the mechanisms underlying willingness to buy (WTB) will help us identify neural indicators for predicting the performance of innovative products. Using functional magnetic resonance imaging, we asked participants to view products created by combining two components, including high applicability new combinations (HANCs), which provide a novel and practical application; and low applicability new combinations (LANCs), which provide no additional value. First, we found that WTB generally involves activation of the parahippocampal gyrus.

Predictive Value of Dynamic Changes in Hemoglobin Levels During Early Pregnancy for the Development of Anemia During Pregnancy.

Background: Anemia affects over 30% of pregnancies globally and is associated with adverse maternal-fetal outcomes, underscoring the critical need for early risk prediction.

Objective: This study aimed to assess the predictive value of early pregnancy hemoglobin levels for anemia development in mid- and late pregnancy.

Methods: We conducted a retrospective cohort analysis of 1999 singleton pregnancies with neuraxial labor analgesia at Beijing Tongzhou District Maternal and Child Health Hospital (January 2022-January 2023).

Hafnium hydride Nanosheets with reactive oxygen and nitrogen species and cell-free DNA-dual scavenging capabilities for inflammatory bowel disease treatment.

Inflammatory bowel disease (IBD), a chronic inflammatory gastrointestinal disease, is closely related to diverse inflammatory factors like reactive oxygen and nitrogen species (RONS) and cell-free DNA (cfDNA). Herein, tannic acid (TA) modified hafnium hydride nanosheets (HfH@TA NSs) with a thickness of 1-4 nm, prepared by liquid-phase exfoliation, were explored as a high-performance anti-inflammatory agent for IBD treatment. By virtue of the high specific surface area of two-dimensional structure, HfH@TA NSs can effectively not only scavenge RONS, but also eliminate cfDNA, thus inhibiting the pro-inflammatory responses.

Risk prediction models for permanence of temporary stoma after radical surgery of rectal cancer: a systematic review.

Objective: To methodologically assess the prediction model for temporary stoma permanence in patients with rectal cancer and provide evidence-based guidance for the construction and clinical application of related models.

Methods: From launch to January 3, 2025, computer searches were performed in nine databases. Two researchers independently searched the literature, and the Critical Appraisal and Data Extraction Checklist for Systematic Evaluation of Predictive Modelling was used to extract data.