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Air-boosted vacuum preloading (AVP), an innovative soil improvement methodology extensively employed in subgrade enhancement projects, demonstrates exceptional efficacy in accelerating soil consolidation processes and improving load-bearing characteristics of soft foundation. Current understanding remains constrained by insufficient theoretical exploration of AVP consolidation mechanisms, particularly regarding underdeveloped analytical frameworks. Therefore, this investigation establishes an analytical model for AVP-assisted consolidation incorporating attenuation of vacuum and boost pressure. Fundamental governing equations were formulated through rigorous analysis of vacuum load propagation patterns, accounting for pressure dissipation along both vertical and radial coordinates. The proposed solutions integrate PVD-induced soil disturbance effects and three-dimensional fluid migration patterns. Model validation was achieved through systematic degeneration analysis, confirming consistency with established solutions in specific boundary conditions. Parametric sensitivity analysis revealed significant correlations between consolidation efficiency and key operational variables when benchmarking against conventional models. Crucially, computational findings emphasize that neglecting pressure attenuation mechanisms leads to non-conservative estimates of consolidation progression rates. Enhancement of consolidation rate was observed with higher vacuum loading coefficients and increased Poisson ratios. A limitation section is also introduced to provide critical insights into improving the theoretical investigations on the consolidation of AVP-improved ground.
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http://dx.doi.org/10.1038/s41598-025-04243-6 | DOI Listing |
Swiss Med Wkly
May 2025
Mycobacterial and Migrant Health Research Group, University of Basel Children's Hospital Basel and Department of Clinical Research, University of Basel, Basel, Switzerland.
Aim: Globally, tuberculosis incidence shows notable sex disparity, with higher rates observed in males. While this pattern is well documented in adults from high-incidence countries, the influence of sex on tuberculosis incidence in children and adolescents, particularly in low-incidence settings, remains unclear. This study investigated sex-specific tuberculosis incidence rates across all age groups, focusing on adolescents, in a low-incidence country.
View Article and Find Full Text PDFPatient
September 2025
Patient Services, Anthony Nolan, 2 Heathgate Place, London, NW3 2NU, UK.
Background: There is increasing interest in using patient-reported outcome measures (PROMs) to assess quality of life (QoL) following hematopoietic cell transplant (HCT). However, there is limited consensus on how such data should be collected within HCT services. This survey study investigated health professionals (HCPs) views towards QoL data collection and factors affecting the use of PROMs within HCT centres in the UK.
View Article and Find Full Text PDFOmega (Westport)
September 2025
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Pregnancy loss is a traumatic experience, and the quality of care can vary significantly across healthcare settings. However, evidence on the impact of different types of care on psychological outcomes is limited. This study examined the relationship between specialized care for parents experiencing pregnancy or neonatal loss and the level of Prolonged Grief Disorder (PGD) and Post-Traumatic Stress Disorder (PTSD) symptoms, as well as the role of midwifery support, one month post-loss.
View Article and Find Full Text PDFMetab Eng
September 2025
Department of Chemical Engineering, the Pennsylvania State University, University Park, Pennsylvania, USA; Center for Bioenergy Innovation, Oak Ridge, Tennessee, USA. Electronic address:
Clostridium thermocellum is an increasingly well-studied organism with considerable advantages for consolidated bioprocessing towards ethanol production. Here, a genome-scale resource balance analysis (RBA) model of C. thermocellum, ctRBA, is reconstructed based on a recently published stoichiometric model (iCTH669), global proteomics, and C MFA datasets to analyze proteome allocation and the burden imposed on metabolism with regard to ethanol yield and titer.
View Article and Find Full Text PDFNeuroscience
September 2025
Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawińskiego Str., 02-106 Warsaw, Poland.
This review consolidates the most recent information regarding the role of microRNAs (miRNAs) that target the oestrogen receptor beta (ESR2/ERβ) gene in the pathophysiology of emotional disorders, with a particular emphasis on stress-related conditions and anxiety. Since in silico predictions frequently precede experimental validation and algorithms such as TargetScan and DIANA-microT identified possible miRNA binding sites on ESR2 based on sequence complementarity, we demonstrate a high degree of accuracy in predicting functional interactions. Parallel evidence unrelated to the studied biological contexts supports the idea that miRNAs may regulate ERβ signalling in emotional disorders, thereby further supporting miRNA-ESR2 interactions.
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