FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation.

High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice.

An Olive Oil-Based High-Fat Diet Promotes Obesity-Driven Metastasis of Triple-Negative Breast Cancer.

Obesity is strongly associated with triple-negative breast cancer (TNBC). A better understanding of the molecular mechanisms driving obesity-induced TNBC progression could facilitate development of precision dietary intervention strategies. Here, we used murine models of obesity induced by different high-fat diets (HFDs) to examine their impact on TNBC progression.

Host Shaping Associated Microbiota in Hydrothermal Vent Snails from the Indian Ocean Ridge.

Snails at hydrothermal vents rely on symbiotic bacteria for nutrition; however, the specifics of these associations in adapting to such extreme environments remain underexplored. This study investigated the community structure and metabolic potential of bacteria associated with two Indian Ocean vent snails, and . Using microscopic, phylogenetic, and metagenomic analyses, this study examines bacterial communities inhabiting the foot and gland tissues of these snails.

Graphene oxide-based dual-color thin-film fluorescent nanolabels for enhanced immunochromatographic detection of pesticides.

Background: The excessive use of pesticide pollutants in agricultural production seriously threatens food safety. Traditional detection techniques are difficult to meet the detection requirements due to the complex sample pretreatment and high detection costs. The immunochromatography method (ICA) is simple to operate and fast, and is suitable for on-site rapid detection.

Identification of lysosome-related molecular subtypes and diagnostic biomarkers in diabetic nephropathy.

Objective: Lysosomes hold a pivotal role in the initiation and advancement of diverse diseases. Nevertheless, the specific biological functions of lysosomes in diabetic nephropathy (DN) remain undisclosed. This study seeks to uncover relevant lysosome-related molecular subtypes and biomarkers for DN through bioinformatics analysis.

Efficacy and safety of cold snare polypectomy for outpatient treatment of sessile polyps smaller than 10mm.

Background: Screening colonoscopy plays a critical role in reducing colorectal cancer incidence by identifying and removing polyps. Simple and safe treatment is the most common request of both doctors and patients. Cold snare polypectomy (CSP) is increasingly favored for polyps < 10 mm, yet concerns remain regarding residual tissue.

Financial toxicity and psychological distress in cardiovascular non-cancer multimorbidity: a latent profile analysis and causal weighting.

Background: Cardiovascular disease with multimorbidity imposes substantial long-term financial burdens. Financial toxicity, the financial burden associated with healthcare, is increasingly recognized as a psychosocial stressor affecting health outcomes among chronically ill populations. However, its psychological heterogeneity in non-cancer patients is understudied.

Preliminary safety risk assessment of parabens in children's cosmetics sold in China.

Since adverse health outcomes of parabens added in children's cosmetics have been reported, it is important to investigate preliminary risk characteristic assessment of parabens preservatives in children's cosmetics. This study aimed to calculate exposure parameters using a combination experimental data and an exposure assessment tool to make safety assessment for parabens in children's cosmetics. The paraben concentration of different formulation types of 63 products of children's cosmetic products were measured by High Performance Liquid Chromatography.

Crotonylation of IDH1 alleviates MASLD progression by enhancing the TCA cycle.

Metabolic dysfunction-associated steatotic liver disease (MASLD), potentially ameliorated by bariatric-metabolic surgery, remains a global health concern in the absence of approved drugs. Protein post-translational modifications (PTMs) are crucial for MASLD. However, the functional significance of lysine crotonylation (Kcr) remains unclear.

Multi functional carbon dots for precision cancer treatment: Synthesis regulation, performance enhancement, and future applications.

Carbon dots (CDs) are an emerging kind of carbon nanomaterials with characteristic sizes less than 10 nm, graphitized carbon nuclei and a rich variety of surface functional groups. Due to its simple and rapid synthesis, unique electronic structure, excellent photoluminescence properties, good biocompatibility, and environmental friendliness, CDs have been widely used in fields i.e.

A Versatile and Bioinspired Hierarchical Nanoflower Coating for Enhanced Photodriven Antimicrobial Efficacy against Foodborne Pathogens.

Contamination by pathogenic microbes frequently occurs on the surfaces of solid materials, posing serious threats to food safety and human health. To mitigate the spread of pathogens and reduce the risk of antimicrobial resistance, there is an urgent need for nanostructured surface modification materials that offer high bactericidal efficiency without relying on conventional antimicrobial agents or antibiotics. In this study, we report a green and facile approach for fabricating antimicrobial nanoflower (PDA-Cu NFs) coatings on solid substrates, including polystyrene, glass, and stainless steel via one-step biomimetic mineralization.

Associations among melanocortin-4 receptor rs17782313 gene polymorphisms, 12-week aerobic exercise combined with low-fat diet and degree of reduction in blood lipids in adults with obesity.

Purpose: This study investigates the relationships between melanocortin-4 receptor (MC4R) rs17782313 gene polymorphisms, low-fat diet, aerobic exercise, and the reduction in blood lipid levels in individuals with obesity.

Methods: A total of 240 adults living with obesity were enrolled to take part in a 12-week program that combined exercises with dietary interventions. Measurements taken included body weight, body mass index (BMI), plasma lipids, fasting insulin (FIN), and insulin resistance (Homeostasis Model Assessment, HOMA-IR).

On-Demand Ammonia Capture and Separation with Open Aluminophosphate Frameworks.

The development of adsorbents for ammonia capture and separation is a challenging task, with significant industrial relevance. We report herein, for the first time, open aluminophosphate frameworks for on-demand ammonia adsorption. Under ambient conditions, the AlPO-18 molecular sieve exhibits exceptional dynamic ammonia uptake of 3.

Occurrence, spatial and temporal distribution, sources and ecological risk assessment of halogenated polycyclic aromatic hydrocarbons (HPAHs) in sediments of the East China Sea.

Halogenated polycyclic aromatic hydrocarbons (HPAHs) in marine environment have attracted increasing attention due to their persistence, bioaccumulation potential, and ecological toxicity. However, systematic investigations on their contamination levels, compositional distribution, and source apportionment in the surface sediments of the East China Sea (ECS) remain limited. In this study, 25 HPAHs were quantitatively analyzed in ECS surface sediments, revealing total concentrations ranging from 14.

Polystyrene microplastics alter plankton community and enhance greenhouse gas emissions: A case study in the China coastal sea.

Brominated volatile halocarbons (Br-VHCs) emitted from the ocean are the main ozone-depleting substances and greenhouse gases, yet their production dynamics by microorganisms under anthropogenic stressors such as microplastics perturbation are unknown. Here, through coupled ship-based incubations (Yellow Sea) and laboratory experiments, we demonstrate that 1 μm polystyrene (PS) microplastics addition inhibited phytoplankton growth with maximal suppression rates of 82.35% and increased dissolved organic carbon (DOC) accumulation by 91.

The prevalence and risk factors of hyperuricemia in patients with Newly-diagnosed coronary artery disease from 2017 to 2021.

Backgrounds: This study aimed to evaluate the prevalence and determinants of hyperuricemia in patients with newly-diagnosed coronary artery disease (CAD) after percutaneous coronary intervention.

Methods: Hyperuricemia was defined as a serum urate level of > 5.6 mg/dl.

Hyalinizing trabecular tumor of the thyroid: A comprehensive review of clinicopathological features, diagnostic dilemmas, and emerging molecular insights.

Hyalinizing trabecular tumor (HTT), a rare thyroid neoplasm, is defined by its unique histopathological architecture and diagnostic complexity due to morphological mimicry of papillary thyroid carcinoma (PTC) and medullary thyroid carcinomas (MTC). This review consolidates contemporary insights into HTT's clinicopathological spectrum, diagnostic ambiguities, and molecular underpinnings. Epidemiologically, HTT predominantly affects middle-aged females, manifesting as circumscribed, asymptomatic nodules.

USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1.

Sepsis-induced acute kidney injury (SI-AKI) is a severe condition with limited therapeutic options, resulting in poor prognosis. Ferroptosis exacerbates the damage caused by SI-AKI, but the mechanisms regulating ferroptosis, especially those involving ubiquitination regulators, remain poorly understood. Here, we used a lipopolysaccharide (LPS)-induced human kidney organoid (HKO) model to investigate ferroptosis in SI-AKI.

Irisin-Based Nanocomposites for Antioxidant Purpose and the Promotion of Osteogenesis in the Inflammatory Microenvironment.

Current clinical periodontitis treatments including surgical treatment and antibacterial treatment might cause excessive immune response in the host and cannot effectively promote the regeneration of periodontal tissue. In this study, we explored irisin serving as a novel biomarker in gingival tissues from periodontitis patients and confirmed its immunoregulatory roles, including its capacity to scavenge reactive oxygen species (ROS) and suppress inflammatory responses, through activation of the P53 and PPAR-γ signaling pathways. Furthermore, we established a bioactive glass nanoparticle compound with irisin (IR-nBG) and evaluated its antioxidant and osteoimmunomodulatory properties in a ROS-rich inflammatory microenvironment.

Immune imbalance underlying depressive symptoms in COPD patients: a study based on BDNF, PD-1, MMP-9, and inflammatory cytokines.

Objective: Chronic obstructive pulmonary disease (COPD) is frequently accompanied by a high prevalence of depressive symptoms, particularly during acute exacerbations (AECOPD). However, the immunoinflammatory mechanisms underlying AECOPD-associated depression remain poorly elucidated. This study aimed to investigate the potential roles of brain-derived neurotrophic factor (BDNF), programmed cell death protein 1 (PD-1), matrix metalloproteinase-9 (MMP-9), and key inflammatory cytokines-interleukin-1β (IL-1β), interleukin-10 (IL-10), and tumor necrosis factor- (TNF-α)-in mediating depressive symptoms among hospitalized AECOPD patients.

Design and validation of nurses' knowledge, attitude and practice questionnaire for discharge planning of stroke patients.

Objective: The aim of this study was to design a national and culturally appropriate questionnaire to assess the nurses' knowledge, attitude and practice (KAP) for discharge planning of stroke patients and to test the reliability and validity of this questionnaire.

Methods: This questionnaire was developed using domestic and international literature and combining the KAP theory. It covered eight aspects of basic knowledge, relevant knowledge, psychological cognition, emotional tendency, intentional behavior, assessment, implementation and evaluation of discharge planning for stroke patients.

Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype associated with the highest mortality rate among all breast cancer subtypes, primarily due to the absence of actionable therapeutic targets. Although poly (ADP-ribose) polymerase inhibitors (PARPi) have shown promising therapeutic effects in TNBC patients harboring homologous recombination deficiency (HRD), their clinical benefit remains limited, highlighting an urgent need for novel targets that enhance PARPi efficacy. This study investigates the role of Jab1 in regulating the stability of homologous recombination repair (HRR)-related RNAs and evaluates its potential as a therapeutic target to enhance PARPi sensitivity in TNBC.

Integrative Genomic and Functional Approaches Identify FUOM as a Key Driver and Therapeutic Target in Cervical Cancer.

Background: Cervical cancer remains a global public health challenge, particularly in regions with limited access to screening and vaccination. While high-risk HPV infection is the primary cause, the genetic and molecular mechanisms driving cervical cancer progression are not fully understood.

Objective: This study integrates Mendelian randomization (MR) and single-cell RNA sequencing (scRNA-seq) to identify causal eQTL-related genes and explore their roles in tumorigenesis.

Mechanical Behavior of Topology-Optimized Lattice Structures Fabricated by Additive Manufacturing.

Lattice-based metamaterials have attracted much attention due to their excellent mechanical properties. Nevertheless, designing lattice materials with desired properties is still challenging, as their mesoscopic topology is extremely complex. Herein, the bidirectional evolutionary structural optimization (BESO) method is adopted to design lattice structures with maximum bulk modulus and elastic isotropy.