Associations among melanocortin-4 receptor rs17782313 gene polymorphisms, 12-week aerobic exercise combined with low-fat diet and degree of reduction in blood lipids in adults with obesity.

Purpose: This study investigates the relationships between melanocortin-4 receptor (MC4R) rs17782313 gene polymorphisms, low-fat diet, aerobic exercise, and the reduction in blood lipid levels in individuals with obesity.

Methods: A total of 240 adults living with obesity were enrolled to take part in a 12-week program that combined exercises with dietary interventions. Measurements taken included body weight, body mass index (BMI), plasma lipids, fasting insulin (FIN), and insulin resistance (Homeostasis Model Assessment, HOMA-IR).

A radiomics-based interpretable model integrating delayed-phase CT and clinical features for predicting the pathological grade of appendiceal pseudomyxoma peritonei.

Objective: This study aimed to develop an interpretable machine learning model integrating delayed-phase contrast-enhanced CT radiomics with clinical features for noninvasive prediction of pathological grading in appendiceal pseudomyxoma peritonei (PMP), using Shapley Additive Explanations (SHAP) for model interpretation.

Materials And Methods: This retrospective study analyzed 158 pathologically confirmed PMP cases (85 low-grade, 73 high-grade) from January 4, 2015 to April 30, 2024. Comprehensive clinical data including demographic characteristics, serum tumor markers (CEA, CA19-9, CA125, D-dimer, CA-724, CA-242), and CT-peritoneal cancer index (CT-PCI) were collected.

Analgesic and anti-inflammatory effects of Glycyrrhiza protein in an acute inflammatory pain model: Insights from metabolomic and transcriptomic profiling.

Ethnopharmacological Relevance: Licorice has been used as an herbal remedy in alternative medicinal systems, such as Ayurveda and traditional Chinese medicine (TCM), for millennia. According to traditional Chinese medicine theory, Glycyrrhiza protein (GP) relieves pain. Some studies have found that GP can be used as a drug delivery carrier, indirectly or directly promoting anti-inflammatory and analgesic effects.

Integrated chemical composition, transcriptomics, and network pharmacology to reveal the mechanism of Jia-Wei-Si-Miao-Yong-An Decoction in ACS model rats.

Background: Acute Coronary Syndrome (ACS), as the most critical pathological type of coronary atherosclerotic heart disease, has a high morbidity and lethality, and the long-term treatment of modern medicine is still faced with the problems of restenosis, microcirculation obstruction and drug resistance. The addition of Traditional Chinese Medicine provides new ideas for ACS treatment. Our previous study found that Jia-Wei-Si-Miao-Yong-An decoction (HJ11) can improve the inflammatory response and cardiac function in ACS.

Natural small molecule smart hydrogels inhibited the Hsp90/NF-κB signaling axis in inflammation to achieve sustained antipyretic effect.

In general, pseudoephedrine (PE) is a safe and universally employed in cold medicine, which displays powerful effect on antipyretic. Nonetheless, the sustained drug delivery system can effectively put an end to the above problems attributable to the drawbacks of low bioavailability and short intervals of administration. "Complexation" hydrogels are capturing enormous attention in a diverse array of fields in that there is no necessity to carry out external intervention for drug delivery.

Efficient face information encryption and verification scheme based on full homomorphic encryption.

Emerging global privacy mandates enforce strict requirements for biometric data protection, requiring encrypted processing throughout storage and computation phases. While full homomorphic encryption (FHE)-based face recognition ensures security on platforms like Elastic Compute Service (ECS), three critical compliance gaps persist: 1) about 500× ciphertext expansion in high-dimensional facial features, exceeding practical deployment thresholds, 2) vulnerabilities in live verification scenarios documented by ENISA (83% failure rate in 2024 audits), and 3) absence of mechanisms satisfying IND-CPA and IND-CCA2 standards. These limitations collectively undermine both regulatory adherence and operational efficiency in practical biometric systems.

A case report of monomorphic epitheliotropic intestinal T-cell lymphoma with pulmonary manifestations as the first presentation.

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is defined as a type of lymphoma that occurs in the intestine, but may show extra-intestinal involvement, such as in the skin, brain, lungs, stomach, ovaries, and uterus, which have been previously reported. The disease has no specific clinical manifestations and is often diagnosed by pathological examination as a complication of intestinal perforation or obstruction. The difficulty of making a timely diagnosis is further compounded when the disease begins with non-gastrointestinal symptoms.

[Correlation Analysis of Serum Complement Level and Prognosis in Diagnosis of Aggressive Non-Hodgkin Lymphoma].

Objective: To explore the relationship between serum complement levels at diagnosis and prognosis in patients with aggressive non-Hodgkin lymphoma(NHL).

Methods: The clinical data of 102 patients with aggressive non-Hodgkin lymphoma diagnosed in the First Hospital of Lanzhou University from February 2017 to March 2023 were selected to analyze the correlation between serum complement C3 and C4 levels and prognosis of patients with aggressive NHL at the time of initial diagnosis. The optimal cut-off point of C3 and C4 were obtained by calculating the Jorden index through the receiver operating characteristic（ROC） curve, and 102 patients were divided into low C3 group (C3< 1.

Substance basis and fermentation mechanism study of the analgesic and anti-inflammatory effects of Tibetan medicine Wuwei Ganlu based on JiuQu fermentation.

Ethnopharmacological Relevance: Wuwei Ganlu, as an integral part of the Tibetan medical system known as "Sowa Rigpa" originates from the formulations documented in the "Four Tantras". It is recognized by UNESCO as an intangible cultural heritage, representing a body of traditional knowledge and practice. Fermentation, a crucial step in the preparation of Wuwei Ganlu, has not been fully understood in terms of its mechanisms and its impact on the material basis and pharmacological efficacy of the medicine.

Revealing the scientific connotation of compatibility of Chinese medicine medica based on self-assembly technology.

Chinese materia medica (CMM) compatibility is one core content in the theory of Traditional Chinese Medicine (TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through non-covalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for self-assembly.

Understanding filamentous cyanobacteria and their adaptive niches in Lake Honghu, a shallow eutrophic lake.

Freshwater lakes globally are witnessing an escalation in the frequency and intensity of cyanobacterial harmful blooms. However, underlying factors influencing the succession or coexistence of cyanobacteria, especially filamentous ones, remain poorly understood. Lake Honghu, a Ramsar Wetland of International Importance with degrading aquatic ecological quality, served as a case study to elucidate the intricate relationship between environmental changes and cyanobacterial dynamics.

Cognitive Function After Stopping Folic Acid and DHA Intervention: An Extended Follow-Up Results from the Randomized, Double Blind, Placebo-Controlled Trial in Older Adults with Mild Cognitive Impairment.

Background: Our previously randomized controlled trial (RCT) showed daily oral folic acid (FA), docosahexaenoic acid (DHA) and their combined treatment for 6 months could significantly improve cognitive function in mild cognitive impairment (MCI) individuals.

Objective: This study aimed to evaluate whether this benefit seen in the treatment group would sustain after stopping intervention when patients returned to a real-world.

Methods: RCT (ChiCTR-IOR-16008351) was conducted in Tianjin, China.

A novel strategy of bloom forming cyanobacteria Microcystis sp. in response to phosphorus deficiency: Using non-phosphorus lipids substitute phospholipids.

Despite significant reductions in phosphorus (P) loads, lakes still experience cyanobacterial blooms. Little is known regarding cellular P regulation in response to P deficiency in widely distributed bloom causing species such as Microcystis. In this study, we investigated changes in P containing and non-P lipids contents and their ratios concomitantly with the determinations of expression levels of genes encoding these lipids in cultural and field Microcystis samples.

Application value of real-time 3D speckle tracking imaging in left atrial function evaluation of patients with paroxysmal atrial fibrillation.

Objective: To evaluate left atrial volume and function in patients with paroxysmal atrial fibrillation (AF) combined with left atrial appendage thrombosis and patients with paroxysmal AF without left atrial appendage thrombosis by 3-dimensional speckle tracking imaging (3D-STI), and to explore the application value of this set of parameters in the evaluation of left atrial function in patients with paroxysmal AF.

Materials And Methods: A total of 40 patients with paroxysmal AF admitted from December 2018 to December 2020 were selected as the observation group. All patients with paroxysmal AF in the observation group underwent transesophageal echocardiography.

The diagnostic value of multimodal imaging based on MR combined with ultrasound in benign and malignant breast diseases.

We aimed to construct and validate a multimodality MRI combined with ultrasound based on radiomics for the evaluation of benign and malignant breast diseases. The preoperative enhanced MRI and ultrasound images of 131 patients with breast diseases confirmed by pathology in Aerospace Center Hospital from January 2021 to August 2023 were retrospectively analyzed, including 73 benign diseases and 58 malignant diseases. Ultrasound and 3.

The value of multiparametric MRI radiomics in predicting IDH genotype in glioma before surgery.

Objective: To explore the value of multiparametric magnetic resonance imaging(MRI) radiomics in the preoperative prediction of isocitrate dehydrogenase (IDH) genotype for gliomas.

Methods: The preoperative routine MRI sequences of 114 patients with pathologically confirmed grade II-IV gliomas were retrospectively analysed. All patients were randomly divided into training cohort(n=79) and validation cohort(n=35) in the ratio of 7:3.

The value of ultrasound combined with CT in identifying early low-grade appendiceal mucinous neoplasm and appendicitis.

Objective: The aim of this study is to investigate the value of ultrasound combined with computed tomography (CT) in identifying early low-grade appendiceal mucinous neoplasm and appendicitis.

Methods: Patients with early low-grade appendiceal mucinous neoplasm and appendicitis from September 2017 to September 2021, including 40 patients with low-grade appendiceal mucinous neoplasm and 40 patients with appendicitis, were collected in this study. Clinical data as well as ultrasound and CT findings of all patients were retrospectively analyzed.

A model incorporating clinicopathologic and liver imaging reporting and data system-based magnetic resonance imaging features to identify hepatocellular carcinoma in LR-M observations.

Purpose: To evaluate the predictive value of a combination model of Liver Imaging Reporting and Data System (LI-RADS)-based magnetic resonance imaging (MRI) and clinicopathologic features to identify atypical hepatocellular carcinoma (HCC) in LI-RADS category M (LR-M) observations.

Methods: A total of 105 patients with HCC based on surgery or biopsy who underwent preoperative MRI were retrospectively reviewed in the training group from hospital-1 between December 2016 and November 2020. The LI-RADS-based MRI features and clinicopathologic data were compared between LR-M HCC and non-HCC groups.

Scientific connotation of the compatibility of traditional Chinese medicine from the perspective of the intestinal flora.

Revealing the connotation of the compatibility of Chinese medicines (CM) is a requirement for the modernization of traditional Chinese medicine (TCM). However, no consensus exists on the specific mechanism of traditional Chinese medicine compatibility (TCMC). Many studies have shown that the occurrence and development of diseases and the efficacy of CM are closely related to intestinal flora (IF), which may provide a new perspective to understand the theory of TCM.

The elite variations in germplasms for soybean breeding.

The genetic base of soybean cultivars ( (L.) Merr.) has been narrowed through selective domestication and specific breeding improvement, similar to other crops.

Perspectives of international multi-center clinical trials on traditional Chinese herbal medicine.

With the introduction of various subjects, such as clinical epidemiology and evidence-based medicine, the qualities and levels of Traditional Chinese Herbal Medicine (TCHM) in China improved substantially, and the processes of internationalization of Traditional Chinese Medicine (TCM) are further accelerated. Since, a variety of drug products in China have been approved for marketing in other countries, and approximately 10 products have submitted the IND application to FDA of United States, of which various Chinese herbal preparations such as compound Danshen dripping pills, Xingling granules, and HMPL-004 have been approved to be investigated in phase III clinical trials. In general, multi-center studies of TCHM are increasing with years, but most of the studies are performed in some certain country, and the actual international multi-center clinical trials are very rare.

Value of diffusion-weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia.

Objective: To investigate the role of diffusion-weighted imaging (DWI) for diagnosis and posttreatment assessment of hepatic fungal infection in patients with acute leukemia.

Methods: Patients with acute leukemia and highly suspected hepatic fungal infection were collected in the study. All the patients underwent MRI examination, including initial and follow-up DWI.

Pleomorphic adenoma of the tongue: A case report.

Rationale: Salivary gland tumors account for approximately 3% of all tumors, most of which are benign, with pleomorphic adenomas being the most common, occurring mostly in middle-aged women, mostly originating from the major salivary glands and, to a lesser extent, from the minor salivary glands, with the tongue being a very rare site of occurrence. To date, case reports of pleomorphic adenoma at the root of the tongue are also rare.

Patient Concerns: A 56-year-old male patient with no obvious cause of foreign body sensation in the pharynx, sputum, no pain, no blood in the sputum, no dysphagia, and no difficulty in swallowing and breathing, which was significantly aggravated in the past 2 weeks, with difficulty in swallowing, breath-holding on lying down.