Graphene-Enhanced FePO Composites with Superior Electrochemical Performance for Lithium-Ion Batteries.

In this study, we successfully synthesized olivine-type FePO via an in situ oxidation method and further developed two composite cathode materials (o-FePO-1/GR-1 and o-FePO-1/GR-2) by incorporating graphene. The composites were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray Photoelectron Spectroscopy (XPS), revealing a three-dimensional porous layered structure with an enhanced surface area and strong interaction between FePO nanoparticles and graphene layers. Electrochemical tests demonstrated that the composite electrodes exhibited significantly improved performance compared to pristine FePO, with discharge capacities of 147 mAh g at 1C and 163 mAh g at 0.

Coreaction Accelerator Au Nanoparticle-Confined Coordination Polymers with Highly Efficient Electrochemiluminescence for Sensitive Detection of Neurological Disease Biomarkers.

In this study, a highly efficient electrochemiluminescent (ECL) coordination polymer, Au-Zn-DTBA, was synthesized by employing 2,2'-dithiodibenzoic acid (DTBA) as the luminescent ligand and Zn as the metal node as well as Au nanoparticles (AuNPs) as coreaction accelerators confined to DTBA via Au-S bonds for the construction of biosensors for sensitive detection of the biomarker of neurological disease, dopamine. Compared to the Zn-DTBA ECL system without a coreaction accelerator, Au-Zn-DTBA exhibits a 4-fold enhancement in ECL intensity, since AuNPs confined in Zn-DTBA could promote the coreactant KSO to produce abundant sulfate radicals SO for significantly enhancing the ECL efficiency of Zn-DTBA. As a result, an ultrasensitive ECL biosensor employing the Au-Zn-DTBA/KSO ECL system was developed for dopamine detection, achieving a low detection limit of 0.

Identification of multiple genomic alterations and prediction of neoantigens from circulating tumor cells at the single-cell level.

Circulating tumor cells (CTCs) are linked to cancer progression and poor prognosis, offering valuable genetic insights into tumors. Accurate detection of genomic alterations in CTCs is essential for improving cancer diagnosis and treatment. To address this, we develop Uniform Chromosome Conformation Capture (Uni-C), a method for profiling 3D chromatin architecture and genomic alterations at the single-cell level.

Analgesic and anti-inflammatory effects of Glycyrrhiza protein in an acute inflammatory pain model: Insights from metabolomic and transcriptomic profiling.

Ethnopharmacological Relevance: Licorice has been used as an herbal remedy in alternative medicinal systems, such as Ayurveda and traditional Chinese medicine (TCM), for millennia. According to traditional Chinese medicine theory, Glycyrrhiza protein (GP) relieves pain. Some studies have found that GP can be used as a drug delivery carrier, indirectly or directly promoting anti-inflammatory and analgesic effects.

Natural small molecule smart hydrogels inhibited the Hsp90/NF-κB signaling axis in inflammation to achieve sustained antipyretic effect.

In general, pseudoephedrine (PE) is a safe and universally employed in cold medicine, which displays powerful effect on antipyretic. Nonetheless, the sustained drug delivery system can effectively put an end to the above problems attributable to the drawbacks of low bioavailability and short intervals of administration. "Complexation" hydrogels are capturing enormous attention in a diverse array of fields in that there is no necessity to carry out external intervention for drug delivery.

Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.

Background: Parkinson's disease (PD) is a neurodegenerative disease whose cause and molecular mechanism remain unclear. Dingzhen pill (DZP), a water extract from crude herbs, is thought to possibly play a neuroprotective role in PD. However, the underlying pharmacological mechanisms of the DZP and its impact on the potential pathways against PD have not been elucidated.

Brown-shell eggs shows high incidence of blood and meat spots accompanied by unique microbial distribution patterns.

Introduction: The blood and meat spots in eggs are recognized as defects for egg quality. The frequency of blood and meat spots in brown-shell eggs is much higher than that in white-shell eggs in previous studies. However, the actual occurrence frequency and their effects on the microbial composition in eggs remain poorly understood.

Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma.

Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we identify a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT resistance, leading to a "cold" tumor microenvironment. MTAP-deleted OS relies on methionine metabolism and is sensitive to methionine intervention, achieved through either dietary restriction or inhibition of methionine adenosyltransferase 2a (MAT2A), a key enzyme in methionine metabolism.

Characterization of microplastics in human follicular fluid and assessment of their potential impact on mouse oocyte maturation in vitro.

Microplastics (MPs) have been identified in various human tissues and organs. This study aims to evaluate the presence of MPs in human follicular fluid (hFF) and their potential impact on oocyte maturation. Laser direct infrared spectroscopy of 19 hFF samples identified 7956 particles, including 1739 microplastics (21.

Mechanisms of the Compound of Magnoliae Flos and Xanthii Fructus Essential Oils for the Treatment of Allergic Rhinitis based on the Integration of Network Pharmacology, Molecular Docking, and Animal Experiment.

Aim And Objective: Magnoliae Flos (Chinese name: Xin-Yi) and Xanthii Fructus (Chinese name: Cang-Er-Zi) are Chinese herbal medicines and have been used to treat allergic rhinitis (AR). However, the therapeutic effect, active ingredients, and probable processes of a compound of Magnoliae Flos and Xanthii Fructus in the form of essential oils (CMFXFEO) in treating AR have not been reported. This study aims to determine the efficacy of the CMFXFEO on ovalbumin (OVA)-induced AR in a rat model and to use network pharmacology and molecular docking to reveal the hub genes, biological functions, and signaling pathways of CMFXFEO against AR.

Revealing the Mechanism of Baroni in Depression Treatment Through Integrated Network Pharmacology and Transcriptomic Analysis.

: Baroni (HCB) is a traditional herb for the treatment of depression in China. However, the active constituents and the underlying mechanisms of its antidepressant effects remain unclear. The aim of this study was to identify the bioactive constituents of HCB and elucidate its underlying mechanism for the treatment of depression.

Lignin nanoparticle/MXene-based conductive hydrogel with mechanical robustness and strain-sensitivity property via rapid self-gelation process towards flexible sensor.

Conductive hydrogels have been showcased with substantial potential for soft wearable devices. However, the tedious preparation process and poor trade-off among overall properties, i.e.

A bright cyan fluorescence calcium indicator for mitochondrial calcium with minimal interference from physiological pH fluctuations.

Genetically Encoded Calcium (Ca) indicators (GECIs) are indispensable tools for dissecting intracellular Ca signaling and monitoring cellular activities. Mitochondrion acts as a Ca sink and a central player for maintaining Ca homeostasis. Accurately monitoring Ca transients within the mitochondrial matrix that undergo constant pH fluctuations is challenging, as signals of most currently available GECIs suffer from artifacts induced by physiological pH variations.

Rolling-Translated circRUNX2.2 Promotes Lymphoma Cell Proliferation and Cycle Transition in Marek's Disease Model.

Marek's disease (MD), an immunosuppressive disease induced by the Marek's disease virus (MDV), is regarded as an ideal model for lymphoma research to elucidate oncogenic and anti-oncogene genes. Using this model, we found that circRUNX2.2, derived from exon 6 of RUNX2, was significantly upregulated in MDV-infected tumorous spleens.

Efficient removal of Cr(VI) by chitosan cross-linked bentonite loaded nano-zero-valent iron composite: Performance and mechanism.

A nano-zero-valent iron loaded with 2-aminoterephthalic acid cross-linked chitosan/bentonite (2ACB@nZVI) was developed to remove Cr(VI) from aqueous solution through adsorption-reduction. It was characterized by FTIR, XRD, TGA, BET, SEM, EDS, electrochemistry and XPS. This analysis showed that chitosan cross-linked bentonite not only enhanced the adsorption effect of chitosan and its chemical stability, but also provided a good carrier for loading nZVI and effectively improves its reaction activity.

Conditionally restricted detection of nitrite under acidic conditions by activatable fluorescent probes.

As a commonly used food additive, excessive nitrite intake seriously affects people's health in daily life. As the stomach is the main organ involved in nitrite intake, achieving fast and in situ detection of nitrite in the stomach is of great significance for avoiding the hazards caused by nitrite. However, owing to the poor stability or low sensitivity of existing fluorescent probes under acidic conditions, their application for nitrite detection within the stomach remains challenging.

Understanding the Factors Driving Consumers' Willingness to Pay for Gene-Edited Foods in China.

Gene editing contributes to enhancing food security through the creation of novel foods. However, public perception of gene-edited (GE) foods is crucial to their acceptance and adoption. This study expanded the knowledge-attitude-practice model and constructed an integrated framework comprising four dimensions: demographic factors, scientific literacy and beliefs, social trust, and perceptions of gene technology, aimed at explaining the public's attitudes toward GE foods.

Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats.

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovitis and cartilage destruction. The active compound, icariin (ICA), derived from the herb Epimedium, exhibits potent anti-inflammatory properties. However, its clinical utility is limited by its water insolubility, poor permeability, and low bioavailability.

Exploring the influence of students' perceptions of face-to-face collaboration on cognitive engagement and learning outcomes in collaborative programming.

Collaborative programming is being increasingly used to overcome the difficulties of the individual programming process. In this study, we investigated the effect of collaborative perception on cognitive engagement and learning outcomes in collaborative programming. We used a quasi-experimental research to determine the differences in cognitive engagement and learning outcomes of three groups with different levels of collaborative perception.

PLUNC inhibits invasion and metastasis in nasopharyngeal carcinoma by inhibiting NLRP3 inflammasome activation.

Nasopharyngeal carcinoma (NPC) is a malignant tumor that occurs in the nasopharynx. Palate, lung, and nasal epithelium clone (PLUNC) has been identified as an early secreted protein that is specifically expressed in the nasopharynx. The aim of this study was to determine the role and mechanism of PLUNC in NPC.

A Cost-Effective Hemin-Based Artificial Enzyme Allows for Practical Applications.

Nanomaterials excel in mimicking the structure and function of natural enzymes while being far more interesting in terms of structural stability, functional versatility, recyclability, and large-scale preparation. Herein, the story assembles hemin, histidine analogs, and G-quadruplex DNA in a catalytically competent supramolecular assembly referred to as assembly-activated hemin enzyme (AA-heminzyme). The catalytic properties of AA-heminzyme are investigated both in silico (by molecular docking and quantum chemical calculations) and in vitro (notably through a systematic comparison with its natural counterpart horseradish peroxidase, HRP).

APLNR inhibited nasopharyngeal carcinoma growth and immune escape by downregulating PD-L1.

Background: APLNR is a G protein-coupled receptor and our previous study had revealed that APLNR could inhibit nasopharyngeal carcinoma (NPC) growth and metastasis. However, the role of APLNR in regulating PD-L1 expression and immune escape in NPC is unknown.

Methods: We analyzed the expression and correlation of APLNR and PD-L1 in NPC tissues and cells.

Dual-Ligand Ruthenium Coordination Polymer-Derived Self-Enhanced Electrochemiluminescent Emitters for Sensitive Detection of Procalcitonin.

Ru-based electrochemiluminescence (ECL) coordination polymers are widely employed for bioanalysis and medical diagnosis. However, commonly used Ru-based coordination polymers face the limitation of low efficiency due to the long distance between the ECL reagent and the coreactant dispersed in detecting solution. Herein, we report a dual-ligand self-enhanced ECL coordination polymer, composed of tris(4,4'-dicarboxylic acid-2,2'-bipyridyl) ruthenium(II) dichloride (Ru(dcbpy)) as ECL reactant ligand and ethylenediamine (EDA) as corresponding coreactant ligand into Zn metal node, termed Zn-Ru-EDA.

LncRNA AFAP1-AS1 mediates breast cancer cell proliferation and migration through the miR-21/PTEN axis.

LncRNAs play various effects, mostly by sponging with miRNAs. Based on public databases integrating bioinformatics analyses and further validation in breast cancer (BC) tissue and cell lines, the effect of lncRNA AFAP1-AS1 on breast cancer cell proliferation and migration was verified. It might work via the miR-21/PTEN axis.