Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In this study, a highly efficient electrochemiluminescent (ECL) coordination polymer, Au-Zn-DTBA, was synthesized by employing 2,2'-dithiodibenzoic acid (DTBA) as the luminescent ligand and Zn as the metal node as well as Au nanoparticles (AuNPs) as coreaction accelerators confined to DTBA via Au-S bonds for the construction of biosensors for sensitive detection of the biomarker of neurological disease, dopamine. Compared to the Zn-DTBA ECL system without a coreaction accelerator, Au-Zn-DTBA exhibits a 4-fold enhancement in ECL intensity, since AuNPs confined in Zn-DTBA could promote the coreactant KSO to produce abundant sulfate radicals SO for significantly enhancing the ECL efficiency of Zn-DTBA. As a result, an ultrasensitive ECL biosensor employing the Au-Zn-DTBA/KSO ECL system was developed for dopamine detection, achieving a low detection limit of 0.41 nM and outperforming most previously reported dopamine biosensors. This strategy demonstrates the significant potential of coreaction accelerators based on the confining effect, offering a novel approach for increasing ECL efficiency and expanding its application in clinical analysis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acssensors.5c01053 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mesoporous Zr MOFs regulated by linear ligand replacement strategy to achieve single Ru(bpy) molecule encapsulation for ratio ECL detection of miRNA-21.
Talanta
September 2025
College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Instrument
Rational optimization of the pore size and topology of porous nanocarriers is crucial for improving the loading amount of luminophore and enhancing electrochemiluminescence (ECL) performance. In this study, an equimolar linear ligand replacement strategy was employed to synthesize novel mesoporous metal-organic frameworks (MOFs) for encapsulating Ru(bpy) (Ru@Zr MOFs) under room temperature without an acid modulator. Ingenious ligand substitution allows precise control of pore size, enabling encapsulation at the single-molecule level within mesoporous cages.
View Article and Find Full Text PDFMultisignal Conversion Electrochemiluminescence Strategy Based on Nanozyme-Enhanced Nitrogen-Vacancy/Oxygen-Doped g-CN for the Detection of Cholesterol.
Anal Chem
August 2025
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
The high and stable signal intensity of electrochemiluminescence (ECL) is crucial for establishing highly sensitive ECL biosensors. Here, nitrogen-vacancy/oxygen-doped carbon nitride (OCNNV-650) was first used as an ECL emitter, significantly improving the low ECL activity and poor dispersion of graphitic carbon nitride (g-CN) through a molecular engineering strategy. It is particularly noteworthy that FeO@MoS peroxidases, as coreaction accelerators, are the key to achieving the first and last "signals on", promoting the production of more SO and even promoting the production of •OH radicals when cholesterol is electrocatalyzed to produce HO.
View Article and Find Full Text PDFBimetallic electrocatalyst synergistic effect boosts aggregation-induced electrochemiluminescence of gadolinium-based metal-organic framework for sensitive quantitation of anti-müllerian hormone.
J Colloid Interface Sci
August 2025
Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi),
This study presents the synthesis of a gadolinium-based metal-organic framework (Gd-MOF) via coordination between Gd ions and 1,2,4,5-tetrakis (4-carboxyphenyl) benzene (HTCPB). Gd-MOF demonstrated pronounced aggregation-induced electrochemiluminescence (AIECL) performance. With potassium persulfate (KSO) as a co-reactant, Gd-MOF exhibited a significantly stronger and more stable cathodic electrochemiluminescence (ECL) response, with improved ECL efficiency compared with the HTCPB ligand alone.
View Article and Find Full Text PDFAIEgen-based porous organic polymer-Ag nanoparticles hybrids with coreaction accelerator amplification and covalent rigidification-enhanced electrochemiluminescence for aflatoxin M1 detection.
Food Chem
August 2025
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. Electronic address: x
Developing new high-performance electrochemiluminescence (ECL) emitters is a continuous hotspot. Herein, a novel AgNP-decorated porous organic polymer (AgNPs@ETTBC-BPyDAN-POP, BPyDAN = 2,2'-([2,2'-bipyridine]-5,5'-diyl)diacetonitrile) nanocomposite with coreaction accelerator amplification and covalent rigidification-enhanced ECL was prepared. AgNPs@ETTBC-BPyDAN-POP nanocomposite exhibited excellent ECL performance, not only because abundant AIE-active 4',4″',4″″',4″″″'-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-4-carbaldehyde)) (ETTBC) luminogens were covalently assembled and rigidified into ETTBC-BPyDAN-POP network, which diminished radiationless transition, but also because AgNPs functioned as coreaction accelerators that expedited the generation of coreactant radicals, which in-situ react with adjacent ETTBC intermediates, thereby producing more ETTBC excited states for significantly enhancing the ECL emission.
View Article and Find Full Text PDFCarbohydrazide-induced low triggering potential electrochemiluminescence from perylene-based metal-organic framework for bioanalysis.
Biosens Bioelectron
August 2025
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:
3,4,9,10-perylenetetracarboxylic acid (PTCA), as a typical polycyclic aromatic hydrocarbon (PAH), has become a special electrochemiluminescence (ECL) luminophore by virtue of its high quantum yield and excellent photoelectric properties. However, its aggregation-caused quenching (ACQ) effect and high ECL potentials (usually greater than -1.5 V vs Ag/AgCl) limited its application.
View Article and Find Full Text PDF