Magneto-Electrochemical Deposition of Faceted Copper Microcrystals for Nitrate-to-Ammonia Electrocatalysis.

Electrochemical deposition is a facile and effective method for the in situ growth of metal electrocatalysts; however, it is difficult to optimize their morphology and performance due to the kinetics-controlled growth at high current density. Herein, we develop a new magneto-electrochemical deposition technique to prepare the faceted microcrystals of copper (Cu) catalysts for highly efficient electrocatalytic nitrate-to-ammonia conversion. The field generates a Lorentz force on the flow of Cu ions near the cathode surface, which retards the mass transport to predeposited Cu particles and increases the density of Cu nucleation sites due to the magnetohydrodynamics (MHD) effect.

Bimetallic electrocatalyst synergistic effect boosts aggregation-induced electrochemiluminescence of gadolinium-based metal-organic framework for sensitive quantitation of anti-müllerian hormone.

This study presents the synthesis of a gadolinium-based metal-organic framework (Gd-MOF) via coordination between Gd ions and 1,2,4,5-tetrakis (4-carboxyphenyl) benzene (HTCPB). Gd-MOF demonstrated pronounced aggregation-induced electrochemiluminescence (AIECL) performance. With potassium persulfate (KSO) as a co-reactant, Gd-MOF exhibited a significantly stronger and more stable cathodic electrochemiluminescence (ECL) response, with improved ECL efficiency compared with the HTCPB ligand alone.

An electrochemiluminescence sensor based on the antenna effect of lanthanide bimetallic-organic framework and europium(III) electrocatalyst as a co-reactant accelerator for sensitive detection of serum amyloid A.

Serum amyloid A (SAA) is a more sensitive indicator for the early detection of infections compared to traditional biomarkers like C-reactive protein. This study aimed to construct a highly sensitive electrochemiluminescence (ECL) immunosensor employing lanthanide bimetallic-organic framework (Eu/Tb-MOF) in conjunction with CoSn(OH)-Au nanocomposites for precise quantification of SAA. The sensor was constructed using an Eu/Tb-MOF, where Eu and Tb functioned as the central metal ions and 1,3,5-tris(4-carboxyphenyl)benzene (HBTB) served as the organic ligand.

Neutrophil extracellular traps induced by Haemonchus contortus excretory-secretory proteins varies among goats, gerbils, and mice.

Background: Previous studies indicated that infection with Haemonchus contortus is host-specific (goat: susceptible host; gerbil: paratenic host; mouse: resistant host). Neutrophils play an essential role in host defense against parasitic infection through phagocytic engulfment, reactive oxygen species (ROS) generation, and neutrophil extracellular traps (NETs) formation. NETs are large web-like complexes consisting of a DNA scaffold decorated with various proteins components, including histones, myeloperoxidase, and elastase.

Orchestrating Gut Disorders by Oral Delivery of a Living-Synthetic Hybrid Hydrogel.

Elevated intestinal inflammation, reactive oxygen species (ROS), and gut microbiota dysbiosis are prominent features of various intestinal disorders. In this work, we develop an oral inulin-based hydrogel delivery system (LICH) containing living probiotics and hyaluronic acid (HA)-modified carbon dot (CD) nanoenzymes to orchestrate gut disorders. Utilizing the hydrophobic properties of HA under acidic conditions, LICH contracts its network to safeguard probiotics during gastric transit.

Eimeria tenella aspartyl protease is identified as a potential TLR15 ligand and activates macrophages and dendritic cells in chickens.

Toll-like receptor (TLR)-mediated recognition of specific ligands is critical for initiating innate immunity against Eimeria infections. However, the avian-specific TLR15 has unclear immunological functions, including its specific ligands and role in anti-coccidia immunity. In this study, an aspartyl protease from Eimeria tenella (EteASP) was identified as a potential TLR15 ligand by co-immunoprecipitation.

Aptamer-chitosan modified chlorogenic acid derived nanoparticles for enhancing target treatment in diarrhea-predominant irritable bowel syndrome.

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common chronic non-organic gastrointestinal disorder often associated with low-grade intestinal inflammation that disrupts gut function. However, current therapies remain inadequate for achieving sustained symptom relief. In this study, chlorogenic acid-derived carbon nanoparticles (CHA CNs), synthesized via a hydrothermal method, were further encapsulated within ssDNA aptamer modified chitosan (Apt-CS) to yield a multifunctional nanomedicine (Apt-CS@CHA CNs) with anti-inflammatory, ROS-scavenging, and microbiota-regulating properties.

A X-Band Integrated Passive Device Structure Based on TMV-Embedded FOWLP.

In this paper, the fabrication and testing of an integrated passive device (IPD) structure for X-band FMCW radar based on the fan-out wafer-level packaging (FOWLP) process are discussed. First, a transition line structure is added to the IPD structure to increase the upper impedance limit of the substrate, so as to reduce the process implementation difficulty and development cost. Second, the vertical soldered SubMiniature Push-On Micro (SMPM) interfaces testing method is proposed, reducing the testing difficulty of the dual-port structure with the antenna.

The role of systemic inflammation in the formation and rupture of intracranial aneurysms in moyamoya disease: a retrospective cohort study.

Background: Intracranial aneurysms (IAs) and their rupture are serious complications in patients with Moyamoya disease (MMD). However, specific risk factors for IA formation and rupture in MMD remain underexplored.

Methods: We conducted a retrospective analysis of 450 MMD patients, evaluating the prevalence and characteristics of IAs.

An Electrochemiluminescence immunosensor based on terbium metal-organic gel emitter and CoMnO electrocatalyst for the sensitive detection of N-terminal pro-brain natriuretic peptide.

The construction of a sensitive electrochemiluminescence (ECL) immunosensor for the detection of N-terminal pro-brain natriuretic peptide (NT-proBNP) is demonstrated in this paper using terbium metal-organic gel (Tb-MOG) as an ECL emitter. Firstly, stable ECL signal was obtained using the easily synthesized Tb-MOG as the emitter and persulfate (SO) as the co-reactant. Secondly, the reduction of SO was catalyzed by the introduction of CoMnO nanoflower as a co-reaction promoter, which further enhanced the ECL intensity.

Atmospheric pressure plasma treatment increases the antioxidant capacity of the serum in vitro.

The interaction of atmospheric pressure plasma (APP) with the liquids has been fully studied, and multiple biomedical applications of APP-activated liquids have also been verified. However, there is still no direct evidence regarding the interaction between APP treatment and serum. In the present study, the rat serum was treated with the helium APP device.

Synthesis of churros-like VSe nanostructures for ultrasensitive electrochemical detection of oxalic acid in urine with portable point-of-care diagnostic devices.

The binding of oxalic acid (OA) with metal ions, particularly calcium ions, is a key factor in kidney stone formation, as it produces insoluble calcium oxalate, which crystallizes and accumulates in the kidneys. Consequently, OA in urine is commonly considered a significant biomarker for clinical diagnosis and early screening of kidney stones. This study reports churros-like VSe nanostructures synthesized using a solvothermal method (high pressure and temperature) for sensitive and selective electrochemical detection of OA in urine.

Immunomodulatory effects of Eimeria maxima surface antigen (EmSAG) as an IFN-γ inhibitory molecule on peripheral blood mononuclear cells (PBMCs) and T cell subsets in chickens.

Eimeria maxima (E. maxima) infection inhibits the expression of IFN-γ, a cytokine that is essential for the Th1 immune response and plays a key role in combating this parasite. In our preliminary investigations, we identified the E.

DFT calculations guide the design of dual-responsive molecule 9,10-phenanthrenequinone-sydnone.

With the aid of density functional theory (DFT) calculations, we designed and synthesized a dual-responsive molecule 9,10-phenanthrenequinone-sydnone PQ-Syd, enabling tandem orthogonal reactions with furan-2(3)-one derivatives and bicyclo[6.1.0]nonyne (BCN) for turn-on and fluorescence modulation.

Development of an Experimental Platform for Gamma Knife Radiosurgery in Mouse Brains.

The limited availability of post-Gamma Knife radiosurgery (GKRS) samples and the unsuitability of clinical GKRS devices for small animals highlight the need to develop devices that enable the application of a clinical GKRS device in mouse models. This study introduces a novel platform specifically designed for utilizing the Leksell Gamma Knife in mouse studies. The 3D-printed device comprises a positioning platform and a head fixation device.

Circular RNAs perspective: exploring the direction of immunotherapy for colorectal cancer.

Circular RNAs (circRNAs) are multifaceted molecules that play a pivotal role in regulating gene expression at both transcriptional and post-transcriptional levels. Their expression is highly tissue-specific and developmentally regulated, making them critical players in various physiological processes and diseases, particularly cancer. In colorectal cancer, circRNAs exhibit significantly dysregulated expression patterns and profoundly influence disease progression through diverse molecular mechanisms.

High-temperature energy storage properties of polyetherimide composites with tailored boron nitride quantum dots.

Polymer film capacitors are currently being extensively investigated due to their advantages of outstanding power density and processability. However, the charge-discharge efficiency and energy density at high temperature for polymer dielectrics need to be further developed to fulfill the potential applications. In this study, sandwiched polyetherimide (PEI) composites with boron nitride quantum dots (BNQDs) have been prepared, in which BNQD/PEI composite as the outer layer prevents the diffusion of charge carriers with low conduction loss, and the relaxor P(VDF-TrFE-CFE) inner film serves as high electric displacement.

Efficacies of different surgical approaches in the treatment of hyperextension tibial plateau fractures.

Objective: To investigate the clinical efficacies of an anteromedial combined with anterolateral approach versus posteromedial combined with anterolateral approach in the treatment of hyperextension tibial plateau fractures.

Methods: A retrospective analysis was conducted on the data of 112 patients with hyperextension tibial plateau fractures treated in the Orthopedics Department of No. 215 Hospital of Shaanxi Nuclear Industry from January 2020 to December 2022.

Characterization of the trehalase function of Haemonchus contortus and its immunomodulatory effect on host PBMCs.

Trehalase can hydrolyze trehalose and is the first key enzyme in the chitin synthesis pathway of arthropods. However, little is known about the function of trehalase in Haemonchus contortus (HcTre). In this study, the purified recombinant HcTre protein (rHcTre) was obtained by prokaryotic expression technology, and it was proved that rHcTre protein has trehalase activity.

The lamina-spinous process-ligament complex implantation for the spinal stability: A case report and review of literature.

Rationale: The posterior cervicothoracic fusion is a common surgical skill for the treatment of spinal diseases. Since postoperative complications contribute to compressive neurological symptoms, this case is reported to provide a surgical option for the preservation of spine stability and bone fusion.

Patient Concerns: A 36-year-old male presented numbness of both lower limbs for more than half a year, accompanied by unstable walking for more than 2 months.

Chromosome-scale genome assembly of Zoysia japonica uncovers cold tolerance candidate genes.

Zoysiagrass stands out as a crucial native turfgrass due to its exceptional abiotic stress tolerance, extensive adaptability, and high ornamental value. In this study, we generated a high-quality chromosome-level genome assembly of Compadre (COM) zoysiagrass, leveraging PacBio SMRT sequencing and Hi-C scaffolding technologies. The resulting genome assembly (312.

Integration of ATAC-seq and RNA-seq reveals the dynamics of chromatin accessibility and gene expression in zoysiagrass response to drought.

The 'X4' accession of zoysiagrass demonstrated superior drought tolerance compared to other accessions. Integration analysis of transcriptomics and epigenomics revealed a positive correlation between ATAC-seq peak intensity and gene expression levels. Six motifs involved in regulating drought responses were identified, which are similar to the domains of the ERF and C2H2 transcription factor families.

Immunotherapy promoting spontaneous regression of non-irradiated brain Metastases following gamma knife treatment: an intracranial abscopal effect?

Radiotherapy has been shown to potentially induce systemic anti-tumor immunity, a phenomenon that may be further enhanced by immune checkpoint inhibitor (ICI) therapy. However, whether this phenomenon occurs following Gamma Knife radiosurgery (GKRS) for brain metastases (BMs) and its potential clinical implications remain poorly understood. We retrospectively analyzed 36 non-small-cell lung cancer (NSCLC) patients with multiple BMs treated with multi-session GKRS.

Bioorthogonal Reactions for Bioactive Sulfur Species Delivery.

Bioorthogonal chemistry has emerged as a powerful tool for the development of controllable drug delivery systems. Bioactive sulfur species, which participate in complex sulfur signaling pathways, play crucial roles in various physiological and pathological processes. However, achieving precise and controlled administration of these sulfur species remains challenging due to their unique physicochemical properties.

Enzymes involved in trehalose-chitin synthesis in Haemonchus contortus could be vaccine candidates for goats.

Background: Trehalose-6-phosphate synthase (HcTPS) and trehalose-6-phosphate phosphatase (HcGOB) are key enzymes for trehalose synthesis in Haemonchus contortus. In addition, previous studies have also demonstrated that HcTPS and HcGOB can regulate the function of host immune cells in vitro, and are important immunosuppressive molecules. Therefore, this study evaluated the potential of HcTPS and HcGOB as vaccine candidates through in vitro and in vivo experiments.