Global Assessment of current and future chikungunya virus transmission risk using optimized maxent modeling.

Chikungunya virus (CHIKV) primarily spreads through an urban transmission cycle involving humans and two principal mosquito vectors, Ae. aegypti and Ae. albopictus, especially in densely populated areas, posing significant public health challenges as climate change alters vector habitats.

The effects of palatal anchorage device on molar distalization with clear aligner: Three-dimensional finite element analysis.

Introduction: This study aimed to analyze the biomechanical effects of the combined use of clear aligner and palatal anchorage devices (transpalatal arch [TPA], combination of TPA and microimplant [MI]) during maxillary molar distalization.

Methods: Three-dimensional finite element models were established to simulate molar distalization, incorporating 7 configurations: Without-TPA, TPA-no-MI, TPA-with-MI1, TPA-with-MI2, TPA-with-MI3, TPA-with-MI4, and TPA-with-MI5. The 3-dimensional displacements of upper teeth and von Mises stress distribution in the periodontal ligament were evaluated.

Identification of Recurrence-associated Gene Signatures and Machine Learning-based Prediction in IDH-Wildtype Histological Glioblastoma.

Glioblastoma (GBM) is a highly aggressive brain tumor with frequent recurrence, yet the molecular mechanisms driving recurrence remain poorly understood. Identifying recurrence-associated genes may improve prognosis and treatment strategies. We applied weighted gene co-expression network analysis (WGCNA) to transcriptomic data from IDH-wildtype histological GBM in the CGGA-693 (n = 190) and CGGA-325 (n = 111) cohorts to identify recurrence-associated genes.

Geographical Variation of Diet Composition of in Jiangxi, China Based on DNA Metabarcoding.

Food resources are the fundamental basis for the survival and reproduction of animals. Diet research is the foundation for understanding their ecological habits and is of great significance for evaluating their survival status and carrying out effective protection and management. South China sika deer () is the most endangered subspecies of wild sika deer in China, with a small population and a shrinking distribution area.

Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma.

Background: Invasive Cerebral Aspergillosis (ICA) is a rare fungal infection affecting the brain, primarily seen in individuals with compromised immune systems. Despite various treatment options, substantial cerebral granulomas caused by ICA still result in high mortality and recurrence rates.

Case Presentation: We report a rare instance of ICA in a 30-year-old pregnant woman.

The lamina-spinous process-ligament complex implantation for the spinal stability: A case report and review of literature.

Rationale: The posterior cervicothoracic fusion is a common surgical skill for the treatment of spinal diseases. Since postoperative complications contribute to compressive neurological symptoms, this case is reported to provide a surgical option for the preservation of spine stability and bone fusion.

Patient Concerns: A 36-year-old male presented numbness of both lower limbs for more than half a year, accompanied by unstable walking for more than 2 months.

Effectiveness and safety of ICIs for the treatment of advanced CC: a systematic review and meta-analysis.

Background: The use of immune checkpoint inhibitors has recently become a promising and innovative therapeutic option for patients suffering from advanced recurrent or metastatic cervical cancer(CC), and several studies of immunotherapy have been published or have revealed stage-by-stage results at international congresses. Nevertheless, there is a lack of meta-analyses of ICIs for advanced CC in past Meta-analysis.

Method: This meta-analysis rigorously followed the PRISMA guidelines, using Review Manager V.

Construction of a beeswax-based olive oil bigels system encapusulation of β-carotene by xanthan gum/gellan gum/inulin and evaluation of extrusion spreading performance using finite element Abaqus simulations.

This study focused on the preparation of olive oil bigels with different ratios of xanthan gum/gellan gum hydrogels and beeswax oleogels. The microscopic analysis confirmed that the bigels system exhibited a hydrogel-in-oleogel structure. With the addition of inulin, the system transitioned into a bi-continuous network, which enhanced phase continuity and stability.

Discovery of potent, highly selective, and orally bioavailable factor XIa inhibitors for anticoagulant therapy.

Factor XIa (FXIa) has emerged as a promising target for novel anticoagulant development since inhibiting it can reduce thrombosis without significant bleeding risks. Despite a few FXIa inhibitors entering clinical trials, none have been approved for the market yet. Here, we present highly selective and orally bioavailable FXIa inhibitors derived from compound 1, 4-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-5-methoxypyridin-2(1H)-one.

Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant .

Discovering new strategies to combat the multidrug-resistant bacteria constitutes a major medical challenge of our time. Previously, artesunate (AS) has been reported to exert antibacterial enhancement activity in combination with β-lactam antibiotics via inhibition of the efflux pump AcrB. However, combination of AS and colistin (COL) revealed a weak synergistic effect against a limited number of strains, and few studies have further explored its possible mechanism of synergistic action.

Jingui Shenqi Wan alleviates bone loss induced by primary osteoporosis by inhibiting osteoblast pyroptosis.

Objective: The primary objective of this study was to elucidate the underlying pharmacological mechanisms by which Jingui Shenqi Wan (JGSQW) alleviates postmenopausal osteoporosis (PMOP). Through a systematic investigation, we sought to identify the specific molecular pathways through which JGSQW modulates the progression of PMOP, thereby providing a scientific basis for its clinical application.

Methods: We established an ovariectomized (OVX) mouse model to simulate estrogen deficiency-induced PMOP.

Tailoring of levansucrase product size by a comparative molecular dynamics approach.

Levan is widely used as food additives. Its utilization is significantly influenced by its molecular weight. Bacillus subtilis levansucrase (Bs-SacB) and Priestia megaterium levansucrase (Pm-SacB) yield levan of different weights.

Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis.

An imbalance in the microbiota-gut-brain axis exerts an essential effect on the pathophysiology of depressive and anxiety disorders. Our previous research revealed that the timing of inulin administration altered its effects on chronic unpredictable mild stress (CUMS)-induced anxiety and depression. However, it is still unclear if the gut-brain axis is primarily responsible for these effects.

The Radio of RDW/ALB: A Cost-Effective Biomarker for Early-Stage Risk Stratification in Acute Ischemic Stroke.

Background And Aims: The red blood cell distribution width (RDW) to albumin (ALB) ratio (RAR) has been identified as a prognostic indicator for mortality in critically ill patients across various diseases. Nevertheless, the impact of RAR on clinical functional prognosis in Acute ischemic stroke (AIS) remains uncertain. This study aimed to evaluate the prognostic significance of RAR in AIS patients.

[Site-directed mutagenesis enhances the activity of dextranase from KQ11].

Dextranase is an enzyme that specifically hydrolyzes the α-1, 6 glucoside bond. In order to improve the activity of dextranase from KQ11, site-directed mutagenesis was used to modify the amino acids involved in the "tunnel-like binding site". A saturating mutation at position 507 was carried out on this basis.

Clinical evaluation of enhanced recovery versus conventional care in the perioperative period for intradural extramedullary spinal tumors: a study protocol for a multicenter, randomized controlled trial.

Background: This randomized clinical trial protocol aimed to investigate the comparative efficacy of an enhanced recovery after surgery (ERAS) protocol versus traditional perioperative care programs in patients with intradural extramedullary spinal tumors.

Methods: The study included 180 patients aged 18-80 years, who were randomly assigned to two groups: Group A receiving traditional perioperative care and Group B receiving accelerated rehabilitation perioperative care. The nurse responsible for patient care was informed of the group assignment, but the patients themselves remained blinded to the intervention.

Biosynthesis of α-keto acids and resolution of chiral amino acids by l-amino acid deaminases from Proteus mirabilis.

Chiral amino acids and their deamination products, α-keto acids, have important applications in food, medicine, and fine chemicals. In this study, two l-amino acid deaminase genes from Proteus mirabilis, PM473 of type Ⅰ and PM471 of type Ⅱ were cloned and expressed in Escherichia coli respectively, expected to achieve the chiral separation of amino acids. Extensive substrate preference testing showed that both deaminases had catalytic effects on the d-amino acid component of the D, l-amino acids, and PM473 has a wider catalytic range for amino acids.

Strain-induced ferroelectric polarization reversal without undergoing geometric inversion in blue SiSe monolayer.

Ferroelectricity in two-dimensional (2D) systems generally arises from phonons and has been widely investigated. On the contrary, electronic ferroelectricity in 2D systems has been rarely studied. Using first-principles calculations, the ferroelectric behavior of the buckled blue SiSe monolayer under strain are explored.

Xp21 DNA microdeletion syndrome in a Chinese family: clinical features show retinitis pigmentosa and chronic granuloma.

Xp21 DNA microdeletion syndrome is a very rare disease characterized by retinitis pigmentosa (RP), chronic granulomatous disease (CGD), and McLeod syndrome (MLS). Due to the complex and diverse clinical manifestations, early diagnosis remains a challenge for many physicians. In this study, for the purpose of determining the pathogenic gene variants and definitive diagnosis in a patient medically backgrounded with RP and CGD from a normal Chinese family, whole-exome sequencing (WES) was performed in this proband and copy number variation (CNV) was further verified in other family members by qPCR.

Sliding ferroelectricity and the moiré effect in Janus bilayer MoSSe.

Two-dimensional van der Waals layered materials have attracted extensive attention in the field of low-dimensional ferroelectricity, on account of their readily delaminated structure and high-density information storage advantages. Here, we report the sliding ferroelectricity and moiré effects on the ferroelectricity in Janus bilayer MoSSe based on first-principles calculations. We focus on the changes of in-plane and out-of-plane polarizations due to sliding, and the calculations demonstrate that the in-plane and out-of-plane polarizations can be switched simultaneously by sliding.

Vaccination against SARS-CoV-2 contributed to reducing the prevalence of depression in Chinese adults - A cross-sectional study.

Background: SARS-CoV-2 vaccination has been reported to improve mental health. However, few relevant data were collected in China. The study aimed to evaluate the impact of SARS-CoV-2 vaccination on the risk of depression in China and risk factors contributing to depression.

Modification of the Loop Region Near the Substrate Tunnel to Alter the Hydrolytic Process of Dextranase.

Dextranases are hydrolases that exclusively catalyze the disruption of α-1,6 glycosidic bonds. A series of variant enzymes were obtained by comparing the sequences of dextranases from different sources and introducing sequence substitutions. A correlation was found between the number of amino acids in the 397-401 region and the hydrolytic process.

Mechanism analysis of a novel natural cationic modified dextran flocculant and its application in the treatment of blue algal blooms.

Blue algae, a type of harmful microalgae, are responsible for causing harmful algal blooms that result in severe environmental issues. To address this problem, a biopolysaccharide-based flocculant was developed for treating blue algae blooms. This flocculant was created by modifying high molecular weight dextran using the natural cationic monomer betaine (Dex-Bet), making it environmentally friendly.