Dynamic Relevance Between Reflux Events and Esophageal Motility in Patients With Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease.

Objectives: The association between reflux events and esophageal motility abnormality is unclear. We aimed to determine the relevance between reflux events and esophageal motility in proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD).

Methods: Patients with PPI-refractory or PPI-responsive GERD were enrolled.

Gold Nanoparticles-Functionalized Ultrathin Graphitic Carbon Nitride Nanosheets for Boosting Solar Hydrogen Production: The Role of Plasmon-Induced Interfacial Electric Fields.

The design of photocatalysts capable of generating localized surface plasmon resonance (LSPR) effects represents a promising strategy for enhancing photocatalytic activity. However, the mechanistic role of plasmonic nanoparticles-induced interfacial electric fields in driving photocatalytic processes remains poorly understood. To produce a Schottky junction, varying amounts of Au nanoparticles widely utilized to broaden the light absorption were loaded onto ultrathin carbon nitride sheets (Au/UCN).

CsAc-Mediated Dynamic Reconstruction of Chloride Perovskite Films for High-Performance Self-Powered Near-UV Photodetectors.

Methylammonium lead chloride perovskite (MAPbCl), with its wide bandgap of ∼3 eV, exhibits unique advantages for near-UV to UV optoelectronic devices. However, the fast crystallization kinetics and significant solubility differences of MAPbCl precursors in solvents cause discontinuous films with high surface defect densities, severely limiting device performance. This study introduces a solution mediated dissolution recrystallization strategy to address the aforementioned issues, namely, employing a CsAc/methanol solution to dynamically reconstruct preformed MAPbCl films.

InP Quantum Dots with a Strain-Engineered Gradient Shell for Enhanced Optical Performance and Stability.

InP quantum dots have emerged as a promising ecofriendly alternative to cadmium-based QDs for next-generation display applications. However, red-emitting InP QDs synthesized via aminophosphine precursors still suffer from broad emission spectra and limited stability. In this study, we present a strain-engineered InP/ZnSe/ZnSeS/ZnS QD structure featuring a gradient alloyed ZnSeS shell that effectively mitigates lattice mismatch, reduces strain accumulation, and enhances shell uniformity.

The importance of measuring the endometrial cavity length in deciding the ideal place for embryo transfer: a retrospective cohort study.

Background: The relationship between clinical pregnancy rates and embryo transfer positioning remains a matter of considerable debate, with persistent inconsistencies reported across existing studies. A notable limitation of existing studies is their failure to systematically account for anatomical variations in the endometrial cavity dimensions. The purpose of the present study was to determine the ideal location for embryo transfer according to different endometrial cavity lengths.

Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization.

The relationship between epigenetic age acceleration (EAA) and midlife cognitive function remains unclear, with limited causal evidence. We investigated this association in 1252 Black and White middle-aged adults from the Bogalusa Heart Study (BHS) and conducted a two-sample Mendelian randomization (MR) analysis using GWAS summary statistics for EAA (N = 34,710) and cognition (N ≤ 106,162). In BHS, higher Hannum age acceleration, PhenoAge acceleration, and GrimAge acceleration (GrimAA) were each associated with slower processing speed (p < 0.

G4SNVHunter: An R/Bioconductor Package for Evaluating SNV-Induced Disruption of G-Quadruplex Structures Leveraging the G4Hunter Algorithm.

G-quadruplexes (G4s) are nucleic acid secondary structures with important regulatory functions. Single-nucleotide variants (SNVs), one of the most common forms of genetic variation, can potentially impact the formation of G4 structures if they occur within G4 regions. However, there is currently a lack of software tools specifically designed to assess such effects.

Multi-omics dissection of super-enhancer heterogeneity reveals subtype-specific transcriptional drivers in triple-negative breast cancer.

As a clinically heterogeneous breast cancer subtype, triple-negative breast cancer (TNBC) currently lacks effective targeted therapies. The subtype-specific heterogeneity of tumor phenotypes and gene expression programs poses challenges for the treatment of TNBC. However, while progress has been made in understanding the epigenetic and molecular mechanisms of TNBC, studies on the role of super-enhancers (SEs) in TNBC remain limited, particularly in the exploration of preclinical models at the subtype level.

Plants respond to herbivory through sequential induction of cheaper defenses before more costly ones.

Plants encounter natural antagonist threats of varying intensity and respond by activating multiple defense traits. Due to the fitness costs associated with producing defense traits, plants are expected to activate less costly traits first, reserving more costly defenses for potentially more severe damage ("cheaper first hypothesis"), but evidence to date is scarce. Here, we tested this hypothesis by measuring six putative defense traits in the annual plant Ambrosia artemisiifolia.

Physical models and numerical modeling for 280 nm AlGaN-based emission-and-detection dual functional integrated devices by managing hole transport and recombination.

In this work, physical models for 280 nm AlGaN-based light emitting diode (LED) with monolithically integrated photodetector (PD) having the same multiple quantum wells (MQWs) structure have been established for the first time, with the aid of which, numerical calculations have been studied. Asymmetric MQWs have been proposed to improve the optoelectronic coupling efficiency, i.e.

Spread spectrum photon counting compressed depth imaging method.

The pseudo-random spread spectrum photon counting three-dimensional imaging community is able to acquire detailed time-correlated photon counting depth profiles by collecting a large amount of data about a scene and applying the matched filtering (MF) algorithm. However, it limits their ability to process, transmit, and store. To solve this problem, we report the structural time-correlated sparse representation depth reconstruction framework.

EPS8L2 drives colorectal cancer cell proliferation and migration via YBX1-dependent activation of G3BP2 transcription.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, characterized by molecular heterogeneity and limited therapeutic options. Here, we identified EPS8L2 as a novel driver of colorectal tumorigenesis. EPS8L2 is significantly upregulated in CRC tissues and negatively correlated with patients' prognosis.

A reconfigurable multi-channel on-chip photonic filter for programmable optical frequency division.

Recent advancements have broadened the application of photon filters based on Bragg gratings within optical communication networks and optical input/output interfaces. Traditional gratings, however, suffer from a fixed refractive index modulation distribution once manufactured, constraining their adaptability and flexibility. This study introduces a reconfigurable multi-channel photon filter on a silicon nitride on insulator platform.

Chromosome-level genome assembly of the Durum wheat cultivar Langdon.

Durum wheat (Triticum turgidum ssp. durum, 2n = 4x = 28, BBAA) is the second most cultivated lineage of wheat after hexaploid common wheat. Langdon is a prominent durum wheat cultivar, highly valued for its crucial role in the development of synthetic hexaploid wheat and its importance in agricultural research.

Dual-mode immunotherapy: ultrasound responsive zinc-based nano-contract agents synergistically activate the GAS-STING pathway for enhanced tumor sono-metalloimmunotherapy.

Triple-negative breast cancer has previously been considered to a weak tumor immunogenicity. A strategy combining sono-immunotherapy and metal ion interference therapy holds promise for the tumor immune environment. 2,2-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH), functioning as a sonosensitizer, can produce alkyl radicals that can trigger sono-oxidative stress in neoplastic cells.

Vanillin-mediated green synthesis of polyacrylic acid/chitosan dual-network hydrogels with antibacterial properties and enhanced mechanical performance.

The polyphenol-metal catalytic scheme plays a crucial role in the synthesis of polyacrylic acid (PAA) hydrogels. Herein, vanillin (VA) not only initiates dynamic redox reactions with Fe to accelerate the polymerization of acrylic acid but also forms Schiff-base bonds with chitosan (CS), thereby facilitating the formation of a CS molecular network. Consequently, VA enables rapid, environmentally friendly synthesis of dual-network hydrogels comprising PAA and CS.

Predicting pathological response of resectable esophageal squamous cell carcinoma to neoadjuvant anti-PD-1 with chemotherapy using serum inflammation indexes.

Background: Inflammatory indexes are increasingly being considered to predict treatment response in tumors. This study aimed to investigate the efficacy of serum inflammatory indexes in predicting pathological response in patients with esophageal squamous cell carcinoma (ESCC) receiving anti-PD-1 neoadjuvant immunochemotherapy (NICT).

Methods: We retrospectively collected clinical and laboratory data from 116 ESCC patients who received NICT.

Can Percutaneous Kyphoplasty Be a New Solution for Vertebral Fractures in Patients With Diffuse Idiopathic Skeletal Hyperostosis? Retrospective Study.

Background: Diffuse idiopathic skeletal hyperostosis (DISH) is a metabolic disease that is prevalent in elderly patients and is characterized by spinal ankylosis. Traditional surgical treatment requires open long-segment internal fixation. Percutaneous kyphoplasty (PKP), as a minimally invasive spinal surgery technology, can accurately relieve pain and improve quality of life.

Application of Transverse Tibial Bone Transfer in Diabetic Foot Patients: A Comprehensive Evaluation of Postoperative Prognostic Factors and Risk Factors.

Objective: Diabetic foot is a serious complication of diabetes, often leading to poor prognosis and increased risk of amputation. Transverse tibial bone transport (TTT) has emerged as a promising limb salvage technique. However, some patients still experience adverse postoperative outcomes.

Integrated Single-Cell Analysis Dissects Regulatory Mechanisms Underlying Tumor-Associated Macrophage Plasticity in Hepatocellular Carcinoma.

: Tumor-associated macrophages (TAMs) are critical regulators of the hepatocellular carcinoma (HCC) microenvironment, yet their epigenetic heterogeneity and regulatory programs remain poorly defined. : We performed integrative analysis on single-cell RNA-seq and ATAC-seq profiling of HCC patients to dissect TAM subtypes at high resolution. By correlating chromatin accessibility with gene expression, we identified cell-type-specific candidate -regulatory elements (CREs).

The Relevance of G-Quadruplexes in Gene Promoters and the First Introns Associated with Transcriptional Regulation in Breast Cancer.

The role of G-quadruplexes (G4s) in gene regulation has been widely documented, especially in gene promoters. However, the transcriptional mechanisms involving G4s in other regulatory regions remain largely unexplored. In this study, we integrated the G4-DNA data derived from 22 breast cancer patient-derived tumor xenograft (PDTX) models and MCF7 cell line as potential breast cancer-associated G4s (BC-G4s).

Advanced Ensemble Staking Model Employing cfDNA Fragmentation for Early Detection of Esophageal and Gastric Cancer.

Esophageal and gastric cancers are aggressive malignancies with poor prognoses due to late-stage diagnosis. Our study recruited 275 healthy participants, 201 gastric cancer patients, 74 esophageal patients and 103 patients with precancerous conditions. The participants were assigned into training and validation cohorts.

Engineered PD-L1 nanoregulators for enhanced tumor immunotherapy.

The programmed death ligand 1 (PD-L1) pathway plays a central role in enabling tumors to escape immune detection, making it a prime target for cancer immunotherapy. While immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have shown remarkable clinical success, their therapeutic potential is constrained by significant challenges. These include immune-related opposing actions, appearance of resistance mechanisms, and inconsistent patient response rates.

A transferrin-targeted nanoplatform for MRI-guided visualization and potent suppression of tumors and pulmonary metastatic lesions.

While targeted theranostics for cancer remains a pivotal research frontier, conventional ligand conjugation strategies exhibit persistent limitations in off-target accumulation and suboptimal tumor specificity, ultimately failing to achieve reliable detection of early-stage lesions or metastatic nodules while demonstrating insufficient therapeutic payload delivery. In this study, the manganese sulfide (MnS) nanoplatform was synthesized using transferrin (Tf) with tumor-targeting properties as a carrier by a simple fabrication method. Notably, compared to clinically prevalent Gd-based contrast agents, Tf-MnS exhibited superior -weighted magnetic resonance imaging (MRI) contrast performance, with the longitudinal relaxation () reaching 7.

Transferrin-Targeted Nanoarchitectonics with Efficient Metastasis Inhibition Enabling Tumor T-T Dual-Mode Magnetic Resonance Contrast Enhancement.

The development of T-T dual-mode contrast agents is expected to improve cancer diagnostic capabilities in response to the limitation of traditional single-mode magnetic resonance imaging (MRI) contrast agents. In this study, a pH-responsive dual-mode MRI nanoprobe, FeO@MnS-transferrin (FMT), is prepared with the objective of augmenting tumor visualization and chemodynamic therapy (CDT). FMT achieved precise tumor targeting by binding to transferrin receptors on cancer cells via the transferrin molecules on their surface.