Neural mechanisms underlying implicit emotion regulation deficit in relational and nonrelational trauma PTSD: Insights from the Nested Hierarchical Model of Self.

Background: Posttraumatic stress disorder (PTSD) exhibits marked heterogeneity, with relational (R; interpersonal) and nonrelational (NR; environmental) trauma subtypes demonstrating distinct psychopathological trajectories. Despite clinical recognition of these differences, their neurobiological underpinnings of emotion processing remain poorly understood. Guided by the Nested Hierarchical Model of Self (NHMS) - which posits trauma-type-specific disruptions in hierarchical self-processing systems - this study investigated neural mechanisms differentiating among PTSD subtypes during implicit emotion regulation.

An Integrated Grid Interface of Electrode for Sodium-Ion Battery.

Sodium-ion batteries (SIBs) attract the research interest of many scientists due to their cost-effectiveness, the abundance of natural sodium resources, and the great potential to replace metal lithium batteries. However, they also encounter substantial issues including sluggish ion kinetics, substantial volume changes, and interfacial instability during cycling. In this study, a GDY/SnO/GDY heterostructured anode is fabricated using a grid encapsulation strategy, where SnO nanoparticles are dispersed within a framework of graphdiyne (GDY) nanowalls.

Integrated single-cell and bulk transcriptome analysis reveal lactate metabolism-related signature and T cell alteration in atrial fibrillation.

Background: Atrial fibrillation (AF) is linked to modifications in T cell-mediated immunity. Although lactate metabolism influences T cell differentiation and function, its specific role in AF and associated immune processes remains inadequately understood.

Methods: We performed an integrated transcriptomic analysis utilizing both bulk and single-nucleus RNA sequencing data derived from hearts exhibiting AF and those in sinus rhythm.

LEF-6 phosphorylation regulates the binding and trafficking of baculovirus late gene transcripts.

The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) LEF-6 has been shown to accelerate the infection cycle of AcMNPV, but its specific function is yet to be defined. In the present study, we identify LEF-6 as an RNA-binding protein that preferentially interacts with viral late transcripts. We demonstrate that the N-terminal half of LEF-6, which contains two typical ribonucleoprotein (RNP) motifs, is responsible for RNA binding, but its C-terminal half is required for the binding specificity to viral RNAs and for fulfilling its function in promoting virus infection.

Near-Infrared Triggered Black Phosphorus/Zinc Oxide Nanocoatings Are Used to Resist Bacterial Infections in Additively Manufactured NiTi Alloy Implants.

Additive manufacturing of NiTi alloys has emerged as a promising option for bone implants. However, the bioinertness and poor corrosion resistance of the alloy limit its clinical applications. More critically, the absence of antibacterial properties increases the risk of postoperative biofilm infections.

Crown Ether-Peptide Rotaxanes.

We report on the metal-free active template synthesis of crown ether-peptide rotaxanes. A 24-crown-8 ring is sufficiently small that the side chains of canonical branched amino acids act as barriers that trap the macrocycle on the particular glycine residue used to assemble the rotaxane. The resulting crown ether-tripeptide rotaxane can subsequently be extended from either or both N- and C-termini of the axle.

Does diabetes status modify the association between the triglyceride-glucose index and major adverse cardiovascular events in patients with coronary heart disease? A systematic review and meta-analysis of longitudinal cohort studies.

Background: The triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, has been shown to be closely associated with cardiovascular risk. However, it remains unclear whether diabetes status affects the association between the TyG index and the risk of major adverse cardiovascular events (MACEs) in patients with coronary heart disease (CHD). The aim of this study is to systematically evaluate the relationship between the TyG index and MACEs among CHD patients with different diabetes statuses.

Controllable Preparation of Hierarchically Charge-Separated Interface to Effectively Promote the Desolvation and Kinetics of Lithium Ions.

Solid-electrolyte interphase (SEI) is one of the key factors to determine the performance of batteries. Electrolyte additives enhance SEI performance for fast charging and long cycle life but introduce system-level uncertainties, including cathode degradation, safety hazards, and cost escalation. In this study, we prepare a composite electrode (BPQDs/GDYNTs) featuring a charge-separated interface structure to improve the SEI directly without auxiliary additives.

Integrated Single-Cell Analysis Dissects Regulatory Mechanisms Underlying Tumor-Associated Macrophage Plasticity in Hepatocellular Carcinoma.

: Tumor-associated macrophages (TAMs) are critical regulators of the hepatocellular carcinoma (HCC) microenvironment, yet their epigenetic heterogeneity and regulatory programs remain poorly defined. : We performed integrative analysis on single-cell RNA-seq and ATAC-seq profiling of HCC patients to dissect TAM subtypes at high resolution. By correlating chromatin accessibility with gene expression, we identified cell-type-specific candidate -regulatory elements (CREs).

The recurrence and multi-organ involvement of giant penile plexiform neurofibroma in an adult with neurofibromatosis type 1: a case report.

Background: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with malignant potential, affecting various anatomical regions, predominantly the head and neck. Urogenital involvement is relatively uncommon. In particular, penile neurofibromatosis is exceedingly rare, with fewer than 20 cases documented globally.

Acupuncture Alleviates Blood-Brain Barrier Damage After Delayed rtPA Thrombolysis for Acute Ischemic Stroke by Regulating Ferroptosis.

Background: Acute ischemic stroke (AIS) is the second leading cause of death and disability worldwide. Recombinant tissue plasminogen activator (rtPA) was the first FDA-approved thrombolytic drug for AIS. However, delayed administration of rtPA exacerbates brain injury and increases the risk of hemorrhagic transformation (HT) and mortality.

The Genus Stauntonia DC.: Botany, Phytochemistry, Bioactivity, and Application.

Background: The plants of genus Stauntonia DC. are important Chinese medicines. To better develop and utilize the edible and medicinal values of Stauntonia DC.

Survival analysis of PLWH on antiretroviral therapy in Henan Province from 2004 to 2024.

There is a significant gap in data regarding the survival time and the factors influencing the survival of people living with HIV (PLWH) undergoing antiretroviral therapy (ART) in Henan Province, a region severely impacted by the AIDS epidemic.Investigating survival and influencing factors after ART can provide valuable insights to enhance patient management strategies and improve the prognosis for PLWH.This retrospective cohort study compiled case data and follow-up records of PLWH receiving ART at the Infectious Disease Hospital of Henan Province between 2004 and 2024.

Internet-based acceptance and commitment therapy for bipolar disorder: A randomized controlled pilot trial.

Internet-based Acceptance and Commitment Therapy (iACT) offers a promising, scalable intervention format for individuals with bipolar disorder (BD), yet its feasibility and preliminary efficacy remain underexplored. This pilot randomized controlled trial evaluated the acceptability, feasibility, and initial efficacy of a 7-day self-guided iACT program delivered via a secure, mobile-responsive platform. Seventy individuals were screened, of whom 60 clinically stable adults with BD (aged 18-60) met eligibility criteria and were randomized to either the iACT group (n = 30) or an active control group receiving digital psychoeducation (n = 30), yielding a recruitment rate of 85.

Corrosion Resistance and Bacteriostatic Properties of DCPD-PMTMS-CS Coating on Additive Manufacturing Preparation of NiTi Alloy Surface.

The nickel-titanium (NiTi) alloy implant materials produced by using the laser powder bed melting (LPBF) technique exhibit significant potential for application. The coating modification method can further enhance the surface biological functions of the alloy implants. This study presents a coating of calcium dihydrogen phosphate, siloxane, and chitosan (DCPD-PMTMS-CS) applied to the surface of NiTi alloys through electrochemical deposition and dip coating methods.

[Genetic analysis of a family with Dentinogenesis imperfecta type Ⅰ caused by a novel mutation in the COL1A2 gene].

Objective: To investigate the clinical phenotype and genetic characteristics of a family with Dentinogenesis imperfecta type Ⅰ(DGI-Ⅰ).

Methods: Clinical data were collected from a patient with DGI-Ⅰ admitted to the Reproductive Medicine Department of the Affiliated Hospital of Jining Medical University in March 2024. Clinical and familial data were retrospectively collected.

Phycocyanin functionalized selenium nanoparticles for type I photodynamic antibacterial therapy and wound healing.

Photodynamic therapy (PDT) has emerged as a promising treatment for drug-resistant bacterial infections by avoiding the abuse of antibiotics. However, most PDTs rely on reactive oxygen species (ROS) generated a type II process, which limits the antimicrobial effect in a hypoxic microenvironment. Herein, we reported phycocyanin functionalized selenium nanoparticles (Se@PC NPs) for type I photodynamic antibacterial therapy and wound healing.

Resting-State Brain Activity Changes and Their Genetic Correlates in Mild Traumatic Brain Injury.

Mild traumatic brain injury (mTBI) often leads to persistent cognitive and emotional symptoms, but the underlying neurobiological mechanisms remain unclear. Although previous studies have reported alterations in resting-state brain activity in mTBI patients, the findings have been inconsistent, and the genetic basis of these changes has not been fully explored. A coordinate-based voxel-wise meta-analysis was conducted to investigate resting-state brain activity changes in mTBI, using nine datasets from 374 patients and 302 healthy controls (HCs).

Deciphering Haploid Chromosome Conformation Alternation in Down Syndrome by Multiple Haploid Omics Analysis.

For chromosome abnormalities (CA), such as Down syndrome (DS), the influence of genomic variations to chromosome conformation and gene transcription remains elusive. Based on the complete genomic sequence from the parents of the DS trisomy patient, we systematically delineated an atlas of parental-specific haploid single nucleotide polymorphism (SNP), copy number variation (CNV), three-dimensional (3D) genome, and RNA expression profiles of the diencephalon in the DS patient. The integrated haploid multi-omics analysis demonstrated that one-dimensional genomic variations including SNPs and CNVs in the DS patient are highly correlated with the alterations of the 3D genome and the subsequent gene transcription.

Overcoming the Damping-Elasticity Paradox via 3D-Printed NiTiSn Nanocomposite.

Developing high damping alloys (HDAs) with large elastic strain has attracted growing attention due to the increasing demand for energy absorption with overload reliability and reusability. However, damping capacity inherently conflicts with elasticity, because the former requires a liable movement of crystal defects while the latter opposite. To deal with the damping-elasticity paradox, the advantage of pseudobinary eutectic reaction and rapid cooling of laser powder bed fusion is taken to fabricate a bulk NiTiSn nanocomposite with a two-level hierarchical structure.

Glycine intervention can alleviate imidacloprid-induced spermatogenic damage in rats.

Imidacloprid (IMI) is the first neonicotinoid pesticide with documented associations to substantial harm in multiple organs, notably impacting spermatogenesis in the reproductive system. Given the inevitable exposure to pesticides like IMI through dietary sources, employing dietary interventions to counteract the spermatogenic system damage caused by IMI exposure is a promising approach. Glycine (Gly), an amino acid abundantly found in various dietary sources, has been observed to be diminished in rat individuals exposed to IMI.

Effects of different drying methods on the antioxidant profiles and volatile organic compounds of blueberry pomace.

The effects of hot air drying (HAD), microwave-assisted hot air drying (MHAD) and vacuum freeze drying (VFD) on the antioxidant and volatile profiles of blueberry pomace (BP) were investigated. The dried BP produced by VFD showed the highest content of antioxidant components and strongest antioxidant activity. MHAD shortened the drying time by 62.

A uranyl-based luminescent dosimeter for ultralow-dose tracking of UV and X-ray radiation.

Herein, we report a novel uranyl-based organic-inorganic hybrid dosimeter, designated as U-OX-PIP. Remarkably, U-OX-PIP exhibits UV/X-ray-induced fluorescence quenching responses, which are characterized by a gradual suppression of the uranyl emission signature. The pronounced fluorescence quenching behavior of U-OX-PIP enables its application as a highly sensitive radiation-responsive material.

Tertiary amine N-oxide zwitterionic lipids facilitate muscle-selective mRNA vaccine delivery for enhancing cDC1-mediated antitumor efficacy.

Lipid nanoparticles (LNPs) have emerged as a groundbreaking platform for delivering messenger RNA (mRNA)-based vaccines and therapeutics. However, clinically approved LNPs administered intramuscularly often lead to unintended liver antigen expression, raising safety concerns related to excessive immune activation and potential tissue damage. Extensive research has focused on optimizing LNPs to adjust their tissue specificity and immunogenicity, while the role of helper lipids as structural components has received little attention.