Anxiety, depression and family resilience: A three-level meta-analysis.

Background: Perceived family resilience, which refers to the subjective assessment of family members regarding their family's ability to effectively adapt and maintain stability during challenging times, has been negatively correlated with mental health issues such as anxiety and depression in numerous studies; however, the strength of this association has varied significantly across previous research. This study fills this gap through a three-level meta-analysis.

Method: This study aims to obtain reliable estimates of effect sizes and explore potential moderating factors in the relationship between perceived family resilience and symptoms of anxiety and depression.

Bacteroides dorei RX2020-derived bile acid alleviates influenza virus infection through TGR5 signaling.

Background: The role of the gut microbiome in respiratory infections is increasingly recognized. We have found that a gut commensal strain, Bacteroides dorei RX2020 (B. dorei) previously isolated from healthy human fecal microbiota, alleviates influenza virus infection, but the underlying mechanisms remain elusive.

Neural mechanisms underlying implicit emotion regulation deficit in relational and nonrelational trauma PTSD: Insights from the Nested Hierarchical Model of Self.

Background: Posttraumatic stress disorder (PTSD) exhibits marked heterogeneity, with relational (R; interpersonal) and nonrelational (NR; environmental) trauma subtypes demonstrating distinct psychopathological trajectories. Despite clinical recognition of these differences, their neurobiological underpinnings of emotion processing remain poorly understood. Guided by the Nested Hierarchical Model of Self (NHMS) - which posits trauma-type-specific disruptions in hierarchical self-processing systems - this study investigated neural mechanisms differentiating among PTSD subtypes during implicit emotion regulation.

Structural brain correlates in major depressive disorder, anxiety disorders, and post-traumatic stress disorder: a diffusion tensor imaging meta-analysis.

The high comorbidity of major depressive disorder (MDD), anxiety disorders (ANX), and post-traumatic stress disorder (PTSD) complicates the study of their structural neural correlates, particularly in white matter (WM) alterations. Using fractional anisotropy (FA), this meta-analysis aimed to identify both unique and shared WM characteristics for these disorders by comparing them with healthy controls (HC). The aggregated sample size across studies includes 3,661 individuals diagnosed with MDD, ANX, or PTSD and 3,140 HC participants.

Trend of Chinese adolescent anxiety symptoms before and after COVID-19: A cross-temporal meta-analysis with segmented regression.

Adolescent anxiety symptoms are a global concern, and studying their trends and influencing factors in China is essential due to unique cultural and social dynamics impacting mental health. This study presents a cross-temporal meta-analysis of research employing the GAD-7 to assess anxiety symptoms among Chinese adolescents. Systematic searches were conducted across databases including CNKI, Wanfang, VIP, Web of Science, PubMed, Scopus, ProQuest, and Wiley, resulting in the inclusion of 66 articles (67 studies) spanning data collection from 2016 to 2023.

Lactiplantibacillus plantarum GUANKE Alleviates Intestinal Barrier Damage Caused by Influenza Infection in Mice.

Influenza, a highly transmissible acute respiratory illness caused by influenza viruses, is responsible for annual seasonal epidemics and poses a substantial global disease burden. While primarily recognized for its respiratory manifestations, influenza infection exhibits significant extrapulmonary effects, particularly through disrupting gut microbiota composition and compromising intestinal barrier integrity. This study investigates the protective efficacy of Lactiplantibacillus plantarum strain GUANKE against influenza-associated intestinal pathology in a murine model.

Internet-based acceptance and commitment therapy for bipolar disorder: A randomized controlled pilot trial.

Internet-based Acceptance and Commitment Therapy (iACT) offers a promising, scalable intervention format for individuals with bipolar disorder (BD), yet its feasibility and preliminary efficacy remain underexplored. This pilot randomized controlled trial evaluated the acceptability, feasibility, and initial efficacy of a 7-day self-guided iACT program delivered via a secure, mobile-responsive platform. Seventy individuals were screened, of whom 60 clinically stable adults with BD (aged 18-60) met eligibility criteria and were randomized to either the iACT group (n = 30) or an active control group receiving digital psychoeducation (n = 30), yielding a recruitment rate of 85.

Exploring emotion regulation in PTSD with Insomnia: A task-based fMRI study.

Background: Sleep disturbances and difficulties in emotion regulation are core symptoms of post-traumatic stress disorder (PTSD) and are closely related. However, the neural mechanisms underlying this relationship remain underexplored. To address this gap, we used task-based functional magnetic resonance imaging (fMRI) to examine brain mechanisms related to emotional processing and regulation in PTSD patients with and without insomnia.

Empathy training for counselling novices: A randomized controlled trial using machine learning and natural language processing.

Objective: Empathy is a critical skill for effective counselling, yet novice counsellors often struggle to develop it. Traditional training methods may not sufficiently address the complexities of empathic development. This study aims to develop and assess an empathy training programme using machine learning (ML) and natural language processing (NLP) to enhance empathy in novice counsellors.

Serum ferritin levels linked to cognitive decline and biomarker profiles in dementia with lewy bodies.

Objective: Elevated serum ferritin levels have been associated with neurodegenerative diseases, yet their specific role in dementia with Lewy bodies (DLB) remains insufficiently explored.

Method: A total of 434 participants were enrolled, including 217 controls, 217 Alzheimer's disease (AD) patients, and 89 DLB patients. Demographic and clinical characteristics, cognitive performance, and neurobehavioral symptoms were evaluated.

Evaluating antibiotic use patterns and compliance in Shanxi province hospitals: a 7-year retrospective study of national clinical improvement system data (2015-2021).

Objective: With the increasing prevalence of antimicrobial resistance (AMR), the rational use of antibiotics is crucial. This study aimed to evaluate the antibiotic use patterns and influencing factors of compliance in Shanxi Province Hospitals between 2015 and 2021 and provide data support for the management of antibiotics.

Design: This was a retrospective observational study of trends in antibiotic use and data reporting trends in the context of antimicrobial stewardship (AMS).

Evolution and Drivers of Online Social Support Among Adolescents and College Students: A Cross-Temporal Meta-Analytic Study.

Introduction: This cross-temporal meta-analysis examined 16-year trends (2006-2022) in online social support among Chinese adolescents and college students, aiming to address an underexplored area in developmental and longitudinal research.

Methods: Analyses included 86 studies conducted in mainland China (N = 66,059; 41.68% male; Mage = 18.

Family Resilience and Perceived Stress: A Three-Level Meta-Analysis.

Although numerous studies have observed a negative correlation between family resilience and perceived stress, the strength of this relationship has exhibited significant variability in previous research. This study aimed to elucidate the relationship between family resilience and perceived stress, investigating the moderating roles of various factors. Employing a three-level meta-analysis, the research scrutinized 23 selected studies involving 17,480 participants and 99 effect sizes, following a comprehensive literature search and screening.

Effects of ulinastatin on therapeutic outcomes and inflammatory markers in pediatric septic shock patients.

This study aims to investigate the effects of ulinastatin on therapeutic outcomes and inflammatory markers in children with septic shock. This study selected 117 children with septic shock admitted to our hospital from April 2023 to April 2024. Among them, 7 children had comorbidities, 3 dropped out during the research process, 5 did not continue to participate in the study due to other reasons, and 4 explicitly refused to participate.

Machine learning approaches for classifying major depressive disorder using biological and neuropsychological markers: A meta-analysis.

Traditional diagnostic methods for major depressive disorder (MDD), which rely on subjective assessments, may compromise diagnostic accuracy. In contrast, machine learning models have the potential to classify and diagnose MDD more effectively, reducing the risk of misdiagnosis associated with conventional methods. The aim of this meta-analysis is to evaluate the overall classification accuracy of machine learning models in MDD and examine the effects of machine learning algorithms, biomarkers, diagnostic comparison groups, validation procedures, and participant age on classification performance.

Genomic, Probiotic, and Functional Properties of RX2020 Isolated from Gut Microbiota.

Background/objectives: Gut microbiota is essential for maintaining host immune homeostasis and has been confirmed to be closely related to some intestinal and extraintestinal diseases. , as the dominant bacterial genus in the human gut, has attracted great attention due to its excellent metabolic activity, but there are few studies on species. In our previous study, a gut commensal strain, RX2020 (), was isolated from healthy human feces and exhibited superior flavonoid metabolic activity, prompting further analysis of its uncharacterized genomic features, probiotic potential, safety, and immunomodulatory activity.

Safety Assessment of GUANKE Based on Whole-Genome Sequencing, Phenotypic, and Anti-Inflammatory Capacity Analysis.

GUANKE ( GUANKE) is a Gram-positive bacterium isolated from the feces of healthy volunteers. Whole-genome sequencing analysis (WGS) revealed that the genome of GUANKE consists of one chromosome and two plasmids, with the chromosome harbors 2955 CDS, 66 tRNAs, and 5 rRNAs. The genome is devoid of virulence factors and Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.

The effect of social robot interventions on anxiety in children in clinical settings: a systematic review and meta-analysis.

Aims: Children in clinical settings are prone to anxiety due to developmental limitations, which hinders treatment progress. This systematic review and meta-analysis aimed to evaluate the efficacy of social robot interventions compared to routine care or alternative non-pharmacological strategies in reducing anxiety among children aged 4-12 years undergoing medical procedures in clinical settings, based on evidence from randomized controlled trials.

Methods: The review protocol was prospectively registered in PROSPERO.

Digital Psychological Interventions for Adults in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

This study evaluates the effect of digital psychological interventions on anxiety, depression, and stress symptoms in adults affected by the pandemic. A systematic search across five digital databases, from 1 January 2020 to 6 March 2024, identified 36 studies encompassing 8,662 participants. Compared with all control conditions, random-effects meta-analyses indicated that digital psychological interventions significantly reduced anxiety ( = -0.

Cerebral microbleeds: prevalence and relationship to clinical features in cognitive impairment with lewy body disease.

Background: The burden of cerebral microbleeds (CMBs) is greater in patients with dementia with Lewy bodies (DLB) than in those with Parkinson disease dementia (PDD), while few studies have been carried out in a large sample size, or focused on the prodromal stage. Thus, we investigated the clinical prevalence of CMBs and its relationship to clinical features in patients with DLB, PDD, mild cognitive impairment with Lewy bodies (MCI-LB) and Parkinson's disease with MCI (PD-MCI) in this study.

Methods: In this retrospective multicenter cohort study, the study population consisted of 486 patients with DLB, 262 cases with PDD, 74 cases with MCI-LB and 107 cases with PD-MCI from 22 memory clinics between January 2018 and June 2022 in China.

The associations between PTSD symptom clusters, insomnia, and depressive symptoms in Chinese adolescents with low and high levels of internet addiction: A cross-lagged network analysis.

Objective: The prevalence of COVID-19-related posttraumatic stress disorder (PTSD), depression, and insomnia remains high in Chinese adolescents. Existing research suggests strong links between them and the influence of internet addiction (IA) on their development. This study therefore examined a longitudinal network of these psychological symptoms and explored the influence of IA on them.

Preclinical Safety Assessment of the Oral Administration of Lactobacillus plantarum GUANKE in Animal Models.

Probiotics have a long history as fermented food or food supplements. The health benefits and safety profiles of probiotics are strain-specific and should be evaluated individually. The aim of this study was to assess the safety of the Lactobacillus plantarum GUANKE (GUANKE) strain by conducting pharmacological studies, oral toxicity assessments, and investigating the colonization and translocation of GUANKE in experimental animal models.

More Cyberbullying, Less Happiness, and More Injustice-Psychological Changes During the Pericyberbullying Period: Quantitative Study Based on Social Media Data.

Background: The phenomenon of cyberbullying is becoming increasingly severe, and many studies focus on the negative psychological impacts of cyberbullying survivors. However, current survey methods cannot provide direct and reliable evidence of the short-term psychological effects of cyberbullying survivors, as it is impractical to measure psychological changes before and after such an unpredictable event in a short period.

Objective: This study aims to explore the psychological impacts of cyberbullying on survivors during the pericyberbullying period, defined as the critical time frame surrounding the first cyberbullying incident, encompassing the psychological changes before, during, and after the event.

Efficacy of a process-based, Mobile-delivered personalized CBT for anxiety disorders: Study protocol for a randomized controlled trial.

Background: Internet-based Cognitive Behavioral Therapy (ICBT) is effective in treating anxiety disorders, yet there is room for improvement in treatment response and reduction in dropout rates. This study proposes a personalized, modular ICBT intervention that leverages the extended evolutionary meta-model to provide a dynamic and adaptive treatment approach, aiming to enhance usability and efficacy.

Methods: The trial will be conducted in two phases.

Abnormal network homogeneity in patients with bipolar disorder in attention network.

Bipolar disorder (BD) is a complex psychiatric condition marked by significant mood fluctuations that deeply affect quality of life. Understanding the neural mechanisms underlying BD is critical for improving diagnostic accuracy and developing more effective treatments. This study utilized resting-state functional magnetic resonance imaging (rs-fMRI) to investigate functional connectivity within the ventral and dorsal attention networks in 52 patients with BD and 51 healthy controls.