A family of homologous metal heteromaterials with chemically bonded metallic interface.

Heteromaterials made of two different components have been widely studied; their interfacial bonding is essential to control their properties. How to prepare a chemically bonded metallic interface remains elusive, despite its importance for structural and functional materials. Here we synthesized a family of homologous metal heteromaterials (HMHs) featuring chemically bonded metallic interfaces, which endow them with strong interfacial binding forces and metallic conductivity.

The development and validation of postpartum hemorrhage prediction models for pregnancies with placenta previa totalis based on coagulation function indexes: a retrospective cohort study.

Background: The objective of this study is to establish and validate models that can accurately predict postpartum hemorrhage (PPH) in women with placenta previa totalis prior to undertaking cesarean delivery.

Methods: A retrospective cohort study was conducted on 306 pregnancies with placenta previa totalis delivered between January 2011 and June 2022. The pregnancies were classified into two groups, PPH group and non-PPH group, based on bleeding volume and red blood cell transfusion.

Inherited thrombophilia in a Han Chinese family caused by prothrombin Ile441Met mutation.

Background: Inherited thrombophilia (IT) is a genetically determined predisposition to thromboembolic events. Beyond the well-known G20210A mutation, there has been limited research on other prothrombin mutations in the Chinese population.

Objectives: This study aimed to identify and characterize a novel prothrombin mutation in a Han Chinese family with IT.

Effects of reversing the light-dark cycle on growth performance and intestinal health in heat-stressed broilers.

Heat stress (HS) has severely restricted the growth and yield of poultry. Reversal light-dark cycles (RLD) are a low-cost and highly effective method to regulate circadian rhythms. However, current studies have not demonstrated whether this method can improve the intestinal injury induced by HS in broilers.

The Predictive Value of the Combination of Serum RBP4, ALP, IL-1β for Postoperative Recurrence of Intrahepatic Bile Duct Stones.

Objective: To investigate the predictive value of serum retinol-binding protein (RBP4), alkaline phosphatase (ALP), and interleukin (IL)-1β for postoperative recurrence of intrahepatic bile duct stones (IBDS).

Methods: This retrospective study included 320 patients with intrahepatic bile duct stones (IBDS) admitted to our hospital from May 2020 to May 2022, all of whom underwent laparoscopic choledocholithotomy combined with choledochoscopy. Patients were divided into a recurrence group and a non-recurrence group based on their postoperative status.

Optimal gestational weight gain in women with pregestational type 2 diabetes: a population-based cohort study in China.

Background: The global prevalence of pregestational type 2 diabetes mellitus (T2DM) has increased concurrently with increasing rates of overweight and obesity. Effective weight management during pregnancy is critically associated with maternal and neonatal outcomes. However, no universally accepted guidelines for gestational weight gain (GWG) in high-risk pregnancies with T2DM currently exist.

Machine learning-enhanced on-chip micro-ring resonator platform for detection and recognition of low-concentration gas mixtures.

Micro-ring resonator (MRR) platforms based on silicon-on-insulator substrates have shown great potential for gas detection applications. However, challenges such as weak signal intensity and insufficient selectivity remain in the detection of low-concentration mixed gases. To overcome these limitations, this study proposes a machine learning-enhanced silicon nitride-based micro-ring resonator chip for the detection and recognition of methane (CH), carbon dioxide (CO), and hydrogen sulfide (HS) gas mixtures.

LMNB1 and LMNB2 as Prognostic Risk Factors in Hepatocellular Carcinoma: Therapeutic Potential of GSK461364 via Downregulation of LMNB1 and LMNB2 Expression.

Introduction: This study aims to explore the potential of LMNB1 and LMNB2 as prognostic risk factors in hepatocellular carcinoma (HCC) and investigate small-molecule drugs targeting both for therapeutic application.

Methods: LMNB1 and LMNB2 expression in HCC was assessed using TCGA data and validated in clinical specimens. Kaplan-Meier and Cox models evaluated prognostic relevance.

Two-point lifting/retracting technology for transumbilical single-port laparoscopic cholecystectomy based on the anatomical features of Calot's triangle.

Background: Among the rapidly developing single-incision laparoscopic cholecystectomy (LC) techniques, transumbilical single-incision LC is increasingly replacing the traditional LC, with advantages of minimal invasion, slight postoperative pain, faster recovery. Despite the advantages mentioned above, the currently available specialized single-port laparoscopic instruments are hindered by high costs and limited applications, challenging their widespread use in medical facilities.

Aim: To design a two-point lifting/retracting (TPLR) technique for transumbilical single-port LC (TUSPLC) based on the anatomical features of the Calot's triangle (or cystohepatic triangle) and investigate its surgical feasibility.

Triple dimensional psychology knowledge encouraging graph attention networks to exploit aspect-based sentiment analysis.

As a fine-grained sentiment analysis subtask in the natural language processing (NLP) community, aspect-based sentiment analysis (ABSA) aims to predict the sentiment polarity of the aspect terms according to the given sentence. In previous research, external affective knowledge has been utilized to enhance the representation of the sentiment information contained in the text, which has achieved impressive progress in ABSA task. However, it is worth noting that the external knowledge employed is usually leveraged from the single-dimensional perspective, which lacks diversified and multiple-dimensional exploration and leads to insufficient comprehension of the complex sentiment information.

Two-dimensional robot-assisted physeal-sparing medial patellofemoral ligament reconstruction can achieve favourable clinical outcomes for skeletally immature patients with recurrent patellar dislocation.

Purpose: The surgical treatment of recurrent patellar dislocation (PRD) in adolescents faces particular difficulties, since the integrity of open growth plates may be compromised by standard surgical methods used in adults. This study aimed to review a series of adolescents with RPD who underwent robot-assisted physeal-sparing medial patellofemoral ligament (MPFL) reconstruction, compare the clinical results with those of a non-robot-assisted group, and measure the vertical distance between Schöttle point and the physis intraoperatively.

Methods: This retrospective clinical analysis included 55 adolescents with RPD who had no significant bone deformities and underwent MPFL reconstruction using either a robot-assisted technique or a non-robot-assisted method between February 2019 to November 2023.

Diagnosis-informed neuro-subtyping reveals subgroups of autism spectrum disorder with reliable and distinct functional connectivity profiles.

Background: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by heterogeneous symptoms and neurobiological features, which hinders the identification of reliable biomarkers. Until recently, ASD neuro-subtyping has emerged to detect neural features in each subgroup.

Methods: We implemented neuro-subtyping of ASD using a semi-supervised clustering method, HeterogeneitY through DiscRiminative Analysis (HYDRA), guided by the labeling information of ASD/controls, together with a multi-scale dimension reduction method of high-dimensional input features.

Pregnancy outcomes in patients with increased nuchal translucency using non-invasive prenatal testing and first trimester ultrasound.

Background: Increased nuchal translucency (NT) during first-trimester ultrasound (US1) is linked to genetic and congenital abnormalities. However, its relevance in the era of non-invasive prenatal testing (NIPT) remains debated, and data on pregnancy outcomes in cases of increased NT with normal NIPT results are limited. The purpose of this study was to investigate the correlation between NT thickness and perinatal outcomes considering the results of NIPT and the findings of US1.

High-frequency repetitive transcranial magnetic stimulation protects against 6-OHDA-induced Parkinson's disease symptoms by modulating the proNGF-p75NTR-sortilin pathway.

Background: High-frequency repetitive transcranial magnetic stimulation (HF rTMS) is a promising non-invasive treatment for Parkinson's disease (PD) in clinical settings. However, the precise mechanisms are incompletely understood. The proNGF-p75NTR-sortilin signaling pathway is closely associated with nigrostriatal dopaminergic (DA) neuron degeneration, a hallmark feature of PD.

Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells.

Background: In acute kidney injury (AKI), inflammatory crosstalk between tubular epithelial cells (TECs) and immune cells drives disease progression. Although the Axl-SOCS3 axis in myeloid cells typically suppresses inflammation, TEC-specific SOCS3 deletion paradoxically protects against AKI, suggesting a cell type-specific pro-inflammatory role.

Methods: We induced AKI via bilateral ischemia/reperfusion (IRI) in mice.

Associations between maternal glycemic level and lipid profile and adverse pregnancy outcomes in women with type 2 diabetes mellitus: a retrospective study from China.

Purpose: To investigate the associations between maternal glucose and lipid metabolism and adverse pregnancy outcomes in women with type 2 diabetes mellitus (T2DM).

Methods: A retrospective cohort of pregnant women with T2DM who delivered at Peking University First Hospital was included. Univariate and multivariate logistic regression were used to identify risk factors.

Soluble and pocket engineering of D-amino acid oxidase and its application in the biotransformation of L-glufosinate.

L-glufosinate (L-PPT) is a chiral herbicide with high herbicidal activity, environmental friendliness and significant market potential. The kinetic resolution of commercially available DL-PPT into optically pure L-PPT through four-enzyme one-pot biocatalysis presents a promising approach. D-amino acid oxidase (DAAO) catalyzes the conversion of D-PPT to 2-oxo-4-[(hydroxy)(methyl)phosphinyl] butyric acid (PPO), playing a critical role in the synthesis of L-PPT.

Robot-Assisted Individualized Medial Patellofemoral Ligament Reconstruction in Skeletally Immature Patients With Recurrent Patellar Dislocation: A Single-Center Retrospective Study.

Background: The surgical treatment of patellar instability in children and adolescents can be challenging, as successful surgical techniques used in adults may pose a risk to the open growth plate when applied in this younger population.

Purpose: To review a series of adolescent patients with recurrent patellar dislocation who underwent robot-assisted individualized medial patellofemoral ligament (MPFL) reconstruction.

Study Design: Case series; Level of evidence: 4.

Effect of Surface Hydrophobicity of Fluorescent Nanopolymer Microspheres on the Stability of CO Foam.

Nanopolymer microspheres have been widely studied in the development of low-permeability reservoirs as an effective material to improve foam stability. However, there are few studies on the foam stability mechanism of nanopolymer microspheres. In this work, the effect of surface hydrophobicity of fluorescent nanopolymer microspheres PARC(Flu-Ac) on the stability of CO foam was investigated by using foam performance as an evaluation index.

Thyrotrophin receptor antibody: objective and quantitative inflammatory indicator in patients with thyroid eye disease.

Context: Accurate assessment of the inflammatory status in thyroid eye disease (TED) is crucial for diagnosis and treatment; however, this assessment remains challenging.

Objectives: To study whether thyrotrophin receptor antibody (TRAb) can be utilized as a quantitative and objective indicator of the inflammatory status in patients with thyroid eye disease (TED).

Methods: We gathered and analyzed TRAb and clinical characteristics from 226 consecutive TED patients.

Analysis of brain network effective connectivity in juvenile myoclonic epilepsy.

Juvenile Myoclonic Epilepsy (JME) is a prevalent idiopathic generalized epilepsy whose neurophysiological mechanisms remain elusive. This study aims to elucidate the aberrant brain network patterns in JME through a multi-modal fMRI approach combining local consistency, functional connectivity, and causal interaction analysis. Resting-state fMRI data were acquired from 37 JME patients and 35 healthy controls.

Hydroxychloroquine for preventing hypertensive pregnancy disorders in recurrent spontaneous abortion: a retrospective cohort study in a single referral center.

Objective: We aimed to assess the effectiveness of hydroxychloroquine (HCQ) in preventing hypertensive pregnancy disorders (HPD) among women with recurrent spontaneous abortion (RSA).

Study Design: This retrospective cohort study included 462 pregnant women with RSA. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were used to balance baseline characteristics between HCQ and non-HCQ groups.

Harnessing multi‑omics to revolutionize understanding and management of osteosarcoma: A pathway to precision medicine (Review).

Osteosarcoma, the most prevalent primary bone malignancy in children and adolescents, poses significant challenges due to its aggressive nature and propensity for metastasis. Despite advances in treatment, survival rates for high‑risk patients remain unsatisfactory, underscoring the urgent need for innovative approaches. This review explores the vital role of multi‑omics‑integrating genomics, transcriptomics, proteomics and metabolomics‑in unraveling the complex biological landscapes of osteosarcoma.

Advanced lightweight deep learning vision framework for efficient pavement damage identification.

Pavement crack serves as a crucial indicator of road condition, directly associated with subsequent pavement deterioration. To address the demand for large-scale real-time pavement damage assessment, this study proposes a lightweight pavement damage detection model based on YOLOv5s (LPDD-YOLO). Initially, a lightweight feature extraction network, FasterNet, is adopted to reduce the number of parameters and computational complexity.

Surface-Modified Micro-Ring-Resonator Sensors for HMGB1 Detection on a Chip-Scale Platform.

High mobility group box 1 (HMGB1) is considered a pivotal mediator and biomarker in inflammatory diseases, garnering increasing attention for precise detection. Silicon on insulator (SOI) integrated waveguide biosensors have the advantages of high sensitivity, easy functionalization, and compatibility with CMOS technology, promising enhanced sensing of HMGB1. Here, we propose a chip-scale, cost-effective HMGB1 sensor device based on a micro-ring resonator (MRR), which is surface functionalized by a chemical bonding method.