Early hyperferritinemia in polytrauma: a biomarker of systemic inflammation and mortality risk in a multicenter cohort study.

Background: Severe polytrauma is one of the leading causes of death and disability worldwide. Hyperferritinemia is increasingly recognized as a biomarker of critical illness, yet its prognostic significance in polytrauma remains underexplored. This multicenter study investigates the temporal dynamics of serum ferritin in polytrauma patients and its association with systemic inflammation, organ dysfunction, and mortality.

Overexpressing neurogenic differentiation factor 1 in Müller cells improves retinal function after optic nerve crush injury in adult mice.

Optic nerve injury leads to axonal degeneration and the death of retinal ganglion cells, which ultimately causes vision loss. Notably, current treatments are limited. In the present study, we explored whether neurogenic differentiation factor 1 (NeuroD1 or ND1) overexpression in retinal Müller cells may repair the retina after optic nerve crush in mice.

Drought-Induced Coordination of Photosynthesis, Stomata, and Hydraulics in Maize Leaves Between Sensitive and Tolerant Varieties.

Identification of drought-tolerant maize varieties in the context of climate change is critical. Although many studies have reported that the coordination of stomatal and hydraulic conductance of plant leaves ensures the net photosynthetic rate, it is unclear whether the arrangement of these three parameters is consistent among maize varieties differing in drought tolerance. Therefore, in this study, gas exchange parameters, hydraulic properties, and stomatal structure of leaves from eight maize varieties under full and deficit irrigation (DI) were determined.

The Role of Fear of Negative Evaluation and Loneliness in Linking Insecure Attachment to Social Media Addiction: Evidence from Chinese University Students.

Background And Objectives: With the widespread integration of digital media into daily life, social media addiction (SMA) has become a growing concern for university students' mental health. Based on attachment theory, this study examined how attachment anxiety and avoidance influence SMA through fear of negative evaluation (FNE) and loneliness.

Methods: A sample of 400 Chinese university students completed the 16-item short version of the Experiences in Close Relationships Scale (ECR), the 8-item Brief Fear of Negative Evaluation Scale (BFNE), the 6-item Revised UCLA Loneliness Scale-Short Form (RULS-6), and the 6-item Bergen Social Media Addiction Scale (BSMAS).

Negatively Regulates Virulence via Enhancing Effector Expression and Suppressing Host Immune Responses.

The soil-borne fungal pathogen causes devastating vascular wilt disease in numerous crops, including cotton. In this study, we reveal that , a highly conserved sarcosine oxidase gene, is significantly upregulated during host infection and plays a multifaceted role in fungal physiology and pathogenicity. Functional deletion of leads to increased fungal virulence, accompanied by enhanced microsclerotia formation, elevated carbon source utilization, and pronounced upregulation of effector genes, including over 50 predicted secreted proteins genes.

TomoGRAF: An X-ray physics-driven generative radiance field framework for extremely sparse view CT reconstruction.

Objectives: Computed tomography (CT) provides high spatial-resolution visualization of 3D structures for various applications. Traditional analytical/iterative CT reconstruction algorithms require hundreds of angular samplings, a condition may not be met practically for physical and mechanical limitations. Sparse view CT reconstruction has been proposed using constrained optimization and machine learning methods with varying success, less so for ultra-sparse view reconstruction.

Evaluations of Community-based Healthcare Management for Patients with Chronic Viral Hepatitis - Shanghai Municipality, China, 2012-2023.

What Is Already Known About This Topic?: Current strategies for chronic viral hepatitis prevention and control include immunization, prevention of mother-to-child transmission, expanded testing, antiviral therapy, and national drug price negotiations. To advance high-quality, integrated prevention and treatment services, a decentralized service delivery approach may be beneficial.

What Is Added By This Report?: The chronic viral hepatitis community-based healthcare management program in Shanghai delivered comprehensive service packages across 4 categories encompassing 10 distinct interventions, including epidemiological investigation, health education, free testing, community dispensing services, and immunization to family caregivers.

Tailored Fe catalyst microenvironment for highly efficient syngas conversion to olefins with low CO emissions.

Achieving highly efficient syngas conversion to olefins on the Fe-based catalysts is promising, but remains a big challenge due to the twin coexistence of the Fischer-Tropsch to olefins (FTO) and water gas shift (WGS) reactions. Herein, we developed a strategy via regulating the microenvironment of Fe catalyst and controlling the diffusion behaviors of critical intermediates to successfully realize the syngas conversion to olefins with low CO emission. A Fe@C catalyst with Fe species encapsulated in porous carbon was fabricated and achieved high single-pass olefins yield (>30%) and low CO selectivity (around 20%) simultaneously, which has ranked the top among the ever-reported advanced oxide-zeolite, Co-based, and Fe-based catalysts.

HHAvatar: Gaussian Head Avatar with Dynamic Hairs.

Creating high-fidelity 3D head avatars has always been a research hotspot, but it remains a great challenge under lightweight sparse view setups. In this paper, we propose HHAvatar represented by controllable 3D Gaussians for high-fidelity head avatar with dynamic hair modeling. We first use 3D Gaussians to represent the appearance of the head, and then jointly optimize neutral 3D Gaussians and a fully learned MLP-based deformation field to capture complex expressions.

Resilience and professional identity among young healthcare workers in a Shanghai megahospital during COVID-19: a cross-sectional study.

Background: Public health crises such as the COVID-19 pandemic place immense psychological and professional pressure on healthcare workers, particularly those early in their careers. While much research has focused on burnout and stress, fewer studies have examined the role of professional identity and its organizational determinants among actively employed young healthcare professionals.

Methods: This cross-sectional study surveyed 326 young healthcare workers (≤40 years old) across clinical, research, and administrative roles in a megahospital in Shanghai, China.

Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse.

B cells are central drivers of central nervous system (CNS) autoimmune disorders, including multiple sclerosis (MS). Although the brain meninges normally maintain a stringently non-self-reactive B cell repertoire, how disruption of this local immune tolerance contributes to pathology remains unclear. Here, we demonstrated that autoreactive B cells at the brain border accelerated neuroinflammation by directly engaging encephalitogenic T cells.

Cultural translation of the constipation assessment a study on the reliability and validity of the Chinese version of the constipation severity index.

Background: Assessing the severity of constipation in patients is important for tailoring treatment plans and monitoring outcomes. However, validated assessment tools for constipation severity are limited in China.

Objective: This study aimed to evaluate the psychometric properties of the Chinese version of the Constipation Severity Index (CSI).

Precision prognostication in neuroblastomas via clinically validated E2F activity signatures.

Background: Neuroblastoma (NB) is the most common extracranial solid tumor in children, with high-risk NB (HR-NB) exhibiting dismal survival rates due to aggressive biology and therapy resistance. E2F transcription factors (E2Fs) are pivotal regulators of cell cycle progression and immune modulation, yet their prognostic and therapeutic implications in NB remain underexplored.

Methods: Using transcriptomic data from the GEO, TARGET, and E-MTAB-8248 cohorts, we identified E2F-associated molecular subtypes via consensus clustering.

OTUB1-SLC7A11 Axis Mediates 4-Octyl Itaconate Protection Against Acetaminophen-Induced Ferroptotic Liver Injury.

Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, plays a crucial role in acetaminophen (APAP)-induced hepatotoxicity. While 4-octyl itaconate (4-OI) demonstrates protective effects against APAP toxicity, its molecular mechanisms remain to be fully elucidated. Through an innovative integration of untargeted metabolomics and pathway analysis, we unveil a novel dual mechanism by which 4-OI prevents APAP-induced ferroptosis.

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour.

Specialized immune cells that reside in tissues orchestrate diverse biological functions by communicating with parenchymal cells. The contribution of the innate immune compartment in the meninges and the central nervous system (CNS) is well-characterized; however, whether cells of the adaptive immune system reside in the brain and are involved in maintaining homeostasis is unclear. Here we show that the subfornical organ (SFO) of the brain is a nucleus for parenchymal αβ T cells in the steady-state brain in both mice and humans.

RpS24 Is Required for Meiotic Divisions and Spermatid Differentiation During Drosophila Spermatogenesis.

In Drosophila, testes contain highly heterogeneous ribosome populations. Several ribosomal proteins (RPs) have been shown to play specific and distinct roles during different stages of spermatogenesis. However, the detailed functions and mechanisms of RPs in spermatogenesis remain unclear.

Factors influencing the anxiety and depression status in patients undergoing in vitro fertilization-embryo transfer assisted pregnancy.

Women undergoing in vitro fertilization-embryo transfer (IVF-ET) can suffer from anxiety and depression at various levels during the process. This study aimed to assess the anxiety and depression statuses (primary outcome) and influencing factors (secondary outcome) among patients undergoing IVF-ET. A 2019-2020 survey at Northwest Women's and Children's Hospital studied IVF-ET patients, evaluating anxiety and depression with GAD-7 and PHQ-9 alongside demographic data, using logistic regression for influencing factors.

Seasonal Variation in the Diversity of the Gut Microbiota of Short-Faced Moles Reveals the Associations of Climatic Factors on the Gut Microbiota of Subterranean Mammals.

The composition of animal gut microbiota is significantly affected by a variety of factors. Seasonal variation in environmental factors is believed to have a significant impact on the composition of mammalian gut microbiota. Therefore, studying the seasonal differences in gut microbiota diversity in wildlife is of great importance to explore their ecological adaptability.

Analysis of brain network effective connectivity in juvenile myoclonic epilepsy.

Juvenile Myoclonic Epilepsy (JME) is a prevalent idiopathic generalized epilepsy whose neurophysiological mechanisms remain elusive. This study aims to elucidate the aberrant brain network patterns in JME through a multi-modal fMRI approach combining local consistency, functional connectivity, and causal interaction analysis. Resting-state fMRI data were acquired from 37 JME patients and 35 healthy controls.

Study on the regulatory effects of Δ4-DES and LACS genes on the synthesis of LC-PUFAs, based on the transcriptome changes induced by fluridone in Aurantiochytrium limacinum OUC86.

In this study, fluridone was utilized to induce Aurantiochytrium limacinum OUC86 to identify the key genes involved in the synthesis of Long-chain Polyunsaturated Fatty Acids (LC-PUFAs). With the increase of fluridone concentration, the lipid content increased, the proportion of EPA was the highest under the treatment of 75 mg/L fluridone ethanol solution. Transcriptome sequencing analysis of A.

Cross-sectional and longitudinal trajectory analyses of sleep duration and frailty among middle-aged and older Chinese adults.

The relationship between sleep duration and frailty remains unclear, particularly regarding their bidirectional nature and temporal dynamics in the Chinese population. This study aimed to investigate the cross-sectional association, developmental trajectories, and interactions between sleep duration and frailty in Chinese middle-aged and older adults. Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), which included 12,942 participants for cross-sectional analysis and 11,192 participants for the longitudinal trajectory study.

Additive Effects of Multiple Global Change Drivers on Terrestrial Nitrogen Cycling Worldwide.

Global change has dramatically altered the Earth's biogeochemical cycles. However, the interactive effects of multiple global change factors (GCFs) on terrestrial nitrogen (N) cycling worldwide remain unclear, limiting the ability to predict how future global change will affect the global N cycle. We conducted a meta-analysis of 108 published articles to evaluate the main and interactive effects of elevated CO, N addition, warming, and altered precipitation on soil N pools (NH , NO , and organic N) and transformation rates (N mineralization, nitrification, and denitrification) across terrestrial ecosystems.

Exploring the mediating role of Charlson comorbidity index in the association between body mass index and depression in U.S. adults: NHANES 2007-2020.

Objective: The relationship among body mass index (BMI), Charlson comorbidity index (CCI), and depression forms a complex interplay that affects both physical and mental health. However, whether CCI mediates the association between BMI and depression remains unclear. In this study, we aimed to elucidate the mediating role of CCI in the relationship between BMI and depression.

Transperitoneal robotic-assisted versus laparoscopic partial nephrectomy for renal duplication: a comparative clinical analysis.

This retrospective study aimed to compare the efficacy and safety of robotic-assisted laparoscopic partial nephrectomy (RALPN) versus laparoscopic partial nephrectomy (LPN) in pediatric patients with renal duplication. Data from 105 pediatric patients who underwent surgery for renal duplication at the Department of Pediatric Surgery, Fujian Provincial Hospital, between January 2019 and March 2024 were reviewed. Patients were categorized into two groups based on surgical approach: RALPN and LPN.

Pseudomonas aeruginosa community-acquired pneumonia following soil ingestion: A case report.

Background: Pseudomonas aeruginosa (P. aeruginosa) is an uncommon etiological agent in community-acquired pneumonia (CAP), typically associated with nosocomial or healthcare-associated infections, particularly in patients with underlying structural lung abnormalities or immunosuppression. P.