Reading ability in children with intermittent exotropia and its association with binocular visual function and visual information processing capability.

Purpose: To evaluate children's reading performance with intermittent exotropia (IXT) and investigate possible associations among reading abnormalities, binocular visual function, and visual information processing.

Methods: This cross-sectional, case-control study involved 61 children with basic-type IXT and 40 healthy controls aged 7 to 13. Reading performance was assessed objectively using the Development Eye Movement (DEM) test and subjectively with the Dyslexia Checklist for Chinese Children (DCCC).

Correction to "Systematical Mutational Analysis of FRATtide against Osteoclast Differentiation by Alanine Scanning".

[This corrects the article DOI: 10.1021/acsmedchemlett.4c00127.

Development and external validation of a predictive model for lung metastases in kidney cancer based on clinical and laboratory features.

Background: Lung metastases (LMs) are common and clinically significant in kidney cancer, contributing to poor prognosis and limited treatment response. Early detection of patients at high risk for LMs is crucial for developing personalized treatment strategies.

Methods: This retrospective study included 2652 patients with kidney cancer, pathologically confirmed, from two medical centers between 2000 and 2020.

Environmental Variation Contributes to Head Phenotypes in Workers of (Hymenoptera: Formicidae).

Integrating color polymorphism with intra-species morphological traits offers substantial opportunities to study the eco-evolutionary mechanisms underlying local population responses to heterogeneous and dynamic environments. In this study, we examined the head phenotypic diversity and intraspecific morphological traits of (Mayr, 1866) workers across 22 sites in mainland China, ranging from 24°47' N to 47°51' N in latitude and 88°07' E to 126°43' E in longitude, covering an altitudinal range up to 1243 m. We classified the head phenotypes of these workers into four types and investigated environmental variables explaining the levels of polymorphism, quantified by the Shannon diversity index and head phenotype ratios.

Global spillover of land-derived microbes to Ocean hosts: Sources, transmission pathways, and one health threats.

Terrestrial pathogens are increasingly being detected in marine organisms, raising concerns about ecosystem sustainability, biodiversity loss, and threats to human health. Over the past two decades, reports of microbial contaminants crossing from land to sea have increased, suggesting shifts in pathogen ecology driven by environmental changes and human activities. Pathogens originating on land can spread, adapt, and persist in marine environments, infecting a wide range of hosts and potentially re-entering terrestrial environments.

Sepsis increases the risk of dementia in middle-aged and elderly adults: a large prospective cohort study.

Background & Aims: Sepsis is associated with dementia; however, there is little real-world evidence to study the long-term risk of sepsis for dementia. This study investigated the long-term risk of dementia after sepsis, combined with genetic data, to identify the effects of apolipoprotein E (APOE) on the relationship between sepsis and dementia and provide data support for the later management of sepsis.

Methods: This large-scale, prospective cohort study evaluated participants from the UK Biological Sample Bank.

Recent Advances in Targeted Protein Degradation Molecular Glues as Anticancer Drugs.

Molecular glues have emerged as a novel class of targeted protein degraders with broad potential in cancer therapy. By inducing proximity between E3 ubiquitin ligases and oncogenic proteins, these agents activate the ubiquitin-proteasome system to drive selective protein degradation. This review systematically explores the application strategies of molecular glues in the targeted degradation of cancer-related proteins located in different subcellular compartments: nuclear cancer proteins (Ikaros, Helios, Aiolos, B-cell lymphoma 6 protein, cyclin K, RNA binding motif protein 39) and cytoplasmic cancer proteins (β-catenin, casein kinase 1α, G1 to S phase transition factor 1).

cliCRISPR: crRNA-limited CRISPR/Cas12a system for multiplexed detection.

The CRISPR/Cas12a system is extensively employed for nucleic acid detection, where crRNA is typically administered in excess to quantify target levels. However, its non-specific trans-cleavage activity poses challenges for achieving multiplexed detection within a single-pot CRISPR/Cas12a assay. In this study, we introduce a crRNA-limited strategy for multiplexed detection based on the CRISPR/Cas12a system, termed cliCRISPR.

Predictive modeling of surgical outcomes in lumbar stenosis and degenerative scoliosis using 3D gait-based spine-pelvic compensation analysis.

Objective: To explore the clinical value of a surgical effect prediction model for patients with lumbar spinal canal stenosis and degenerative scoliosis (LSS-DS). The model is based on the spine-pelvis compensation state measured by a three-dimensional gait system.

Methods: A total of 215 patients with LSS-DS who underwent surgery from January 2022 to December 2024 were enrolled.

Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors.

Checkpoint blockade immunotherapy has emerged as a transformative approach in cancer treatment by activating tumor-infiltrating T cells. However, the efficacy of PD-L1 blockade is restricted in "cold" tumors, which are characterized by low immunogenicity, presenting a challenge to immunotherapy. This study introduces an innovative strategy, utilizing cathepsin-cleavable -(2-hydroxypropyl) methacrylamide (HPMA) polymer-assisted combined photodynamic therapy (PDT) and PD-L1 degradation for the first time, effectively treating T cell-deficient tumors.

A reagent-free, fouling-resistant electrochemical multifunctional peptide sensor for highly sensitive and rapid detection of Alzheimer's disease biomarkers.

β-amyloid (Aβ) aggregates are critical biomarkers for the early diagnosis of Alzheimer's disease (AD). Numerous studies have shown that blood-based detection of Aβ aggregates can achieve similar or higher diagnostic accuracy than clinical cerebrospinal fluid tests. In this study, a reagent-free, anti-fouling electrochemical sensor based on a peptide aptamer was developed.

Lightweight Class Incremental Semantic Segmentation Without Catastrophic Forgetting.

Class incremental semantic segmentation (CISS) aims to progressively segment newly introduced classes while preserving the memory of previously learned ones. Traditional CISS methods directly employ advanced semantic segmentation models (e.g.

Non-destructive in situ monitoring of photosynthetic quotient in open microalgae cultivation.

Photosynthetic quotient (PQ)-based feedback strategy is emerging as a promising approach for precise optimization the cultivation of microalgae. However, the absence of in situ and non-destructive monitoring methods remains a critical bottleneck in open systems. Here, an intermittent aeration (IA) cultivation mode was constructed for measuring PQ of Nannochloropsis oceanica.

Self-Assembled Molecular Glue Prodrug System for Enhanced Synergistic Tumor Therapy by Combining CDK12 Protein Degradation and Immunotherapy.

Molecular glue degraders have recently emerged as a promising strategy for targeting proteins previously considered undruggable. Among these, CR8 has demonstrated potent anticancer efficacy by effectively degrading cyclin-dependent kinase 12 and cyclin K. However, its clinical application is restricted by nonspecific toxicity to normal cells and tissues.

Differentiation of benign and malignant breast lesions by ultrasound localization microscopy.

Objective: We investigated the role of ultrasound localization microscopy (ULM) qualitative and quantitative parameters in distinguishing benign from malignant breast lesions.

Methods: The ULM qualitative and quantitative parameters of breast lesions were recorded. A receiver operating characteristic (ROC) curve was applied to assess the diagnostic performance of ULM.

A general "gas-liquid" synthesis strategy towards centimeter-scale two-dimensional non-layered semiconductors.

Two-dimensional (2D) non-layered semiconductors have attracted tremendous research interest due to their exotic structural and electronic properties compared with their layered counterparts. However, the lack of large-scale growth methods greatly hinders their application. In this work, we have proposed a gas-liquid heterogeneous reaction strategy to suppress the diffusion of the involved reactants, resulting in the anisotropic growth of centimeter-scale 2D non-layered CdS film at the gas-liquid interface.

Age-associated morphology and transcriptome analyses reveal functional transformation of Malpighian tubules of cicadas in response to development and niche shift.

Malpighian tubules (MTs) of insects are integral to osmoregulation, detoxification, immunity and stress responses. Cicadas experience an ecological transition from subterranean to aboveground during ontogeny. However, little is known about the morphological/functional differences related to MTs between their nymphal and adult stages and potential molecular mechanisms underlying the transition.

Value of CT-Based 3D Reconstruction in Analyzing Fracture Line Distribution in Postmenopausal Women with Osteoporotic Pelvic Fractures.

Objective: This study aimed to evaluate the application value of CT-based 3D reconstruction in analyzing the distribution of pelvic fracture lines and to identify key factors, that affect fracture patterns in postmenopausal women with osteoporotic pelvic fractures.

Methods: A total of 150 postmenopausal female patients with osteoporotic pelvic fractures who underwent CT scans in our radiology department from June 2022 to June 2023 were included. Subjects were divided into a normal group (n=60) and a pelvic fracture group (n=90).

ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP-Wnt pathway.

Human embryonic stem cells (hESCs) serve as an ideal cell source for generating hematopoietic stem cells (HSCs). In embryonic hematopoiesis, hemogenic endothelium has been identified as a source of HSCs, yet the regulatory mechanisms remain elusive. Here, through dynamic gene expression profiling analysis and verification, we find that ELTD1 expression parallels genes related to the specification of hemogenic endothelium progenitors (HEPs) from hESCs and is highly expressed in the HEPs.

Intervention of Bazi Bushen Capsule on Benign Prostatic Hyperplasia Concomitant with Erectile Dysfunction Induced by Testosterone Supplementation in Spontaneously Hypertensive Rats.

Objective: To explore the intrinsic relationship between benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) and evaluate the therapeutic effects of Bazi Bushen Capsule (BZBS).

Methods: A model of BPH concomitant with ED was established by using testosterone-supplemented spontaneously hypertensive rats (SHRs). Forty SHRs were divided into 4 groups based on the random number table (n=10 per group), including the model group (SHR+T), the BZBS low-dose group (SHR+T+BZ-low), the BZBS high-dose group (SHR+T+BZ-high), and the finasteride group (SHR+T+Fi).

Anomalous pH-Dependence of Ru for Hydrogen Electrochemistry.

The essence of the classic pH-dependent catalytic behavior of Pt toward hydrogen electrochemistry has been debated for decades. In stark contrast, Ru represents a unique exception by exhibiting intrinsically anomalous pH dependence among Pt-group metals, significantly challenging the universal validity of the existing mechanistic system derived from classic pH effects. To decode the chemical essence beneath the unique anomalous pH dependence, refined multidimensional structural characterizations and electrical transport spectroscopic studies reveal that the electron delocalization on Ru surface enables strong oxophilicity and unique pH-dependent coverage of OH*, essentially different from the H*-dominated Pt surface.

Radon escape effect on its progeny's activity in naturally occurring radionuclide decay series.

We performed theoretical research on radon escape effect on activity of its progenies in Th, Ra, U, and Ra decay series. Based on the research results, we predicted that radon escape does not affect activity of its progenies in Th and Ra series. However, radon escape does affect the activity of its progenies, except for Pb, Bi and Po, in U and Ra decay series.

Bazi Bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in SAMP8 mice.

Ethnopharmacological Relevance: Bazi Bushen Capsule (BZBS), a traditional Chinese medicine formulation composed of multiple bioactive herbal components, has been validated in multicenter randomized double-blind controlled trials for its potent anti-aging properties. Previous studies from our group have demonstrated that BZBS effectively restores gut microbiota homeostasis and attenuates the impairment of intestinal barrier function, thereby ameliorating age-related cognitive decline. However, the specific molecular mechanisms by which BZBS modulates key microbial-metabolite networks to delay brain aging remain poorly understood and warrant further investigation.

Snow Leopard habitat vulnerability assessment under climate change and connectivity corridor in Xinjiang Uygur autonomous region, China.

Climate change is recognized as one of the greatest challenges to global biodiversity. The endangered snow leopard (Panthera uncia), an apex predator in high-altitude mountain ecosystems, serves as an important indicator of ecological health. Understanding the impacts of climate change on snow leopard distribution patterns is essential for developing effective conservation strategies.

Climate Change and Human Pressure: Assessing the Vulnerability of Snow Leopard () Habitat Integrated With Prey Distribution on the Qinghai-Tibet Plateau.

Climate change is significantly altering the distribution of large carnivores and their primary prey species, with particular emphasis on the changing prey distribution in high-altitude regions. The Qinghai-Tibet Plateau, known for its rich biodiversity, is highly sensitive to climate change, affecting the habitats of snow leopards () and blue sheep (). Our study identified blue sheep as the primary prey of snow leopards through metagenomic analysis and used bioclimatic data and Land Use/Cover Change (LUCC) information to model habitat suitability under three climate scenarios (RCP 2.