Prenatal and Postnatal Ultrasonographic Characteristics of Immature Teratoma in the Gastric Wall: A Case Report.

Teratomas are germ cell tumors from three embryonic germ layers. Immature teratomas in the gastric wall are extremely rare. A 31-year-old pregnant woman underwent prenatal ultrasound at 36 weeks, revealing a fetal abdominal mass.

BRD4 acts as a transcriptional repressor of RhoB to inhibit terminal erythropoiesis.

Background: Terminal erythropoiesis is a complex multistep process involving coordination of gene transcription and dramatic nuclear condensation, which leads to the expulsion of nuclei to generate reticulocytes. However, we lack a comprehensive understanding of the key transcriptional and epigenetic regulators involved.

Methods: We used a high-throughput small molecule screen in primary CD34-derived human erythroblasts to identify targets that promoted terminal erythropoiesis, and further confirmed the phenotype in different differentiation systems by inhibitors and shRNAs of different BRD4 isoforms.

ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP-Wnt pathway.

Human embryonic stem cells (hESCs) serve as an ideal cell source for generating hematopoietic stem cells (HSCs). In embryonic hematopoiesis, hemogenic endothelium has been identified as a source of HSCs, yet the regulatory mechanisms remain elusive. Here, through dynamic gene expression profiling analysis and verification, we find that ELTD1 expression parallels genes related to the specification of hemogenic endothelium progenitors (HEPs) from hESCs and is highly expressed in the HEPs.

Evaluation on activity and efficacy of Bacillus thuringiensis var. israelensis and S-methoprene against the Asian tiger mosquito, Aedes albopictus (Diptera: Culicidae), in discarded tires.

The Asian tiger mosquito, Aedes albopictus Skuse (Diptera: Culicidae), is an important vector of various arboviruses. Effective control of mosquito vectors is essential to prevent the transmission of mosquito-borne diseases; however, sustainable larval control against this species has been notoriously difficult. To enhance effective larval control against Ae.

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts.

Premature senescent fibroblasts (PSFs) play an important role in regulating the fibrotic process after myocardial infarction (MI), but their effect on cardiac fibrosis remains unknown. Here, the investigation is aimed to determine whether PSFs contribute to cardiac fibrosis and the underlying mechanisms involved. It is observed that premature senescence of fibroblasts is strongly activated in the injured myocardium at 7 days after MI and identified that Kdm4a is located in PSFs by the analysis of scRNA-seq data and immunostaining staining.

Single Administration of AAV-mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2-Induced Lysosomal Dysfunction in Hair Cells.

Haploinsufficiency of the ATP6V1B2, a subunit of V-ATPases, underlies genetic disorders including Dominant deafness-onychodystrophy (DDOD), deafness, onychodystrophy, osteodystrophy, mental retardation and seizures (DOORS), and Zimmermann-Laband syndromes, all characterized by congenital hearing loss and onychodystrophy. Effective therapies for ATP6V1B2-associated hearing loss remain elusive. The study generates a hair cell-specific knockout mouse (Atp6v1b2;Atoh1) recapitulating the human phenotypes, with pathological features including hair cell loss and abnormal lysosomal morphology and function.

Clinical characteristics and outcomes of BCMA-targeted CAR-T cell recipients with COVID-19 during the Omicron wave: a retrospective study.

Patients with relapsed or refractory multiple myeloma (R/R-MM) are more susceptible to develop severe coronavirus disease 2019 (COVID-19) for their immunocompromised states. Despite good responses to B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cell therapy, deficiencies in humoral immunity following CAR-T cell infusions can still cause life-threatening complications in these patients. We conducted a comparative study to delineate the clinical characteristics and outcomes between recipients of BCMA-targeted CAR-T cell therapy who contracted COVID-19 vs.

Taming Pancreatic Cancer: Kurz-Derived 4-Hydroxy-2-Methoxy-6-Tridecylphenyl Acetate as a Potent Tubulin Polymerization Inhibitor for Targeted Pancreatic Ductal Adenocarcinoma Therapy.

Pancreatic ductal adenocarcinoma (PDAC) is a major global health challenge owing to late diagnosis and inherently metastatic nature. Although surgical intervention offers a potential remedy, only few patients are eligible, and drug resistance further complicates treatment. The therapeutic limitations have catalyzed a search for alternative treatments, particularly natural products.

Error Characteristic Analysis and Filtering Algorithm for GNSS Time-Series Data.

Under regional environmental conditions such as open-pit mines and construction sites, there are usually fixed GNSS measurement points. Around these fixed stations, there are also mobile GNSS measurement modules. These mobile measurement modules offer advantages such as low power consumption, low cost, and large data volume.

Successful Treatment of Large Left Ventricular Thrombosis During Extracorporeal Membrane Oxygenation (ECMO): A Case Report and Review of the Literature.

We report a rare complication of left ventricular giant thrombus in a patient with fulminant myocarditis after venoarterial extracorporeal membrane oxygenation therapy. This case report offers simple anticoagulant treatment experiences to eliminate significant LV thrombosis in patient undergoing extracorporeal membrane oxygenation, so that patients do not need surgery.

Association of Methylenetetrahydrofolate Reductase Gene rs1801133 Polymorphism and Controlling Nutritional Status (CONUT) Score with Colorectal Cancer Susceptibility.

Background: Susceptibility to some cancers is linked to methylenetetrahydrofolate reductase () polymorphisms and the Controlling Nutritional Status (CONUT) score in some populations. However, their relationship with susceptibility to colorectal cancer (CRC) susceptibility in the Hakka Chinese population remains unclear.

Methods: In total, 620 CRC patients and 734 controls were enrolled.

An Investigation of Extended-Dimension Embedded CKF-SLAM Based on the Akaike Information Criterion.

Simultaneous localization and mapping (SLAM) faces significant challenges due to high computational costs, low accuracy, and instability, which are particularly problematic because SLAM systems often operate in real-time environments where timely and precise state estimation is crucial. High computational costs can lead to delays, low accuracy can result in incorrect mapping and localization, and instability can make the entire system unreliable, especially in dynamic or complex environments. As the state-space dimension increases, the filtering error of the standard cubature Kalman filter (CKF) grows, leading to difficulties in multiplicative noise propagation and instability in state estimation results.

Hypoxia Microenvironment Preconditioning Attenuated Myocardial Ischemia-Reperfusion Injury via Stc1-Mediating Cardiomyocyte Self-Protection and Neutrophil Polarization.

Ischemic preconditioning (IPC) therapy application to attenuate myocardial ischemia-reperfusion (MI/R) injury in clinical practice remains challenging. The secretome, derived from hypoxia-preconditioned cardiomyocytes (SHPC), potentially mimics the IPC microenvironment and facilitates IPC clinical translation. This study aims to determine whether SHPC can be a feasible alternative to IPC for attenuating MI/R injury, and to identify the functional factor of SHPC.

Chimeric antigen receptor-T cell therapy for T cell-derived hematological malignancies.

Relapsed/refractory T cell-derived malignancies present with high heterogeneity and poor prognoses. Recently, chimeric antigen receptor (CAR)-T cell therapy has shown remarkable safety and efficacy in the treatment of B cell-derived malignancies. However, the treatment of CAR-T cells in T cell-derived malignancies has more limitations, such as fratricide, T cell aplasia, and tumor contamination, mainly because of the similarity between normal and malignant T cells.

RNA-Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post-Transcriptional Manner.

Stimulating cardiomyocyte (CM) dedifferentiation and cell cycle activity (DACCA) is essential for triggering daughter CM formation. In addition to transcriptional processes, RNA-binding proteins (RBPs) are emerging as crucial post-transcriptional players in regulating CM DACCA. However, whether post-transcriptional regulation of CM DACCA by RBPs could effectively trigger daughter CM formation remains unknown.

Enhancing HIV/STI decision-making: challenges and opportunities in leveraging predictive models for individuals, healthcare providers, and policymakers.

The prevention and control of human immunodeficiency virus and sexually transmitted infections (HIV/STI) face challenges worldwide, especially in China. Prediction tools, which analyze medical data and information to make future predictions, were once mainly used in HIV/STI research to help make diagnostic or prognostic decisions, has have now extended to the public as a freely accessible tool. This article provides an overview of the different roles of prediction tools in preventing and controlling HIV/STI from the perspectives of individuals, healthcare providers, and policymakers.

Genomic and phenotypic landscapes of X-linked hereditary hearing loss in the Chinese population.

Background: Hearing loss (HL) is the most common sensory birth deficit worldwide, with causative variants in more than 150 genes. However, the etiological contribution and clinical manifestations of X-linked inheritance in HL remain unclear within the Chinese HL population. In this study, we focused on X-linked hereditary HL and aimed to assess its contribution to hereditary HL and identify the genotype-phenotype relationship.

Association of Oral Microbiome Diversity and All-Cause Mortality in the General US Population and in Individuals With Chronic Diseases: A Prospective Cohort Study.

Aim: To investigate whether oral microbiome diversity is associated with all-cause mortality in the general US population and in individuals with chronic diseases.

Materials And Methods: We included 8224 individuals with oral microbiome diversity data from the National Health and Nutrition Examination Survey (2009-2012), representing 164,000,205 US adults, using a survey-weighted analysis method. Cox regression analyses were performed to identify the association between oral microbiome diversity and all-cause mortality.

Establishment of a humanized mouse model using steady-state peripheral blood-derived hematopoietic stem and progenitor cells facilitates screening of cancer-targeted T-cell repertoires.

Background: Cancer-targeted T-cell receptor T (TCR-T) cells hold promise in treating cancers such as hematological malignancies and breast cancers. However, approaches to obtain cancer-reactive TCR-T cells have been unsuccessful.

Methods: Here, we developed a novel strategy to screen for cancer-targeted TCR-T cells using a special humanized mouse model with person-specific immune fingerprints.

Using empirical dynamic modeling to identify the impact of meteorological factors on hemorrhagic fever with renal syndrome in Weifang, Northeastern China, from 2011 to 2020.

Background: Hemorrhagic Fever with Renal Syndrome (HFRS) continues to pose a significant public health threat to the well-being of the population. Given that the spread of HFRS is susceptible to meteorological factors, we aim to probe into the meteorological drivers of HFRS. Thus, novel techniques that can discern time-delayed non-linear relationships from nonlinear dynamical systems are compulsory.

A Study on Dimensionality Reduction and Parameters for Hyperspectral Imagery Based on Manifold Learning.

With the rapid advancement of remote-sensing technology, the spectral information obtained from hyperspectral remote-sensing imagery has become increasingly rich, facilitating detailed spectral analysis of Earth's surface objects. However, the abundance of spectral information presents certain challenges for data processing, such as the "curse of dimensionality" leading to the "Hughes phenomenon", "strong correlation" due to high resolution, and "nonlinear characteristics" caused by varying surface reflectances. Consequently, dimensionality reduction of hyperspectral data emerges as a critical task.

Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation.

Background: Erythroid and myeloid differentiation disorders are commonly occurred in leukemia. Given that the relationship between erythroid and myeloid lineages is still unclear. To find the co-regulators in erythroid and myeloid differentiation might help to find new target for therapy of myeloid leukemia.

Point Cloud Denoising and Feature Preservation: An Adaptive Kernel Approach Based on Local Density and Global Statistics.

Noise removal is a critical stage in the preprocessing of point clouds, exerting a significant impact on subsequent processes such as point cloud classification, segmentation, feature extraction, and 3D reconstruction. The exploration of methods capable of adapting to and effectively handling the noise in point clouds from real-world outdoor scenes remains an open and practically significant issue. Addressing this issue, this study proposes an adaptive kernel approach based on local density and global statistics (AKA-LDGS).